Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Blind psychiatrist Mark Angelotti has just enrolled in a drug trial that holds out hope of restoring his eyesight when he is enlisted to act as an expert witness in a case that is rocking the Chicago

An eye-opening account of how Congress today really works—and doesn’t—that follows the dramatic journey of the sweeping financial reform bill enacted in response to the Great Crash of 2008.The foundin

A penultimate entry in the series that includes the best-selling Hitler's War builds on the events of the previous four novels to reimagine a desperate Nazi response to a war on two fronts from the pe

Examines the poem, written in 1819, in response to a group of peaceful demonstrators being killed and injured by British troops that has inspired artists and leaders around the world and became a batt

Invite your jittery mind into quiet slips of timed or untimed writing experiments that are designed to encourage your timid heart to forge forgotten feelings and entice your shy-self to make friends w

Long before A Game of Thrones became an international phenomenon, #1 New York Times bestselling author George R. R. Martin had taken his loyal readers across the cosmos. Now back in print after almost

From one of Sweden's most successful criminal defense laywers comes an unflinching look at Stockholm's underworld. Jorge Barrio is a drug dealer who's in jail again after his accomplices flipped on hi

Even before A Game of Thrones, George R. R. Martin had already established himself as a giant in the field of fantasy literature. The first of two stunning collections, Dreamsongs: Volume I is a rare

Drug dealers, hustlers, brothels, dirty politics, corrupt cops . . . and sorcery. Welcome to Low Town. In the forgotten back alleys and flophouses that lie in the shadows of Rigus, the finest city of

IDENTIFYING THE ENIGMATIC HERO In this volume of Ghost in the Shell, Marcelo Jarty, the hero of a democratic revolution, and South American drug dealer, has been coming to Japan periodically and no

In this prequel to the highly praised The Blue Cotton Gown, Patricia Harman reaches back to her youthful experiments in living a fully sustainable and natural life in the 1960s and ’70s in rural Minne

THE BOOK BEHIND THE SECOND SEASON OF GAME OF THRONES, AN ORIGINAL SERIES NOW ON HBO. A SONG OF ICE AND FIRE: BOOK TWO In this thrilling sequel to A Game of Thrones, George R. R. Martin has created a

What Jonathan Lethem did for Brooklyn, Matt Burgess does for Queens in this exuberant and brilliant debut novel about a young drug dealer having a very bad weekend. Alfredo Batista has some worries. O

If you need to know it, it’s in this book! Cracking the AP Psychology Exam, 2012 Edition, includes: ‧ A step-by-step guide to writing high-scoring free response essays ‧ In-depth reviews of every

Opening in England at the turn of the twentieth century, C is the story of Serge Carrefax, whose father experiments with wireless communication while running a school for deaf children. Serge grows up

Drug dealers, hustlers, brothels, dirty politics, corrupt cops . . . and sorcery. Welcome to Low Town. In the forgotten back alleys and flophouses that lie in the shadows of Rigus, the finest city of

Featuring stunning, all-original artwork, award-winning artist John Picacio captures in striking detail twelve of the legendary characters from George R. R. Martin’s acclaimed series A Song of Ice and

He wanted to change the past, but first he would have to alter the future...A new deadly drug is about to flood the streets of New York City. The police have no leads on who is producing the drug, or

Reading this book will make you less sure of yourself—and that’s a good thing. In The Invisible Gorilla, Christopher Chabris and Daniel Simons, creators of one of psychology’s most famous experiments,

During her two decades at The New England Journal of Medicine, Dr. Marcia Angell had a front-row seat on the appalling spectacle of the pharmaceutical industry. She watched drug companies stray from t

We see the first measurement of the earth's circumference, accomplished in the third century B. C. by Eratosthenes using sticks, shadows, and simple geometry. We visit Foucault's mesmerizing pendulum

Twelve-year-old Toulouse “Tull” Trotter lives on his grandfather’s vast Bel-Air parkland estate with his mother, the beautiful, drug-addicted Katrina—a landscape artist who specializes in topiary lab

In response to deepening concerns of the threat of germ warfare and bioterrorism, Germs, Biological Warfare, Vaccinations: What You Need to Know is the first book to discuss traditional methods of com

In her introduction, essayist Kaminer argues that the first response of the Bush administration to September 11th "was a law enforcement crackdown and a demand for new restrictions on liberty, althoug

1. Wasserstein says in the preface that most of these essays were written in response to a To Do list she’d composed when she turned forty: “lose weight, exercise, read more, improve female friendship

A NEW ORIGINAL SERIES, NOW ON HBO.Here is the first volume in George R. R. Martin’s magnificent cycle of novels that includes A Clash of Kings and A Storm of Swords. As a whole, this series comprises

Drawing on both their own fieldwork from 1991 to 1999 and older written sources, Stewart and Strathern explore how the Duna have remade their rituals and associated myths in response to the outside in

Examines the Palestinian uprising that began in September 2000, discussing its origins, its consequences, the role of the United States, the response of the Israeli government, and the impact on the f

In Laura Restrepo's stunning novel, a feud between two Colombian drug families escalates into a bloody, high-stakes war that will leave no one in its path untouched. The Barragans and the Monsalves ar

Erudite, witty and often controversial, The London Review of Books informs and entertains its readers with a fortnightly dose of the best and liveliest of all things cultural.This anthology brings tog

Provides guidance in mapping migraine profiles and information on breakthrough drug therapies, children's migraines, the links between migraines and PMS and menstruation, headache support groups, nond

NATIONAL BESTSELLER ● READ WITH JENNA BOOK CLUB PICK AS FEATURED ONTODAY● From Laila Lalami—the Pulitzer Prize and National Book Award finalist and a “maestra of literary fiction” (NPR)—comes a riveting and utterly original novel about one woman’s fight for freedom, set in a near future where even dreams are under surveillance.Sara has just landed at LAX, returning home from a conference abroad, when agents from the Risk Assessment Administration pull her aside and inform her that she will soon commit a crime. Using data from her dreams, the RAA’s algorithm has determined that she is at imminent risk of harming the person she loves most: her husband. For his safety, she must be kept under observation for twenty-one days.The agents transfer Sara to a retention center, where she is held with other dreamers, all of them women trying to prove their innocence from different crimes. With every deviation from the strict and ever-shifting rules of the facility, their stay is extended. Months p

The incredible true story of the decade-long quest to bring down Paul Le Roux—the creator of a frighteningly powerful Internet-enabled cartel who merged the ruthlessness of a drug lord with the techno

Imagine that Alice had walked into a bar instead of falling down the rabbit hole. In the tradition of J. R. Moehringer’s The Tender Bar and the classic reportage of Joseph Mitchell, here is an i

Early in her literary career Nadezhda Lokhvitskaya, born in St. Petersburg in 1872, adopted the pen-name of Teffi, and it is as Teffi that she is remembered. In prerevolutionary Russia she was a liter

Wild meets The Boys in the Boat, a memoir about the quest for Olympic gold and the triumph of love over fear Forty years ago, when a young Ginny Gilder stood on the edge of Boston’s Charles R

James A. Michener, the acclaimed author of sweeping historical blockbusters, chronicles his personal involvement in one of the most dramatic elections of the twentieth century: the 1960 presidential r

Since the dawn of time, humans have looked into the enigmatic faces of cats and wonderedwho are you? In this collection of connect-the-dots adventures, expert illustrator and cat motive decoder A. R.

New York Times bestselling author Joe Abercrombie delivers the stunning conclusion to the epic fantasy trilogy that began withHalf a King, praised by George R. R. Martin as “a fast-paced tale of betra

Reminiscent of the early work of Jhumpa Lahiri, Ayelet Tsabari’s award-winning debut collection of stories is global in scope yet intimate in feel, beautifully written, and emotionally powerful. From