Lc-nmr

The book is designed as a reference for chemists, NMR spectroscopists, chromatographers, students, and research professionals who are engaged in the isolation and NMR spectral characterization of complex organic molecules. The content guides the reader through the process of selecting the appropriate experiments and isolation systems while providing a foundation of basic theory and spectral interpretation. It discusses new and robust technologies that expand the limits of detection in NMR spectroscopy and includes examples of applications relevant to problems in pharmaceutical development.

Nina C. Gonnella, Ph.D., is a senior research fellow at Boehringer Ingelheim. She heads the NMR group (consisting of solution, solid-state, and LC-NMR capability) and shares co-responsibility for the single-crystal x-ray facility. She also manages the open-access NMR facility for all of the chemical development, providing training and application support. At Boehringer Ingelheim, Nina has been the lead scientist in establishing a solid-state NMR Center of Expertise. She promoted high technology standards of excellence to achieve state-of-the-art performance in integrating LC-NMR and microcryo-NMR technology to address unmet needs in the elucidation of degradation products and drug substance impurities. Her work involves characterization of compounds using solution and solid-state NMR and single-crystal x-ray as well as using hyphenated LC-NMR technologies to determine structures of low-level isolates.