Phosphodiesterase-4(PDE4), an important component of the cyclic adenosine
monophosphate (cAMP) cascade, selectively metabolizes cAMP in the brain to the
inactive monophosphate. Their inhibitors may offer novel strategies in the treatment of
depression. However, its development as antidepressant drugs has been encumbered
by their side effects profile of non-selective PDE inhibitors like nausea, emesis,
gastrointestinal side-effects, and vascular toxicity. These side-effects can be minimized
by specifically targeting isozymes in the particular tissue or the cell of interest. So, we
were interested in developing novel, PDE4 inhibitors with better isozyme selectivity and
further explore their potential as anti-depressant and anxiolytics.
The novel pharmacophoric requirements derived from nitraquazone and its related
compounds as potential PDE4 inhibitors that include key elements: a) a planar scaffold
providing a HBA and b) two hydrophobic substituent's with their corresponding linker
(1 and 2). On the basis of the proposed pharmacophore, six different series of N4
substituted quinoxaline based carboxamides with variations on linker-1 and/or
unsubstituted/substituted hydrophobe, and while two series of N3 substituted quinazoline
based carboxamides which are positional isomer of quinoxaline-carboxamides were
designed as per the pharmacophoric requirements as novel PDE4 inhibitors.
外文書商品之書封，為出版社提供之樣本。實際出貨商品，以出版社所提供之現有版本為主。部份書籍，因出版社供應狀況特殊，匯率將依實際狀況做調整。
無庫存之商品，在您完成訂單程序之後，將以空運的方式為你下單調貨。為了縮短等待的時間，建議您將外文書與其他商品分開下單，以獲得最快的取貨速度，平均調貨時間為1~2個月。
為了保護您的權益，「三民網路書店」提供會員七日商品鑑賞期(收到商品為起始日)。
若要辦理退貨，請在商品鑑賞期內寄回，且商品必須是全新狀態與完整包裝(商品、附件、發票、隨貨贈品等)否則恕不接受退貨。
