Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

You may be surprised to learn that microchips are the new oil—the scarce resource on which the modern world depends. Today, military, economic, and geopolitical power are built on a foundation of computer chips. Virtually everything—from missiles to microwaves—runs on chips, including cars, smartphones, the stock market, even the electric grid. Until recently, America designed and built the fastest chips and maintained its lead as the #1 superpower, but America’s edge is in danger of slipping, undermined by players in Taiwan, Korea, and Europe taking over manufacturing. Now, as Chip War reveals, China, which spends more on chips than any other product, is pouring billions into a chip-building initiative to catch up to the US. At stake is America’s military superiority and economic prosperity.Economic historian Chris Miller explains how the technology works and why it’s so important, recounting the fascinating events that led to the United States perfecting the chip design, and to Ameri

From New York Times bestselling author of The Gentle Art of Swedish Death Cleaning, a book of humorous and charming advice for embracing life and aging joyfully.Margareta Magnusson shared with the world her practical Swedish tradition of dstdning, or ';death cleaning'clearing out unnecessary belongings before others must do it for youin her international bestseller The Gentle Art of Swedish Death Cleaning. Now, unburdened by baggage (emotional and actual) she is able to focus on what makes each day worth living, and reveals her discoveries about growing oldersome difficult to accept, many rather wondrous. She reflects on her early days growing up in Sweden and raising her family around the world, offering tips and wisdom on how to age gracefully, such as: don't be afraid to wear stripes, don't resist new technology, let go of what doesn't matter, and much more. As with death-cleaning, it's never too early to begin and The Swedish Art of Aging Well shows us how to prepare for and unders

In the tradition of Silent Spring and The Sixth Extinction, an urgent, "disturbing, empowering, and essential" (Kirkus Reviews, starred review) book about the ways in which chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan. In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe--but the story didn't end there. It turns out our sexual development is changing in broader ways, for both men and women and even other species, and that the modern world is on pace to become an infertile one. How and why could this happen? What is hijacking our fertility and our health? Count Down unpacks these ques

The remarkable untold story of a Jewish orphan who fled Nazi Germany for London, only to be arrested there by the British government and sent to an internment camp for suspected foreign agents on the Isle of Man, alongside a renowned group of refugee musicians, intellectuals, artists, and―possibly―genuine spies.Following the events of Kristallnacht in 1938, Peter Fleischmann evaded the Gestapo’s midnight roundups in Berlin by way of a perilous journey to England via the Kindertransport train. But he could not escape the British police, who came for him in the early hours and shipped him off to Hutchinson Camp on the Isle of Man, under suspicion of being a spy for the very regime he had fled.Peter’s story was no isolated incident. During Hitler’s rise to power in the 1930s, tens of thousands of German and Austrian Jews escaped and found refuge in Britain. Once war broke out in 1939, the nation turned against them, fearing that Nazis had planted spies posing as refugees. Innocent asylum

This lyrical debut novel is at once a passionate coming-of-age story, a meditation on illness and death, and a kaleidoscopic journey through one woman's lifetold in part by the malevolent voice of her disease.Lia, her husband Harry, and their beloved daughter, Iris, are a precisely balanced family of three. With Iris struggling to navigate the social tightrope of early adolescence, their tender home is a much-needed refuge. But when a sudden diagnosis threatens to derail each of their lives, the secrets of Lia's past come rushing into the present, and the world around them begins to transform. Deftly guided through time, we discover the people who shaped Lia's youth; from her deeply religious mother to her troubled first love. In turn, each will take their place in the shifting landscape of Lia's body; at the center of which dances a gleeful narrator, learning her life from the inside, growing more emboldened by the day. Pivoting between the domestic and the epic, the comic and the hea

Futureproof your body and relieve chronic pain resulting from sitting, slouching, and other bad lifestyle habits with this easy-to-perform set of daily stretching and exercise routinesfrom an innovative physical therapist and social media star who coaches dozens of celebrity clients.What if we could easily acquire long-lasting protection for our bodies and escape the chronic pain caused by our sit-all-the-time, slouch-too-much lifestyles? Vinh Pham is a world-class physical therapista member of a new breed that dissects how people really move. He has worked with a broad range of clients, from Olympians to NBA stars to MMA fighters to Golden Globe and Grammy Awardwinning artists. Early in his career, he discovered a disappointing truth: most of his patients came to him already in pain. They had poor, deeply ingrained lifestyle habits that misaligned their joints and tightened their muscles. And the recent epidemic of prolonged sittingwhich represents an all-day assault on the body has

A desperate man attempts to win a reality TV game where the only objective is to stay alive in this #1 national bestseller from Stephen King, writing as Richard Bachman. “Under any name King mesmerizes the reader” (Chicago Sun-Times).Ben Richards is a desperate man. With no job, no money, no way out, and a young daughter in need of proper medical attention, he must turn to the only possibility of striking it rich in this near-future dystopian America: participating in the ultra-violent TV programming of the government-sanctioned Games Network. Ben soon finds himself selected as a contestant on the biggest and the best that the Games Network has to offer: “The Running Man,” a no-holds-barred thirty-day struggle to stay alive as public enemy number one, relentlessly hunted by an elite strike force bent on killing him as quickly as possible in front of an audience all too eager to see that happen. It means a billion dollars in prize money if he can live for the next month. No one has ever

A beautifully designed, full-color collection of paper dolls created by Zelda Fitzgerald, lovingly compiled by her granddaughter, Eleanor Lanahan.Born in Montgomery, Alabama, Zelda Sayre Fitzgerald has long been an American cultural icon. A Southern belle turned flapper, Zelda was talented in dance, painting, and writing but lived in the shadow of her writer husband F. Scott Fitzgerald’s success.The golden couple of the Jazz Age, Zelda and her husband moved around―from hotels to rented villas to apartments in Paris―and Zelda always brought along her paints. Few people know she painted at all, and fewer still know she made paper dolls. But throughout her life, Zelda created dolls, whenever she could, in private. By design, paper dolls are delicate, fragile, and destined for destruction at the hands of children. Zelda’s dolls began as playthings for her daughter, Scottie, born in 1921. Fortunately, Zelda continued to make figures after Scottie outgrew them, first of their family and then

“Hoffman certainly knows how to enchant” (The New York Times Book Review) in this breathtaking conclusion to the Practical Magic series―a spellbinding and bewitching novel that asks how far will you go to change your fate?For over three-hundred years a curse has kept the Owens family from love―but all of that is about to change. The novel begins in a library, the best place for a story to be conjured, when beloved aunt Jet Owens hears the deathwatch beetle and knows she has only seven days to live. Jet is not the only one in danger―the curse is already at work.A frantic attempt to save a young man’s life spurs three generations of the Owens women, and one long-lost brother, to use their unusual gifts to break the curse as they travel from Paris to London to the English countryside where their ancestor Maria Owens first practiced the Unnamed Art. The younger generation discovers secrets that have been hidden from them in matters of both magic and love by Sally, their fiercely protective

A New York Times bestseller, this extraordinary memoir from Huma Abedin―Hillary Clinton’s famously private top aide and longtime advisor―offers “a gripping testament to the power of a woman finding her voice, owning her ambition, and sharing her truth” (Glennon Doyle).Abedin’s stunning memoir garnered an extraordinary amount of media coverage, with appearances on CBS Sunday Morning, the Today show, The Late Show with Stephen Colbert, The View, Late Night with Seth Meyers, Christiane Amanpour, and coverage in many other outlets, including The Washington Post, The New York Times, and NPR.The daughter of Indian and Pakistani intellectuals and advocates, Abedin grew up in the United States and Saudi Arabia and traveled widely. Both/And grapples with family, legacy, identity, faith, marriage, motherhood―and work―with wisdom, sophistication, grace, and clarity.Abedin launched full steam into a college internship in the office of the First Lady in 1996, never imagining that her work at the Wh

A New York Times Notable Book, Critic’s Top Pick, and Top Ten Book of Historical FictionNamed a Best Book of the Year by The Washington Post, NPR, Vogue, The Wall Street Journal, and Bloomberg Businessweek​From one of today’s most brilliant and beloved novelists, a dazzling, epic family saga set across a half-century spanning World War I, the rise of Hitler, World War II, and the Cold War that is “a feat of literary sorcery in its own right” (Oprah Daily).The Magician opens in a provincial German city at the turn of the twentieth century, where the boy, Thomas Mann, grows up with a conservative father, bound by propriety, and a Brazilian mother, alluring and unpredictable. Young Mann hides his artistic aspirations from his father and his homosexual desires from everyone. He is infatuated with one of the richest, most cultured Jewish families in Munich, and marries the daughter Katia. They have six children. On a holiday in Italy, he longs for a boy he sees on a beach and writes the sto

Set in a Harlem high rise, a stunning debut about a tight-knit cast of characters grappling with their own personal challenges while the forces of gentrification threaten to upend life as they know it.Like Gloria Naylor's The Women of Brewster Place and Lin Manuel Miranda's In the Heights, Sidik Fofana's electrifying collection of eight interconnected stories showcases the strengths, struggles, and hopes of one residential community in a powerful storytelling experience. Each short story follows a tenant in the Banneker Homes, a low-income high rise in Harlem where gentrification weighs on everyone's mind. There is Swan in apartment 6B, whose excitement about his friend's release from prison jeopardizes the life he's been trying to lead. Mimi, in apartment 14D, who hustles to raise the child she had with Swan, waitressing at Roscoe's and doing hair on the side. And Quanneisha B. Miles, a former gymnast with a good education who wishes she could leave Banneker for good, but can't seem

From the bestselling author of The Trouble with Goats and Sheep and Three Things About Elsie, a delightfully sinister novel about a married woman living a nice, quiet suburban lifebut things aren't always what they seemLinda has lived in a quiet neighborhood since fleeing the dark events of her childhood in Wales. Now she sits in her kitchen, wondering if this is all there is: pushing the vacuum around and cooking fish sticks for dinner, a far cry from the glamorous lifestyle she sees in the glossy magazines coming through the mail slot addressed to the previous occupant, Rebecca. Linda's husband Terry isn't perfecthe picks his teeth, tracks dirt through the house, and spends most of his time in front of the TV. But that seems fairly standarduntil he starts keeping odd hours at work, at around the same time young women in the town start to go missing. If only Linda could track down and befriend Rebecca, maybe some of that enviable lifestyle would rub off on her and she wouldn't have to

The ';grippingphenomenalgorgeous' (USA TODAY) #1 New York Times bestselling novella collection from master storyteller Stephen King!Readers adore Stephen King's novels, and his novellas are their own dark treat, briefer but just as impactful and enduring as his longer fiction. Many of his novellas have been made into iconic films, including ';The Body' (Stand by Me) and ';Rita Hayworth and Shawshank Redemption' (Shawshank Redemption). The four brilliant tales in If It Bleeds prove as iconic as their predecessors. In the title story, reader favorite Holly Gibney (from the Mr. Mercedes trilogy and The Outsider) must face her fears, and possibly another outsiderthis time on her own. In ';Mr. Harrigan's Phone' an intergenerational friendship has a disturbing afterlife. ';The Life of Chuck' explores, beautifully, how each of us contains multitudes. And in ';Rat,' a struggling writer must contend with the darker side of ambition. If these novellas show King's range, they also prove that cert

An unforgettable debut novel from an award-winning writer: a lively, daring ghost story about a teenage ghost who falls in love with a writer who doesn't know she exists.In 1473, fourteen-year-old Blanca dies in a hilltop monastery in Mallorca. Nearly four hundred years later, when George Sand, her two children, and her lover Frederic Chopin arrive in the village, Blanca is still there: a spirited, funny, righteous ghost, she's been hanging around the monastery since her accidental death, spying on the monks and the townspeople and keeping track of her descendants. Blanca is enchanted the moment she sees George, and the magical novel unfolds as a story of deeply felt, unrequited longingthe impossible love of a teenage ghost for a woman who can't see her and doesn't know she exists. As George and Chopin, who wear their unconventionality, in George's case, literally on their sleeves, find themselves in deepening trouble with the provincial, 19th-century villagers, Blanca watches helpless

The masterful story of a lifelong friendship between two very different women with shared histories and buried secrets, tested in the twilight of their lives, set across the arc of the 20th century.Celebrated children's book author Agnes Lee is determined to secure her legacyto complete what she knows will be the final volume of her pseudonymously written Franklin Square novels; and even more consuming, to permanently protect the peninsula of majestic coast in Maine known as Fellowship Point. To donate the land to a trust, Agnes must convince shareholders to dissolve a generations-old partnership. And one of those shareholders is her best friend, Polly. Polly Wister has led a different kind of life than Agnes: that of a well-off married woman with children, defined by her devotion to her husband, and philosophy professor with an inflated sense of stature. She exalts in creating beauty and harmony in her home, in her friendships, and in her family. Polly soon finds her loyalties torn be

From the New York Times bestselling author of The Good House, the story of two friends, raised in the same orphanage, whose loyalty is put to the ultimate test when they meet years later at a controversial institutionone as an employee; the other, an inmate.It's 1927 and eighteen-year-old Mary Engle is hired to work as a secretary at a remote but scenic institution for mentally disabled women called the Nettleton State Village for Feebleminded Women of Childbearing Age. She's immediately in awe of her employerbrilliant, genteel Dr. Agnes Vogel. Dr. Vogel had been the only woman in her class in medical school. As a young psychiatrist she was an outspoken crusader for women's suffrage. Now, at age forty, Dr. Vogel runs one of the largest and most self-sufficient public asylums for women in the country. Mary deeply admires how dedicated the doctor is to the poor and vulnerable women under her care. Soon after she's hired, Mary learns that a girl from her childhood orphanage is one of th

Set over the course of one summer, this perfect beach read follows a mother and her two daughters as they grapple with heartbreak, young love, and the weight of family secrets.Brian and Margot Dunne live year-round in Seaside, just steps away from the bustling boardwalk, with their daughters Liz and Evy. The Dunnes run a real estate company, making their living by quickly turning over rental houses for tourists. But the family's future becomes even more precarious when Brian develops a brain tumor, transforming into a bizarre, erratic version of himself. Amidst the chaos and new caretaking responsibilities, Liz still seeks out summer adventure and flirting with a guy she should know better than to pursue. Her younger sister Evy works in a candy shop, falls in love with her friend Olivia, and secretly adopts the persona of a middle-aged mom in an online support group, where she discovers her own mother's most vulnerable confessions. Meanwhile, Margot faces an impossible choice driven by

Set in London now, Love Marriage marks the magnificent return of Monica Ali, the Booker Prize shortlisted, ';splendid, daring, brilliant, refreshing' novelist (The New Republic) ';with an inborn generosity that cannot be learned' (The New York Times Book Review).Yasmin Ghorami in twenty-six, in training to be a doctor (like her Indian-born father), and engaged to the charismatic, upper-class Joe Sangster, whose formidable mother, Harriet, is a famous feminist. The gulf between families is vast. So, too, is the gulf in sexual experience between Yasmin and Joe. As the wedding day draws near, misunderstandings, infidelities, and long-held secrets upend both Yasmin's relationship and that of her parents, a ';love marriage,' according to the family lore that Yasmin has believed all her life. A gloriously acute observer of class, sexual mores, and the mysteries of the human heart, Monica Ali has written a captivating social comedy and a profoundly moving, revelatory story of two cultures, tw

A riveting, decades-in-the-writing memoir from the determined young prosecutor who, in two of America's most celebrated trials, managed to convict famed mob boss John Gottiand subsequently took down the Mafia altogether.John Gotti was without a doubt the flashiest and most feared Mafioso in American history. He became the boss of the Gambino Crime Family in spectacular fashionwith the brazen and very public murder of Paul Castellano in front of Sparks Steakhouse in midtown Manhattan in 1985. Not one to stay below law enforcement's radar, Gotti instead became the first celebrity crime boss. His penchant for eye-catching apparel earned him the nickname ';The Dapper Don;' his ability to beat criminal charges led to another: ';The Teflon Don.' This is the captivating story of Gotti's meteoric rise to power and his equally dramatic downfall. Every step of the way, Gotti's legal adversaryJohn Gleeson, an Assistant US Attorney in Brooklynwas watching. When Gotti finally faced two federal rac

From the bestselling author of Good Girl, Bad Girl and When You Are Mine comes a gripping thriller featuring the brilliant forensic psychologist Cyrus Haven as he becomes embroiled in an explosive murder case with disturbing origins.Criminal psychologist Cyrus Haven and Evie Cormac return in this ';powerhouse of a novel' (Booklist, starred review) from internationally bestselling author Michael Robotham, a writer Stephen King calls ';an absolute master...with heart and soul.' Who is Evie, the girl with no past, running from? She was discovered hiding in a secret room in the aftermath of a terrible crime. Her ability to tell when someone is lying helped Cyrus crack an impenetrable case in Good Girl, Bad Girl. Now, the closer Cyrus gets to uncovering answers about Evie's dark history, the more he exposes Evie to danger, giving her no choice but to run. Ultimately, both will have to decide if some secrets are better left buried and some monsters should never be named...

The 1619 Project illuminated the ways in which every aspect of life in the United States was and is shaped by the existence of slavery. Black Ghost of Empire focuses on emancipation and how this opportunity to make right further codified the racial caste systeminstead of obliterating it.To understand why the shadow of slavery still haunts society today, we must not only look at what slavery was, but also the unfinished way it ended. One may think of ';emancipation' as a finale, leading to a new age of human rights and universal freedoms. But in reality, emancipations everywhere were incomplete. In Black Ghost of Empire, acclaimed historian and professor Kris Manjapra identifies five types of emancipationexplaining them in chronological orderalong with the lasting impact these transitions had on formerly enslaved groups around the Atlantic. Beginning in 1770s and concluding in 1880s, different kinds of emancipation processes took place across the Atlantic world. These included the Gradu

In this examination of landscape and memory, four sites of American history are revealed as places where historical truth was written over by oppressive fictionwith profound repercussions for politics past and present.Popular narratives of American history conceal as much as they reveal. They present a national identity based on harvesting the treasures that lay in wait for European colonization. In Whose Ruins tells another story: winding through the US landscape, from Native American earthworks in West Virginia to the Manhattan Project in New Mexico, this history is a tour of sites that were mined for an empire's power. Showing the hidden costs of ruthless economic growth, particularly to Indigenous people and ways of understanding, this book illuminates the myth-making intimately tied to place. From the ground up, the project of settlement, expansion, and extraction became entwined with the spiritual values of those who hoped to gain from it. Every nation tells some stories and supp

#1 New York Times bestselling author Kathy Reichs takes forensic anthropologist Temperance Brennan behind the scenes of a major commercial airliner crash in this pulse-pounding thriller.';Buckle up and take this voyage,' says People. The journey begins with Temperance Brennan hearing shocking news on her car radio. An Air TransSouth flight has gone down in the mountains of western North Carolina, taking with it eighty-eight passengers and crew. As a forensic anthropologist and a member of the regional DMORT team, Tempe rushes to the scene to assist in body recovery and identification. As bomb theories abound, Tempe soon discovers a jarring piece of evidence that raises dangerous questionsand gets her thrown from the DMORT team. Relentless in her pursuit of its significance, Tempe uncovers a shocking, multilayered tale of deceit and depravity as she probes her way into frightening territorywhere someone wants her stopped in her tracks.

A transformative and compassionate memoir by a leading pioneer in medically assisted dying who began her career in the maternity ward and now helps patients who are suffering explore and then fulfill their end of life choices.Dr. Stefanie Green has been forging new paths in the field of medical assistance in dying since 2016. In her landmark memoir, Dr. Green reveals the reasons a patient might seek an assisted death, how the process works, what the event itself can look like, the reactions of those involved, and what it feels like to oversee proceedings and administer medications that hasten death. She describes the extraordinary people she meets and the unusual circumstances she encounters as she navigates the intricacy, intensity, and utter humanity of these powerful interactions. Deeply authentic and powerfully emotional, This Is Assisted Dying contextualizes the myriad personal, professional, and practical issues surrounding assisted dying by bringing readers into the room with D

The next call you take could be your last in this terrifying #1 New York Times bestseller by master storyteller Stephen King!On October 1, God is in His heaven, the stock market stands at 10,140, most of the planes are on time, and graphic artist Clayton Riddell is visiting Boston, having just landed a deal that might finally enable him to make art instead of teaching it. But all those good feelings about the future change in a moment thanks to a devastating phenomenon that will come to be known as The Pulse. The delivery method is a cell phoneeveryone's cell phone. Now Clay and the few desperate survivors who join him suddenly find themselves in the pitch-black night of civilization's darkest age, surrounded by chaos, carnage, and a relentless human horde that has been reduced to its basest nature...and then begins to evolve. There's really no escaping this nightmare. But for Clay, an arrow points the way home to his family in Maine, and as he and his fellow refugees make their harrow

From a renowned surgeon and historian with five decades of experience comes a remarkable history of surgery's developmentspanning the Stone Age to the present dayblending meticulous medical studies with lively and skillful storytelling.There are not many events in life that can be as simultaneously life-frightening and life-saving as a surgical operation. Yet, in America, tens-of-millions of major surgical procedures are performed annually but few of us pause to consider the magnitude of these figures because we have such inherent confidence in surgeons. And, despite passionate debates about healthcare and the endless fascination with surgical procedures, most of us have no idea how surgeons came to be because the story of surgery has never been fully told. Now, Empire of the Scalpel elegantly reveals the fascinating history of surgery's evolution from its earliest roots in Europe through its rise to scientific and social dominance in the United States. From the 16th-century saga of An

Never Let Me Go meets Black Mirror in this thrilling dystopian debut about a tech company that deletes unwanted memories, the consequences for those forced to contend with what they tried to forget, and the dissenting doctor who seeks to protect her patients from further harm.What if you once had a painful memory removed? And what if you were offered the chance to get it back? Tell Me an Ending follows four characters grappling with the question of what to rememberand what they hoped to forget forever. Finn, an Irish architect living in the Arizona desert, begins to suspect his charming wife of having an affair. Mei, a troubled grad school drop-out in Kuala Lumpur, wonders why she remembers a city she's never visited. William, a former police inspector in England, struggles with PTSD, the breakdown of his marriage, and his own secret family history. Oscar, a handsome young man with almost no memories at all, travels the world in a constant state of fear. Into these characters lives co

From a renowned financial journalist comes a fresh, “engaging” (The New York Times), and profound book that draws on hundreds of hours of exclusive interviews with many of the world’s super-investors to demonstrate that key insights for building wealth apply to life as well.Billionaire investors. If we think of them, it’s with a mixture of awe and suspicion. Clearly, they possess a kind of genius―the proverbial Midas Touch. But are the skills they possess transferable? And do they have anything to teach us besides making money?In Richer, Wiser, Happier, William Green draws on interviews that he’s conducted over twenty-five years with many of the world’s greatest investors. As he discovered, their talents extend well beyond the financial realm. The most successful investors are mavericks and iconoclasts who question conventional wisdom and profit vastly from their ability to think more rationally, rigorously, and objectively. They are master game players who consciously maximize their o

A delightful, entertaining guide to some of the best short novels of all time from a bestselling historian, author, and lifelong reader.Fall back into the joys of literature with an extraordinary book for book lovers: a compulsively readable, deeply engaging list of great short novels. A journey into short fiction designed with our contemporary attention spans in mind, Great Short Books suggests fifty-eight excellent short novels, all easily readable in a week or less―a “baker’s dozen” approach to a fun, fascinating year of reading.From hard-boiled fiction to magical realism, the 18th century to the present day, Great Short Books spans genres, cultures, countries, and time to present an enchanting and diverse selection of acclaimed and canonical novels. From works in translation like Yu Miri’s ​Tokyo Ueno Station and Marguerite Duras’s The Lover to popular, acclaimed authors like F. Scott Fitzgerald and Stephen King, this compilation is a celebration of classics from the historic to co

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiolo

An epic account of the decades-long battle to control what has emerged as the world’s most critical resource―microchip technology―with the United States and China increasingly in conflict.You may be surprised to learn that microchips are the new oil―the scarce resource on which the modern world depends. Today, military, economic, and geopolitical power are built on a foundation of computer chips. Virtually everything―from missiles to microwaves―runs on chips, including cars, smartphones, the stock market, even the electric grid. Until recently, America designed and built the fastest chips and maintained its lead as the #1 superpower, but America’s edge is in danger of slipping, undermined by players in Taiwan, Korea, and Europe taking over manufacturing. Now, as Chip War reveals, China, which spends more on chips than any other product, is pouring billions into a chip-building initiative to catch up to the US. At stake is America’s military superiority and economic prosperity.Economic

* A People Best Book of the Year * Time and The Washington Post’s Most Anticipated List * Longlisted for the Andrew Carnegie Medal for Excellence *From the MacArthur genius, two-time Pulitzer Prize finalist, and playwright, this “captivating, insightful memoir” (Kirkus Reviews, starred review) is “a beautiful meditation on identity and how we see ourselves” (Real Simple).With a play opening on Broadway, and every reason to smile, Sarah Ruhl has just survived a high-risk pregnancy when she discovers the left side of her face is completely paralyzed. She is assured that 90 percent of Bell’s palsy patients experience a full recovery―like Ruhl’s own mother. But Sarah is in the unlucky ten percent. And for a woman, wife, mother, and artist working in theater, the paralysis and the disconnect between the interior and exterior brings significant and specific challenges. So Ruhl begins an intense decade-long search for a cure while simultaneously grappling with the reality of her new face―one

From Pulitzer Prize winner Annie Proulx―whose novels are infused with her knowledge and deep concern for the earth―comes a riveting, revelatory history of our wetlands, their ecological role, and what their systematic destruction means for the planet.A lifelong environmentalist, Annie Proulx brings her wide-ranging research and scholarship to the subject of wetlands and the vitally important yet little understood role they play in preserving the environment―by storing the carbon emissions that greatly contribute to climate change. Fens, bogs, swamps, and marine estuaries are the earth’s most desirable and dependable resources, and in four stunning parts, Proulx documents the long-misunderstood role of these wetlands in saving the planet.Taking us on a fascinating journey through history, Proulx shows us the fens of 16th-century England to Canada’s Hudson Bay lowlands, Russia’s Great Vasyugan Mire, America’s Okeefenokee National Wildlife Refuge, and the 19th-century explorers who began

James Beard Award–winning writer Aleksandra Crapanzano shares the secrets of the cakes Parisians bake at home: the gâteau in its many splendors from the simplest yogurt cakes to deceptively easy bûches de Noël, from nut tortes to boozy flourless chocolate cakes, from yuzu madeleines to rum-soaked babas.When we think of French desserts, we tend to imagine ornate creations and confections. Perhaps we envision a tarte Tatin, but rarely a homemade cake, whipped up on a weeknight with little fuss. But that is exactly what Parisians make and eat. Gâteaux are simple, delicious cakes, both sweet and savory, served to family and friends.You might expect elaborate home baking to rival the extraordinary pâtisseries in town. Who hasn’t wondered if the French are born knowing how to make the exquisitely fine layers of puff pastry for a mille-feuille, or how to poach a soft meringue for an île flottante? As food-columnist Aleksandra Crapanzano spent time with Parisian friends who were cooking at h

Master storyteller Stephen King presents the “powerful” (Time) #1 New York Times bestselling classic thriller about a housekeeper with a long-hidden secret from her past―one that tests her own will to survive.When Vera Donovan, one of the wealthiest and most ill-natured residents of Maine’s Little Tall Island, dies suddenly in her home, suspicion is immediately cast on her housekeeper and caretaker, Dolores Claiborne. Dolores herself is no stranger to such mistrust, thanks to the local chatter and mysterious circumstances surrounding her abusive husband’s death twenty-nine years earlier.But if this is truly to be the day of Dolores Claiborne’s reckoning, she has a few things of her own that she’d like to get off her chest...and begins to confess a spirited, intimate, and harrowing tale of the darkest secrets hidden within her hardscrabble existence, revealing above all one woman’s unwavering determination to weather the storm of her life with grace and protect the one she loves, no mat

驚悚點子貌似永遠不見枯竭的恐怖大師帶來又一場盛大的夏日驚駭饗宴。背負家計重擔的少年遇見了名叫雷達的狗與牠年邁的主人，從老人臨終前的手中接過的那捲錄音帶裡，有著某人守了一輩子的秘密，通往另一個世界的秘密…Legendary storyteller Stephen King goes deep into the well of his imagination in this spellbinding novel about a seventeen-year-old boy who inherits the keys to a parallel world where good and evil are at war, and the stakes could not be higher—for their world or ours.Charlie Reade looks like a regular high school kid, great at baseball and football, a decent student. But he carries a heavy load. His mom was killed in a hit-and-run accident when he was ten, and grief drove his dad to drink. Charlie learned how to take care of himself—and his dad. Then, when Charlie is 17, he meets a dog named Radar and his aging master, Howard Bowditch, a recluse in a big house at the top of a big hill, with a locked shed in the backyard. Sometimes strange sounds emerge from it. Charlie starts doing jobs for Mr. Bowditch and loses his heart to Radar. Then, when Bowditch dies, he leaves Charlie a ca

“THE BOOK CHINA DOESN’T WANT YOU TO READ.” ―CNN​SELECTED AS A BEST BOOK OF THE YEAR by THE ECONOMIST and FINANCIAL TIMESThis “powerful and disturbing” (Bill Browder, author of Red Notice) New York Times bestseller is narrated by a man who, with his wife, Whitney Duan, rose to the top levels of power and wealth―and then fell out of favor. Whitney had been disappeared four years before, but this book led to her dramatic reemergence.As Desmond Shum was growing up impoverished in China, he vowed his life would be different. Through hard work and sheer tenacity he earned an American college degree and returned to his native country to establish himself in business. There, he met his future wife, the highly intelligent and equally ambitious Whitney Duan who was determined to make her mark within China’s male-dominated society. Whitney and Desmond formed an effective team and, aided by relationships they formed with top members of China’s Communist Party, the so-called red aristocracy, he vau

From veteran wine writer and James Beard Award winner Alice Feiring, an insightful and entertaining memoir of wine, love, heartbreak, and the never-ending process of coming-of-age.Called everything from the Patti Smith to the Ruth Bader Ginsburg of natural wines, Alice Feiring is a special sort of wine writerthe kind who dares to disagree with wine ';experts,' and who believes wholeheartedly that the best wine writing is about life. To Fall in Love, Drink This is both a love letter to wine and a lifelong coming-of-age story. In a series of candid, wise, and humorous personal essays, Feiring serves up a memoir in vignettes. She tells the story of her parents' divorce, her first big wine assignment, the end of an eleven-year relationship, the death of her father, a near-fatal brush with a serial killer, pandemic lockdown, and moreand suffuses each with love, romance, pain, joy, and wine. Each essay is ';accompanied' by a no-nonsense wine take-away designed to answer the questions everyd

New York Times bestselling author Megan Miranda returns with a gripping and propulsive thriller that opens with the disappearance of a journalist who is investigating a string of vanishings in the resort town of Cutter's Passwill its dark secrets finally be revealed?Ten years ago, Abigail Lovett fell into a job she loves, managing The Passage Inn, a cozy, upscale resort nestled in the North Carolina mountain town of Cutter's Pass. Cutter's Pass is best known for its outdoor offeringsrafting and hiking, with access to the Appalachian trail by way of a gorgeous waterfalland its mysterious history. As the book begins, the string of unsolved disappearances that has haunted the town is once again thrust into the spotlight when journalist Landon West, who was staying at the inn to investigate the story of the vanishing trail, then disappears himself. Abby has sometimes felt like an outsider within the community, but she's come to view Cutter's Pass as her home. When Landon's brother Trey sho