Polymer Nanoparticles for Nanomedicines ― A Guide for Their Design, Preparation and Development

This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to embark on a project in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book will also discuss the translation of technology from research to practice, considering aspects related to industrialization of preparation, and aspects of regulatory and clinical development.

Christine Vauthier is Director of Research at the Centre National de la Recherche Scientifique (CNRS). She received her Ph.D. in polymer chemistry from the?Louis Pasteur?University at Strasbourg, France. She joined the University of Paris South, Faculty of Pharmacy as a research assistant. She has been a visiting scientist at the Center for Chemical Controlled Delivery, University of Utah, USA and at the Federal University of Pernambuco, Recife, Brazil. Currently, she is at the Institut Galien Paris Sud, UMR CNRS 8612, Universite Paris Sud. Her research concentrates on the interface between the physico-chemistry of polymer colloids and the conception of nanomedicines for mucosal and intravenous administration of drugs including antisense oligonucleotides and siRNA. Starting with the characterization of polymer nanoparticles, her main interest is the understanding of the interactions of nanomedicines with biological systems. Dr. Vauthier is an author and coauthor of more than 100 research papers and more than 20 review papers and book chapters on nanoparticle preparation and characterization methods and the application of nanoparticles as drug delivery systems. She has presented more than 100 communications at invited conferences. She serves as an editor for Pharmaceutical Research.