Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

In this marvelously original book, three-time Pulitzer Prize finalist Leslie Savan offers fascinating insights into why we’re all talking the talk—Duh; Bring it on!; Bling; Whatever!—and what this r

In a pasture in Kansas one early spring mornA horse quite unlike other horses was born.His coat was coal black so they named the horse “Blackie,”And before very long folks found out he was wacky! Meet

A brief, lyrical novel with a powerful emotional charge, Rules for Old Men Waiting is about three wars of the twentieth century and an ever-deepening marriage. In a house on the Cape “older than the R

Here, one of America’s most popular military historians re-creates, using their own moving and powerful voices, the true stories of the U.S. Marine pilots who flew the Allies to victory in World War I

Now, for the first time in paperback, here is the remarkable story of Sandra Day O’Connor’s family and early life, her journey to adulthood in the American Southwest that helped make her the woman she

Kabbalah of Creation is a new translation of the early Kabbalah of Rabbi Isaac Luria, founder of the most influential Jewish mystical school of the last 400 years. Living in relative obscurity in Nort

From one of the greatest historians of the Spanish world, here is a fresh and fascinating account of Spain’s early conquests in the Americas. Hugh Thomas’s magisterial narrative of Spain in the New Wo

A debut collection of short fiction offers a compassionate, insightful, and original exploration of the complexities and challenges of American childhood, in such tales as "The Age of Exploration," "R

From one of the greatest historians of the Spanish world, here is a fresh and fascinating account of Spain’s early conquests in the Americas. Hugh Thomas’s magisterial narrative of Spain in the New Wo

A history of the D-Day landings, co-authored by a decorated field commander, draws on archival data, oral testimonies, and new interviews to reveal how Allied forces overcame the German army in spite

Acclaimed as one of the most original talents to emerge in the last decade, award-winning author Laurie R. King returns to Folly Island to deliver her most stunning achievement yet--a breathtaking nov

In Nine Horses, Billy Collins, America’s Poet Laureate for 2001–2003, continues his delicate negotiation between the clear and the mysterious, the comic and the elegiac. The poems in this collection r

Escaping religious persecution in England in the early 1600s, young Edmund Steed flees his homeland in pursuit of freedom and the New World. After joining Captain John Smith on his courageous journey

Now, for the first time in paperback, here is the remarkable story of Sandra Day O’Connor’s family and early life, her journey to adulthood in the American Southwest that helped make her the woman she

Consuelo and Antoine de Saint-Exupery met in Buenos Aires in 1930—she a seductive young widow, he a brave pioneer of early aviation, decorated for his acts of heroism in the deserts of North Africa. H

Includes an afterword by the author In the Freud Archives tells the story of an unlikely encounter among three men: K. R. Eissler, the venerable doyen of psychoanalysis; Jeffrey Moussaieff Masson, a f

The book opens with the shocking and senseless execution of a Tarrytown college boy on the West Side Highway. Over time, the case leads detectives to the Wild Cowboys, a drug gang whose size and pench

This thorough introduction to the world of paleontology has been completely revised and updated, reflecting changes in the ways that fossils are viewed and interpreted. Using the fluid writing style t

In 1957, Ryszard Kapuscinski arrived in Africa to witness the beginning of the end of colonial rule as the first African correspondent of Poland's state newspaper. From the early days of independence

GAME OF THRONES: A NEW ORIGINAL SERIES, NOW ON HBO.Rarely has there been a tale as gripping, or one as likely to seize the minds and hearts of a generation, as George R. R. Martin's epic high fantasy

An eminent neurologist explores the role of reason in human evolution and daily consciousness, explaining how the mind works and offering a thoughful defense of the value of science and rationality. R

"Fascinating...clearly stated, interesting and provoking.... A plainspoken account of living in Asia."??--San Francisco ChronicleAnyone who has heard his weekly commentary on NPR knows that T. R. Reid

The three most powerful ultratraditionalist movements in the Catholic Church are engaging in mysterious initiation ceremonies, using brainwashing techniques involving ego destruction, moral and spirit

Current Affairs/Asian StudiesPerhaps no nation in recent history has undergone as total a transformation as China has in the past twenty-five years. For Chinese leaders, the death of Mao Zedong, the r

Tells the story of how the best college basketball players of the early 1950s adjusted the outcome of the games they played in exchange for money from gamblers and, in doing so, became part of a natio

This groundbreaking study uncovers fascinating new data on sudden shifts in religious and nonreligious belief. Amazing Conversions explores, for the first time ever, the reasons why converts join, and

"Well-illustrated, undeniably useful, Murray's book is truly welcome." --Architectural Design"Informed in content and concise in style . . . a perfect introduction to the architecture of the Italian R

A thorough study of the life and history of the Virgin Mary explores her role in theological discussions, popular and modern devotion, and apparitions, from images in the early church to current visio

An illustrated guide to safe, simple, drug-free pain relief--for ailments ranging from headaches to ulcers--explains how to use Chinese massage and pressure techniques to ease pain and prevent its ret

Discusses uncooperative elders, drug misuse, the financial concerns of the elderly, vision loss, hearing loss, nutrition, exercise, and support for caregivers

Shots rang out in Savannah's grandest mansion in the misty,early morning hours of May 2, 1981. Was it murder or self-defense? For nearly a decade, the shooting and its aftermath reverberated through

In this thoroughly researched study, G.A. Wells has squarely faced the question of whether a man named Jesus lived, preached, healed, and died in Palestine during the early years of the first century

Dr. Drew A. Hyland traces the origins of philosophy from its earliest roots in Babylonian and Homeric-Hesiodic mythology to its flowering in the Pre-Socratic imagination. Using selections from the Epi

In an economic future centered on artificially-intelligent platforms, how can their power be balanced to ensure a broad prosperity for everyone?Our world is dominated by a handful of tech platforms. They provide great conveniences and entertainment, but also stand as some of the most effective instruments of wealth extraction ever created, seizing immense amounts of money, data, and attention from all of us.An economy driven by digital platforms and AI influence offers the potential to enrish us, but also threatens to marginalize entire industries, widen the wealth gap, and foster a two-class nation.Tim Wu—the preeminent scholar and former White House official who coined the phrase “net neutrality”—explores the rise of platform power and details the risks and rewards of working within such systems.The Age of Extractiontells the story of an Internet that promised widespread wealth and democracy in the 1990s and 2000s, only to create new economic classes and aid the spread of autocracy i

In the epic follow-up to theNew York TimesbestsellerSword Catcher, praised by George R. R. Martin as “everything I look for in fantasy,” Lin and Kel must chart a perilous course between love and lies.Kel Saren, body double to Conor, crown prince of the dazzling city of Castellane, is caught between two worlds. In order to protect his beloved prince, Kel must find the culprits responsible for a massacre at the royal palace—and the only clues are held by the Ragpicker King, the notorious criminal who rules Castellane’s underworld. The trail Kel follows leads back to the Hill, where among decadent nobles and glittering parties a dark conspiracy to destroy the royal family has taken hold—a conspiracy headed up by the monstrous Artal Gremont, the man engaged to marry the woman Kel adores.Meanwhile, Lin Caster must face the aftermath of the greatest risk she’s ever taken. To save the life of a dying friend, Lin has falsely claimed to be the Goddess Reborn, the legendary heroine destined to s

An exclusive thriller writer's retreat hosted on a private island turns lethal when one of the authors is found murdered in this twisty locked room mystery.When renowned anonymous author J. R. Alastor hires former aspiring writer Mila del Angél to host a writing retreat at his private manor off the coast of Maine, she jumps at the chance—particularly since she has an ax to grind with one of the invitees. The guest list? Six thriller authors, all masters of deceit, misdirection, and mayhem.Confess the crimes, survive the tropes.Alastor and Mila have masterminded a week of games, trope-fueled riddles, and maybe a jump scare or two—the perfect cover for Mila to plot a murder of her own. But when a guest turns up dead—and it’s not the murder she planned—Mila finds herself trapped in a different narrative altogether.One by one, you'll lose your turn.With a storm cutting off the island, and the body count rising, Mila must outwit a killer who knows literally every trick in the book.Until onl

A veteran British journalist living in Hong Kong investigates the disappearance of a student protester in this atmospheric novel from the New York Times notable author of The Forgiven―soon to be a major motion picture.“There came a sound of rubber bullets being fired along Java Road and the sad crowing of sirens as if to herald a future even more unpleasant than the present.”After twenty years as a journalist in Hong Kong, ex-pat Englishman Adrian Gyle has very little to show for it. Evenings are whiled away with soup dumplings and tea at Fung Shing, the restaurant downstairs from his home on Java Road, that “most melancholy street in the city, the street where the dead congregated.” It is through these jaded eyes that Gyle watches the city around him--once overflowing with wine dinners and private members’ clubs--erupt in violence as pro-democracy demonstrations hit ever closer to home. But just as Gyle prepares to turn his back on Hong Kong, he finds one last intrigue: the alluring R

The bold and boundlessly original debut novel from the Oscar®-winning screenwriter of Being John Malkovich, Adaptation, Eternal Sunshine of the Spotless Mind, and Synecdoche, New York.B. Rosenberger R

Marsha Linehan tells the story of her journey from suicidal teenager to world-renowned developer of the life-saving behavioral therapy DBT, using her own struggle to develop life skills for others.Gro

“A mesmerizing, head-spinning—and sometimes madcap-hilarious—take of have and have-nots.”—People (Book of the Week) NAMED ONE OF THE BEST BOOKS OF THE YEAR BY R