TOP
英國出版界指標大獎肯定!A.F. Steadman 獲年度作家,《史坎德》系列帶你踏上熱血奇幻旅程
Handbook of Analysis of Oligonucleotides and Related Products
90折

Handbook of Analysis of Oligonucleotides and Related Products

商品資訊

定價
:NT$ 3913 元
優惠價
903522
無庫存,下單後進貨(到貨天數約30-45天)
下單可得紅利積點 :105 點
商品簡介

商品簡介

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use.

Topics discussed include:

  • Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing
  • Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE
  • Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography
  • Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm)
  • Approaches for the accurate determination of molar extinction coefficient of oligonucleotides
  • Accurate determination of assay values
  • Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals
  • Strategies for determining the chemical stability of oligonucleotides
  • The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development
  • Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics

This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

購物須知

外文書商品之書封,為出版社提供之樣本。實際出貨商品,以出版社所提供之現有版本為主。部份書籍,因出版社供應狀況特殊,匯率將依實際狀況做調整。

無庫存之商品,在您完成訂單程序之後,將以空運的方式為你下單調貨。為了縮短等待的時間,建議您將外文書與其他商品分開下單,以獲得最快的取貨速度,平均調貨時間為1~2個月。

為了保護您的權益,「三民網路書店」提供會員七日商品鑑賞期(收到商品為起始日)。

若要辦理退貨,請在商品鑑賞期內寄回,且商品必須是全新狀態與完整包裝(商品、附件、發票、隨貨贈品等)否則恕不接受退貨。

優惠價:90 3522
無庫存,下單後進貨
(到貨天數約30-45天)

暢銷榜

客服中心

收藏

會員專區