p53

The second edition of p53 Protocols expands upon the first edition with progress in p53 research since the publication of the first edition. In p53 Protocols, Second Edition expert researchers in the

This volume, p53, was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical gene

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into

The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology. This book provides insights into the progress of the p53 field and the prosp

p53 is a critical tumor suppressor protein that controls cell division and is often mutated in cancer. This volume examines the structure and function of the p53 protein, its regulation of DNA repair,

All of us have lurking in our DNA a most remarkable gene, which has a crucial job - it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and d

All of us have lurking in our DNA a most remarkable gene. Its job is straightforward – to protect us from cancer. This gene – known simply as p53 – constantly scans our cells to ensure that they grow

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the fie

The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with

從西方科學之初起，時間就是一個挑戰性的的題目。與牛頓物理之革命不可分，它也是Boltzmann之成就之靈感泉源。...

This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays

依考選部命題大綱編著榮獲考選部指定國家考試參考用書關於本套書◎本套書內容齊全、範圍廣闊，收錄最新醫學與護理知識、最新時事與切合臨床情境的護理準則，是一套能提供護理科系學生及臨床護理人員專業知識的學習良伴。特色如下：‧依考選部最新護理師國考命題大綱及現今臨床情況編著，為國家考試參考用書，歷屆國考題目重點特以黑體標示。‧在全書一開始即特闢專章介紹何謂「概念圖」，及概念圖在護理上的運用，並附實例供讀者參考。‧專欄 "INFO" 收錄最新醫學與護理知識，提供相關時事及臨床消息；"NOTE" 提醒重要護理與治療注意事項。‧章末另闢「護理計畫表」及「情境模擬案例研討」之內容，透過具體案例，協助讀者將每章重點做統整、分析與運用。本版特色‧消化、呼吸兩大章國考重點章節以全彩呈現，便於識別、學習與思考。‧精繪各章插圖，並依臨床現況新增多幅圖片、照片，使學習內容更具體清晰。各章新增內容‧與健康照護有關的社會心理概念與護理：壓力評估、焦慮評估等。‧免疫功能疾病：HIV RNA檢測、HIV垂直傳染預防、台灣愛滋病學會2020年《愛滋病檢驗及治療指引》、EULAR/ACR 2019 SLE診斷標準、抗磷脂質症候群（APS）、DMARDs。‧癌症：致癌／抑癌基因異常（p53）、TNM分期系統種類、雷射手術、腹腔高壓氣霧化學療法（PIPAC）、uracil-tegafur（UFT）、酪胺酸激酶接受器抑制劑（TKR inhibitors）、化療引起的周邊神經病變護理、《癌症疼痛之藥物治療指引》止痛二階梯等。‧傳染病：TOCC、嚴重特殊傳染性肺炎（COVID-19）、猴痘等。‧危急病人：失血量分級、快速依序器官衰竭評分（qSOFA）、連續器官功能衰竭評估計分（SOFA）、2021敗血症及敗血性休克治療指引、中毒處理原則等。‧消化系統：頰黏膜癌、高解析度食道壓力檢查、漸進式吞嚥困難、胃癌雙向化學治療、原發性／續發性腹膜炎、吸收不良症候群、結腸直腸癌分期、肛門瘻管、各類型黃疸比較、B肝口服抗病毒藥、C肝DAA藥物、代償性／代償不全的肝硬化臨床表徵、自發性細菌性腹膜炎、PIVKA-Ⅱ等。‧內分泌系統：口腔灼熱症候群、teprotumumab（Tepezza®）、葛瑞夫茲氏眼睛病變治療、庫欣氏症候群診斷流程更新、2022年第2型糖尿病高血糖處理流程、美國糖尿病學會2021年HbA1c控制標準、糖尿病視網膜病

《抑癌基因》一書講述了發現這個基因的故事，並闡述了人體細胞癌變奧秘的核心。《抑癌基因》不是乾巴巴地引用基因教材，而是結合實例，選取真實的案例，為讀者介紹癌症基因的發生、發展與防治。p53的突變極易造成癌變在家族中遺傳，本書不僅限於實驗室，而是帶領讀者進入到更廣闊的世界，去研究岡比亞的發黴花生與肝癌的關係，去巴西南部與遺傳性癌症的家庭見面，去更多的國家——從中國到伊朗，在人類的日常生活中洞察p53的

Michael D. WendtProtein-Protein Interactions as Drug TargetsShaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev KumarTargeting the MDM2-p53 Protein-Protein Interaction for New Cance

本書的目標是讓學生能於最短時間內獲得重要的分子生物學知識。本書係作重點整理，並強調各章節的相互關聯，使學生對分子生物學有一個全盤性、整體性的概念。分子生物學的進展日新月異，例如組織蛋白乙醯化在基因轉錄所扮演的角色、「基因守護者」p53的調控機轉等。這些新發現在本書皆有詳細的介紹，本書亦引導學生搜尋與分子生物學相關的網路資訊。