Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The rise of globalization and financialization as seen from a barge—one Swedish barge, to be exact, built in 1979"The many-headed hydra of neoliberalism has found its chronicler." —Sven Beckert, author ofEmpire of Cotton"I’ve rarely read a book that so deftly entwines a single, accessible story with the broad forces of globalization. A stunningly original history."—Maya Jasanoff, author ofThe Dawn WatchWhat do a barracks for British troops in the Falklands War, a floating jail off the Bronx, and temporary housing for VW factory workers in Germany have in common?The Balder Scapa:a single barge that served all three roles. Though the name would eventually change toFinnboda 12.And then toSafe Esperia.And later on, to theBibby Resolution.And after that . . . in short, a vessel with so many names, and so many fates, that to keep it in our sights—as the protagonist of this fascinating economic parable—Ian Kumekawa has no choice but to call it, simply, the Vessel.Despite its sturdy steel stru

The gripping new Jack Reacher thriller from the #1New York Timesbestselling authors Lee Child and Andrew ChildReacher wakes up, alone, in the dark, handcuffed to a bed in a makeshift hospital room. His few possessions are gone. He has no memory of getting there. The last thing he can recall is the car he had hitched a ride in getting run off the road. The driver was killed. The people who staged the attack assume Reacher was the driver's accomplice and patch up his wounds as they plan to make him talk. A plan that will backfire spectacularly . . .

An exhilarating novel about one American family, the dark moment that shatters their suburban paradise, and the wild legacy of trauma and inheritance, from the New York Times bestselling author of Fleishman Is in Trouble“Were we gangsters? No. But did we know how to start a fire?”In 1980, a wealthy businessman named Carl Fletcher is kidnapped from his driveway in a cloistered town on the nicest part of Long Island, brutalized, and held for ransom. He is returned to his wife and kids less than a week later, only slightly the worse, and the family begins the hard work of moving on with their lives, resuming their prized places in the saga of the American dream, comforted in the realization that though their money may have been what endangered them, it is also what assured them their safety, too.But nearly forty years later, when Carl’s mother dies and the family comes home to mourn her, it becomes clear that perhaps nobody ever got over anything, after all. Carl has spent the ensuing yea

Three estranged siblings return to their family home in New York after their beloved sister's death in this unforgettable story of grief, identity, and the complexities of family, from the acclaimed author ofCleopatra and Frankenstein.The three Blue sisters are exceptional—and exceptionally different.Avery, the eldest and a recovering heroin addict turned strait-laced lawyer, lives with her wife in London;Bonnie, a former boxer, works as a bouncer in Los Angeles following a devastating defeat; andLucky, the youngest, models in Paris while trying to outrun her hard-partying ways. They also had a fourth sister, Nicky, whose unexpected death left Avery, Bonnie, and Lucky reeling. A year later, as they each navigate grief, addiction, and ambition, they find they must return to New York to stop the sale of the apartment they were raised in.But coming home is never as easy as it seems. As the sisters reckon with the disappointments of their childhood and the loss of the only person who held

New York Timesbestselling author Eowyn Ivey returns to the mythical Alaska landscape of her Pulitzer Prize finalistThe Snow Childwith an unforgettable reimagining ofBeauty and the Beastthat asks the question: can love save us from ourselves?Birdie’s keeping it together, of course she is. So she's a little hungover sometimes on her shifts, and has to bring her daughter Emaleen to work while she waits tables at an Alaskan roadside lodge, but it's a tough town to be a single mother and Emaleen never goes hungry. Still, she remembers happier times—trout fishing with her grandfather and hiking in the tundra—being free in the world of nature.Arthur Neilsen is a soft-spoken recluse, with scars across his face, who brings Emaleen back to safety when she gets lost in the woods one day. He speaks with a strange cadence, appears in town only at the change of seasons, and most people avoid him. But for Birdie, he represents everything she’s ever longed for. He lives in a cabin in the mountains on

A shield maiden blessed by the gods battles to unite a nation under a power-hungry king—while also fighting her growing desire for his fiery son—in the first book of a Norse-inspired fantasy romance duology from the bestselling author of The Bridge Kingdom series.Bound in an unwanted marriage, Freya spends her days gutting fish, but dreams of becoming a warrior. And of putting an axe in her boorish husband’s back.Freya's dreams abruptly become reality when her husband betrays her to the region's jarl, landing her in a fight to the death against his son, Bjorn. To survive, Freya is forced to reveal her deepest secret: She possesses a drop of a goddess's blood, whichmakes her a shield maiden with magic capable of repelling any attack.It was foretold such a magicwould unite the fractured nation of Skaland beneath the one who controls the shield maiden’s fate.Believing he's destined to rule Skaland as king, the fanatical jarl binds Freya with a blood oath and orders Bjorn to protect her fr

An electric debut novel about the daughter of Afghan refugees and her year of nightclubs, bad romance, and self-discovery—a portrait of the artist as a young woman setin a Berlin that can't escape its historyA girl can get in almost anywhere, even if she can’t get out."A no-bullsh*t must-read debut."—Kaveh Akbar"Kaleidoscopic, full of style and soul.”—Raven Leilani"Radiant with longing, eroticism, and beauty."—Sarah Thankham MatthewsIn Berlin’s artistic underground, where techno and drugs fill warehouses still pockmarked from the wars of the twentieth century, nineteen-year-old Nila at last finds her tribe. Born in Germany to Afghan parents, raised in public housing graffitied with swastikas, drawn to philosophy, photography, and sex, Nila has spent her adolescence disappointing her family while searching for her voice as a young woman and artist.Then in the haze of Berlin's legendary nightlife, Nila meets Marlowe, an American writer whose fading literary celebrity opens her eyes to a

NATIONAL BESTSELLER • In this captivating atmospheric novel from theNew York Timesbestselling author ofThe Unmaking of June Farrow,a woman investigates her twin brother’s mysterious death while confronting the ghosts of her own haunted past.James and Johnny Golden were once inseparable. For as long as she can remember, James shared an almost supernatural connection with her twin brother, Johnny, that went beyond intuition—she could feel what he was feeling. So, when Johnny is killed in a tragic accident, James knows before her phone even rings that her brother is gone and that she’s alone—truly alone—for the first time in her life.When James arrives in the secluded town of Six Rivers, California, to settle her brother’s affairs, she’s forced to revisit the ominous events of their shared past and finally face Micah, the only other person who knows their secrets—and the only man she has ever loved.But as James delves deeper into Johnny’s world, she realizes that their unique connection h

From the Booker Prize-winning author of The Regeneration Trilogy comes the powerful third installment to the Women of Troy series. In The Voyage Home, Pat Barker skillfully reimagines Greek mythology, chronicling a perilous journey undertaken by the enslaved healer Ritsa and her cruel mistress Cassandra.AN INSTANT UK BESTSELLER“Barker’s vision of a world shaped by violence, a key theme in all her fiction, is equal to the tragic grandeur of ancient myth....More brilliant work from one of world literature’s greatest writers.” —Kirkus Reviews *starred review*I never saw Cassandra as a victim. I saw a woman as focused on a single aim as any raptor stooping to its prey; but then, I had more opportunities to observe her ruthlessness than most. I was in her power, you see. I was her slave.Pat Barker has crafted the latest in a brilliant reimagining of Greek mythology, and The Voyage Home is the work of a writer at the height of her powers. In this third outing, she fo

An exciting, thought-provoking novel about globalization, climate change and finding your place in a changing worldMaya lives in a remote house on the cost, spending her time hanging out with her friends and surfing, while her mother bakes for the local café and her father works as a fisherman. They lead a simple life and though they often struggle to get by financially they are happy and secure. But Maya’s world is about to be upended. When her dad's fishing boat sinks in a ferocious storm and he ends up in hospital fighting for his life the famiy lose their only means of earning money and life takes on a perilous turn. Desperate for a change Maya's parents make the decision to start over by moving to an island in the Pacific – a place they are sure is paradise.Life in their new home starts to take on an order and while Maya misses her friends she finds a new companion in a girl who lives close by. Maya’s parents, however, seem to be unable to make a true commitment to their new life

Visceral stories that center the bodies, memories, myths, and relationships of Asian American women, from the National Book Award "5 Under 35" honoree and author of BestiaryIn "Auntland," a steady stream of aunts adjust to American life by sneaking surreptitious kisses from women at temple, buying tubs of vanilla ice cream to prepare for citizenship tests, and hatching plans to name their daughter "Dog." In "The Chorus of Dead Cousins," ghost-cousins cross space, seas, and skies to haunt their live-cousin, wife to a storm-chaser. In “Xífù,” a mother-in-law tortures a wife in increasingly unsuccessful attempts to rid the house of her. In "Mariela," two girls explore one another's bodies for the first time in the belly of a plastic shark while in "Virginia Slims," a woman from a cigarette ad comes to life. And in "Resident Aliens," a former slaughterhouse serves as a residence to a series of widows, each harboring her own calamitous secrets. With each tale, K-Ming Chang gives us her ow

A family is upended when their small-town life becomes the latest battlefield in the culture wars in this of-the-moment novel for readers of Meg Wolitzer and Fleishman Is in TroubleLife for Ethan and

The National Book Award-winning and New York Times bestselling author of Let the Great World Spin tells an epic story rooted in the real-life friendship between two men united by loss in this daring,

The landmark five-book investigation of uncertainty, chance, volatility, risk, and decision-making in a world we don't understand--now in a beautifully designed, cloth-bound hardcover boxed set.Nassim

In this revelatory, intimate memoir from the author of Dead Man Walking, the nation's foremost leader in efforts to abolish the death penalty shares the story of her growth as a spiritual leader, spea

A definitive statement on aesthetics, art, and modernity includes essays on specific artistic tendencies throughout the modern era, from Dresden in 1764 to New York in 1941.

The story of a legendary designer who pioneered high-end streetwear, from a storefront in Harlem to the red carpet in Hollywood, dressing everyone from Salt-N-Pepa and Eric B. & Rakim to Beyonc&ea

#1 NEW YORK TIMES BESTSELLER • Pulitzer Prize–winning author Jon Meacham helps us understand the present moment in American politics and life by looking back at critical times in our histor

In 2007, Christopher Hitchens, Richard Dawkins, Sam Harris, and Daniel Dennett filmed a landmark discussion about modern atheism. The video went viral. Now in print for the first time, the transcript

Pope Francis examines the role of millennials in the future of the Catholic Church in this urgent call to believers of all generations to work together to build a better world.Since his election in 20

A woman's disappearance shakes up a strange northern town that is stuck in the 1980s, in a wildly imaginative novel that combines elements of The Handmaid's Tale, Stranger Things and Twin Peaks.Why ca

A “riveting family saga” (Mary Karr), set in the American West, about sibling rivalry, dark secrets, and a young girl’s struggle with freedom and artistic desire In the years after W

An in-depth account of the First Battle of Ypres, a turning point in World War I—and in the history of warfare The First Battle of Ypres changed how wars are fought.

The overlooked middle sister in Jane Austen’s Pride and Prejudice casts off her prim exterior and takes center stage in this fresh retelling of the classic novel.I will tell you the story of how I kne

Pulitzer Prize–winning author Jon Meacham helps us understand the present moment in American politics and life by looking back at critical times in our history when hope overcame division and fe

A long-awaited English translation of the groundbreaking oral history of women in World War II across Europe and Russia—from the winner of the Nobel Prize in Literature“A landmark.”—Timothy Snyder, au

A memoir of race, inequality, and the power of literature told through the life-changing friendship between an idealistic young teacher and her gifted student, jailed for murder in the Mississippi Delta“Reading with Patrick could be the most affecting book you’ll read this year.”—The Christian Science Monitor“Powerful.”—The Seattle Times“Tender.”—O: The Oprah MagazineRecently graduated from Harvard University, Michelle Kuo arrived in the rural town of Helena, Arkansas, as a Teach for America volunteer, bursting with optimism and drive. But she soon encountered the jarring realities of life in one of the poorest counties in America, still disabled by the legacy of slavery and Jim Crow. In this stirring memoir, Kuo, the child of Taiwanese immigrants, shares the story of her complicated but rewarding mentorship of one student, Patrick Browning, and his remarkable literary and personal awakening.Convinced she can make a difference in the lives of her teenaged students, Miche

The tensions in a tight-knit neighborhood—and a seemingly happy marriage—are exposed by an unexpected act of violence in this provocative new novel from the #1 New York Times bestselling a

In this brilliant crime novel from the author of Missing, Presumed, a detective investigates her most personal case yet: a high-profile murder in which her own family falls under suspicion.“[Sus

Before the Corleones, before the Lannisters, there were the Borgias. One of history’s notorious families comes to life in a captivating novel from the author of The Birth of Venus. “In the

In the tradition of The Things They Carried and Redeployment, a short story collection from a U.S. Navy veteran who completed five combat tours in Iraq and Afghanistan--a remarkable portrait of the ab

True stories of sudden death in the classic collection by a master of American journalism “Reporters love murders,” Calvin Trillin writes in the introduction to Killings. “In a pinch

Illustrated Brief History of Time/Universe in a Nutshell 2 Book Bindup-New HC Edition.

Told in Salman Rushdie’s unparalleled prose, this inventive and timely new novel follows a real-estate tycoon and his mysterious, powerful family. In scope and literary ambition, it’s The Great Gatsby

A rural, working-class New England town elects a New York hedge fund millionaire as its mayor in this inspired novel for our times—fiction in the tradition of Jonathan Franzen and Jennifer Egan, with

"Bringing together dozens of voices in her distinctive style, War's Unwomanly Face is Svetlana Alexievich's collection of stories of women's experiences in World War II, both on the front lines, on th

A compulsively readable debut novel about marriage, immigration, class, race, and the trapdoors in the American Dream—the unforgettable story of a young Cameroonian couple making a new life in New York just as the Great Recession upends the economy Winner of the PEN/Faulkner Award • A New York Times Notable Book • Longlisted for the PEN/Open Book Award • An ALA Notable Book NAMED ONE OF THE BEST BOOKS OF THE YEAR BY NPR • The New York Times Book Review • San Francisco Chronicle • The Guardian • St. Louis Post-Dispatch • Chicago Public Library • BookPage • Refinery29 • Kirkus Reviews Jende Jonga, a Cameroonian immigrant living in Harlem, has come to the United States to provide a better life for himself, his wife, Neni, and their six-year-old son. In the fall of 2007, Jende can hardly believe his luck when he lands a job as a chauffeur for Clark Edwards, a senior executive at Lehman Brothers. Clark demands punctuality, discretion, and loyalty—and Jende is eager to please

For readers of Orange Is the New Black and The Glass Castle, a riveting memoir about a lifelong secret and a girl finding strength in the most unlikely place In 1979, Liz Pryor is a seventeen-year-o

True stories of sudden death in the classic collection by a master of American journalism “Reporters love murders,” Calvin Trillin writes in the introduction to Killings. “In a pinch, what the lawye

From the author of In the Country of Men, a Man Booker Prize and National Book Critics Circle Award finalist, comes a beautifully written, uplifting memoir of his journey home to his native Libya in s