Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The fourth book in a hilarious, heart-warming series for children from Costa Award-winning author A.L. Kennedy, illustrated by celebrated cartoonist Gemma Correll. Hold onto your underpants - there's

Shortlisted for the Blue Peter Awards 2022 Best Books with Facts*A positive, reassuring and anxiety-eliminating book helping children change the way they think about the world*Pandemics, war, terror, natural disasters - the world seems to be full of bad news and it can all feel, well, a little bit scary. But this is just part of the story. There are in fact tons of great things happening, from robots improving health care and trees healing the planet, to everyday people helping their community with acts of kindness and the businesses fighting for good in the world.In Good News, children will learn to become fake news detectives, sussing out what's real and what isn't. They'll discover the good news - the amazing anecdotes, case studies and figures around the globe that are making a difference. And they'll learn that if we all continue to work together, things can only keep getting better and better.Empowering, reassuring and confidence-boosting, this book is a positive antidote for tes

A Sunday Times Children's Book of the Year pick From the imagination of Tom Gates' multi-million-copy bestselling creator Liz Pichon... 'Following up a best-selling series like Tom Gates is no easy feat, but Liz Pichon does so in huge style in Shoe Wars [...] Bursting with imagination and fabulous gadgets, Shoe Wars is full of Pichon's characteristic warmth, humour and quirky illustrations.' The Bookseller Welcome to Shoe Town - and meet brother and sister Bear and Ruby Foot. They are running out of time to rescue their inventor dad from his hideous boss, Wendy Wedge.She'll do ANYTHING to win the glitzy Golden Shoe Award and knows that entering flying shoes is her hot ticket to the trophy. Flying shoes that Ruby and Bear just happen to be hiding... Get ready for a gadget-packed, wedge-of-your-feet adventure like no other! Laughs and pictures on every single page! More praise for Shoe Wars: 'As with the Tom Gates books, every page here is dynamic and attention-grabbing, packed with cart

Unipiggle and Princess Pea are so excited to be on HOLIDAY! They can't wait to build sandcastles and explore the magical underwater town, Mermaid Springs. But then the King is swept away in a WHIRLPOO

《魔女宅急便》——宮﨑駿動畫靈感來源的原著小說，全新英譯版再現溫暖魔法。十三歲的半吊子小魔女琪琪，帶著愛吐槽的黑貓吉吉，飛往陌生海港小鎮展開一年修行。原以為能輕鬆帶來幸福，卻發現真正的魔法，藏在每日的努力與真心中。結合幻想與生活氣息，這是一段屬於成長、勇氣與友情的美好旅程。Soar into the modern classic about a young witch and her clever cat―the inspiration for the Hiyao Miyazaki film that became a phenomenom!Half-witch Kiki never runs from a challenge. So when her thirteenth birthday arrives, she’s eager to follow a witch’s tradition: choose a new town to call home for one year.Brimming with confidence, Kiki flies to the seaside village of Koriko and expects that her powers will easily bring happiness to the townspeople. But gaining the trust of the locals is trickier than she expected. With her faithful, wise-cracking black cat, Jiji, by her side, Kiki forges new friendships and builds her inner strength, ultimately realizing that magic can be found in even the most ordinary places.Blending fantasy with the charm of everyday life, this enchanting new translation will inspire both new readers and dedicated fans.“A gentle

Half vampire, half fairy, totally unique! Isadora is special because she is different. In this brand new adventure, Isadora is going to be a bridesmaid at her aunt's wedding, and she's SO excited! But with a mischievous older cousin and a bored baby sister to deal with, getting through the special day isn't exactly going to be a piece of cake. Can Isadora make sure there's a happy ending.. . ?

Discover a world of wonder on a seaside stroll with this beautiful picture book from the National Trust. Chasing waves and having fun, water sparkling in the sun . .. Look what I found! A curly seashell. Inside it shines bright, like a pearl.Set off on an adventure to find treasure, from swirly sea shells to mysterious mermaid's purses, then learn more about each object with richly-illustrated and informative nature notes. Packed full of fascinating facts alongside a gentle rhyming narrative and encouraging children to get outside and explore their surroundings, this is a nature treasure hunt series for the whole family to enjoy. Every Nosy Crow paperback picture book comes with a free 'Stories Aloud' audio recording - just scan the QR code and listen along! Other titles in the series include: Look What I Found in the Woods

本系列由暢銷作家 Mac Barnett 創作，以「作者的童年其實是祕密間諜生涯」為幽默設定，打造一套節奏明快、充滿笑點的間諜故事。故事融合間諜冒險、誇張行動與真實歷史事件，讓孩子在閱讀中自然接觸世界史與地理知識。文字與插畫配合，降低閱讀門檻，也提升趣味性。是一套能讓孩子笑著翻頁、在不知不覺中把書讀完的系列。James Bond meets Diary of a Wimpy Kid with this groundbreaking new fully-illustrated chapter book series Mac B., Kid Spy. The precious Crown Jewels have been stolen, and there's only one person who can help the Queen of England: her newest secret agent, Mac B. Mac travels around the globe in search of the stolen treasure...but will he find it in time?From secret identities to Karate hijinks, this fast-paced, witty and historically inspired chapter book will keep readers guessing until the very last page. With full-color illustrations and fascinating historical facts masterfully sprinkled throughout, this series offers adventure, intrigue, absurdity, history and humor. Discover this totally smart and side-splittingly funny new series, and experience what it's really like to be a kid spy.套書包以下書籍：#1: Mac Undercover (9781338143591)Before

The Queen of England calls on her trusty spy, Mac B., once again. This time, Mac must navigate secret tunnels beneath the Berlin Wall in order to retrieve cheat codes from a Soviet scientist. Floppy d

The third magical bookwandering adventure in the nationally bestselling Pages & Co. series, featuring Tilly Pages as she journeys to Washington, DC, to wander inside the books at the Library of Co

Eric Carle's classic story of finding your voice is newly joining the premier reader line, Step into Reading One day, a little cricket is born and meets a big cricket who chirps his welcome. But the little cricket cannot make a sound. The cricket meets many insects, but it isn't until he meets a beautiful female cricket that he can finally chirp hello Step 3 Readers feature engaging characters in easy-to-follow plots about popular topics; for children who are ready to read on their own.

All four books in the beloved Wayside School series by bestselling and Newbery Medal-winning author Louis Sachar are now available in this collectible set!This paperback box set features all four books, each with new cover and interior art and full of hilarious stories, zany art, and a quadruple serving of absurdity.More than fifteen million readers have laughed at the stories of Sideways Stories from Wayside School, Wayside School Gets a Little Stranger, Wayside School Is Falling Down, and the newly released Wayside School Beneath the Cloud of Doom.So what are you waiting for? Come visit Wayside School!本套書包含以下4本Sideways Stories from Wayside SchoolWayside School Is Falling DownWayside School Gets a Little StrangerWayside School Beneath the Cloud of Doom

Billy and his family are off to the seaside, in another laugh out loud title from the popular "Billy and the Mini Monsters" series: fun, sandcastles and uh-oh, monster-stealing seagulls! Billy and his

Prince Lucas and Clara have to save their dragon friend, Ruskin, from a dangerous spell in this sixteenth fantastical adventure of The Kingdom of Wrenly series.There is only one place throughout the e

A highly illustrated middle-grade series that celebrates new friendships, first crushes, and getting out of your comfort zone―now in paperbackEver since they can remember, fifth graders Kenzie (aka Ke

Whether Congress is in session or not, here is an enthralling overview about the branch of our government closest to average Americans.Best-selling adult author and the first woman to become executive

Travel through time, grab your magnifying glass and seek out incredible facts about ancient history in this search-and-find adventure, packed with over 200 things to spot! Spanning continents and cove

A stunning non-fiction book illuminating the secrets of animal camouflage with a search-and-find twist. Now you see them, now you don't. Cloaked in a riot of colour, pattern and texture are a dozen cr

《The Lightning Catcher》是Clare Weze所著的一本科幻冒險兒童小說，適合9至12歲的讀者。故事講述男孩Alfie隨家人搬到偏遠村莊Folding Ford後，發現這裡天氣極為怪異：夏天樹上有霜凍、花園水桶中有小龍捲風、某些地方只下雨不淋濕周圍等。Alfie和他的朋友Sam對這些怪異現象感到好奇，開始調查村裡最怪異的科學家Nathaniel Clemm的庭院。在稍微闖入後，他發現一個神祕的盒子，打開它後釋放出一個閃著電光、敏捷且神秘的生物Whizzy。這個生物帶來許多麻煩和危險，Alfie因此被誤解和指責。他必須找到化解風暴和說服村民相信這一切的方式。小說結合了奇幻與現實，描繪Alfie在新環境中的適應、面對偏見、與家人間的成長，還穿插了有關氣象、生物和電學的知識。全書節奏緊湊，情節充滿想像力與懸念，同時探討友情、身份認同和家庭關係，是一部寓教於樂的精彩中級讀物.'This exciting, science-packed novel is a cracking read and bursts with action, warmth and humour' - BookTrust Great Books Guide 2021'This is great fun; an energetic middle-grade debut with a fresh contemporary feel and a good dash of Stranger Things' - The BooksellerAlfie has noticed a few things since his family moved to Folding Ford. He really misses life in the city. He and his sister don't exactly fit in here. But the most interesting one is that the weather is BONKERS. One frost-covered branch on one tree in the middle of June? A tiny whirlwind in a bucket in the garden? Only in Folding

Best-selling author Rick Riordan presents author Tehlor Kay Mejia's thrilling adventure based on the Mexican legend of La Llorona, now in paperback.*"A new hero's fantastic and fantastical adventure--

Write your legend, draw your destiny, and take flight!The legend starts with you!Do you love to draw or write? Do you have your very own dragon stories to tell? In this official Wings of Fire journal,

Activity book meets adventure in this series that is Choose Your Own Adventure meets I Survived meets doodle book! Doodle, decide, and demolish your way out of history’s greatest events—the perfect bo

Molly, Rosie, and Simon test the laws of physics to rescue a lucky soccer ball before the big game in the fifth book of this heavily illustrated, two-color chapter book series by Stick Dog author Tom

《The Last Kids on Earth》首度推出全彩漫畫，帶來六個新冒險。故事從一次被怪物打斷的「桌遊之夜」開始，Jack 與好友為了決定誰該上陣，舉辦「故事比拼」。每個角色都輪番講述自己的末日歷險：有的誇張逗趣，有的驚險刺激，甚至連怪獸伙伴也加入，形成一場色彩繽紛、笑料不斷的敘事競賽。不同的說故事方式，凸顯角色個性，也讓讀者感受到這群孩子在末日世界中仍保持創意與勇氣。The first ever full-colour graphic novel in the New York Times bestselling series with over ten million copies in print! Now an award-winning Netflix show! Includes SIX brand new Last Kids stories by Max Brallier, featuring full-colour artwork by Anoosha Syed, Xavier Bonet, Lorena Alvarez, Jay Cooper, Christopher Mitten and The Last Kids on Earth series illustrator Douglas Holgate! When a vicious monster attacks the tree house (rudely interrupting board game night!), our human heroes and their monster pals must decide who is brave enough to battle the beast alone. The only way to choose? An epic, end-of-the-world STORY SHOWDOWN! Jack launches into an epic, totally-heroic, super rad story of one of his many post-apocalyptic adventures. Soon, Quint, Dirk, June and Skaelka, and even Globlet regale the

A boy and his neighborhood friend Louise spend their days creating chalk-drawing worlds around their homes. When Louise asks the boy what he has in his head, the boy's imagination takes the reader on

Why is a GBP5 note worth GBP5? Where do coins come from? What do banks actually do? All this and so much more is answered in A Quick History of Money, a crash course from cash cows to cryptocurrency.

From the author of The Ride comes a heartwarming story about a father-son relationship and how music allows us to bond with one another and express ourselvesA father and son embark on a journey across the city, but as they get on the train and plug in their music, do they really know where they will end up? Where will the music take them? Hop on board and take a musical ride through the city and into outer space, to the beach and to the stadium, and the protest and the parlor of an elderly couple with their grand piano. What does music make you feel? What is your favorite song? And what can it inspire you to do?

In this poignant and emotionally heart-wrenching tale, famous curmudgeon Catwad faces loss, fear, and struggles with his own mortality when his best friend Blurmp receives news of...wait, who are we k

The tenth book in the laugh-out-loud adventure series set in the MOST AWESOME treehouse! Filled with cartoon illustrations, this is perfect for fans of Dog Man and Diary of a Wimpy Kid.The 130-Storey Treehouse is the tenth book of Andy Griffiths and Terry Denton's wacky treehouse adventures, where the laugh-out-loud story is told through a combination of text and fantastic comic book-style illustrations'The kind of book I would have loved as a kid' – Tom Fletcher, author of The Danger GangWe've added 13 new levels to our treehouse – it used to be 117 storeys, but it keeps on growing!Now there's a soap bubble blaster, a GRABINATOR (it can grab anything from anywhere at any time), a time-wasting level, a toilet paper factory (because you can never have too much toilet paper) and an extraterrestrial observation centre . . . which will come in handy when giant flying eyeballs from outer space come to grabinate us!Well, what are you waiting for? Come on up!Climb more fun-filled levels by co

The New York Times and USA Today bestselling series!My brother Jonah's dream has come true. We have FINALLY landed in his favorite fairy tale: Jack and the Beanstalk!It's a lot of fun meeting Jack. Bu

Dog Man and Petey face their biggest challenges yet in the tenth Dog Man book from worldwide bestselling author and illustrator Dav Pilkey.Dog Man is down on his luck, Petey confronts his not so purr-

吃進肚子的東西，到底經歷了什麼神奇旅程？跟著一位腸道裡的「好菌導遊」，你將探訪人體消化系統：嘴巴怎麼開始消化？胃為什麼會咕嚕叫？還有肝臟、腸道、腺體和許多你可能從沒想過的器官祕密！這本圖像式科普漫畫以幽默畫風和誇張情節，讓讀者一邊大笑、一邊認識身體運作機制。Chew on this! Science Comics: The Digestive System is the latest volume in First Second’s action-packed nonfiction graphic novel series for middle-grade readers!Every volume of Science Comics offers a complete introduction to a particular topic―dinosaurs, the solar system, volcanoes, bats, robots, and more. These gorgeously illustrated graphic novels offer wildly entertaining views of their subjects. Whether you're a fourth grader doing a natural science unit at school or a thirty-year-old with a secret passion for airplanes, these books are for you!In this volume, visit the inside of your mouth, stomach, liver, intestines, and other organs that make up the gastrointestinal tract! Your guide to the gut is a friendly bacterium who will take you on a journey beyond imagination. Uncover how food is transformed into nutrients! Explore strange and dangerous glands

Spurred by a newfound awareness of false advertising, Stink Moody becomes the proverbial kid in a candy store as his letter-writing campaign yields him heaps of free rewards.When Stink buys a mammoth

Toto再度出任務，這次是和皇室有關的大事！這次Toto與夥伴受命接待法國大使，最後一站是倫敦塔參觀動物界珍寶——鑽石貓項圈。但當他們抵達時，項圈竟然失竊，而Toto反被誤認為是小偷！為了洗刷冤屈，她展開一場跨越書店、下水道與白金漢宮的城市追查行動。途中不僅要解開層層謎題，還得面對意想不到的反派出現。From bestselling children's author and TV broadcaster, Dermot O'Leary, comes an action-packed new adventure from Toto the ninja cat - the crown jewels are missing and the thief is on the run! Purrfect for fans of The Aristocats, The Secret Life of Pets and Atticus Claw Breaks the Law. Toto and her friends are due to be looking after the French ambassador on a day of sightseeing, finishing at the Tower of London to see the animal world's crown jewels: a sacred diamond cat collar. But when they arrive, the collar has disappeared - and what's worse, it looks like Toto is responsible! Toto is almost arrested, but she escapes to try and get to the bottom of the mystery and clear her name.She and her friends will have to follow some strange clues that will take them to a secret bookshop, Buckingham Palace and the rats' underground city in the

Discover the magical world of the wood in this information book for young children, with over 80 flaps to lift. There are lots of things to explore, and animals to discover.

What is a virus? What do they do? How can we protect ourselves from them? Learn the answer to these questions and lots more in this fascinating lift-the-flap book.

Girl by day. Cat by night. Ready for adventure. In the fifth book of this chapter book series, Kitty, a little girl with catlike superpowers, is on a mission to stop a thief from ruining her town’s an

本書是為初階讀者量身打造的橋梁書，將「怪物與孩子」的經典想像，轉化為輕快又安心的故事。Monster 住在床底下，Boy 睡在床上，兩人原本屬於不同世界，卻在一次意外中建立起友誼。雙色插畫，幫助讀者理解情節，也降低閱讀負擔。適合親子共讀，或孩子獨立閱讀。This is the beginning of an exciting two-color illustrated chapter book series about the friendship between Monster and Boy.When Monster (who lives under the bed) meets Boy (who sleeps in the bed), Boy starts to scream—and Monster promptly swallows him. It's the beginning of a beautiful friendship!Told with a warm, cozy voice, the story is brought to life with adorable two-color illustrations. Filled with adventure and humor, this chapter book is perfect for sharing with kids just aging out of picture books and for newly independent readers.We are publishing two new Monster and Boy titles each year.

9789814857970 Captain Underpants #1: Adventures of Captain Underpants (彩色版)(平裝本)Fourth graders George Beard and Harold Hutchins are a couple of class clowns. The only thing they enjoy more than playing practical jokes is creating their own comic books. And together they've created the greatest superhero in the history of thier elementary school: Captain Underpants! His true identity if SO secret, even HE doesn't know who he is!9789814864008 Captain Underpants #2: Attack of the Talking Toilets (彩色版)(平裝本)George and Harold are usually responsible kids - whenever anything bad happens, George and Harold are usually responsible! This time, their latest prank backfires, and they accidentally invent an army of terrifyingtalking tiolets. Luckily, they know a superhero with enough snap in his waistband to save the day! This looks like another job for the amazing Captain Underpants!9789814864015 Captain Underpants #3: Invasion of Incredibly Naughty (彩色版)(平裝本)George and Harold ha

George and Harold are behind bars for a crime they didn't commit, and are soon pulled from prison by a time-travelling tyrant named Tippy Tinkletrousers! Now the boys are going back in time to the car