Hybrid Modeling in Process Industries

This title introduces the underlying theory and demonstrates practical applications in different process industries using hybrid modeling. The fundamental part covers questions on “How to develop a hybrid model?”, “How to represent and identify unknown parts?”, “How to enhance the model quality by design of experiments?” and “How to compare different hybrid models?” together with tips and good practices for the efficient development of high quality hybrid models. The application part covers the utilization of hybrid modeling for typical process operation and design applications in industries such as chemical, petrochemical, biochemical, food and pharmaceutical process engineering.

Jarka Glassey currently works as a Reader at the School of Chemical Engineering and Advanced Materials, Newcastle University, UK. She gained her academic qualifications in chemical engineering at the STU Bratislava, Slovakia and PhD in biochemical process modelling at Newcastle University, UK. She is a Chartered Engineer, Fellow of the Institution of Chemical Engineers (IChemE) and currently serves on the IChemE Council. She is the Executive Vice President of the European Society of Biochemical Engineering Sciences (ESBES) and she also currently chairs the Modelling, Monitoring, Measurement & Control (M3C) Section of ESBES. Her research interests are particularly in the area of bioprocess modelling, monitoring, whole process development and optimization. She published extensively in this area and over the years collaborated with a wide range of industrial partners in real-life bioprocess development and modelling applications.

Moritz von Stosch works as a postdoc-researcher at the Systems Biology and Engineering group, University Nova de Lisboa and he also is the team-leader of HybPAT, a spin-off initiative with the aim to provide Hybrid modeling solutions for an efficient implementation of PAT. In 2011 he earned his PhD at the Faculty of Engineering of the University of Porto. He was awarded his Diploma in Engineering from the RWTH-Aachen University in Germany. Moritz von Stosch is a leading expert on hybrid modelling methods and their application to bioprocess problems. He is, for instance, 1st author of six publications on hybrid modeling and co-author of several others. In the last year, he co-organized an expert meeting on "Hybrid modeling for QbD and PAT in biopharma",which was integrated into the ESBES M3C panel series and he also co-organized the 1st Hybrid modeling summer school. Just recently, upon invitation he gave a talk on "Hybrid modeling for QbD and PAT in bioprocess optimization" at the ISPE Nordic Biotechnology conference at Copenhagen, Denmark.

.