Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A wry literary masterpiece, God Hates Us All is a coming-of-age tale for the apathetic generation. Hank Moody's self-loathing yet darkly likeable narrator is a college drop-out-turned-accidental-drug

Beloved stoner comedian TOMMY CHONG is now older, wiser, and officially an EX-CON. On the morning of February 24, 2003, agents of the U.S. Drug Enforcement Administration launched a sting called Oper

The newest installment of the New York Times bestselling Peachtree Bluff series follows three generations of Murphy women as they come together to face a hurricane that threatens their hometown―and the holiday season―in this “book equivalent of a warm and fuzzy pair of socks” (E! Online).When the Murphy women are in trouble, they always know they can turn to their mother, Ansley. So when eldest daughter Caroline and her husband announce they are divorcing―and fifteen-year-old daughter Vivi acts out in response―Caroline, at her wits end, can’t think of anything to do besides leave her with Ansley in Peachtree Bluff for the holidays. After all, how much trouble can one teenager get into on a tiny island?Quite a lot, as it turns out.As the “storm of the century” heads toward Peachtree Bluff, Ansley and her husband, Jack, with Vivi in tow, are grateful they’re planning to leave for the trip of a lifetime. But Vivi’s recklessness forces the trio to shelter in place during the worst hurrican

In this newest Prison Camp installment, #1 New York Times bestselling author J. R. Ward pens a heart-wrenching tale of love and betrayal in the Black Dagger Brotherhood world…Framed for the grisly murder of his shellan, Kane is condemned to the notorious prison camp―unaware of the dark truth behind his arranged mating. Centuries later, when he is horribly burned while attempting to save others, he prays he’ll finally be reunited in the Fade with his mate…not knowing what revelations await him.Nadya is a self-taught nurse who does what she can to ease the suffering of the prisoners. When Kane comes under her care, she cannot help but empathize with his condition for very personal reasons―and as the guards take him away one last time, she fears he is facing a terrible death.After a daring rescue, Kane is offered a treatment that will change his very nature. Choosing life, for the time being, he goes back for the female who took such good care of him―but his duty to Nadya sets him on a co

A rapier-sharp, hilariously irreverent collection of true-life essays from the beloved author of Sippy Cups Are Not for Chardonnay.Stefanie Wilder-Taylor has never been one to take the conventional r

Still Alice is a compelling debut novel about a 50-year-old woman's sudden descent into early onset Alzheimer's disease, written by Lisa Genova, who holds a Ph. D in neuroscience from Harvard Universi

The seventh edition of a comprehensive, informative, and easy-to-use guide draws together Eastern, European, and American Indian methods of using herbs for medicinal purposes, providing simple herbal

Award-winning actor, rapper, and producer Ice-T unveils a compelling and astonishing memoir of his early life robbing jewelry stores until he found fame and fortunewhile a handful of bad choices sent his former crime partner down an incredibly different path. Ice-T rose to fame in the late 1980s, earning acclaim for his music before going on to capture television audiences as Odafin ';Fin' Tutuola in Law & Order: Special Victims Unit​. But it could have gone much differently. In this gripping and candid memoir, Ice-T and Spike, his former crime partnercollaborating with New York Times bestselling author Douglas Centuryrelate the shocking stories of their shared pasts, and how just a handful of decisions led to their incredibly different lives. Both grew up in violent, gang-controlled Los Angeles neighborhoods and worked together to orchestrate a series of jewelry heists in LA and across the US. But while Ice-T was discovered rapping in a club and got his first record deal, Spike wa

The New York Times bestselling author of The Unhoneymooners returns with an effervescent, "emotional...and surprising" (Shondaland) novel about what happens when two people with everything on the line are thrown together by science--or is it fate? Perfect for fans of The Rosie Project and One Plus One. In this "sexy, science-filled, and surprising romance full of warmth and wit" (Kirkus Reviews, starred review), single mom Jess Davis is a data and statistics wizard, but no amount of number crunching can convince her to step back into the dating world. After all, her father was never around, her hard-partying mother disappeared when she was six, and her ex decided he wasn't "father material" before her daughter was even born. Jess holds her loved ones close but working constantly to stay afloat is hard...and lonely. But then Jess hears about GeneticAlly, a buzzy new DNA-based matchmaking company that's predicted to change dating forever. Finding a soulmate through DNA? The reliability o

An Indie Next PickAn O, The Oprah Magazine Titles to Pick Up NowA People Book PickA New York Post Best Book of the WeekA Parade Most Anticipated Books of Early 2020A Bustle Most Anticipated Books of J

TV's POPULAR GHOST HUNTERS REVEAL ALL-NEW, NEVER-BEFORE-TOLD STORIES FROM THEIR SPOOKY EARLY INVESTIGATIONS!For the first time ever, Jason Hawes and Grant Wilson, founders of The Atlantic Paranormal

Detectives Jeppe Kørner and Anette Werner race to solve a series of sordid murders linked to some of the most vulnerable patients in a Danish hospital in this sequel to the #1 international bestseller The Tenant that is “brimming with personality, eccentric characters, and plenty of mystery and intrigue” (Crime by the Book).Hospitals are supposed to be places of healing. But in the coronary care unit at one of Copenhagen’s leading medical centers, a nurse fills a syringe with an overdose of heart medication and stealthily enters the room of an older male patient.Six days earlier, a paperboy on his route in central Copenhagen stumbles upon a macabre find: the naked body of a dead woman, lying in a fountain with arms marked with small incisions. Cause of death? Exsanguination―the draining of all the blood in her body.Copenhagen investigator Jeppe Kørner, recovering from a painful divorce and in the throes of a new relationship, takes on the case. His partner, Anette Werner, now on matern

Following the events of The Umbrella Lady, young Saffron Faith Anders searches for family and love in this spine-tingling gothic fairy tale from the New York Times bestselling author of the Flowers in the Attic series and Landry series―now popular Lifetime movies.After escaping the trauma of the Umbrella Lady’s home, thirteen-year-old Saffron Faith Anders is determined to find the father who abandoned her all those years ago. But when she finds him in a nearby town, Saffron is shocked to discover that he has married a woman he clearly had been involved with before her mother’s death. Worse, her father insists Saffron pretend to be his niece so he can continue to con his new wife’s family. Desperate for her father’s love, she goes along with the farce, but it soon becomes clear that perhaps it is better to face the world alone than trapped in a toxic and potentially dangerous family.

The thirteenth entry in the #1 New York Times bestselling series from the “prolific and talented” (Publishers Weekly) Ann Rule focuses on crime victims who had no idea they were in life-threatening danger, often from the very people they trusted the most.In this collection’s featured case, a family man dedicated to naturopathic healing embarks on a passionate affair with a flight attendant, but his jealous rages frighten her. When she finally leaves after a brutal attack, she has no idea that her tormentor would reappear in her life―with deadly consequences.Other cases include: a woman who masterminds her husband’s murder just to gain his inheritance; the sadistic criminal whose prison release damages a presidential campaign and ends in a bitter double tragedy; the shocking DNA link between a horrifying crime and a cold case; and finally, the man who crisscrosses the world in deadly pursuit of a beautiful woman.Once again, the country’s best true crime writer brings her “absolutely riv

A laugh-out-loud funny collection of insightful and razor-sharp essays on motherhood in our post-apocalyptic world from comedian Natasha Leggero.When Natasha Leggero got pregnant at forty-two after embarking on the grueling IVF process, she was over the moon. But once her feelings of bliss dissipated, she couldn’t help but shake the lingering question: Am I doing this right? And then, Should I be doing this if the world is about to end?In The World Deserves My Children, Natasha explores themes like “geriatric” motherhood, parenting in an environmental panic, fear and love, discipline (and conflicting schools of thought on how not to raise a brat), and more. Ultimately, Natasha determines that motherhood is worth it. After all, where do you think the next five generations of humans will be if the only people who are having kids don’t believe in science? The world deserves my children.

The flame of rebellion burns across the solar system in this dazzling conclusion to Linden A. Lewis’s stunning First Sister trilogy perfect for fans of Red Rising, The Handmaid’s Tale, and The Expanse.Astrid is finally free of the Sisterhood, yet her name carries on. She’s called the Unchained by those she’s inspired and the Heretic by those who want her voiceless once more. Now Astrid uses knowledge of the Sisterhood’s inner workings against them, aiding the moonborn in raids against abbeys and Cathedrals, all the while exploring the mysteries of her forgotten past.However, the Sisterhood thrives under the newly appointed Mother Lilian I, who’s engaged in high-stakes politics among the Warlords and the Aunts to rebuild the Sisterhood in her own image. But the evil of the Sisterhood can’t be purged with anything less than fire....Meanwhile, Hiro val Akira is a rebel without an army, a Dagger without a Rapier. As protests rock the streets of Cytherea, Hiro moves in the shadows, driven b

With deeply personal and uplifting essays in the vein of Black Girls Rock!, You Are Your Best Thing, and I Really Needed This Today, this is “a necessary testimony on the magic and beauty of our capacity to live and love fully and out loud” (Kerry Washington).When Tracey M. Lewis-Giggetts wrote an essay on Black joy for The Washington Post, she had no idea just how deeply it would resonate. But the outpouring of positive responses affirmed her own lived experience: that Black joy is not just a weapon of resistance, it is a tool for resilience.With this book, Tracey aims to gift her community with a collection of lyrical essays about the way joy has evolved, even in the midst of trauma, in her own life. Detailing these instances of joy in the context of Black culture allows us to recognize the power of Black joy as a resource to draw upon, and to challenge the one-note narratives of Black life as solely comprised of trauma and hardship.“Lewis-Giggetts etches a stunning personal map that

Dial up the heat this holiday season with this collection of two sizzling novels from the Black Dagger Brotherhood World series from the #1 New York Times bestselling author and “master of her craft” (New York Journal of Books) J.R. Ward.In Where Winter Finds You, Trez meets a mysterious woman who he believes to be the reincarnation of his dead lover. Therese, meanwhile, is also facing an identity crisis after just discovering that she is adopted. She’s determined to make it on her own, but her undeniable attraction to Trez may disrupt her plans. Can these two lost souls find the courage to trust their hearts in a story of redemption and self-discovery?Then in A Warm Heart in Winter, Blay and Qhuinn, one of the Black Dagger Brotherhood’s most iconic couples, are looking forward to their official mating ceremony. But when tragedy strikes just before the happy event, all hope seems lost. As everyone in the mansion rallies around them, a warm heart amid a freak winter storm ensures the su

The complete collection of the New York Times bestselling trilogy from Stephen King and Richard Chizmar!In Gwendy’s Button Box, twelve-year-old Gwendy Peterson’s life is forever changed when she is given a mysterious wooden box by a stranger for safekeeping. It offers enticing treats and vintage coins, but he warns her that if she presses any of the box’s beautifully colored buttons, death and destruction will follow.Years later, in Gwendy’s Magic Feather, she’s a successful novelist with a promising future in politics. But when the button box suddenly reappears in her life, she must decide if she is willing to risk everything for its temptations.And in the thrilling conclusion Gwendy’s Final Task, evil forces seek to possess the button box and it is up to Senator Gwendy Peterson to keep it from them at all costs. But where can one hide something so destructive from such powerful entities?

Mother doesn’t always know best in this atmospheric and twisty novel from the #1 New York Times bestselling author of the Flowers in the Attic series and Landry series―now popular Lifetime movies.When former teacher Paula Eden adopts Faith and Trevor, she is astounded by their natural intelligence and decides to homeschool them to nurture their brilliance. But as the years go on, Faith and Trevor itch for more independence.When Faith sets her sights on a handsome young man visiting from out of town, Paula grows increasingly desperate to preserve her small family and her plans for the children to carry on her legacy. Luckily, she has a cohort in loyal Trevor, who will do anything to please his mother, even at the risk of hurting his sister and potentially changing their lives forever.

From one of rap’s most personal and evocative writers comes a stirring memoir about how Boosie Badazz, one of the industry’s most controversial figures, was able to overcome insurmountable odds to make his music dreams a reality.A Baton Rouge native who began rapping at age fourteen, Boosie Badazz was already a cult hero in Louisiana when, in 2009, he was sentenced to two years in prison. The next year, he was indicted on even more serious charges, eventually landing him on Death Row. Prosecutors played Boosie’s music in the courtroom in an attempt to paint him as a thug with no chance of redemption. However, against overwhelming odds and the backdrop of a social media campaign to #FreeBoosie, he was freed in March of 2014 with a rare second chance to make his music dreams come true.In this evocative and compelling memoir, Boosie explores the relationship between his life on the streets with his ceaseless tear through the rap industry. From near-death experiences to a ruthless bout wit

Master storyteller Stephen King, whose ';restless imagination is a power that cannot be contained' (The New York Times Book Review), presents an unforgettable and relentless #1 New York Times bestseller about a good guy in a bad job.Billy Summers is a man in a room with a gun. He's a killer for hire and the best in the business. But he'll do the job only if the target is a truly bad guy. And now Billy wants out. But first there is one last hit. Billy is among the best snipers in the world, a decorated Iraq war vet, a Houdini when it comes to vanishing after the job is done. So what could possibly go wrong? How about everything. This spectacular can't-put-it-down novel is part war story, part love letter to small town America and the people who live there, and it features one of the most compelling and surprising duos in King fiction, who set out to avenge the crimes of an extraordinarily evil man. It's about love, luck, fate, and a complex hero with one last shot at redemption. You won

The acclaimed New York Times and USA TODAY bestselling novel of small-town evil that ';is genuinely chilling and something brand-new and exciting' (Stephen King) and ';unforgettable' (Harlan Coben). In the summer of 1988, the mutilated bodies of several missing girls begin to turn up in a small Maryland town. The grisly evidence leads police to the terrifying assumption that a serial killer is on the loose in the quiet suburb. But soon a rumor begins to spread that the evil stalking local teens is not entirely human. Law enforcement, as well as members of the FBI, are certain that the killer is a living, breathing madmanand he's playing games with them. For a once peaceful community trapped in the depths of paranoia and suspicion, it feels like a nightmare that will never end. Recent college graduate Richard Chizmar returns to his hometown just as a curfew is enacted and a neighborhood watch is formed. Amid preparing for his wedding and embarking on a writing career, he soon finds hims

A history of the colorful and complex kingdom of cosplay and fandom fashion by Andrew Liptak, journalist, historian, and member of the legendary fan-based Star Wars organization the 501st Legion. In recent years, cosplay-the practice of dressing up in costume as a character-has exploded, becoming a mainstream cultural phenomenon. But what are the circumstances that made its rise possible? Andrew Liptak-a member of the legendary 501st Legion, an international fan-based organization dedicated to the dark side of Star Wars-delves into the origins and culture of cosplay to answer this question. Cosplay: A History looks at the practice's ever-growing fandom and conventions, its roots in 15th-century costuming, the relationship between franchises and the cosplayers they inspire, and the technology that brings even the most intricate details in these costumes to life. Cosplay veterans and newcomers alike will find much to relish in this rich and comprehensive history.

The battle continues in this silkpunk fantasy as science and destiny collide against the will of the gods in this final installment in the epic Dandelion Dynasty series from Hugo, Nebula, and World Fantasy Awardwinning author Ken Liu.The concluding book of The Dandelion Dynasty begins immediately after the events of The Veiled Throne, in the middle of two wars on two lands among three people separated by an ocean yet held together by the invisible strands of love. Harried by Lyucu pursuers, Princess Thra and Pkyu Takval try to reestablish an ancestral dream even as their hearts grow in doubt. The people of Dara continue to struggle against the genocidal Lyucu as both nations vacillate between starkly contrasting visions for their futures. Even the gods cannot see through the Wall of Storms, for only mortal hearts can decide mortal fates. Award-winning author Ken Liu fulfills the covenants first laid out a decade ago in a series delving deep into the connection between national myths an

Forbidden passions have been the hallmark of the Dollanganger clan since Flowers in the Attic debuted more than forty years ago. In this third book of a new related trilogy, witness the birth of the Dollanganger curse as Corrine Foxworth's children learn that family is but destiny by another, crueler name.As a young girl in France, Marlena Hunter's life was a fairy tale. She had a talented artist for a father, a doting mother, and a brother she couldn't be closer to. She loved her family; she just didn't know what her family actually was. When a car crash kills their parents, Marlena and Yvon lose not only France, but also their identity. Sent to Richmond, Virginia, they arrive at the home of two aunts they've never met before, who tell them that their true last name is Dawson, that their father had fled the family years backand that now the family is calling in the debt. Trapped in a mansion with as many secrets as rooms, Marlena yearns for escape. But in America, you can either mak

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Pretty Mess meets #Girlboss in this part memoir, part entrepreneurial manifesto from The Real Housewives of New Jersey's "Powerhouse in Pigtails."Margaret Josephs is a hustler. She's a tough cookie. S

;A luscious, layered story of inheritance, heartbreak, reinvention, and family. I adored this book.' Kristan Higgins, New York Times bestselling author When a deed to an apartment in Paris turns up in

#1 New York Times and USA TODAY bestselling author Charlaine Harris is at her best in this alternate history of the United States where magic is an acknowledged but despised power in this third instal

“I know this is going to sound hyperbolic, but when I’m reading Ken Liu’s stories, I feel like I’m reading a once-in-a-generation talent. I’m in awe.” —Jamie Ford, New York Times bestselling author“Ca

From the eponymous star of one of the most popular reality shows in Fuse’s history, this no-holds-barred memoir and “snappily dictated story of inverted cultural norms in the wards of New Orleans” (Ea

In this riveting, “gory, and action-packed” (Jonathan Maberry) survival thriller, set in the expansive world of Robert Kirkman’s The Walking Dead series, three people from different walks of life in C

One Christmas wish, two brothers, and a lifetime of hope are on the line for hapless Maelyn Jones in In a Holidaze, the quintessential holiday romantic novel by Christina Lauren, the New York Times be

Stranger Things meets World War Z in this heart-racing conspiracy thriller as a lonely young woman teams up with a group of fellow outcasts to survive the night in a town overcome by a science experim

A retired widow in rural Connecticut wakes to an unexpected visit from her childhood best friend whom she hasn’t seen in forty-nine years.A man arrives at a Pennsylvania hotel to introduce his estrang

In the vein of The Book of M comes a fast-paced, character-driven literary apocalyptic novel that explores life, love, and loss in a post-truth society.In the aftermath of a deadly outbreak―reminiscen

Station Eleven meets Never Let Me Go in this debut novel set in an unsettling near future where the dead can be uploaded to machines and kept in service by the living.In the wake of a highly contagiou

In the tradition of modern classics The Dinner and A Gentleman in Moscow comes The Waiter, in which the finely tuned balance of a grand European restaurant (that has seen better days) is irrevocably u

Sisterhood is forever…whether you like it or not.Prep meets Girls in White Dresses in Genevieve Sly Crane’s deliciously addictive, voyeuristic exploration of female friendship and coming of age that w