Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Who says cats and dogs don't get along? A snobby cat and a good-natured dog team up--sort of--to solve the mystery of a missing classroom pet in this playful illustrated chapter book told in letters. Simon the cat and Baxter the dog have finally learned how to share their owner, Andy. It helps that Simon lives with Andy's mom and Baxter lives with Andy's dad. When a problem comes up, they simply exchange letters to sort it out. Baxter's spelling has even improved . . . though not by much. But then Andy's class pet goes missing, which causes an argument with his friend Noah. Andy is so, so sad. Both Simon and Baxter want to solve the mystery and make Andy happy again. Which pet will collect the clues and piece together the solution? This funny and heartwarming collaboration between Geisel Honor and Edgar Award-winning author Dori Hillestad Butler and bestselling illustrator Kevan Atteberry is a tribute to the love of a good pet and the joy found in new friendship. With eight chapters an

In the second book of this easy-to-read graphic novel series from an award-winning creator, four funny animal friends and their wacky adventures "will inspire young readers to write and draw their own stories" (Dav Pilkey).Baloney and friends will have newly independent readers giggling their way through more day-to-day adventures in the second book of this pitch-perfect graphic novel series. Whether it's writing the lyrics to their own original theme song, having an epic sleepover in a tent, experimenting with an incredible new device that lets them reach for the sky, or thinking deep (or deeply funny) thoughts about the world around them, this new collection of three tales and mini-comics will have you cheering and rooting for Baloney the pig, Bizz the bumblebee, Peanut the horse, and everyone's favorite grumpy rabbit, Krabbit! And at the end, readers will learn to draw each character with different facial expressions and emotions by following clear step-by-step instructions."A sure

新來的冰熊好兇！牠大聲宣布自己是國王，還不聽大家說話。兔子不知所措，熊也不確定該怎麼辦——難道要找狼來幫忙？Gorgeously illustrated and with a classic feel, this is a brilliantly funny story of a rabbit and a bear ... and how to defeat an icebear who wants to be king. Ideal for readers moving on from picture books.'A perfect animal double-act.' The Times, Book of the Week Icebear has arrived in Rabbit and Bear's valley, and he wants to be king. He's big and scary, and the more kind and understanding the animals are, the meaner he becomes. Rabbit is confused: Bear has always been able to fix their problems in the past - but maybe this time he needs to ask for help from someone else.Does Wolf have the answer to the bad king's demands ... or will Rabbit and the other animals find the solution within themselves? From novelist and playwright Julian Gough, and the winner of the Roald Dahl Funny Prize, Jim Field, this is a story of friends, enemies, and how to avoid being pooped on by an icebear. 'Rabbit's Bad Habits is a breath of fresh air in c

The enjoyable and accessible activities in this workbook help children develop dividing skills. Friendly animal characters illustrated by talented Italian artist Elisa Paganelli gently guide children

Calling all Raina Telgemeier fans! It’s back to school for Katie the Catsitter in this purr-fectly irresistible graphic novel series about friendship, heroes, and cats (lots of cats)!Katie loves skating with the Wheelas and the fact that she’s officially a superhero sidekick. But now that school’s starting, everything’s changing. The Mousetress is getting blamed for things Katie knows she didn’t do. Sidekick training is NOT as exciting as she’d hoped. Katie’s best friend Beth is back in town and Beth’s new boyfriend is always hanging around (ugh!). Not to mention that all of Katie’s friends are mad at her. Fixing this will be harder than any skateboarding trick. But with the help of 217 slightly out of the ordinary cats, Katie’s going to try!Can she clear the Mousestress’s name, uncover the real supervillain, and become the sidekick (and the friend) she’s always dreamed of being?“Readers will revel in the heroic antics.” –The New York Times

Graphic novel fans, prepare yourselves for a trip you won't soon forget! New York Times bestselling author Dan Gutman and veteran illustrator Jim Paillot have brought you a second zany My Weird School graphic novel!A.J. and his friends have the chance to win a trip to Dizzyland--if they can finish 5,000 books first. Dr. Carbles, the evil president of the Board of Education, doesn't think they can do it. But the Ella Mentry School kids are nothing if not determined!Will they achieve their theme park dreams? Or does Dr. Carbles have other plans for the school? Full of visual gags, fun pop culture references, and hilarious full-color illustrations, this is the weirdest graphic novel in the history of the world!With more than 30 million books sold, the My Weird School series really gets kids reading!

Another graphic novel in this fun series spin-off of The Baby-sitters Club, featuring Kristy's little stepsister Karen has to get glasses She doesn't want them, especially because school pictures are going to be taken soon. But she picks out some pretty pink ones and thinks she looks very grown-up.Then Yicky Ricky at school starts calling her names, like Owl Girl and Googly Eyes. If Karen wears her glasses for the school picture, Ricky will make fun of her. If she doesn't wear them, she'll feel like she's afraid to be herself. Glasses or no glasses, that Ricky is going to get it

Your favorite characters are now part of the Who HQ library!Journey to deep space and learn how James Tiberius Kirk became one of the greatest space heroes in the Star Trek universe.From appearances i

Join Thea Stilton and the Thea Sisters on an adventure to find the seven secret treasures The search for the seven secret treasures continues. In this incredible adventure the Thea Sisters come across the legendary Jewel of the Queen. They cross rivers of ice, deserts of fire, and other fascinating places on their journey to find it.

Karen Brewer, Big SisterEverybody used to love Karen. She was cute. She was the littlest sister. But now baby Emily is in their family, and Karen feels left out.Then Emily gets sick and everybody has

In Cat Kid Comic Club, Li'l Petey, Flippy, and Molly introduce twenty-one rambunctious, funny, and talented baby frogs to the art of comic making. As the story unwinds with mishaps and hilarity, reade

全彩橋梁書《Press Start!》登入超級小兔的電玩世界，跟著擁有飛毛腿的超級小兔勇闖驚險刺激的冒險任務！全新版本套書，除了五本平裝本，更支援StoryPlus專屬音檔APP，隨點隨聽免下載。Rabbit Boy is a super-fast and super brave, but he's also a video game character living in a video game world. What will happen when Sunny, the boy playing th game, loses each level? Will it be game over for Super Rabbit Boy and all his friends?#1 Game Over, Super Rabbit Boy! Uh-oh, Animal Town is in trouble! Meanie King Viking has created a dreaded robot army to spread No Fun across the land. On top of that, he has stolen the happiest and most fun animal ever, Singing Dog. There is only one person who can save the day -- Super Rabbit Boy! Super Rabbit Boy is super fast and super brave, but he's also a video game character living in a video game world. What will happen when Sunny, the boy playing the game, loses each level? Will it be game over for Super Rabbit Boy and all his friends?#2 Super Rabbit Boy Powers Up! Baddie King Viking is tired of always losing to hero Super Rabbit Boy. So h

Geronimo must get to the bottom of this martial arts mystery!Geronimo Stilton is invited to a rat-jitsu martial arts championship in a snowy faraway land, much to the famouse reporter’s surprise. With

《神奇樹屋》跟上圖像小說熱潮！跟著主角傑克與安妮打開書本穿越時空到中世紀冒險，全彩漫畫重新詮釋暢銷冒險讀本系列，給7至12歲讀者不同以往的閱讀選擇。The #1 bestselling chapter book is now a graphic novel! Magic. Mystery. Time-travel. Get whisked back to the time of medieval knights with Jack and Annie!A castle. A knight. A quest! When the magic tree house whisks Jack and Annie back to the Middle Ages, they’re looking for a knight. Instead, they find the Great Hall of a castle where a feast is under way. But Jack and Annie aren’t exactly welcome guests!For the first time in graphic novel—live the adventure again with new full-color vibrant art that brings the magic to life!

A dark, gothic adventure set deep in a Bavarian forest, with angels and owls and magic and a boy who isn't all that he seems to be... A cherub is blown into Cassie Engel's bedroom during a thunderstor

Eisner Award-winning cartoonist James Kochalka returns with another uproariously funny caper for Banana Fox to sniff out in this critically acclaimed series from Graphix Chapters!Booie Hoo!Banana Fox'

When an ancient supernatural book threatens the world, Doctor Strange and Ironheart will have to follow its trail of destruction to stop it Brave the spookiest corners of the Marvel Action Universe with the Sorcerer Supreme and armored teen genius Riri Williams as they hunt the legendary Iron-Bound Book of Shuma-Gorath. Along the way they'll hear fearful tales of its past: Iron Man's encounter with a horrifying post-modern Prometheus The time teenage monster hunter Else Bloodstone came up against a werewolf... in Captain America's clothing Spider-Man and Nadia Van Dyne, the Unstoppable Wasp, against a possessive symbiote out for Peter Parker's soul Then, in the fearful finale, the heroes learn who's behind the Book's chaos. And that person has one final fright to call forth Writer Jeremy Whitley (My Little Pony, Unstoppable Wasp) unearths his inner ghost-storyteller, with help from artists Gretel Lusky (Primer), Derek Charm (Squirrel Girl, Star Wars Adventures), Sweeney Boo (Marvel Act

Evil wizard Astrid brings the Garden of Beasts to life and the Dragon Masters must go into battle in the latest installment of this New York Times bestselling series!Pick a book. Grow a Reader!This se

本書為暢銷書World of Science系列書中的特別版。A* STAR(新加坡科技研究局)的科學家Germaine Yong，想像一個名叫Guss年輕細菌，在人類消化系統中經歷了一場神奇的歷險，透過書中生動有趣的漫畫，使小讀者能夠了解我們的消化系統，跟著Guss一同冒險並學習如何保持健康！書中除了輕鬆活潑的全彩漫畫，最後還搭配相關英文詞彙填字遊戲，本書適合所有年齡層的讀者，讓我們一起了解人體的奧妙!*本書互動功能需依書中說明下載APP(Snap Learn)後使用。In this Special Edition comic book in the bestselling World of Science series, A* STAR scientist Germaine Yong imagines the human digestive system as an exciting journey for a young bacteria named Guss. Learn about the ins and outs of our digestive system and how to stay healthy, while having fun with Guss. And, augmented reality features will bring Science learning to life and engage readers of all ages!

本書為暢銷書World of Science系列書中的特別版。A* STAR(新加坡科技研究局)的科學家Germaine Yong，想像一個名叫Guss年輕細菌，在人類消化系統中經歷了一場神奇的歷險，透過書中生動有趣的漫畫，使小讀者能夠了解我們的消化系統，跟著Guss一同冒險並學習如何保持健康！書中除了輕鬆活潑的全彩漫畫，最後還搭配相關英文詞彙填字遊戲，本書適合所有年齡層的讀者，讓我們一起了解人體的奧妙!*本書互動功能需依書中說明下載APP(Snap Learn)後使用。In this Special Edition comic book in the bestselling World of Science series, A* STAR scientist Germaine Yong imagines the human digestive system as an exciting journey for a young bacteria named Guss. Learn about the ins and outs of our digestive system and how to stay healthy, while having fun with Guss. And, augmented reality features will bring Science learning to life and engage readers of all ages!

兒童科學百科，以對話方式解答孩子對生活周遭的十萬個為什麼。全套20冊，收錄為何要建金字塔、火山為什麼爆發等內容，每本皆附QR-Code音檔，搭配文字、聆聽對話，更容易牢記知識。A collection of twenty titles from our perennially popular I Wonder Why series, with its winning question and answer format and cased in attractive slipcase.This highly popular and long-running series explores the questions that young readers ask about the world around them in an unrivalled child-friendly style. The conversational format is perfect for delivering solid information in a natural, amusing and imaginative way.本套書附書盒，包含以下20本平裝讀本，每本均附音檔QRcode--01- I wonder why camels have humps 為何駱駝有駝峰02- I wonder why caterpillars eat so much 為何毛毛蟲吃這麼多03- I wonder why Columbus crossed the Ocean 為何哥倫布要橫越大西洋04- I wonder why there's a hole in the sky 為何天空中有洞05- I wonder why kangaroos have pouches 為何袋鼠有育兒袋06- I wonder why leaves change colour 為何樹葉會變顏色07- I wonder why mice are musical 為何老鼠是音樂家08- I wonder why my tummy rumbles 為何我的肚子會咕囉咕嚕叫09- I wonder why planes have wings 為何飛機有翅膀10- I wonder why pyramids were

A Netflix Original series!The third book in the New York Times, USA Today, and Wall Street Journal bestselling series, with over 7 million copies in print!"Terrifyingly fun! Delivers big thrills and even bigger laughs."--Jeff Kinney, author of the #1 New York Times bestseller Diary of a Wimpy KidJack’s friends make a startling discovery: they may not be the last kids on earth, after all. This is great news for everyone… except Jack. Once they’ve found other humans, his friends won’t stick around for long! Jack’s only hope for keeping things the way they are is to prove that everything here is perfect, life is crazy fun, and nothing else could be any better. After all, they live in a mind-clobberingly cool tree fort, speed through town playing real-life Mario Kart, have a crew of monster buddies, and battle zombies on the regular. That's as good as it gets!One problem: it’s hard convincing his friends that everything is great when they’re being hunted by a monstrous Nightmare King and a

How do you move water? Can we grow food where it does not rain? Find out more about dams, aqueducts and working with water.Working with Water, a Level 3 Reader, is A1+ in the CEFR framework and supports YLE Movers exams. The longer text is made up of sentences with up to three clauses, some expression of future meaning, comparisons, contractions and relative clauses.

Sixteen different reptiles battle it out in a huge fight! Who will be the champion?This nonfiction reader compares and contrasts 16 ferocious reptiles. Readers will learn about each animal's anatomy,

與活潑的馬區家四姊妹們一起經歷生活中的高潮和低谷。冬天非常寒冷，他們的父親出外打仗。梅格、喬、貝絲和艾米縮衣節食，但她們卻十分關心窮人。才華橫溢的四姐妹們對自己的未來有著遠大的夢想，但事情並不總是那麼容易。而與鄰家男孩的新友誼不知不覺中改變了一切……*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Join the lively March sisters as they go through highs and lows in life. It is cold in winter and their father is away at war. Meg, Jo, Beth and Amy have little to eat, yet they care for the poor. The talented sisters have big dreams about their future, but things aren't always easy. A new friendship with the boy next door somehow changes things.

彼得潘的生活一點也不無聊！永遠長不大的男孩-彼得潘，帶著溫蒂和她的兄弟們進行了一次狂野的冒險。他們帶著仙女小叮噹，飛到遙遠的夢幻島。在那裡，他們和迷失男孩們一起住在一棵樹下，躲避海盜。跟著彼得和朋友們的幻想，直到嗜血的虎克船長出現......他們能逃脫嗎？滴答滴答滴答...*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Life with Peter Pan is hardly dull! The boy who never grows up takes Wendy and her brothers on a wild adventure. With fairy Tinker Bell, they fly far, far away to Neverland. There, they live under a tree with the Lost Boys and hide from the pirates. Follow Peter and friends in their fantasies until bloodthirsty Hook creeps up. Can they escape? Tick tick tick ...

劉備以為他是獨自一人拯救人們脫離苦難。幸運的是，一路上他遇到了兩個英勇的好人，他們一起組建了一支軍隊。這三個人相處得非常融洽，相互合作，所以他們決定不再只是朋友，他們結拜為兄弟！與劉備、關羽、張飛一起抗擊惡霸，保衛疆土！*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Liu Bei thinks he is all alone in saving people from troublemakers. Luckily, he meets two good guys who are brave and heroic. Together, they start an army. The three men get along so well that they decide they won't just be friends. They'll be brothers! Join Liu Bei, Guan Yu and Zhang Fei as they fight against bullies and protect China!

與活潑的馬區家四姊妹們一起經歷生活中的高潮和低谷。冬天非常寒冷，他們的父親出外打仗。梅格、喬、貝絲和艾米縮衣節食，但她們卻十分關心窮人。才華橫溢的四姐妹們對自己的未來有著遠大的夢想，但事情並不總是那麼容易。而與鄰家男孩的新友誼不知不覺中改變了一切……*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Join the lively March sisters as they go through highs and lows in life. It is cold in winter and their father is away at war. Meg, Jo, Beth and Amy have little to eat, yet they care for the poor. The talented sisters have big dreams about their future, but things aren't always easy. A new friendship with the boy next door somehow changes things.

劉備以為他是獨自一人拯救人們脫離苦難。幸運的是，一路上他遇到了兩個英勇的好人，他們一起組建了一支軍隊。這三個人相處得非常融洽，相互合作，所以他們決定不再只是朋友，他們結拜為兄弟！與劉備、關羽、張飛一起抗擊惡霸，保衛疆土！*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Liu Bei thinks he is all alone in saving people from troublemakers. Luckily, he meets two good guys who are brave and heroic. Together, they start an army. The three men get along so well that they decide they won't just be friends. They'll be brothers! Join Liu Bei, Guan Yu and Zhang Fei as they fight against bullies and protect China!

讓我們一起加入唐三藏、孫悟空、豬八戒與其他朋友的大冒險！孫悟空很調皮，但和他在一起很有趣！看著唐三藏面對許多問題，並一步一步地克服它們。豬八戒非常努力地克服了自己的弱點，這點激勵了大家。那麼，你要一起加入這場旅程嗎？*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Join Tripitaka, Sun Wukong, Zhu Bajie and many other friends on a great adventure! Sun Wukong might be mischievous, but he's fun to be with! Watch as Tripitaka faces a lot of problems and overcomes them, one step at a time. Be inspired by Zhu Bajie, who has many weaknesses and tries very hard to cope with them. So, are you in?

彼得潘的生活一點也不無聊！永遠長不大的男孩-彼得潘，帶著溫蒂和她的兄弟們進行了一次狂野的冒險。他們帶著仙女小叮噹，飛到遙遠的夢幻島。在那裡，他們和迷失男孩們一起住在一棵樹下，躲避海盜。跟著彼得和朋友們的幻想，直到嗜血的虎克船長出現......他們能逃脫嗎？滴答滴答滴答...*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Life with Peter Pan is hardly dull! The boy who never grows up takes Wendy and her brothers on a wild adventure. With fairy Tinker Bell, they fly far, far away to Neverland. There, they live under a tree with the Lost Boys and hide from the pirates. Follow Peter and friends in their fantasies until bloodthirsty Hook creeps up. Can they escape? Tick tick tick ...

讓我們一起加入唐三藏、孫悟空、豬八戒與其他朋友的大冒險！孫悟空很調皮，但和他在一起很有趣！看著唐三藏面對許多問題，並一步一步地克服它們。豬八戒非常努力地克服了自己的弱點，這點激勵了大家。那麼，你要一起加入這場旅程嗎？*本書互動功能需依書中說明下載APP(Snap Learn)後使用。Join Tripitaka, Sun Wukong, Zhu Bajie and many other friends on a great adventure! Sun Wukong might be mischievous, but he's fun to be with! Watch as Tripitaka faces a lot of problems and overcomes them, one step at a time. Be inspired by Zhu Bajie, who has many weaknesses and tries very hard to cope with them. So, are you in?

A 2018 Goodreads Choice Awards Finalist for Middle GradeA 2018-2019 New Hampshire Great Stone Face Book Award NomineeNominated for the 2020 Bluestem Award: Illinois' Grades 3-5 Readers' Choice AwardNominated for the 2019-2020 Nebraska Golden Sower Award (Chapter Books)The #1 New York Times bestselling Magic Misfits series from acclaimed and wildly popular celebrity Neil Patrick Harris is now available as a boxed set!Join the Magic Misfits as they discover adventure, friendship, and more than a few hidden secrets in this beautifully designed boxed set, which includes all four books in the unique and always surprising series: The Magic Misfits, The Magic Misfits: The Second Story, The Magic Misfits: The Minor Third, and The Magic Misfits: The Fourth Suit.Whether you're a long-time expert at illusion or simply a fan of stage magic, hold on to your top hat!

If you think monsters don't exist, just ask Theodora Hendrix. The second in a brilliantly funny new series, perfect for fans of Amelia Fang.After facing down an evil hag, a thieving skele-crow and an army of the undead, ten-year-old Theodora Hendrix is certain she can handle anything – that is, until she meets the unpleasant Inspector Shelley and her even more unpleasant pet rat. Shelley and Ratsputin have come to spy on the Monstrous League of Monsters, and are determined to make trouble at every turn. Then Theodora makes a discovery of her own: a cursed beetle. She needs to destroy it without attracting the attention of the inspector – and fast. The stakes couldn’t be higher: if Theodora fails, her beloved monster family will rot in the dankest, darkest prisons of Transylvania…

The Story Orchestra series brings classical music to life for children through gorgeously illustrated retellings of classic ballet stories paired with 10-second sound clips of orchestras playing from their musical scores.包含以下4種書9780711241503 The Story Orchestra: Swan Lake (精裝音效書) Discover the spellbinding magic of Swan Lake in this musical retelling of the ballet – push the button on each beautiful scene to hear the vivid sound of an orchestra playing from Tchaikovsky’s score.9781786030931 The Story Orchestra: Sleeping Beauty (精裝音效書) In this retelling of the classic ballet story, bring Tchaikovsky's Sleeping Beauty to life by pressing the musical notes on each page. Join the King and Queen as they throw a party for their new baby, Princess Aurora. But when a terrible guest arrives and places a curse on princess, the kingdom must find the one special person who can defeat it...9781786030689 The Story Orchestra: The Nutcracker-Press the Note to Hear Tchaikovsky's Music (精裝音效書) Follow Cla

Myths! Lies! Secrets! Uncover the hidden truth about history’s pandemics, from the Black Death to COVID-19. Perfect for fans of I Survived! and Nathan Hale’s Hazardous Tales.During the Black Death in the 14th century, plague doctors wore creepy beaked masks filled with herbs. RIGHT?WRONG! Those masks were from a plague outbreak centuries later―and most doctors never wore anything like that at all!With a mix of sidebars, illustrations, photos, and graphic panels, acclaimed author Kate Messner delivers the whole truth about diseases like the bubonic plague, cholera, smallpox, tuberculosis, polio, influenza, and COVID-19.Discover the nonfiction series that smashes everything you thought you knew about history! Don’t miss History Smashers: The Mayflower, Women’s Right to Vote, Pearl Harbor, Titanic, and American Revolution.

A box set of the bestselling Baby-sitters Little Sister graphic novels by Ann M. Martin and Katy Farina!Join Karen on her adventures in Stoneybrook. Whether she's spying on a neighbor who she thinks i

The wildly popular, bestselling sci-fi series by Katherine Applegate and Michael Grant returns in a new full-color graphic novel series, adapted by Chris Grine.Rachel is still reeling from the news that Earth is secretly under attack by parasitic aliens, the Yeerks. Now she and her friends are the planet's only defense -- five kids who, purely by chance, stumbled onto a downed spacecraft and were given the power to morph into any animals they touch.The team's best lead is their assistant principal, Mr. Chapman, who is the human host to a high-ranking Yeerk official. It's not much, but Rachel's always been a daredevil, and she volunteers to infiltrate Chapman's home.Rachel is tough. She's fearless. But what she finds inside may be more than even she can handle.

6 color paperback titles are included in this boxset--#1: The Adventures of Captain Underpants #2: Captain Underpants and the Attack of the Talking Toilets #3: Captain Underpants and the Invasio

Join the dolls as they choose and decorate a Christmas tree, have a walk in a snowy forest, go ice skating on a snowy afternoon and watch as twinkly Christmas lights are switched on. Have fun choosing