This volume, p53, was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical gene
The second edition of p53 Protocols expands upon the first edition with progress in p53 research since the publication of the first edition. In p53 Protocols, Second Edition expert researchers in the
This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into
The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology. This book provides insights into the progress of the p53 field and the prosp
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the fie
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with
p53 is a critical tumor suppressor protein that controls cell division and is often mutated in cancer. This volume examines the structure and function of the p53 protein, its regulation of DNA repair,
All of us have lurking in our DNA a most remarkable gene. Its job is straightforward – to protect us from cancer. This gene – known simply as p53 – constantly scans our cells to ensure that they grow
All of us have lurking in our DNA a most remarkable gene, which has a crucial job - it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and d
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays
