Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Babies who've grown up with the bestselling touchy-feely books will love That's not my... Activity Books!Discover sea-themed things to spot, pictures to finish, shapes to trace and words to learn - all packed into the pages of this fun first activity book. Don't forget to spot little white mouse on every double page!- Perfect for children aged 2 years and above- Helps develop vocabulary and fine motor skills- Bright, bold, eye-catching illustrations support visual development- Keeps children entertained on-the-go- Discover more in the series, from favourite animals to exciting vehicles

Explore farm life in this interactive and playful board book, which places the child at the center of the action. Move the slider mechanism to answer funny questions about baby farm animals, and lift the flaps to find hidden creatures!Each spread is packed with fun and includes an engaging question about the farm. Decide and slide to choose your answer! Features: Six multiple choice questions about different farm scenesVibrant, bold and funny illustrations from Susie Hammer will keep little ones entertained and engagedA multi-sensory reading experience, with a slider and flaps to liftSpot the Quizzy Bean characters on each spread and lift the flaps to find out who's hidingEncourages active engagement and interaction, and helps children to express their knowledge and preferencesEach title in the series explores key Early Years concepts across the questions, for example: shape, colour or size. From Rebecca Atkinson and Susie Hammer, this entertaining series is perfect for preschoolers to

How exactly did technical expertise come to be a central tenet to the work of international organisations? The Technocratic International reconstructs the neglected history of expert mobilisation at early moments of institutionalised international cooperation in the nineteenth century.

Elmo and the pet rock Rocco star in a Funko Pop!Sesame StreetLittle Golden Book!Young children, as well as Sesame Street fans and Little Golden Book collectors of all ages, will delight in reading about the funny ongoing feud between Elmo and Zoey’s pet rock, Rocco, in this Little Golden Book illustrated in the iconic Funko Pop! style.Sesame Workshop, the nonprofit educational organization behind Sesame Street, aims to help kids grow smarter, stronger, and kinder through its many unique domestic and international initiatives. These projects cover a wide array of topics, which address specific needs, such as girls' education, financial empowerment, and autism. Sesame Street is the most trusted name in early learning.Little Golden Books enjoy nearly 100% consumer recognition. They feature beloved classics, hot licenses, and new original stories. . . the classics of tomorrow.

Commemorate the innumerable ways the African American community has shaped the foundation of the United States in this stunning, poetic picture book from the Caldecott Honor-winning team behind Freedom in Congo Square.Black hands molded clay, chiseled marble,rendered portraits, and painted vistas.Black hands penned literary testamentsthat have stood the test of time.Since the United States won independence in 1776, African Americans have contributed greatly to the nation’s culture, politics, economy, and landscape. Black Hands celebrates the countless contributions of African Americans—from building the White House, birthing jazz, and landing a man on the moon to pushing for social justice. Black excellence, however, has too often been overlooked.Black Hands reunites Newbery Honor winner Carole Boston Weatherford and Coretta Scott King award-winning illustrator R. Gregory Christie to chronicle the remarkable progress of African Americans, even in the face of adversity.

Strong Bridges is a book about a contradiction and the opportunity it offers. For decades, social network theory has drawn its maps of advantage from the idea that brokers sit astride structural holes, reaping value from weak ties that bridge disconnected worlds. But what if some of those bridges are not weak? What if the real advantage lies not just in structure, but in trust forged in interpersonal history regardless of structure? This is the puzzle Strong Bridges takes up. It begins with guanxi, the colloquial Chinese term for relationship advantage, often dismissed as cultural peculiarity or corruption. But the authors treat guanxi as a strategic research site, not a cultural relic. They view it a niche-word pointing to a broader category of human experience. Combining analytic rigor with quality network data, they pull apart the Siamese twins of tie strength and network structure, documenting the prevalence and competitive value of high-trust ties that span structural holes, i.e.,

Perfect for sharing with preschoolers, this delightful activity book is full of easy but fun nature things to draw, paint and craft - as well as some simple picture puzzles.From sweet pebble mice to fluffy pinecone owls to twiggy hedgehogs, you're sure to find something for everyone - and gathering the natural materials is a great excuse to get outside. Rainy day? Use the rain to make colourful raindrop art! A lovely way to spend time together and keep kids busy, without a screen in sight!- Easy projects, using everyday materials- Builds hand-eye coordination, concentration and pen control

Help your child build early literacy skills in this colorful wipe-clean board book from the bestselling learn-to-read Bob Books program!My First Bob Books for toddlers and preschoolers are inspired by Bob Books, the bestselling phonics program that's been teaching children to learn to read for more than forty years. Developed with reading experts, My First Bob Books encourage a love of reading while simultaneously building foundational pre-reading skills. My First Bob Books -- Read. Play. Grow!Help prepare your child to learn to read with this interactive activity book!The included wipe-clean pen allows for repeated practice, which builds kids' confidence and helps them master early literacy skills. The handle and included pen make it perfect for fun at home or on the go!This book features: Upper and lowercase letters. Letters have directional arrows to help with letter formation. Alphabet activities including matching, tracing, and look-and-find activitiesSturdy board book pagesA wipe

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Domesticated uses novel archaeological methods to rewrite the narrative of the rise of social complexity in the western and eastern Eurasian steppe. Through the study of ancient proteins, DNA, and isotopes, as well as traditional archaeology, Alicia R. Ventresca-Miller tracks the adoption of domesticated animals and plants to show how cultivated species transformed societies during the eras preceding the Silk Road networks. Economies in this region shifted from hunting and gathering to the use of ruminant livestock, horse dairying and riding, and finally to the cultivation of grains, marking major thresholds in human history. Ventresca-Miller proposes a model for how this happened--from the initial introduction of the animal or plant to their acceptance, solidification, an

Using all five senses and a dash of imagination, the ordinary walk back from school becomes a super-sized adventure!Normally Zarah and her brother are collected from school by their dad, who rushes them home taking every shortcut. But today Uncle Jerome is collecting them, and he takes 'The long way home'. Reluctant to go further than necessary at first, the children are soon caught up in amazing adventures, due to their uncle's sense of fun and imagination.

An jam-packed Bluey birthday sticker activity book!HIP, HIP, HOORAY! It's time for birthday celebrations!Play pass the parcel, decorate a duck cake and make bracelets with Bluey and Bingo in this birthday sticker activity book! It's jam-packed with activities including spot the difference, dot to dot and lots of colouring in to keep the biggest Bluey fans entertained. With over 100 stickers included, this activity book is the perfect birthday gift!Happy Birthday!Don’t miss these other awesome Bluey books:Bluey: Bluey and Bingo’s Fancy Restaurant CookbookBluey: Family and Friends Colouring in Sticker BookBluey: How to DrawBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun co

本書以R語言中的ggplot2包為核心，結合多種常用擴展包，系統講解科研圖表的構建邏輯與實現方法。內容涵蓋軟件環境配置、數據導入與整理、幾何對象、美學映射、比例尺、坐標系以及主題設置等關鍵環節，全面覆蓋科研可視化的核心流程。書中案例精選自Nature、Nature Communications、Nature Microbiology等國際期刊，基於其公開發表的真實數據進行改編，深入講解柱狀圖、散點圖、箱線圖、熱圖、Circos圖、桑基圖與網絡圖等多種常用科研圖形的繪製方法，幫助讀者在真實的科研語境中掌握高質量圖表的構建能力與可視化思維。

Emperor Li Longji (r. 712–756), also known as Tang Xuanzong and the Brilliant Emperor (Minghuang), ruled over China at the height of her political, military, and cultural dominance. While his Tang dynasty reached the zenith of its power under his reign, his fascination with women and religion, coupled with his neglect of government, sowed the seeds of decline. The empire ultimately collapsed in a nationwide rebellion. Emerging from the crisis greatly weakened and deprived of power, Longji lived day by day, hoping for a reunion with his beloved woman, who had been murdered and was now in heaven.

This book addresses the relationship between efficient management of critical minerals and sustainability in the Global South, including Sub-Saharan Africa. Critical minerals are essential raw materials for the technologies that are pivotal in today's energy transition. However, critical mineral host states and communities face social, economic, ecological, political, technological, and governance injustices.The book contends that the criteria currently used in assessing criticality and critical mineral development do not fulfil the sustainable development ambitions of developing countries and that broader considerations must be taken into account to include the stakeholders involved as well as the spatial dimension of the critical mineral value chain. In particular, the book argues that the law must consider the broader context in which minerals become critical to particular processes. It positions this argument within the current context of climate change, the just energy transition,

Accelerate your toddler's education in first words and shapes using this engaging board book designed by a professional artist and licensed speech therapist Scribble Scrabble takes your young child on an adventure as they learn new words and shapes through life-like paintings, bright colors, and an animal friend who guides them along the way. Written by licensed speech therapist Tabitha Paige, Scribble Scrabble features strategically chosen first words that include a child's earliest developing sounds, such as m, b, p, t, etc. With beautiful hand-painted art from Tabitha, this is the perfect baby book for a baby shower gift! So join our little mouse friend on a creative adventure as he takes your child through this first words book in a fun and interactive way!

Why should we think about the home? Most would agree that it is central to children's development-a healthy, stable, and hopefully loving environment where they can prepare for adulthood. But for women, the duties and expectations bound up with life at home have historically often meant stunted development, confinement to the home and domestic work, subordination to a man who goes in and out of the home freely. While societal advancements have helped to close this gap for some, these problems endure for many. The writings of women philosophers, some going back many centuries, reveal insights on these challenges that deserve close study. In No Place Like Home, Sandrine Berg鋊 calls attention to women philosophers' ideas and arguments, starting in antiquity and continuing into the twenty-first century. Through their writings, she examines the concept of the home in all its historical richness and variety, thus reinstating the home as a philosophical problem, worthy of deep inquiry. Berg鋊

Little Wandle Code ensures effective reading intervention in early KS3. This tried and tested programme with accompanying resources comprising 10 age-appropriate, levelled and fully decodable anthologies plus 3 workbooks will support all students who are not meeting age-related expectations when they begin secondary school.

The CSB Holy Bible for Kids, Large Print, Economy Edition features easy-to-read 10-point type, a fun and engaging cover design, kid-friendly gospel presentation, and full-color illustrated insert pages connecting Christ to key events and characters in Scripture. This affordable economy style Bible for kids makes a great first Bible and is designed to be accessible and affordable for churches, ministries, and individuals to provide children a Bible of their own. FEATURES: Fun and engaging cover design for kids Kid-friendly gospel presentation 40 insert pages with colorful illustrations and Christ Connections Easy-to-read 10-point type Topical concordance to help kids discover important truths in the Bible Complete text of the Christian Standard Bible(R) (CSB) Presentation page for gift-giving or awards Part of what makes the CSB Outreach Bible for Kids so special is the readable, faithful-to-the-original text of the Christian Standard Bible(R). The CSB's optimal blend of accuracy and re

Play Hide and Seek with Bluey!It’s time to play Hide and Seek! Can Bluey find everyone without getting distracted? Join the search and see who Bluey meets along the way. SQUAWK!Now everybody, hide! “Ready or not, here I come!”Play Hide and Seek with Bluey and Bingo in this brilliant board book!Don’t miss these other awesome Bluey books:Bluey: The WeekendBluey: Granny MobileBluey: BBQBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

★ 荒謬任務 × 真實科學！用化學實驗破解超狂危機★ 海盜求生、恐龍蛋運送、秘密訊息傳遞——科學就是最強超能力！★ 步驟清楚的趣味實驗，讓孩子邊玩邊學、動手探索STEM世界★ 暢銷童書作家 Swapna Haddow × 科普漫畫插畫家 Jess Bradley 爆笑合作當荒謬任務遇上真正的科學，冒險就開始了！本書以爆笑情境帶出化學原理，搭配簡單易懂的實驗，讓孩子在動手操作中理解科學概念。從秘密訊息到瞬間冰淇淋，每一個實驗都像一場小小冒險。結合漫畫式插圖與幽默故事，是讓孩子愛上STEM的最佳入門讀物。A funny children’s illustrated science book with experiments for ages 8+ that is new for 2026Bonkers dilemmas that can be solved with science and a bunch of brilliant chemistry experiments.Survive at sea with pirates! Carry a dinosaur egg across the jungle! Send secret messages! Make diamonds from pencils!Explore a bunch of ridiculous (and not-so-ridiculous) dilemmas – with solutions from the astonishing world of chemistry.Sounds unbelievable? Test the science for yourself, with easy-to-follow experiments throughout!What are you waiting for? Let’s become millionaires!Written by bestselling and award-winning author Swapna Haddow, with brilliantly funny colour illustrations from award-winning illustrator Jess Bradley.BOOK 1 OUT NOW: How to

Measure the speed of light like Albert Einstein! Train to be an astronaut like Mae Jemison! Communicate with chimpanzees like Jane Goodall! This book will make YOU a scientist as you explore 25 different scientific ideas inspired by ground-breaking scientists through history!Discover 25 of the world's most incredible scientists in this fact-filled book full of step-by-step science experiments that are easy to try at home. From making your own volcano and extracting DNA from a strawberry to exploring electricity, evolution and gravity, this imaginative book is jam-packed with ideas for aspiring scientists everywhere!*Friendly, accessible text written by planetary physicist, science presenter and school science teacher Dr Sheila Kanani MBE, author of Blue Peter Award-shortlisted How to Be an Astronaut and Can You Get Rainbows in Space?*Featuring biographies of 25 fantastic scientists, plus an exciting science-based experiment to try on every spread.*Vibrant, full colour illustrations on

Babies who've grown up with the bestselling touchy-feely books will love That's not my... Activity Books!Discover zoo-themed things to spot, pictures to finish, shapes to trace and words to learn - all packed into the pages of this fun first activity book. Don't forget to spot little white mouse on every double page!- Perfect for children aged 2 years and above- Helps develop vocabulary and fine motor skills- Bright, bold, eye-catching illustrations support visual development- Keeps children entertained on-the-go- Discover more in the series, from favourite animals to exciting vehicles

An exciting new business ethics textbook that looks at the most pressing contemporary issues including data ethics, technology and equality and diversity.

Many laws penalize conduct not because it is inherently wrongful, but because the government has prohibited it. Criminalizing Disobedience examines this important yet underexplored aspect of modern criminal law. Such "disobedience offenses" include: administration of justice crimes (contempt, obstruction of justice, perjury); failure-to-assist crimes (hindering prosecution, receiving stolen property, money laundering, failures to register or to report); regulatory offenses (involving, for example, environmental, drug, or medical device laws); preventive offenses (attempt, possession of weapons or drugs); and national security offenses (treason, espionage, export control and sanctions violations). What unifies these otherwise disparate offenses is that their core wrong lies in noncompliance with legal directives - not in unjustifiably harming or endangering others - and the principal reason to refrain from such conduct is simply that the government has said not to do it. By contrast, la

★ 牛津權威打造，孩子的第一本世界地圖書★ 專為 5歲以上 小讀者設計，輕鬆學習地理與地圖概念★ 全彩地圖＋可愛小鳥導覽角色，閱讀有趣又好懂★ 建立地圖閱讀、地理知識與世界觀的最佳入門書《Oxford First Atlas》是專為5歲以上兒童設計的地圖入門書，透過色彩鮮明的地圖與簡單易懂的說明，帶孩子認識世界各地的位置與特色。書中結合地圖符號、基礎座標概念與有趣的地理知識，並由可愛的小鳥角色陪伴探索，幫助孩子建立地理概念與閱讀地圖的能力。The perfect introductory atlas for use at home or school. It helps build children's locational knowledge, map skills, and subject vocabulary. With a friendly bird character, it takes children on a journey from local experiences, around the world, and up into space.The perfect first atlas that helps build locational knowledge, map skills, and subject vocabulary.Help young learners explore their world with confidence using the newly updated Oxford First Atlas - the perfect first atlas for home learning, school projects, and early geography skills. Designed specifically for children aged 5+ and fully aligned with the EYFS and Key Stage 1 Geography Curriculum, this beautifully illustrated atlas builds early map-reading skills, locational knowledge, and key vocabulary in a

★ 牛津權威編纂，兒童第一本英語字典首選★ 專為 5歲以上 小讀者設計，定義清楚、例句易懂★ 全彩3D插圖＋清晰字母索引，查找快速又有趣★ 依據 Oxford Children’s Corpus 兒童語料庫打造《Oxford First Dictionary》是專為5歲以上兒童設計的第一本英語字典，提供清楚易懂的單字解釋與例句，幫助孩子擴展詞彙並提升拼字與閱讀理解能力。書中搭配全彩插圖、發音提示與字母索引設計，查找方便、學習有趣，是孩子在家或學校建立英語基礎的理想工具書。With age-appropriate definitions and example sentences, the Oxford First Dictionary is perfect for use at home or in school, helping expand children's vocabulary, improve spelling, and support comprehension.The perfect first dictionary to help expand younger children's vocabulary and improve spelling.Help children build strong early language skills with the newly updated Oxford First Dictionary - a trusted tool for supporting vocabulary development, spelling, and reading comprehension at home or at school. Key features include:• Suitable for children aged 5+ with age-appropriate definitions and example sentences• Pronunciation breakdowns for harder to say words• Clear, accessible alphabetical layout, with alphabet thumb tags down the side of pages for

Get ready for bed with Bluey in this Bedtime Little Library. These chunky mini books are perfect for little hands. Stories include Fruit Bat, Daddy Putdown, Burger Shop and Sleepytime.It’s the perfect little gift for big Bluey fans. Night-night Bluey!Don’t miss these other awesome Bluey books:Bluey: Bluey and Friends Little LibraryBluey: Bluey Playtime Little LibraryBluey: Little LibraryBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK.Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Jasper, Mo, and Ruby learn all about soccer while they play in their town's World Cup tournament in the second installment of this action-packed, fully illustrated early chapter book series!Pick a book. Grow a Reader! This series is part of Scholastic's early chapter book line, Branches, aimed at newly independent readers. With easy-to-read text, high-interest content, fast-paced plots, and illustrations on every page, these books will boost reading confidence and stamina. Branches books help readers grow!It's time for the Raintree Forest World Cup! Jasper's class is taking part in a World Cup tournament with other third grade classes in the neighborhood. But Jasper is not as excited as everyone else to learn all about soccer, especially since the new student Sofia seems like a soccer know-it-all! Will Jasper be any good at playing soccer? And will his team be victorious in the Raintree Forest World Cup?Engaging black-and-white artwork appears on every page, and game-time scenes are to

Mo Willems, a #1 New York Times bestselling author and illustrator, teams up with celebrated Emmy-nominated actress, comedian, and musician Kate Micucci for the tenth book in the ELEPHANT & PIGGIE LIKE READING! early reader series.Award-winning actor, comedian, musician, and artist Kate Micucci teams up with #1 New York Times bestselling author and illustrator Mo Willems as part of the Theodor Seuss Geisel Award-winning early reader series Elephant & Piggie Like Reading!When Monster meets Puppet, they decide to put on a show. Puppet knows what Monster should do! Monster should tell a joke! Monster should dance! Monster should sing! But the more Monster does, the more Puppet wants MORE. What should Monster do when The Monster and Puppet Show! is not fun any ... MORE!?!Kate Micucci's vibrant pop art and humorous storytelling cleverly explore themes of friendship, peer pressure, boundaries, and self-preservation. This funny beginning reader, for kids ages 4 to 8, supports early re

If one day buds bloom and birds chirp, and the next day a late snow falls from the sky, is it spring? Will it ever be spring? An evergreen, child-friendly picture book that explores themes of patience, hope, the seasons, and nature by the New York Times bestseller and Caldecott Medalist Kevin Henkes.A flower in the garden down the street. Birds in the sky. Buds on the branches in the park. It must be spring.But wait! What is this icy gust of wind? Why are snowflakes falling from heavy gray clouds? Will it ever be spring? Yes, says the sun. Just be patient.Kevin Henkes, the #1 New York Times bestseller who has been awarded the Caldecott Medal, two Caldecott Honors, two Newbery Honors, two Geisel Honors, the Children's Literature Lecture Award, and Children's Literature Legacy Award, among numerous other honors, has created a masterful and classic picture book that combines an evocative call-and-response text with delicate and lovely illustrations. Readers will be left assured that the s

An introductory review of electric energy using examples, numerical calculations and theory to describe the basic elements of the field. Coverage includes electric infrastructure, the grid, system operations, renewable energy, alternating current circuits, three-phase power, power electronics, blackouts and future power systems.

The heartwarming, magical Japanese bestseller about grief, love and a cat who will do anything to see his beloved owner againThe heartwarming Japanese bestseller about grief, love and a cat who will do anything to see his beloved owner again'A much-needed dose of comfort and positivity' SHANNA TANAfter a long and happy life with a loving human family, tabby cat Fuuta has passed into the afterlife. But he is not as far from his owner Michiru as it seems. Sometimes the divide between the lands of the living and the dead can be traversed.Eager to see Michiru again, Fuuta interviews for a position at Café Pont, which sits in the liminal space between the two worlds. The café is known for its unique service: its living customers can request meetings with the person they'd most like to see again, through the specially selected spirits of messenger cats.Fuuta must investigate and deliver his messages without unnerving the living, or worse, upsetting the balance of the universe itself. It is a

This open access book examines the role played by international, regional, and national legal frameworks in holding corporations operating in the natural resource sector accountable for human rights violations in the Global South. Influential scholars from across the world address pressing issues concerning the integration of business and human rights standards for better governance of natural resources. They focus particularly on extractive and multinational companies in the Global South and their role in the transition to net zero societies.The book also examines legal mechanisms for corporate accountability under international, human rights and transnational law, using case studies from selected countries across Africa, Asia, and Latin America. The book reviews proposals for an enforceable legal framework to hold corporations accountable for human rights abuses and environmental damage. It considers initiatives such as the OECD Guidelines on Multinational Enterprises, the UN Guiding

Children will love using the stickers to decorate eggs and bonnets, ready for the Easter parade, and sticking on sweet treats and hidden eggs in scenes of celebration. With over 150 stickers.- Encourages creativity as children can choose where to place the stickers in each scene.- Features child characters enjoying Easter preparations.