Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Building upon the early history of the HIV pandemic laid out in the 2008 book A Decade of HAART, this book explores the scientific breakthroughs and global response to the HIV pandemic from the mid-1990s through 2023.

Business Statistics: Communicating with Numbers takes a comprehensive and contemporary approach that aims to bridge the gap between how statistics is taught and applied in the business world. This title not only prepares students in basic statistics but also gets them excited about further exploration of data analytics. The authors emphasize communicating with numbers rather than number crunching, through relatable case studies with relevant statistical methods and takeaways. This title incorporates timely examples from various fields, reinforces core features from previous editions, uses Excel and R to analyze data and solve problems, and includes new improvements, such as a revised chapter on data visualization, an exclusive chapter on logistic regression, and digital enhancements such as a big data capstone project with algorithmic exercises that span across multiple chapters.

Edited by Simran Jeet Singh, Modeling Religious Pluralism brings together global leaders and experts to share experiences and practical advice on bridging divides across religious difference.

The deeds and misdeeds of aristocrats, past and present, never lose their appeal, whether on screen or in real life. But who are they, and why do they matter? This ground-breaking book explores the origins and development of early-modern elites, revealing the similarities between the organization and behaviour of leading families all over Europe.

Business and Economics is a highly regarded title that equips students with a conceptual understanding and interpretation of statistics and its applications in the business world, while also promoting diversity, equity, and inclusion. The 2024 release takes a step-by-step approach, ensuring that beginners can easily grasp the concepts and succeed in a basic statistics course. With a focus on real-world application, this title uses examples and exercises to illustrate how statistics can be applied to solve current business scenarios. Additionally, the authors recognize the growing importance of data analytics and support the development of these basic skills through an application-based section on data analytics at the end of each chapter along with easily accessible data sets for practice. This title primarily uses Excel, Minitab, and MegaStat to demonstrate statistical analyses, helping users create graphical and descriptive statistics and conduct hypothesis testing.

Concerns about political polarization and threats to democratic ideals are on the rise in the US. The Authoritarian Divide takes on both of these issues by showing how authoritarian predispositions--desires for social conformity and in-group conformity--have influenced American political preferences, voting, and partisanship in recent decades. Voters have increasingly sorted into political parties based on their levels of authoritarianism, with higher levels tending toward the Republican Party and lower levels to Democratic. The authors reveal complexities in this trend, including the outsized effect on White Americans, the dependence on parties offering certain types of choices, and the different ways education level factors into the sorting process. Drawing from nationally representative samples, panel data, and experiments, the book demonstrates that authoritarianism has increasingly structured a wide range of attitudes and has become a growing influence on vote choice. The analysis

Go on a sensory adventure with everyone's favourite touch and feel baby book series!Turn the pages to discover tactile eggs in this delightful Easter addition to the much-loved That's not my... series. From shiny spots and stripes, to silky ribbons and finally an irresistibly fluffy chick - there are lots of different touchy-feely textures to explore.- Bright, bold, eye-catching illustrations support visual development- Fuzzy, furry, smooth and soft touchy-feely patches on every page for sensory development- Designed for shared storytime, That's not my... books build communication skills- Repetitive text to encourage call and response for developing language- The little white mouse to spot on every page encourages observation skillsWith so many titles to choose from, there's a That's not my... book for everyone.

Go on a sensory adventure with everyone's favourite touch and feel baby book series!Four delightful jigsaws specially designed for little hands are embedded in the pages of this sturdy board book. Each jigsaw piece has touchy-feely textures which will help to develop sensory awareness and the concept of matching.- Bright, bold, eye-catching illustrations support visual development- Fuzzy, furry, smooth and soft touchy-feely patches on every page for sensory development- Designed for shared storytime, That's not my... books build communication skills- Repetitive text to encourage call and response for developing language- The little white mouse to spot on every page encourages observation skillsWith so many titles to choose from, there's a That's not my... book for everyone.

A double dose of gripping psychological suspense, pairing two complete novels and two rare short stories, from six-timePulitzer Prizefinalist Joyce Carol Oates. Two serial killers – one female, one male – murder in the name of a higher cause. Ideal for fans of Alice Munro, Ann Patchett and Anne Tyler.

Poole’s "Linear Algebra: A Modern Introduction, Cengage International Edition", 5th, prepares students to transition from computational to theoretical mathematics. Balancing theory and application, the conversational writing style combines traditional presentation with student-centered learning. Theoretical, computational and applied topics are presented in a flexible, integrated way. Stressing geometric understanding before computational techniques, vectors and vector geometry are introduced early to help students visualize concepts and develop mathematical maturity for abstract thinking. Numerous applications drawn from a variety of disciplines reinforce that linear algebra is a valuable tool for modeling real-life problems.

Slavery in Early Modern Philosophy 1500-1765 contains thirty-four philosophical texts about slavery composed in Europe and America between 1500 and 1765. These readings demonstrate that debates about slavery deserve a central place in the history of philosophy, and are crucial for understanding early modern moral and political philosophy, as well as the development of the concept of race and the history of racism. Included here are many previously unpublished and newly translated texts that discuss various aspects of slavery and represent many different perspectives. Some treat slavery as a purely theoretical issue, others explicitly examine transatlantic slavery, the enslavement of American Indians, or other specific historical institutions. Some criticize slavery, others defend it. Some focus on ethical or political questions, others on epistemological or psychological ones. Some explore the general permissibility of enslavement, others the morality of slave rebellions or the obligat

Firmly based on ancient literature and material evidence, this illustrated biography assesses the life of Agrippina the Younger (15-59 CE). Agrippina was declared "unique" by Tacitus, ancient Rome's most insightful political historian, both for her own political standing and as the daughter of a triumphing general and the sister, wife, and mother of emperors--respectively, Caligula (r. 37-41), Claudius (r. 41-54), and Nero (r. 54-68). Tacitus and other ancient historians depict her with horrified fascination as they vividly chart her growing presence through tumultuous vicissitudes, ending with her murder by her son Nero in 59. Documentary evidence corroborates Agrippina as extraordinary. Among other "firsts," she is the first woman to be portrayed and identified on coins while alive; the first woman whose name is given to a veteran colony; and she appeared in more numerous statuary installations than known for earlier women. Agrippina's life sheds light on Rome's evolution into a mona

限量精裝刷邊版R. F. Kuang's instant #1New York Timesbestselling novel is now available as a stunning Deluxe Collector's Edition featuring a stamped faux-leather case with gold foil, beautiful illustrated endpapers, bookmark ribbon, designed edges, and intricate interior black-and-white illustrations from Nico Delort.Babelis a thematic response toThe Secret Historyand a tonal retort to Jonathan Strange & Mr. Norrellthat grapples with student revolutions, colonial resistance, and the use of language and translation as the dominating tool of the British empire.Traduttore, traditore: An act of translation is always an act of betrayal.1828. Robin Swift, orphaned by cholera in Canton, is brought to London by the mysterious Professor Lovell. There, he trains for years in Latin, Ancient Greek, and Chinese, all in preparation for the day he’ll enroll in Oxford University’s prestigious Royal Institute of Translation—also known as Babel.Babel is the world's center for translation and, more important

Action-packed and full of mystery, this third fantasy novel in the Gargoyles trilogy is a must-read for fans of magic, mythology and the power of friendship.Jake's early experiments with malice at the quarry Source have unleashed a chain reaction - and now darkness is spreading throughout the village.As Sole Guardian of Gargoyle's Rest, Callen must figure out a way to stop the plague of ghasts tormenting the village, and purify a Source that's been putrefying for decades. But when he decides to release the magic from Gargoyle's Rest in the hope that it will dilute the darkened magic, it actually feeds and strengthens a lakeful of half-formed grotesques.Can Callen and his friends overcome their distrust of Jake - and can Callen learn to ask for help - before it is too late?Book 3 in the Gargoyles trilogy.

Cummings/Worley's ORGANIZATION DEVELOPMENT AND CHANGE, 12th Edition, is the most widely-used textbook in the field. It blends rigor and relevance in a comprehensive and clear presentation. The authors work from a strong evidence-based foundation to describe, in practical terms, how behavioral science knowledge can be used to help organizations develop strategies, structures and processes for superior performance, sustainability and social outcomes.

A fun pop-up and flaps board book for curious little ones who loveDisney’s The Lion King! Tactile elements and delightful imagery will encourage the development of motor skills and early learning.Little ones can find adventure with characters from one of Disney’s most-loved films in this adorable pop-up book!Meet Simba, Timon, Pumba, and more in this cute board book which will delight preschoolers with lively, read-aloud rhymes encouraging literacy and surprise pop-up scenes. With the help of parents and caregivers, young readers will have fun turning the sturdy board book pages, guessing what’s hiding under each flap as they reveal each picture, and playing peekaboo!

China’s remarkable journey from poverty to becoming the world’s second-largest economic power is marked by extraordinary urban growth and consumption capacity of its urban population. Central to this development fervor are multifunctional commercial complexes and shopping malls, now key features of modern urban districts. The concept of shopping malls, originally introduced to China by American architects in the 1980s, has since flourished on an even larger scale than their American counterparts.This book delves into the origins of shopping mall development in the United States after World War II, tracing how American architects exported this building type into China’s rapidly evolving urban landscapes, particularly in Beijing, Shanghai, Chengdu, Kunming, and Guangzhou. Using primary sources, statistical analyses, and illustrated case studies, the book explores the evolution of shopping malls as a consequence of China’s profound economic, social, and cultural change over the past four

《R語言醫學數據分析與可視化》以通俗易懂的語言和實際案例，全面講解R語言在醫學數據分析與可視化中的應用。通過理論與實踐相結合的方式，幫助讀者快速掌握R語言的基礎知識及其在醫學科研中的應用。《R語言醫學數據分析與可視化》共包含18章，系統地介紹從R語言入門到醫學數據分析與可視化的完整流程。《R語言醫學數據分析與可視化》首先介紹R語言的基礎知識、數據集的創建與操作、數據輸入輸出等基本技能；隨後，詳細講解數據可視化、統計分析、回歸模型等核心分析方法；同時，深入地探索聚類分析、判別分析、生存分析、Meta分析等高級技術；還涵蓋基因測序數據處理、臨床診斷試驗評價、列線圖、C指數及校準曲線等醫學科研領域的重要工具與方法，並通過大量實例展示如何利用R語言高效地完成醫學數據分析與科研圖表的製作。《R語言醫學數據分析與可視化》內容翔實、邏輯清晰，貼近醫學科研實際需求，特別適合醫學科研人員、臨床醫生、數據分析初學者以及從事醫學統計工作的讀者學習與參考。

A practical guide for Early Years educators on how to find the joy in practice, create imaginative environments for learning and join children on their wonderful Early Years journey.

Using Mindfulness to Promote Mental Health in Schools provides useful knowledge and practical guidance regarding how mental health professionals and educators can effectively use mindfulness-based pra

Given the sometimes extraordinary politicization of culture, it is surprising that Sesame Street has gained acceptance and legitimacy in more than fifty countries. Sesame Street's global success raises two questions. First, how does a US icon like Sesame Street spread around the world, gaining acceptance as a local cultural product? Second, how does the nonprofit that created it, Sesame Workshop, and its partners around the world navigate cultural differences, manage conflicts, and construct shared collective representations to create Sesame Street programs that resonate with local audiences? Tamara Kay answers these questions using data from seven years of intensive ethnographic fieldwork and 200 in-depth interviews with Sesame Workshop staff and international partners-including their real-time interactions-from seventeen countries within four regions around the world. Kay argues that Sesame Workshop's secret is its engagement in coproduction, meaning it works with partners as a trans

Organizing Relation investigates how attachment theory can shift major conversations in literary criticism about connection, personhood, and aesthetic experience. Drawing on the author's experience along with extensive scholarly research into attachment theory, somatic and relational healing, and childhood development, the book delineates the emergence of subjectivity from micro-episodes of attuned connection and the arising of attachment trauma in the absence of adequate experiences of attunement. The emergent understanding of intermittent passages in which embodied presence self-organizes in response to relational episodes prompts a reorganization of how literary studies approaches subjectivity, language, and the body. Organizing Relation pursues that reorganization through a portfolio of readings in nineteenth-century American literature, in which relational turbulence provokes different experiences of power and dependency, opening up passages of dissociated chaos and of brilliant,

Enzymes, Volume 1: Nature's Chemical Machines offers beginning-mid undergraduate students a platform in basic enzymology, including pure enzyme preparation, data collection and analysis, and enzyme study. It supports wider biochemical studies through varied examples, and leads to deeper coverage of the topic in Enzymes, Volume 2: Enzymes at Work.

The ultimate one-stop guide to the subject, this book takes you on a fascinating journey through the questions that have puzzled humanity for more than 2,500 years. From metaphysics and ethics to political philosophy and the philosophy of science, learn a different branch of philosophy across nine separate modules, explaining all of the key ideas of history's greatest thinkers--from Plato and Descartes to de Beauvoir and Nietzsche--and how they still resonate today. Perfect for complete beginners, Philosophy: A Complete Course untangles complex concepts using clear, jargon-free explanations paired with bold infographics, thought experiments, summaries of key works, and practical exercises to assess what you have learned. The book's innovative, graphic approach simplifies even the most challenging ideas like existentialism, empiricism, and dualism, making them easier than ever to understand. Whether you are studying philosophy, expanding your knowledge, or simply exploring life's bigges

《Phonics Step-By-Step 4: Long Vowel Digraphs》 自然發音拼讀系列的第四冊Long Vowel Digraphs (複合長母音)，延續長母音教學主軸，練習常見的複合長母音。複合長母音為兩個母音或字母發一個長母音的音組，認識母音組合變化，產生出新的發音，如：ai/ay、ea/ee、oa/ow等音組。再次強調了學習自然發音法目的，是學習字母之間的對應關係。 《Phonics Step-By-Step 5: Gliding Vowels》 自然發音拼讀系列的第五冊為Gliding Vowels，又被稱作為Diphthong (雙母音) ，是以兩個字母為主軸，共同發一個音節。在音節裡的兩個母音或兩個字母，組合成一個整體的發音，如：a_l、a_u、a_w、o_i、o_y、o_o、u_e、o_u、o_w 等音組，會在發音時從第一個字母開始發音連動滑音到第二個字母，產生嘴型的變化，以及舌位的滑動，而得名。由於有兩個母音或兩個字母的發音，所有雙母音都有發音的起始和結束。 《Phonics Step-By-Step 6: R-Controlled Vowels》 為自然發音拼讀系列第六冊。此冊的 R-Controlled Vowels (受R 控制的母音) 是以受 R 控制的母音為主軸，當母音 a、e、i、o、u後面接上子音 r 時，子音 r 會影響母音的發音，如： ar、er、ir、or、ur 等音組。這些音組也會有長音〔ɝ〕以及短音〔ɚ〕的不同發音，透過反覆的音組練習，學習者可以快速領略自然發音讓你輕鬆說英文的樂趣。 《Phonics Step-By-Step 7:Gliding Blends and Digraphs》 自然發音拼讀系列第七冊 Blends and Digraphs以混合及複合子音為主軸。混合子音包括 l、r、s 的雙子音混搭音組 (l-blends、r-blends、s-blends) 如 bl, br, sw 等，以及加入子音的混搭音組如 shr、str、spl、tw 等，都須拼讀及發出每個子音的聲音。而複合子音的音組如 ch、sh、th、ph、wh、ng、nk 等，都只能發出一個聲音。特定複合子音組合，還會產生特殊讀音。透過本書強化學習者自然發音能力，輕鬆說英文。 《Phonics Step-By-Step 8:

This monograph presents a visually striking exploration of Refik Anadol’s data-driven installation, created for the opening of the new BRUSK museum in Bruges. The book offers exclusive visuals and reflections on the intersection of art, technology, and memory in Anadol’s work.Working at the intersection of art, science, and technology, Refik Anadol is best known for his large-scale immersive installations and public artworks that use machine learning, AI, and big data to visualize complex systems. Anadol’s work transforms raw data – ranging from urban landscapes to brainwaves – into dynamic, multi-sensory experiences, pushing the boundaries of how we perceive space, memory, and reality.For the inaugural programme at BRUSK, the new museum for contemporary art in Bruges, Belgium, Anadol presents a major site-specific installation that immerses visitors in a datadriven landscape unique to the city.

Two Caldecott honorees--and real-life best friends-- team up to illustrate a story of friendship from bestselling author Julie Fogliano. Like the two stars of this story, illustrators Molly Idle and Juana Martinez-Neal know that differences only make a good friendship stronger. In this bouncy, rhyming story, two best friends think about all the little things that don't matter- and the big things that really, really do. With each artist designing and drawing one character, and collaborating on the scenery and details, Molly Idle and Juana Martinez-Neal transformed this sweet story into a celebration of friendship- including their own- and a unique artistic vision. Working remotely, they swapped drawings across the country, using a limited palette of teal and yellow over graphite. As artwork passed back and forth between their mailboxes, childhood versions of each artist came to life and came together on the page into one unified creation. Award-winning author Julie Fogliano's rhythmic r

Go on some out-of-this-world adventures in this LEGO(R) Star Wars(R) activity book that comes with a Grogu minifigure and exclusive Hover Pram mini build! Go on a mission with Grogu! Dive into the world of LEGO(R) Star Wars(TM) like never before in this book that includes tons of mazes, puzzles, doodling, and so many fun activities. Plus, you can follow along Grogu's journey in the comics, and use your minifigure to elevate the play experience with the LEGO play prompts. With activities, stories, a LEGO Grogu minifigure, and everything you need to build an exclusive Hover Pram mini build, this book is the perfect gift for all young Star Wars and Mandalorian fans! (c) & TM 2025 Lucasfilm Ltd.LEGO, the LEGO logo, the Minifigure and the Brick and Knob configurations are trademarks and/or copyrights of the LEGO Group.(c)2025 The LEGO Group. All rights reserved.

A Disney Stitch sticker activity book that lets 3-5 year olds create their own action-packed adventure in a fun graphic novel formatBrowse over 250 reusable stickers and use them to complete the graphic novel-style story alongside Stitch and friends! Perfect for giving young kids an early introduction to storytelling and featuring large, reusable stickers, Kids can add fun speech bubbles and character stickers to every panel – and use even more extra stickers on other creative endeavours.Create your own graphic novel with Disney Stitch themed stickers:*EASY TO USE: Includes more than 250 large, reusable stickers, perfect for small hands*READ AND CREATE: Fill in the book’s many graphic novel-style panels with character and speech bubble stickers – anywhere and everywhere!*DEVELOPS KEY CREATIVE SKILLS: Encourage the development of storytelling skills in kids aged 3-5, enabling young creators to explore their creativityThis unique format allows children to create their own comic strips wi

A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube! Isadora is excited for her cousin Amma to visit for a sleepover. Isadora wants to do vampire things, like shapeshifting and staying up all night. Amma is excited to try doing things fairy style. Can they meet in the middle?An entertaining early reader, retelling Isadora Moon's on-screen adventures!A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube!Isadora is excited for her cousin Amma to visit for a sleepover. Isadora wants to do vampire things, like shapeshifting and staying up all night. Amma is excited to try doing things fairy style. Can they meet in the middle for some fairy-vampire fun?From the world of Harriet Muncaster, Isadora Moon is the bestselling half fairy, half vampire that kids love all around the world. This early reader features an accessible font and simplified language to bridge the gap between picture books and c

A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube! Grandpa is helping Isadora to find the perfect item to take to school for show and tell. It needs to be amazing and, of course, magical! Hidden in the cellar, they find a strange box. Maybe it is just the thing they wished for.An entertaining early reader, retelling Isadora Moon's on-screen adventures!A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube!Grandpa is helping Isadora to find the perfect item to take to school for show and tell. It needs to be amazing and, of course, magical! Hidden in the cellar, they find a strange box. Maybe Oscar can help convince Grandpa that it is just the thing they wished for . . .From the world of Harriet Muncaster, Isadora Moon is the bestselling half fairy, half vampire that kids love all around the world. This early reader features an accessible font and simplified language to bridge the gap betw

A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube! Isadora's is excited for Nova to visit, but Nova wants to play at their human friend Sashi's house instead. Isadora starts to feel left out, so she turns to her fairy magic to help her join in . . .An entertaining early reader, retelling Isadora Moon's on-screen adventures!A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube!Isadora's is excited for Nova to visit, but Nova wants to play at their human friend Sashi's house instead. Isadora starts to feel left out, so she turns to her fairy magic to help her join in . . . but what should she do when her spell doesn't go exactly to plan?From the world of Harriet Muncaster, Isadora Moon is the bestselling half fairy, half vampire that kids love all around the world. This early reader features an accessible font and simplified language to bridge the gap between picture books and chapter book

A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube! Isadora goes for a mermaid sleepover at Delphina's underwater palace. Being far from home is exciting at first, but at bedtime Isadora starts to miss her dad. Can she bring a bit of her vampire magic to the sea kingdom?An entertaining early reader, retelling Isadora Moon's on-screen adventures!A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube!Isadora goes for a mermaid sleepover at Delphina's underwater palace. Being far from home is exciting at first, but at bedtime Isadora starts to miss her dad and their special night flights. Can she bring a bit of her vampire magic to the sea kingdom?From the world of Harriet Muncaster, Isadora Moon is the bestselling half fairy, half vampire that kids love all around the world. This early reader features an accessible font and simplified language to bridge the gap between picture books and chap

A magical early reader based on the Isadora Moon TV series on Sky Kids, Now TV and YouTube. When Nova tells Isadora about Planet Aurelia 's rainbow-swirl skies, she longs to see them. But she can't fly high enough, until her friends help her realise home has its own beautiful sights.An entertaining early reader, retelling Isadora Moon's on-screen adventures!A magical early reader, based on the Isadora Moon animated TV series on Sky Kids, Now TV, and YouTube!Isadora Moon's friend Nova is from Planet Aurelia, where the sky is full of rainbow swirls. Isadora decides she has to see it for herself! But no matter how hard she tries, she can't fly high enough. Can her friends help her realize that home has plenty of beautiful sights to offer, too?From the world of Harriet Muncaster, Isadora Moon is the bestselling half fairy, half vampire that kids love all around the world. This early reader features an accessible font and simplified language to bridge the gap between picture books and chapt