Lipids, Lipoproteins, and Drugs

The First International Symposium on Drugs Affecting Lipid Metabolism was held in Milan in 1960. In the succeeding symposia, as in the first, new data and new ideas emerged which stimulated further research in the field. The present volume comprises the proceedings of the Fifth Symposium. In the area of lipoproteins, we have progressed from descriptions of their chemistry to dis- cus sion of their physiology and of their control of cholesterol metabolism at the cellular level. Workshop sessions explored thrombosis as affected by drugs, risk factors other than diet, animal models for atherosclerosis research and the organization of lipid clinics and clinical trials. All these topics represent advances in knowledge over the last decade. In the area of drugs a number of new compounds were introduced, many of them offer- ing new structural concepts for hypocholesteremic activity. We expect that the next Symposium will offer as many new hypotheses and avenues of approach as did this one. We gratefully acknowledge the assistance of Dr. Sergio Gorini and the Lorenzini Foundation and the contributions of Drs. Cesare Sirtori and Remo Fumagalli all of which helped to assure the success of this Symposium. We also wish to thank Miss Jane T. Kolimaga for her assistance in the preparation of this volume. David Kritchevsky Rodol￡o Paoletti William L. Holme s vii CONTENTS Opening Remarks. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 W. L. Holmes CHEMISTRY AND PHYSIOLOGY OF LIPOPROTEINS The Interaction of Apolipoprotein-Alanine (ApoC-III) with Lipids: Study of Structural Features Required for Binding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .