Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

★ 皇家學會科學圖書獎入圍作，最有故事性的數學史鉅作★ 從阿基米德到人工智慧，一口氣看懂微積分如何改變世界★ 沒有微積分，就沒有電腦、GPS、太空旅行與現代科技文明★ 天才、競爭、爭議與革命交織，一本讀來像史詩冒險的科普傑作這是一本把微積分寫得像歷史小說般精采的科普經典。史蒂芬．史卓格茲不只解釋數學，更帶領讀者看見天才們如何用思想改寫世界。從古代幾何到AI時代，本書呈現微積分如何成為現代文明最深層、也最驚人的力量。Shortlisted for the Royal Society Science Book Prize 2019A magisterial history of calculus (and the people behind it) from one of the world's foremost mathematicians. This is the captivating story of mathematics' greatest ever idea: calculus. Without it, there would be no computers, no microwave ovens, no GPS, and no space travel.But before it gave modern man almost infinite powers, calculus was behind centuries of controversy, competition, and even death. Taking us on a thrilling journey through three millennia, professor Steven Strogatz charts the development of this seminal achievement from the days of Archimedes to today's breakthroughs in chaos theory and artificial intelligence. Filled with idiosyncratic characters from Pythagoras to Fourier, Infinite Powers is a compelling

SHORTLISTED FOR THE 2018 BAILLIE GIFFORD PRIZE When Britain launched its first war on China in 1839, pushed into hostilities by profiteering drug merchants and free-trade interests, it sealed the fate

We like to get along, at home or in the workplace. We don't want to hurt people or offend. Therefore, it is no surprise that numerous famous psychological experiments have proven that we don't tend to

It begins in the fog, with a bleak village funeral. In the early hours of the following morning, Merrily Watkins and her daughter Jane are made aware that Aidan Lloyd, son of a wealthy farmer, will no

It begins in the fog, with a bleak village funeral. In the early hours of the following morning, Merrily Watkins and her daughter Jane are made aware that Aidan Lloyd, son of a wealthy farmer, will no

'Astonishing... With the intensity of a perfect balance between the mythic and the real, The Rain Heron keeps turning and twisting, taking you to unexpected places. A deeply emotional and satisfying r

Forty-five oral histories of iconic rock and R&B hits based on the popular Wall Street Journal column 'Anatomy of a Song'.

In the early 1870's a nighttime view over Britain would have revealed towns lit by the warm glow of gas and oil lamps and a much darker countryside, the only light emanating from the fiery sparks of l

'Memorable... One of [China's] most astute and sensitive foreign observers' Financial Times'Compassionate... full of warmth' GuardianMore than twenty years after teaching English to China's first boom generation at a small college in Sichuan Province, Peter Hessler returned to teach the next generation.At the same time, Hessler's twin daughters became the only Westerners in a student body of about two thousand in their local primary school. Through reconnecting with his previous students now in their forties - members of China's "Reform generation" - and teaching his current undergraduates, Hessler is able to tell an intimately unique story about China's incredible transformation over the past quarter-century. In the late 1990s, almost all of Hessler's students were the first of their families to enrol in higher education, sons and daughters of subsistence farmers who could offer little guidance as their children entered a brand-new world.By 2019, when Hessler arrived at Sichuan Univer

One beautiful September day, three sixty-six-year-old men convene on Martha's Vineyard, friends ever since meeting in college in the 1960s. They couldn't have been more different then, or even today -

In November 1919, a year after the Great War, four Australian servicemen made a unique and epoch-making journey home. In the open cockpit of a twin-engine Vickers Vimy bi-plane, brothers Ross and Keit

The British plan to settle Australia was a high-risk venture. We now take it for granted that the first colony was the basis of one of the most successful nations in the world today. But in truth, the

Kim Byeongsu is losing his mind. Quite literally. He keeps forgetting the little things in life, like basic words, whether or not he has a dog, the last time he killed someone... In his prime, Byeon

'Hugely entertaining' Guardian 'Fascinating' Mail on Sunday In 1882, Jean-Martin Charcot was the premiere physician in Paris, having just established a neurology clinic at the infamous Salpetriere Hos

In the wake of her mother's death, Shalini, a privileged and restless young woman from Bangalore, sets out for a remote Himalayan village in the troubled northern region of Kashmir. Certain that the l

In White Boy Running, Christopher Hope explored how it felt and looked to grow up in a country gripped by an 'absurd, racist insanity'. On a road trip thirty years later, Hope goes in search of today'

In the middle of her life, a writer finds herself in a dark wood, despairing and uncomprehending at how modern Britain has become a place of such greed and indifference. In an attempt to understand he

Robbie Parsons is one of London's finest, a black cab driver who knows every street, every theatre, every landmark in the city by heart. In his backseat is a man with a gun in his hand - a man who sho

Returning to the UK in September 2010 after serving in Iraq as the political adviser to the top American general, Emma Sky felt no sense of homecoming. She soon found herself back in the Middle East t

In 2012, whilst working at the Royal Horticultural Society's library, Fiona Davison unearthed a book of handwritten notes that dated back to 1822. The notes, each carefully set out in neat copperplate

Golden Hill and The Alienist meet Gangs of New York in this sweeping historical crime drama set in 18th century New York. New York, 1799. Justy Flanagan returns to his native city after five years in

Robert Crofts, a young Englishman, arrives in Australia in the 1950s, determined to inhabit the outback. After five years of life on the land, he makes his way to Melbourne where, living in a boarding

Stories of a young man finding his place among family and community in Houston, from a powerful, emerging American voice. In the city of Houston - a sprawling, diverse microcosm of America - the son o

When Ian Buruma arrived in Tokyo as a young film student in 1975, he found a feverish and surreal metropolis in the midst of an economic boom, where everything seemed new and history only remained in

1980: Josephine flees her home in Ireland, hoping never to return. She starts a new, exciting life in London, but as much as she tries, she can't quite leave the trauma of her childhood behind. Se

Katharine Smyth was a student at Oxford when she first read Virginia Woolf's modernist masterpiece To the Lighthouse in the comfort of an English sitting room, and in the companionable silence she sha

Returning to the UK in September 2010 after serving in Iraq as the political adviser to the top American general, Emma Sky felt no sense of homecoming. She soon found herself back in the Middle East t

Tim Waterstone is one of Britain's most successful businessmen, having built the Waterstone's empire that started with one bookshop in 1982. In this charming and evocative memoir, he recalls the child

Grace sees her boyfriend Henry everywhere. In the supermarket, on the street, at the graveyard. Only Henry is dead. He died two months earlier, leaving a huge hole in Grace's life and in her heart. B

Reyna knows her relationship with Boyd isn't perfect, yet as she visits him throughout his three-month stint in prison, their bond grows tighter. Kiki, now settled in New York after a journey that too

The final, thrilling installment in the epic Vespasian series from Robert Fabbri. Vespasian is tasked with the impossible. Should he quell the revolt in Judaea, as Nero the emperor has instructed, or

1980: Josephine flees her home in Ireland, hoping never to return. She starts a new, exciting life in London, but as much as she tries, she can't quite leave the trauma of her childhood behind.Sevente

In 2007, Bolton Crown Court sentenced Shaun Greenhalgh to four years and eight months in prison for the crime of producing artistic forgeries. Working out of a shed in his parents' garden, Greenha

Trust in our politicians is at an all-time low. We're in a "post-truth" era, where feelings trump facts, and where brazen rhetoric beats honesty. But do politicians lie more than they used to? And do

A frank, smart and endearing literary memoir of growing up as the daughter of Apple founder Steve Jobs in the rapidly changing Silicon Valley of the tech boom. Born on a farm and named in a field by h

One of the most influential books on Western understanding and sympathy for Red China in the 1930s