Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The origins of the legendary Black Axe and its first mouse wielder revealed for the first time! Eisner Award-winning creator David Petersen joins forces with Eisner-nominated artist Gabriel Rodr璲uez to bring a brand new prequel chapter in the epic Mouse Guard saga to life--just in time to celebrate the series 20th anniversary! Set at the earliest point in the series' timeline, this epic reveals the origin of the legendary weapon and the courageous mouse to first wield it--Bardrick. As darkness encroaches and monstrous serpents threaten the fragile peace of the Territories, Bardrick must rise to a duty greater than himself and embark on a perilous journey of sacrifice, bravery, and legacy. But with such immense stakes at hand, can the first Black Axe survive the toll of his quest? Featuring stunning sequential art from Rodr璲uez paired with colors by Petersen himself, this hardcover volume beautifully expands the Mouse Guard mythos with the untold history of its earliest heroes. Collects

Federated Learning for the Metaverse: Applications in Virtual Environments provides readers with insights into how federated learning, a decentralized machine learning paradigm, can be strategically applied to address critical aspects of the metaverse. The book covers a wide range of topics, including privacy-preserving personalization, security, collaboration, adaptive learning environments, real-time communication, decentralized governance, language understanding, immersive learning experiences, avatar customization, and dynamic scene rendering.

Additive manufacturing (AM), also known as three-dimensional (3D) printing, is a relatively new manufacturing technique that has gained significant industrial interest. AM is a key low-carbon manufacturing technology incorporating net-shaping whilst avoiding complex process chains. This manufacturing technique is appealing for a variety of applications, including aerospace, oil, gas, marine, automotive, biomedical, and nuclear, due to advantages such as component design freedom, component complexity, light weighting, toolless nature, part consolidation, and decreased material waste. To overcome the performance limitations and to take advantage of the alloy design opportunities provided by AM technology, a new generation of alloys suitable for AM is needed. In addition to this, optimising process parameters and microstructure evolution during AM can lead to improved mechanical, corrosion, fatigue, irradiation, and wear properties, amongst other benefits. With a view to select the best a

When there are suspicious sightings around the bay (ghosts?! a sea monster?!)--who're you gonna call? An elite team of crime-fighting underdogs, that's who! The Misfits are on the case in the hilarious follow-up to the beloved New York Times bestseller! "For any kid who's felt like a misfit, this crackling adventure packs a wallop!" --Lincoln Peirce, creator of Big Nate Oof! When reports of ghosts arise around an abandoned lighthouse, Olive and her elite team of underdogs are immediately thrust into a brand new case. After all, ghosts don't exist . . . right? Real or not, the ghosts draw quite a crowd at Olive's beloved Reforming Arts School, or RASCH (not "rash"). Turns out everyone wants a glimpse of the ghosts, including . . . the nearby marine life?! Between RASCH's ghosts and newfound tourism, rumors soon spiral out of control about a sea monster in the bay--snagging unwanted attention from a corrupt mogul. What is going on at RASCH? Does the mythical creature really exist, and ca

Padawan Reath Silas is being sent from the cosmopolitan galactic capital of Coruscant to the undeveloped frontier―and he couldn’t be less happy about it. He’d rather stay at the Jedi Temple, studying the archives. But when the ship he’s traveling on is knocked out of hyperspace in a galactic-wide disaster, Reath finds himself at the center of the action.The Jedi and their traveling companions find refuge on what appears to be an abandoned space station. But then strange things start happening, leading the Jedi to investigate the truth behind the mysterious station, a truth that could end in tragedy...“Claudia Gray created an absolute masterpiece with incredible depth. This is a must-read for any Star Wars fan in 2021.” - Cultress“The most fun entry of The High Republic line yet.” – ComicBook.com"An emotionally resonant Star Wars adventure like you've never seen before." -- CinelinxEnjoy more adventures from the all-new era of storytelling of the glorious High Republic:Star Wars: Light

Sylvestri Yarrow is on a streak of bad luck with no end of sight. She’s been doing her best to keep the family cargo business going after her mom’s death, but between mounting debt and increasing attacks by the Nihil on unsuspecting ships, Syl is in danger of losing all she has left of her mother. She heads to the galactic capital of Coruscant for help, but gets sidetracked when she’s drawn into a squabble between two of the Republic’s most powerful families over a patch of space on the frontier. Tangled up in familial politics is the last place Syl wants to be, but the promise of a big payoff is enough to keep her interested…Meanwhile, Jedi Knight Vernestra Rwoh has been summoned to Coruscant, but with no idea of why or by whom. She and her Padawan Imri Cantaros arrive at the capital along with Jedi Master Cohmac Vitus and his Padawan, Reath Silas―and are asked to assist with the property dispute on the frontier. But why? What is so important about an empty patch of space? The answer

Playing is an essential part of psychotherapy, and sandplay in particular allows for the development of an active tie between the therapist and the patient. This book analyses the elements that are introduced into therapy through sandplay: implicit memory, the embodied self and empathy, as well as the relationship that is created through the process of this type of therapy. Napoliello focuses on sandplay, but the use of the ideas here extends to the importance of activating a dimension of play in a patient as a way to bridge a link between the conscious and subconscious, on the importance of body language and using past experience to decipher the meaning of physical movements.