Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Arvid Jansen is a young boy who lives on the outskirts of Oslo. It's the early sixties, his father works in a shoe factory and his Danish mother works as a cleaner. Arvid wets his bed at night and has

Early this century Enrico, a young intellectual, leaves the abundantly diverse Austro-Hungarian city of Gorizia with its mixed population and culture, to spend several years living on the Patagonian p

Hailed as a masterpiece, Tinkers, Paul Harding's Pulitzer Prize-winning debut, is a modern classic. Here, in Enon, Harding follows a year in the life of Charlie Crosby as he tries to come to terms wit

'Sorrowland is a wonderland of fantastical and frightening, magical and real. At the centre of this world and leaping off the page is Vern: unstoppable, unforgettable, and unlike anyone you have ever seen before.' MARLON JAMES, Booker Prize-winning author'A fantastical, fierce reckoning ... Sorrowland is gorgeous, and the writing, the storytelling, are magnificent.This country has a dark history of what it's willing to do to black bodies, and Rivers Solomon lays that truth bare in a most unexpected, absolutely brilliant way.' ROXANE GAY__________________________Vern, a Black woman with albinism, is hunted after escaping a religious compound, then she discovers that her body is changing and that she is developing extra-sensory powers.Alone in the woods, she gives birth to twins and raises them away from the influence of the outside world. But something is wrong - not with them, but with her own body. It's itching, it's stronger, it's...not normal.To understand her body's metamorphosis,

★ 顛覆成長迷思！重新定義「經濟」的未來藍圖★ 全球暢銷經典，FT×Forbes年度選書★ 從失控的資本主義，到可持續的全新模型★ 21世紀最具影響力的經濟學新思維當金融危機一再重演、貧富差距不斷擴大、地球資源逐漸枯竭，我們是否該重新思考：經濟，究竟是為了誰而運作？牛津學者凱特・拉沃斯提出一個顛覆性的觀點——傳統經濟學，早已把我們帶往錯誤的方向。從「理性經濟人」的假設，到無止盡追求成長的迷思，她一一拆解這些看似理所當然的信念，並提出全新的「甜甜圈經濟學」模型：在人類基本需求與地球承載極限之間，找到一個平衡的理想空間。這不只是理論，而是一條可實踐的道路。透過全新框架與具體思考，本書帶領我們重新想像未來——一個既能滿足所有人需求，又不會耗盡地球資源的世界。The book behind the hit TED Talk**The Sunday Times Bestseller**Economics is broken, and the planet is paying the price.Unforeseen financial crises. Extreme wealth inequality. Relentless pressure on the environment. Can we go on like this? Is there an alternative?In Doughnut Economics, Oxford academic Kate Raworth lays out the seven deadly mistakes of economics and offers a radical re-envisioning of the system that has brought us to the point of ruin. Moving beyond the myths of ‘rational economic man’ and unlimited growth, Doughnut Economics zeroes in on the sweet spot: a system that meets all our needs without exhausting the planet.The demands of the 21st centur

The incredible new novel and brand new world from the international bestselling author of the Wool trilogy. The old world is buried. A new one has been forged atop the shifting dunes. Here in this lan

A prequel to the worldwide bestseller A Street Cat Named Bob and The World According to Bob, this illustrated children's picture book presents a moving and uplifting tale about one cat in search of a

Get into double trouble with Daisy in this fantastic collection, featuring her first two troublesome tales: Daisy and the Trouble with Life and Daisy and the Trouble with Zoos. Trouble is, which story

Since it was founded in 2003, Good African Coffee has helped thousands of farmers earn a decent living, send their children to school and escape a spiral of debt and dependence. Africa has received ov

Guatemala, in the searing heat. The bones of a child no more than two years old are uncovered when mass graves are excavated. Twenty-three women and children are said to lie where forensic anthropolog

As Lenny's father goes off to fight in the second world war he gives his son a brass badge with a lion and a unicorn on it. Lenny keeps it with him when bombs are dropped on his street and when he has

This classic picture book has sold over 550,000 copies across all formats since it's publication in 1967.Sendak's much-loved favourite, a best-seller and an acknowledged classic of twentieth-century c

Just how are babies made? Erm Well. . . they're delivered by dinosaurs squidged out of tubes and found under stones! In this story the kids put their embarrassed parents straight and dispel the myths

Someone is scraping the scum off the streets of Galway, and they want Jack Taylor to get involved. A drug pusher, a rapist, a loan shark, all targeted in what look like vigilante attacks. And the kill

Sentenced to nine years in Arizona's state prison for distributing Ecstasy, the author finds himself living among gang members, sexual predators and drug-crazed psychopaths. This book tells the story

Someone is scraping the scum off the streets of Galway, and they want Jack Taylor to get involved. A drug pusher, a rapist, a loan shark, all targeted in what look like vigilante attacks. And the kill

A memoir of a man who survived childhood tragedy, Catholic boarding school and chronic drug addiction. It details the author's experience of teenage angst in a tatty seaside town before he ran away to

Steve Coogan was born and raised in Manchester in the 1960s, the fourth of six children. From an early age he entertained his family with impressions and was often told he should 'be on the telly'. Fa

A richly observed and researched personal history of the bygone age of Britain's railways. SOMETIMES you come across a lofty railway viaduct, marooned in the middle of a r

Addresses the many problems parents face in the first three years - from feeding and sleeping problems in the first year, including weaning and early-morning waking, to teething and potty training. Th

'BARNES'S MASTERPIECE' - OBSERVERIn May 1937 a man in his early thirties waits by the lift of a Leningrad apartment block. He waits all through the night, expecting to be taken away to the Big House.

An unusual coincidence occurred early one morning at the most visited war memorial in the US as a shaft of sunlight hit one of the 58,282 names on the Vietnam Veterans Memorial. The name was Larry Byf

A gloriously witty novel from Sebastian Faulks using P.G. Wodehouse’s much-loved characters, Jeeves and Wooster, fully authorised by the Wodehouse estate.Due to a series of extenuating circumstances,

An unusual coincidence occurred early one morning at the most visited war memorial in the United States as a shaft of sunlight hit one of the 58,282 names on the Vietnam Veterans Memorial. The name wa

Focuses on simple Spanish cookery. Using everyday storecupboard ingredients, this title offers a take on the classic tortilla de patatas, making this iconic dish easier than ever, and brings a twist t

Now a major motion picture starring Nicholas Hoult, Teresa Palmer and John Malkovich.‘R’ is a zombie. He has no name, no memories and no pulse, but he has dreams. He is a little different from his fel

Find out what happens after the “I do"s! Delve deeper into all of the emotion and drama. Last time we said goodbye to a mentor and hello to a new mayor, but what will the future hold for the rest of R

'A brisk, lively and vividly written portrait of post-apartheid South Africa' Peter Godwin, author of MukiwaIn the early 1990s, the African National Congress, led by Nelson Mandela, engaged in a histo

Born into a family that had risen from the soil to prosper as lighthouse engineers, Robert Louis Stephenson was much influenced by the environment in which he was raised and the principles held by his

Turning the tables on encyclopaedic tomes on parenthood and their often conflicting advice, this book helps you empower you to relax, trust your instincts and enjoy your new baby. It includes: Early d

Sets out to track down the mythical beast that is a Bugatti Veyron. This title traces the genesis of this machine through Bugatti's long and glorious early days and then through its more turbulent mod

Discover Thrawn’s origins within the Chiss Ascendancy in the first book in an epic new Star Wars trilogy from bestselling author Timothy Zahn.Beyond the edge of the galaxy lies the Unknown Regions: ch

HMS Erebus was one of the great exploring ships, a veteran of groundbreaking expeditions to the ends of the Earth. In 1848, it disappeared in the Arctic, its fate a mystery. In 2014, it was found. Thi

Immerse yourself in this fun world of mermaids! Can you find them all and help them locate their lost treasure in this fun search-and-find adventure across 16 detailed illustrations? From the Merking

Passion. Obsession. Murder. 'Simply one of the most disturbing thrillers I've read in years. In short I loved it, right down to the utterly chilling final line' - Gillian Flynn, author of GONE GIRL___

`A marvel of insight and practicality' Charles Duhigg, author of The Power of HabitWhat do Pixar, Google and the San Antonio Spurs basketball team have in common? In The Culture Code, Daniel Coyle, Ne

First published in 1967, this remarkable title from one of history’s greatest minds remains a must-read in the world of creative thinking. Based on the tenet that an error can lead to the right decis

The Bind charts the rise and fall of Egret Bindings, once the most prestigious firm of bookbinders in London. In 1910 brothers Guy and Victor Egret take on an ambitious commission: a deluxe, jeweled b

In his international bestseller How Children Succeed, Paul Tough introduced us to research showing that personal qualities like perseverance, self-control and conscientiousness play a critical role in

Inspiring and achievable projects, with easy to follow step-by-step instructions, to transform the dull, the discarded and the down-at-heel into something really out of the ordinaryInternational desig