Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Ivan Doig grew up in northern Montana along the Rocky Mountain Front, where Dancing at the Rascal Fair takes place. He has worked as a ranch hand, newspaperman, and magazine editor and writer. His 19

The leading experts on parent-child communication show parents and teachers how to motivate kids to learn and succeed in school.Using the unique communication strategies, down-to-earth dialogues, and

Since its first appearance in 1962, M. L. Rosenthal's classic selection of Yeats's poems and plays has attracted hundreds of thousands of readers. This newly revised edition includes 211 poems and 4

"I put most of myself into that opus," Edith Wharton said of The Reef, possibly her most autobiographical novel. Published in 1912, it was, Bernard Berenson told Henry Adams, "better than any previou

Published in 1926 to explosive acclaim, The Sun Also Rises stands as perhaps the most impressive first novel ever written by an American writer. A roman à clef about a group of American and Engl

In 1937 Ernest Hemingway traveled to Spain to cover the civil war there for the North American Newspaper Alliance. Three years later he completed the greatest novel to emerge from "the good fight," F

Written between 1920 and 1937, when F. Scott Fitzgerald was at the height of his creative powers, these ten lyric tales represent some of the author's finest fiction. In them, Fitzgerald creates vivi

Washington is the most complete, definitive one-volume biography of George Washington ever written. In 1948 renowned biographer and military historian Douglas Southall Freeman won his second Pulitzer

Josephine Tey re-creates one of history's most famous -- and vicious -- crimes in her classic bestselling novel, a must read for connoisseurs of fiction, now with a new introduction by Robert BarnardInspector Alan Grant of Scotland Yard, recuperating from a broken leg, becomes fascinated with a contemporary portrait of Richard III that bears no resemblance to the Wicked Uncle of history. Could such a sensitive, noble face actually belong to one of the world's most heinous villains -- a venomous hunchback who may have killed his brother's children to make his crown secure? Or could Richard have been the victim, turned into a monster by the usurpers of England's throne? Grant determines to find out once and for all, with the help of the British Museum and an American scholar, what kind of man Richard Plantagenet really was and who killed the Little Princes in the Tower.The Daughter of Time is an ingeniously plotted, beautifully written, and suspenseful tale, a supreme achievement from on

The American West centers on three subjects: Native Americans, settlers, and ranchers. Dee Brown re-creates these groups struggles for their place in this new landscape and illuminates the history of

In this strikingly original and groundbreaking book, Dr. Shay examines the psychological devastation of war by comparing the soldiers of Homer's Iliad with Vietnam veterans suffering from post-trauma

Today F. Scott Fitzgerald is better known for his novels, but in his own time, his fame rested squarely on his prolific achievement as one of America's most gifted writers of stories and novellas. Now, a half-century after the author's death, the premier Fitzgerald scholar and biographer, Matthew J. Bruccoli, has assembled in one volume the full scope of Fitzgerald's best short fiction: forty-three sparkling masterpieces, ranging from such classic novellas as "The Rich Boy," "May Day," and "The Diamond as Big as the Ritz" to his commercial work for the Saturday Evening Post and its sister "slicks."For the reader, these stories will underscore the depth and extraordinary range of Fitzgerald's literary talents. Furthermore, Professor Bruccoli's illuminating preface and introductory headnotes establish the literary and biographical settings in which these stories now shine anew with brighter luster than ever.

Traditionally, the human soul is regarded as a nonphysical concept that can only be examined by psychiatrists and theologists. In his new book, The Astonishing Hypothesis, Nobel Laureate Francis Crick

Published in 1934, Tender Is the Night was one of the most talked-about books of the year. "It's amazing how excellent much of it is," Ernest Hemingway said to Maxwell Perkins. "I will say now," John

Watch out, world. Here comes Stephanie Plum, a bounty hunter with attitude. In Stephanie's opinion, toxic waste, rabid drivers, armed schizophrenics, and August heat, humidity, and hydrocarbons are a

A vibrant self-portrait of an artist whose work was his life. In this new collection of F. Scott Fitzgerald's letters, edited by leading Fitzgerald scholar and biographer Matthew J. Bruccoli, we see

Theoretically, the actor ought to be more sound in mind and body than other people, since he learns to understand the psychological problems of human beings when putting his own passions, his loves,

The tragic and fascinating history of the first epic struggle between white settlers and Native Americans in the early seventeenth century: a fresh look at the aggressive expansionist Puritans in New

A riveting novel about marriage in the early twentieth century, by an acclaimed author and founder of the online fiction magazine Narrative.

Leaving Rock Harbor is a historical novel set in a New England mill town in the early 1900s, from New York Times Notable author Rebecca Chace.

A compulsively readable, remarkably candid memoir from world class ultra-marathon runner Charlie Engle chronicling his globe-spanning races, his record-breaking run across the Sahara Desert, and how r

Told with urgency and sharp political insight, Nixonland recaptures America's turbulent 1960s and early 1970s and reveals how Richard Nixon rose from the political grave to seize and hold the presiden

During the early years of her career, while struggling to "keep body and soul apart" (as she ruefully put it later), Dorothy Parker wrote more than three hundred poems and verses for a variety of popu

In the bestselling tradition of Stephen Covey's Seven Habits of Highly Effective People, Jim Collins's Good to Great, and Ray Dalio's Principles, the world's most influential consulting firm McKinsey & Company presents a deep dive into how the best CEOs do their jobs based on extensive interviews with today's most successful corporate leaders from iconic companies such as Netflix, JPMorgan Chase, General Motors, and Sony.Being a CEO at any of the world's largest companies is one of the most challenging, mysterious, misunderstood, and important roles in the world today. The CEOs of the two thousand largest global companies account for more than $40 trillion in annual revenues (more than twice the size of the world's largest economy) and employ 68 million people. Yet even when they reach the position of CEO, very few excel in the role. Thirty percent of Fortune 500 CEOs last fewer than three years, and two out of five new CEOs are perceived to be failing within eighteen months of tak

The fascinating narrative of the remarkable life of Junípero Serra, the intrepid priest who led Spain and the Catholic Church into California in the 1700s and became a key figure in the making of the

The final nail-biting installment in the ten-part, award-winning Hanne Wilhelmsen series—bestselling in Norway and throughout Europe—from Scandinavia’s most celebrated female crime w

A fatal drunk driving accident in the suburbs of Chicago sets in place a series of events that echo through the lives of those close to both the victim and the perpetrator in this radiant novel-in-sto

"When bombs explode at the Islamic Cooperation Council's headquarters in Oslo, detective Hanne Wilhelmsen is on the case in the ninth and penultimate installment of the award-winning series from Norwa

A book that in the haunting tradition of In Cold Blood and The Executioner’s Song lifts away the top layer of evil and finds complexity beneath, this is the bizarre tale of twelve young soldiers who a

In the classic tradition of Sun Tzu’s The Art of War, here for the first time in English is the timeless wisdom of China’s greatest emperor Tang Taizong (598-649 AD) which will show anyone who leads o

An explosive, true-life southern gothic story, Murder in the Bayou chronicles the twists and turns of a high-stakes investigation into the murders of eight women in a troubled Louisiana parish. Soon t

A candid, entertaining memoir told through clothes—for readers of Anjelica Huston, Diane von Furstenberg, and Nora Ephron.Tracy Peacock Tynan grew up in London in the 1950’s and 60s, privy to her pare

An award-winning poet offers a multi-generational portrait of an American family—weaving together the lives of his ancestors, his parents, and his own coming of age in the 60s and 70s in the wake of h

Mary-Margaret O'Reilly is seemingly a harmless enough young woman, ready and willing to help out Father Diamond in the Sacred Heart church in Battersea. She may not be very bright, and she is sadly ov

The Adults is a cracked-up coming of age novel set in the suburbs of Connecticut. In a world of over-sexed and under-sexed parents, suicidal neighbors and horny high school teachers, teenage gi

Zero Decibelsis a passionate exploration of our need for true silence in an age of noise.

Anentertaining and informativeaccount of one man's attempt to live off the food he grows in his backyard in Brooklyn.

G. Pascal Zachary is a foreign correspondent for The Wall Street Journal when he finds love in, of all places, the zoo in Accra, Ghana. That is where he meets Chizo Okon, the surrogate mother for an

Donald Rumsfeld, who as secretary of defense oversaw the army, navy, air force, and marines from 2001 to December 2006, is widely blamed for the catastrophic state of America's involvement in Iraq. In