Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A young poet tells the unforgettable story of his harrowing migration from El Salvador to the United States at the age of nine in this moving, page-turning memoir hailed as "the mythic journey of our era" (Sandra Cisneros)Trip. My parents started using that word about a year ago―“one day, you’ll take a trip to be with us. Like an adventure.” Javier’s adventure is a three-thousand-mile journey from his small town in El Salvador, through Guatemala and Mexico, and across the U.S. border. He will leave behind his beloved aunt and grandparents to reunite with a mother who left four years ago and a father he barely remembers. Traveling alone except for a group of strangers and a "coyote" hired to lead them to safety, Javier’s trip is supposed to last two short weeks.At nine years old, all Javier can imagine is rushing into his parents’ arms, snuggling in bed between them, and living under the same roof again. He cannot foresee the perilous boat trips, relentless desert treks, pointed guns,

An intimate, deeply reported account of the women who made a shocking decision: to leave their comfortable lives behind and join the Islamic State.In early 2014, the Islamic State clinched its control

A down-to-earth and deeply intimate portrait of Pope Francis and his faith, based on interviews with the men and women who knew him simply as Jorge Mario Bergoglio Early on the evening of March 13, 20

A baby's first year is filled with an endless stream of new experiences, contributing profoundly to their physical, mental, and emotional development. Typically at the age of one-year an infant has th

Bitcoin, the digital currency, was introduced in 2009 with little fanfare; five years later, shocking the world, it was worth $14 billion. This book explores the cyber currency by focusing on the rema

Let the weather take the lead and never be bored again! Paint in the rain, send kites soaring in the wind, build ice orbs, and become a snowflake scientist—let the wonders of nature inspire your next

From the acclaimed author of the international best seller Einstein’s Dreams,here is a stunning, lyrical memoir of Memphis from the 1930s through the 1960s that includes the early days of the movies a

In the follow-up to his National Translation Award-winning collection The Undiscovered Chekhov, translator and scholar Peter Constantine brings us more little-known work from the legendary author's ea

From the Pulitzer Prize-winner: the second installment, following Some Luck,of her widely acclaimed, best-selling American trilogy, which brings the journey of a remarkable family with roots in the Io

Aglietta’s pathbreaking book is the first attempt at a rigorous historical theory of the whole development of US capitalism, from the Civil War to the Carter presidency. A major document of the “Regul

When Lilia Albert was a child, her father appeared on the doorstep of her mother's house and took her away. Now, haunted by an inability to remember much about her early childhood, Lilia moves restles

After completing Watanuki's request, Rikuo disappears upon his own ever-mysterious purposes. Fraught with worry over Rikuo, and bearing the new burden of "carrying memories" all by himself, Kazahaya m

The first and only English translation of the centuries-old Tibetan spiritual allegory of King Gesar, a tale on a par withThe Arabian Nights or the King Arthur stories.For hundreds of years, versions of the Gesar of Ling epic have been sung by bards in Tibet, China, Central Asia, and across the eastern Silk Route. King Gesar, renowned throughout these areas, represents the ideal warrior. As a leader with his people's loyalty and trust, he conquers all their enemies and protects the peace. The example of King Gesar is also understood as a spiritual teaching. The "enemies" in the stories represent the emotional and psychological challenges that turn people toward greed, aggression, and envy and away from the true teachings of Buddhism.The epic of Gesar is the longest single piece of literature in the world canon, encompassing some 120 volumes; here the first three volumes are translated, telling of Gesar's birth, his mischievous childhood and his youth spent in exile, a

You know Judy Greer, right? Maybe from The Wedding Planner, 13 Going on 30, Carrie, Arrested Development, or The Descendants. Yes, you totally recognize her. And, odds are, you already feel like she’s

James Wolcott’s career as a critic has been unmatched, from his early Seventies dispatches forThe Village Voice to the literary coverage made him equally feared and famous to his must-read reports on

Combining history, politics, and religion, Mike Aquilina and Jim Papandrea provide practical lessons to be learned from the struggles of the Early Church, lessons that can be applied to the day-to-day

A new perspective on woman’s role in the world of art jewelry at the turn of the twentieth century—from Art Nouveau in France and the Arts and Crafts movement in Britain, to Jugendstil in Germany and

Combining the energy of the early seventies feminist liberation movement, with the perceptive analyses of the trained theorist, Woman’s Estate is one of the most influential socialist feminist stateme

From ancient currency to Adam Smith, from the gold standard to shadow banking and the Great Recession: a sweeping historical epic that traces the development and evolution of one of humankind’s greate

"The story of ancient Israel, from the arrival in Canaan to the destruction of the Kingdom of Judah and the Babylonian exile some six centuries later: the highly anticipated second volume in Everett F

This is the first biography of the short but exciting life of Albert Champion—record-setting bicyclist and motorcyclist, daredevil race car driver, early automobile innovator with thirty US patents, c

A definitive portrait of the iconic Hollywood star draws on new research and insider interviews to provide coverage of his New Jersey upbringing, his early years with Hanna-Barbera, his private life a

Exploring what the author calls the "shaman-poets"—Walt Whitman, Herman Melville, and Emily Dickinson—this book demonstrates how far ahead of their times these writers were in forecasting developments

A step-by-step guide to all aspects of comic book creation--from conceptualization to early drafts to marketing and promotion--written by two of the industry's most seasoned and successful pros.

Shunned by his Quaker community for marrying a servant girl, Daniel Dickinson pursues a new life on the early 19th-century Virginia frontier, where his family's values are tested by the challenges of

A profile of the early-20th-century British king discusses how he disappointed his mother, Queen Victoria, with his notorious gambling, gluttony and womanizing before his nine-year reign, during which

A first publication of the acclaimed writer's personal correspondences includes whimsical teenage reports of her 1880s Red Cloud life, letters written during her early journalism years and the 1940s e

Airpower is credited with success in Afghanistan, Desert Storm, and Serbia, but in Vietnam all of America's aerial might could not defeat a vastly outnumbered Third World force on bicycles. With a pan

A boy-friendly book set during World War One, published for the centennary of the war and accompanied by a digital component to boost interest from the school and library market. It's the early 1

Dead Low Tide is an iconic early thriller from John D. MacDonald, the mastermind behind Cape Fear and the Travis McGee novels. On the coast of Florida, a working stiff is wrongfully accused of murderi

A family of four--mother, father and two boys--move to the South Coast of Norway to a new house on a newly developed site. It is the early 1970s and the family's trajectory, upwardly mobile: the futur

A profile of the controversial Italian poet and nationalist is set against a backdrop of early 20th-century Italy's transition from Romantic idealism to fascism and war and includes coverage of such t

S.E.C.R.E.T. Revealed bares all—the final book in the hot erotic trilogy The only thing that Cassie Robichaud has ever really wanted is Will Foret, the love of her life. But when Will discovers that C

"Rumors had been whispered for more than a year. Outrages that had been accumulating all along took shape as evidence. A mother was knocked down the stairs by her cold-eyed daughter. Four damaged infants were born in one family. Daughters refused to get out of bed. Brides disappeared on their honeymoons. Two brothers shot each other on New Year's Day. Trips to Demby for VD shots common. And what went on at the Oven these days was not to be believed . . . The proof they had been collecting since the terrible discovery in the spring could not be denied: the one thing that connected all these catastrophes was in the Convent. And in the Convent were those women."In Paradise--her first novel since she was awarded the Nobel Prize for Literature--Toni Morrison gives us a bravura performance. As the book begins deep in Oklahoma early one morning in 1976, nine men from Ruby (pop. 360), in defense of "the one all-black town worth the pain," assault the nearby Convent and the women in it. From th

This fascinating blend of popular science and military history examines the science of war, demonstrating the close connection between the discovery of basic physical principles and the development of

In the spirit of her blockbuster #1 New York Times bestseller The Happiness Project, Gretchen Rubin embarks on a new project to make home a happier place. One Sunday afternoon, as she unloaded the dis

Gwathmey Siegel’s buildings represent the pinnacle of late-twentieth and early-twenty-first-century modernist design, and this new volume focuses on a single architectural masterpiece: 400 Fifth Avenu

"From his early seventies dispatches as a fledgling critic for The Village Voice on rock 'n roll, movies, and television, to the literary criticism of the eighties and nineties that made him both fea

A narrative portrait of the intensely private guitarist behind enduring rock band Led Zeppelin draws on 20 years of personal interviews to cover Page's early work with such artists as Tom Jones and Er

Essential Colonial Revival–style stone houses in bucolic settings—on hillsides, beside streams—and their inviting interiors, by the architect who popularized the beloved form. Stone Houses showcases