Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Do You Ship It 2 is a heartfelt romcom about opening yourself up to new possibilities and falling in love with what’s real, perfect for fans of Rainbow Rowell, Holly Bourne and Lynn Painter.Love, rivarly...orcs?Misfit and hardcore fangirl Anissa is finally coming out of her shell. She’s leading a tabletop role-play game with friends, is officially part of the group chat with the girls from college, and she’s managed to bag work experience on the set of her favourite TV show, ‘Of Wrath and Rune’. Things couldn’t be going better. . .That’s until she meets Callum, the hot new actor behind her favourite character on OWAR, and gets totally starstruck. Only Callum writes her off as an obsessive fangirl and now working on set is about to be very awkward. So much for meet your heroes - now he’s her worst enemy.Battling her newfound friendships, her rivalry-turned-maybe-something-more with Callum, and the occasional fictional orc, Anissa’s about to realise that sometimes getting lost in the fan

The Rising Volt Tacklers have arrived in the incredible Paldea region! Ready to tag along? Let's go! Liko and her friends are on a quest to find all of the Six Hero Pokémon. As they arrive in a sunny seaside town, the Rising Volt Tacklers are so excited to relax, shop and try the famous Wiglett sweet buns. But someone else has their eye on that tasty treat – Coral the Explorer! When Liko and Roy grab one of the last bun boxes, Coral challenges the Trainers to an epic battle. Who will win? The Pokémon Young Readers are the perfect starter books to help new readers grow in confidence, learn new vocabulary, develop reading comprehension skills with the Paldea Pokémon pals by their side. Based on the exciting episode ‘A Challenge from the Explorers', from Pokémon Horizons: The Series. Catch and collect our other exciting Pokémon Young Reader books, featuring characters from the new Horizons TV series: Level 1: Meet Sprigatito [9780008743130]Level 1: Meet Fuecoco [9780008743154]Level 1: Mee

Meet Quaxly (Pokemon Young Readers Level 1)Meet Fuecoco (Pokemon Young Readers Level 1)Meet Sprigatito (Pokemon Young Readers Level 1)Special Training with Cap (Pokémon Young Readers Level 2)Adventure on the Horizon (Pokémon Young Readers Level 2)Fuecoco the Berry Thief (Pokémon Young Readers Level 2)Welcome to Galar (Pokémon Young Readers Level 2)Missing Food Mystery (Pokémon Young Readers Level 2)Roar of the Black Rayquaza (Pokemon Young Readers Level 3)Rivals in the Dark of Night (Pokemon Young Readers Level 3)A Challenge from the Explorers (Pokemon Young Readers Level 3)

Anthony Fennell, a journalist, is in pursuit of a story buried at the bottom of the sea: the network of tiny fibre-optic tubes that carry the world’s information across the ocean floor - and what happens when they break.So he has travelled to Cape Town to board the George Lecointe, a cable repair vessel captained by Chief of Mission John Conway. Conway is a talented engineer and fearless freediver - and Fennell is quickly captivated by this mysterious, unnerving man and his beautiful partner, Zanele.As the boat embarks along the west coast of Africa, Fennell learns the rhythms of life at sea. But as the mission falters, tensions simmer - and Conway is thrown into crisis by a terrible, violent tragedy unfolding in the life he has left behind on land.Then Conway disappears; and Fennell must set out to find him.As taut and propulsive as a thriller, and a timeless exploration of narrative and truth, Twist is the work of a master storyteller at the height of his powers.

What will it take to tell the truth when your life depends on a lie? This is the question a blood spatter expert grapples with when she realises she sent the wrong person to prison. The 20th novel from NYT bestseller and Costa-shortlisted crime writer Denise Mina, for fans of Tana French and Elly Griffiths.** FROM THE NY TIMES and Costa shortlisted author, comes a NEW standalone thriller**The truth can set you free. Or destroy your lifeWhen blood spatter expert Claudia O’Shiel finds herself on stage to talk about the most famous criminal case in recent history, she has a choice to make: explain how her evidence put away the man responsible for the brutal double murder? Or tell them the truth – that the real killer is still out there, and if she tries to expose this conspiracy, it won’t just be her life on the line.A taut, intelligent suspense novel for fans of Val McDermid, Elly Griffiths and Tana French, The Good Liar is about power, class, and the lengths we're willing to go for fami

SHORTLISTED FOR THE BOOKER PRIZE 2025 –The astonishing story of one family swept up in the tides of the twentieth century, ranging from Japan to the USA to the North Korean regimeSHORTLISTED FOR THE BOOKER PRIZE 2025WATERSTONES FICTION BOOK OF THE MONTHLONGLISTED FOR THE WOMEN’S PRIZE FOR FICTION 2026A moment is all it takes to shatter a family. The echoes last a lifetime...‘Ferociously smart and full of surprises’ Eleanor Catton‘Engrossing... Full of brains and mystery’TelegraphOne evening, ten-year-old Louisa and her father, Serk, take a walk out on the breakwater. They are spending the summer in a coastal Japanese town. Hours later, Louisa wakes on the beach, soaked to the skin. Her father is missing: presumably drowned.This sudden event shatters their small family. As Louisa and her American mother return to the US, Serk's disappearance reverberates across time and space, and the mystery of what really happened that night slowly unravels.A Bookof the Year for theGuardian,Time,New Y

本書以春天為主題，帶領孩子走進 Acorn Wood 的動物世界，和熟悉的朋友一起迎接溫暖季節。兔子、貓咪、母雞和其他動物們正在享受春日的美好時光，孩子可以透過推、拉、滑動的小機關，參與他們的活動。跟著烏龜在陽光下騎腳踏車，幫狐狸摘一束水仙花，或和豬、獾一起在草地上野餐。簡短、重複的文字搭配豐富的畫面細節，讓孩子一邊操作、一邊觀察，發現春天的各種變化與樂趣。本書改編自深受喜愛的 Tales from Acorn Wood 系列，由 Julia Donaldson 與 Axel Scheffler 創作，是適合幼兒閱讀與互動的春季與復活節小書。推、拉、滑動機關，培養手眼協調春天主題，充滿觀察與發現適合學齡前親子共讀Celebrate Spring with this push, pull and slide book based on the bestselling Tales from Acorn Wood series by Julia Donaldson and Axel Scheffler, creators of The Gruffalo - the perfect Easter gift for preschoolersWelcome to Acorn Wood, where all the animals are enjoying the Spring! Join in the fun with this interactive push, pull and slide book based on the bestselling preschool series, Tales from Acorn Wood.How are Rabbit, Cat, Hen and all their animal friends celebrating the Spring? Push, pull and slide the tabs to find out! Join Tortoise on a sunny bike ride, help Fox pick a lovely bunch of daffodils and enjoy a fun picnic in the meadow with Pig, Badger and friends.With a short,

◎tell、talk、say 都是說，怎麼用才不會搞錯？ ◎put不只是擺放，海報掛牆上、郵票貼紙上，這些情境都能用。 ◎書本翻頁、指引車輛左右轉、調整音量，用turn一字搞定！ ◎想給部屬建議，說You should 聽起來好兇，有更好的說法嗎？ 本書作者船橋由紀子，擁有多年英語教練的資歷， 13年來讓5,000名學生的多益成績在短短2個月內增加 200 分。 作者指出，只需國中程度的動詞就能開口對話， 因為英語裡的5大句型都以「主詞（S）+動詞（V）」開頭， 足夠應付大多數與外國人談話的情境。 本書精選20大基本動詞，以及外國人最常用的百大句型， 設計一套每天只要30分鐘，1個月就能無負擔開口說英語的學習計畫。 ◎開口說英語，國中程度的動詞就夠 說自己在哪裡工作用work at；在哪個領域工作用work in； 自己目前從事的工作怎麼介紹？I’m working as＋職業名。 從介紹工作、職位與產業，work一詞就能搞定。 搭公車，用 get on；搭計程車，換成 get in。 「到了哪裡」，就用 get to； 起床呢？從床上「起來」，當然是用get “up”。 一個 get就能搞定這麼多日常英語。 give 不只表示給予， 日常生活想請別人幫忙，說give me a hand比help me更口語！ give（授予）＋up（上升）＝放棄： I gave up watching TikTok.（我戒掉看抖音。） ◎只要一個動詞就能表達很多情境 點餐用want？外帶用take更道地：I’ll take this one, please. like只代表喜歡？其實，稱讚對方也可以用like：I like your designs。 打開（關掉）電視，用open（close）？正確是：turn on（turn off）。 make翻為「做」好籠統？這些情境都能用make： make的主要概念是「施加外力、創造新事物」，不只製作， 與他人約定、預約是make a promise； 表達某事讓我開心可以說made me happy. 賺錢則說make money……只要一個動詞就能表達很多情境。 用國中程度的

Create individualized nursing care plans with ease and confidence! Ackley & Ladwig's Nursing Problems & Care Planning Handbook, 14th Edition, uses an easy system that guides you through identifying patient problems to implement evidence-based interventions in developing care plans. This thoroughly revised edition offers an evidence-based approach to nursing care planning organized by systems concepts. Care plans are aligned with the Clinical Judgment Measurement Model and include NIC and NOC standardized terminologies. Evidence-based activities and indicators for multiple populations includes adult, pediatric, older adult, behavioral health, and maternal/child health. Edited by noted nursing educators Mary Beth Flynn Makic and Marina Reyna Martinez-Kratz, this reference provides everything you need to write nursing care plans in just one book!Client problems are logically organized by systems concepts.Care plans are aligned to Clinical Judgment Measurement Model principles and compete

At age thirty-five, her thirteen-year relationship ended and food journalist Candice Chung found herself without not only her first love, but her most reliable restaurant review partner. When her retired Cantonese parents offered to be her new plus-ones, she faced a dilemma: was it better to eat together in polite silence, or to try saying the unsayable--to broach how, for the past decade, they had managed to drift so profoundly apart?Soon, a geographer enters her life, and the course of their relationship forces Chung to address what's still left unsaid to her parents. To do so, she must find a new vocabulary--a way to unscramble what her family has been trying to express all along. Not through words, but with food.

From the #1 New York Times bestselling master of international intrigue comes a shocking new stand-alone thriller that thrusts a group of university students, falsely accused of murder, into a treacherous hunt across Europe, all to unlock the secrets buried within a centuries-old book that could change humankind forever.Knowledge can be magic—until it falls into the wrong hands.The ritualistic murder of a British professor at the University of Exeter points to a startling cast of suspects: his own students. All are enrolled in a postgraduate program covering the history of witchcraft, folklore, and spiritualism.All evidence points to Sharyn Karr—an American student. Prior to the professor’s death, he had thrust a centuries-old book upon her. It appears to be the handwritten and encrypted diary of an eighteenth-century mystic and occultist, the Comte de Saint-Germain. The professor begged her to keep the text safe, ending with a warning: Trust no one.Such a responsibility forces her int

A joyful exploration of a child's loving relationship with the land that supports and nurtures her as she grows You Are the Land is a vivid ode to belonging within a family, within a community, and within the natural world. From the day she's born, a child feels the love and power that come with being part of something bigger. She's a new spring leaf, alive and growing, as strong as the ancient cedars and as radiant as the glittering night sky. She is one with the amazing forces of nature that surround and nurture her, and that she nurtures in return. Through inspiring words and sweeping illustrations, renowned artist Steph Littlebird's stunning debut celebrates our connection to the land and shows how we perfectly mirror its beauty and resilience.

From Michael Pollan, author of the #1 New York Times bestselling HOW TO CHANGE YOUR MIND, a dazzling and panoptic exploration of consciousness--what it is, who has it, and why--and a meditation on the limits and bounds of our very humanity When it comes to the phenomenon that is consciousness, there is one point scientists, philosophers, and researchers can all agree on with a level of certainty: that it feels like something to be ourselves. And yet, the fact that each and every one of us has a subjective experience of the world continues to be one of the greatest mysteries in nature. How is it that our mental operations are accompanied by feelings, thoughts, and a sense of self? What would studying the idea of an inner life even look like, considering we have as little distance and perspective on it as fish do of the sea? What began for Michael Pollan as a startling awareness of his own consciousness soon evolved into a greater fascination with this strange and elusive phenomenon. In

You're the unexpected caretaker of a small but mighty monster in this interactive book from the bestselling Choose Your Own Adventure series, now for readers 5-8! Filled with colorful illustrations, these books for little kids make reading together extra fun. But be careful!!! The choices YOU make could land you in a real-life monster movie! You're on a school trip at the Museum of Media, just in time to catch the last day of their exhibit on classic monster movies. When you sneak away to check it out, you stumble upon props from one of your favorites: "Kaiju Gaga." There's even a monster egg from the film! But when you reach out and touch the egg ... it cracks. Is that an eye looking out at you? Should you run back to join your class and pretend like nothing happened? Or do you want to meet whatever's emerging face-to-face, and accept the Kaiju consequences?

★ 當小狐狸遇見黏人小鳥，一場意想不到的陪伴故事開始了★ 關於犯錯、道歉與理解彼此的成長故事★ 柔和水彩插畫與春日森林氣息，讀來溫暖動人一個關於陪伴與理解的溫暖森林故事。當小狐狸 Hazel 救起一隻小藍鳥 Herbert，生活被徹底打亂。透過這段像手足般的關係，孩子能看見犯錯、道歉與彼此理解的重要。柔和插畫與細膩情感，使故事充滿春日般的溫度。When a young fox rescues a baby blue bird, her life is upended by the sudden new addition. Hazel discovers an egg while out for a walk in the woods, and much to her surprise--Tip! Tip! Tap!--out pops a baby bird. She names him Herbert, and from then on, he sticks to her like jam on toast. But Hazel likes her routine, and Herbert's always underfoot. No matter what she's doing, Hazel simply can't get a moment's peace. What's a fox to do?

Follow the incredible story of Rihanna, from a young girl in Barbados to an international superstar and successful businesswoman. Robyn Rihanna Fenty grew up on the Caribbean island of Barbados. Despite a tough childhood that meant she often had to look after her younger brothers, little Rihanna always found time to sing and loved putting on shows for her family. After a life-changing audition, a teenage Rihanna found herself in New York. Her dreams were coming true! Bursting on to the scene with hits like "Umbrella" and "Diamonds," she quickly became one of the most popular artists of all time. With 14 number-one singles to her name, Rihanna is the bestselling female recording artist of the twenty-first century.Alongside her music, Rihanna became a fashion and beauty icon, but she struggled to find make-up that suited her skin tone. She was inspire to launch a game-changing inclusive beauty and fashion brand, Fenty, designed to celebrate people of all different colours, shapes and siz

From New York Times bestselling author and renowned creator Joey Graceffa comes a pulse-pounding YA fantasy where witches hunt witches, magic has a price, and sisterhood is the only thing standing between light and darkness. Welcome to the coven.Each month, a Zodiac Witch is born, her magic written by the stars.Ophelia and Serena--twin sisters born on the cusp of Pisces and Aries--are trapped in the cold confines of an orphanage until fate rips them from obscurity. Suddenly, they are invited into The Twelve, a powerful coven. To join, they must swear to hunt Dark Witches, creatures of spectral beauty and razor-sharp teeth who survive by siphoning magic from young witches.On a secret island, protected by their new sisters, Ophelia and Serena train to use their powers. Serena commands Lightning, raw and untamed. Ophelia wields Water, quiet and waiting. Their paths shift--one chasing power, the other resisting--as the sisters find themselves caught between two destinies. Some choices can

Four adorable doggos and their new friend dive into another adventure-filled session of their favorite role playing game in DnDoggos: Spells Like Trouble, the second book in the hilarious graphic novel series by Scout Underhill. Magnus, Pickles, Tonka, and Zoey are ready to play! After leveling up, the doggos have new spells, new gear, new maps, and even a new friend: Toast the cat! But Maxilla's spell has woken a slumbering giant, and the threatening rumbles are growing louder. Plus, their new friend Toast has an unusual type of magic that is causing all kinds of trouble for our heroes. Will leveling up help the DnDoggos and Toast stop Maxilla before she causes even more trouble? Or will their own magic get the best of them?

A bold celebration of America’s most famous highway.Route 66 is undoubtedly the world’s most beloved road trip, having inspired music, film, books, and countless adventures. Created to mark the highway’s 100-year anniversary,Route 66: A Tribute to an American Iconfollows the Mother Road from Chicago to Los Angeles, spotlighting the legendary, can’t-miss landmarks that make this journey the ultimate all-American road trip.Inside you’ll discover:Must-see stops and attractions, including classic diners, museums, motels, and muffler menMaps for the eight states that Route 66 passes through:Illinois, Missouri, Kansas, Oklahoma, Texas, New Mexico, Arizona, and CaliforniaCurated playlists for each state. Simply scan the Spotify codes found alongside each map and listen at home or on the roadStories of pivotal moments in the road’s history, like the strife of the Eagle-Picher Miners’ strike and the essential guidance of the Green BookProfiles on visionary people, including motel proprietor Lil

Jiyu is the pen name of Shou-Fang Hu-Moore. During graduate studies at the University of Alberta her life took a dramatic turn owing to a leukemia diagnosis. Upon hearing the news, the young man with whom she had only recently entered into a serious relationship and who would soon be attending medical school, immediately proposed to her. Thus started their lifelong journey together dealing with this terminal disease, while continuing their studies and careers. Despite the many physical and mental hardships they faced, he persevered and eventually became a medical doctor, while she unleashed her potential with his constant encouragement and lived her life to the fullest, establishing multiple career paths in interior design, architecture, writing, translation and Mandarin Chinese education.This book is her memoir recounting her ordeals of undergoing cancer treatments, especially a bone marrow transplant, with many immediate and long-term side effects that continue to impact her health a

“PAWSSIBLY the sweetest books on the shelf!” — Ben Clanton, bestselling author of the Narwhal and Jelly seriesFollow the antics of Squash and Ginny in the sixth installment of Cat & Cat Adventures from popular webcomic creator Susie Yi! This chapter book graphic novel series is perfect for fans of Catstronauts, Babymouse, and Catwad.Into the belly of the beast! After recovering the orbs of the Past and Present, Squash, Ginny, and the rest of the crew head to the zoo to secure the Orb of the Future from their greatest enemy yet: the Owl King. But their mission will be no easy feat. After all, the Owl King holds the Orb of the Future, which means he knows their next move even before they do. Their best plan of attack: to have no plan at all!Armed with nothing but their wits (and some snacks, of course) the Spirit Squad must find a way to rescue the third orb and restore the Staff of Knowledge. If not, the Spirit Realm, Human World, and the future of snacking all hang in the balance!

Learn what makes a good friend in this silly story about a girl and her disgruntled animal friends, perfect for fans of Peter Brown's You Will Be My Friend! "I am a good friend!" says the girl and she heads outside to play with her buddies--two squirrels, a snail, and three crows. It's a fun-filled day of games, picnicking, and storytelling, but is everyone having a good time? An unexpected turn of events suddenly challenges the girl to question if she's treating her friends the way they want to be treated. This funny and relatable picture book about growth mindset not only conveys the importance of being considerate and understanding of others' needs but also provides innumerable laughs with its depictions of a sweet, well-meaning little girl who loves her animal friends maybe a little too overzealously.

THE MILLION-COPY INTERNATIONAL BESTSELLER RETURNS WITH A GRIPPING, EDGE-OF-YOUR-SEAT SERIAL KILLER THRILLER. AVAILABLE TO PRE-ORDER NOW! A face in the crowd. A killer in the shadows... ________ On the dark streets of Edinburgh, a killer is waiting. When a body is found, it is only the beginning. Soon there will be seven more. In the city's hospital, renowned surgeon Beth Waterfall is grieving. Her beloved only daughter fell prey to a vicious stalker a year previously - and now he's coming for her too. Edinburgh's police are desperate. After one body comes another, and then another. The brutal deaths are all seemingly unconnected, and yet DS Lively and forensic profiler Dr Connie Woolwine know they are dealing with a serial killer - they just need to prove it.But time is running out, and Beth Waterfall already looks set to be the next victim... The million-copy international bestseller returns with a gripping serial killer thriller that will have you hooked from the first page to the

“The twists are out of this world! You don’t want to miss this one!”– Freida McFaddenFrom indie thriller sensation Natalie Barelli comes a riveting domestic thriller about a woman who finds her darkest secrets published in a bestselling novel – and she'll do anything to keep the past from being rewritten.***Dear Diary. Today I'm going to kill her. Love, Rose.When Rose discovers the contents of her teenage diary splashed across the pages of a bestselling book, she knows her carefully constructed life is about to unravel.The author, Emily Harper, claims the story is fiction, but Rose knows better. Desperate to find out how Emily discovered her deepest secrets, Rose ingratiates herself into Emily's life, posing as an enthusiastic assistant and adoring fan.But as Rose gets closer to the truth, long-buried memories resurface. Slowly, the horrifying events of her teenage years come into focus, revealing that sometimes, the people you trust the most are the ones you should be most afraid of.F

★ 爆笑圖像小說！三人好友團的失控假期大冒險★ 給喜歡《Cat Kid Comic Club》《Hilo》《InvestiGators》的讀者★ 用笑聲與勇氣證明：只要有朋友，再糟的計畫都能變成冒險Nick、Sy與Violet原本各自規畫好完美的假期：電玩訓練、音樂合作與漫畫營隊，卻一個個被突發狀況打亂。面對計畫崩壞與自我懷疑，他們在朋友的支持中重新找回勇氣與信心。這部節奏明快、色彩繽紛的圖像小說，用爆笑冒險與溫暖友情描繪成長中的困惑與勇氣，讓讀者看見做自己與互相扶持的力量。Nick, Sy, and Violet have the perfect vacation planned, but nothing is going according to plan. Now, they’ll have to think fast, get creative, and make a splash in ways they never expected! A fun-filled graphic novel for fans of Cat Kid Comic Club, Hilo, and InvestiGators!Sy’s finally going to prove himself as a pro gamer—if only his dad didn’t insist on a father-son fishing excursion instead.Nick is set to collaborate with his musical hero, DJ French Toast—but their jam session is far from smooth.And Violet? She signed up for Comic Design Camp . . . so why is she suddenly the star of the Drama Camp play?Despite the obstacles, this trio isn’t backing down. Together, they’re ready to take on every obstacle, sink or swim. After all, school break has on

“PAWSSIBLY the sweetest books on the shelf!” — Ben Clanton, bestselling author of the Narwhal and Jelly seriesFollow the antics of Squash and Ginny in the sixth installment of Cat & Cat Adventures from popular webcomic creator Susie Yi! This chapter book graphic novel series is perfect for fans of Catstronauts, Babymouse, and Catwad.Into the belly of the beast! After recovering the orbs of the Past and Present, Squash, Ginny, and the rest of the crew head to the zoo to secure the Orb of the Future from their greatest enemy yet: the Owl King. But their mission will be no easy feat. After all, the Owl King holds the Orb of the Future, which means he knows their next move even before they do. Their best plan of attack: to have no plan at all!Armed with nothing but their wits (and some snacks, of course) the Spirit Squad must find a way to rescue the third orb and restore the Staff of Knowledge. If not, the Spirit Realm, Human World, and the future of snacking all hang in the balance!