Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Retells in verse the Indian fable of the blind men discovering different parts of an elephant and arguing about its appearance, with the blind men depicted as mice

A Polish family in the Middle Ages guards a great secret treasure and a boy's memory of an earlier trumpeter of Krakow makes it possible for him to save his father

This thoroughly updated edition continues to provide a concise overall coverage of colloid and surface chemistry, intermediate between the brief accounts in physical chemistry textbooks and the compre

"Extraordinary. A brilliant, painful, and important book."THE NEW YORK TIMESIf there was any one man who articulated the anger, the struggle, and the beliefs of African Americans in the 1960s, that ma

Ramona is off to kindergarten, and it's the greatest day of her life. So why is she sitting on the bench while the rest of the students play the game gray duck? Laughs and minor upsets abound in an en

Travis Underwood is tired of his gym teacher calling him a wimp and sick of being teased by bodybuilder Rocco. Will a summer membership to the YMCA help him get in shape?

本書從一段流傳於黑夜中的歌聲展開，描寫 Peg Leg Joe 如何以音樂與星空，為被奴役的人指引通往自由的方向。故事中，一家人與夥伴們依循歌詞所暗藏的線索，在夜色下辨認北斗七星，踏上充滿未知的旅程。文字節奏如同歌謠本身，沉穩而富有力量；插畫則以近似原始藝術的筆觸，搭配鮮明色塊，形塑出緊張卻充滿希望的氛圍。畫面構圖富有律動感，使閱讀過程彷彿隨著腳步前進。這本繪本不僅重現歷史，也讓年輕讀者理解自由得來不易，並因此獲得《Booklist》星級書評的高度評價。Illus. in full color. "Winter's story begins with a peg-leg sailor who aids slaves on their escape on the Underground Railroad. While working for plantation owners, Peg Leg Joe teaches the slaves a song about the drinking gourd (the Big Dipper). A couple, their son, and two others make their escape by following the song's directions. Rich paintings interpret the strong story in a clean, primitive style enhanced by bold colors. The rhythmic compositions have an energetic presence that's compelling. A fine rendering of history in picturebook format."--(starred) Booklist.

Part diary and part reportage, The Soccer War is a remarkable chronicle of war in the late twentieth century. Between 1958 and 1980, working primarily for the Polish Press Agency, Kapuscinski covered

Museums have been active in shaping knowledge over the last six hundred years. Yet what is their function within today's society? At the present time, when funding is becoming increasingly scarce, dif

Bold bright colors, miniskirts, a "see-through" dress, an innovative pants suit, and "kooky" accessories typify wardrobes of 2 dolls in this extensively researched and painstakingly rendered collectio

Now back in print with a new foreword by J. I. Packer, this classic study clearly shows the organic unity and continuity of the biblical ethic. Murray addresses ethical questions relating to such topi

Already a Southwestern classic as beautiful, subtle and profound as the desert itself Arturo Islas's The Rain God is a breathtaking masterwork of contemporary literature. Set in a fictional small tow

"[In] a revision of the 1963 edition, [a] brief, clearly written text [tells of a young girl who] learns some interesting facts about fireflies from her grandfather. Alexander uses richly hued pastel

本書以千里達一座可可莊園為舞台，描寫獨立後社會中微妙而複雜的人際張力。當英國人 Garry Johnson 來訪，村中的 obeahman Manko 便預見「麻煩將至」。這份不安很快成真——Garry 愛上了印度女子 Sarojini，原本看似和諧的日常，逐漸被猜忌、競逐與衝突取代。小說透過不同族群之間的互動，細膩呈現殖民遺緒、情感慾望與文化差異如何交織。Sam Selvon 以溫和卻精準的筆觸，融合幽默與民間信仰，使故事在平實敘述中蘊含深層社會觀察，被譽為加勒比文學的重要代表。"I see trouble. Plenty trouble." The village obeahman Manko foresees trouble when an Englishman Garry Johnson comes to stay in the cacao estate of his friend Roger Franklin in Trinidad. Before long his prophecy is fulfilled when the visitor falls in love with the lovey Indian Sarojini. What had been a carefree atmosphere quickly evaporates, replaced with a tension-filled air full of jealousies, rivalries and intrigues as three races interact in post-independence Trinidad.

Prisoner of war, optometrist, time-traveller - these are the life roles of billy pilgrim, hero of this miraculously moving, bitter and funny story of innocence faced with apocalypse slaughterhouse 5 is one of the worlds great anti-war books centring on the infamous fire-bombing of dresden in the second world war, billy pilgrims odyssey through time reflects the journey of our own fractured lives as we search for meaning in what we are afraid to know.

At the top of his class at Harvard Law, he had??his choice of the best in America. He made a deadly??mistake. When Mitch McDeere signed on with??Bendini, Lambert & Locke of Memphis, he thought he?

The Pulitzer Prize-winning journalist recalls his youth in the impoverished mountain region of Virginia, New Jersey suburbia, and Depression-shadowed Baltimore and details his mother's struggle to edu

The Alden children travel on a Mississippi paddle-wheel steamer to visit an old family friend in his cabin near Hannibal, Missouri, and try to discover who is responsible for the mysterious activities

Gustav Mole is lucky enough to be born into a musical family, and this charming tale traces the enriching role that music plays in his life. Gustav's musical education is rich and diverse, covering a

During the late imperial era (1500-1911), China, though divided by ethnic, linguistic, and regional differences at least as great as those prevailing in Europe, enjoyed a remarkable solidarity. What h

The journal of a fourteen-year-old girl, kept the last year she lived on the family farm, records daily events in her small New Hampshire town, her father's remarriage, and the death of her best frien

The basic thesis of the work is that environmental problems are only to be solved by people - people who will be required to make value judgements in conflicts that go beyond narrowly conceived human concerns. Thus people require not only an ethical system, but a way of conceiving the world and themselves such that the intrinsic value of life and nature is obvious, a system based on 'deep ecological principles'. The book encourages readers to identify their own series of such parameters - their own ecosophies. Ecology, Comunity and Lifestyle will appeal to philosophers, specialists working on environmental issues, and the more general reader who is interested in learning some of the foundational ideas of the rapidly expanding field of environmental philosophy.

Illus. in full color. "Mr. Piggott and his sons are a male chauvinist lot who, outside of yelling for their dinner, don't exercise themselves much around the house. When Mrs. Piggott finally tires of the endless chores that sandwich her workday, she leaves the menfolk on their own, with a note saying, 'You are pigs.' With the cooking and housework untended, they soon turn genuinely porcine, a transformation Browne foreshadows with pig faces on the wallpaper, vases, fireplace, phone. As in most of Browne's art, there is more than a touch of irony and visual humor here. Fun to read aloud."--Bulletin, Center for Children's Books.

本書為 Anthony Reid 關於「東南亞商業時代」的重要研究之最終卷，聚焦十五世紀至十七世紀中葉之間，東南亞在全球貿易體系中迅速變動的關鍵時刻。當歐洲正經歷文藝復興與早期資本主義轉型時，東南亞同樣因香料貿易的蓬勃發展，迎來城市化、商業化與國家結構重組的深刻變革。作者指出，貿易導向的城市興起，使國家權力趨於集中與專制，伊斯蘭教、基督教與上座部佛教也在新的政治結構中快速傳播，改變了人們對信仰與個人道德的理解。Reid 將這些變化與歐洲、日本的歷史發展相互對照，同時也審慎分析東南亞在私人資本累積與國家穩定性上的限制。書末探討十七世紀中葉的危機，如何使東南亞逐步退出世界經濟舞台長達數百年。本書以嚴謹學術與清晰敘述見長，是理解東南亞歷史與全球早期現代化進程的重要經典。In The Lands Below the Winds--the first volume of a two-volume set chronicling the rise of Southeast Asian culture during the years from 1450 to 1680--Anthony Reid vividly explored everyday life in the different societies of the region, from diet, housing, commerce, and law to sexual and family relations, patterns of warfare, and popular entertainment. In doing so he enables us to perceive the underlying coherence and splendid variety in the complex mosaic of Southeast Asia.

In the twenty-third century pioneers have escaped the crowded earth for life in self-sustaining orbital colonies. One of the colonies, Rotor, has broken away from the solar system to create its own renegade utopia around an unknown red star two light-years from Earth: a star named Nemesis. Now a fifteen-year-old Rotorian girl has learned of the dire threat that nemesis poses to Earth's people--but she is prevented from warning them. Soon she will realize that Nemesis endangers Rotor as well. And so it will be up to her alone to save both Earth and Rotor as--drawn inexorably by Nemesis, the death star--they hurtle toward certain disaster.

"Boy!" said Ralph to himself, his whiskers quivering with excitement. "Boy, oh boy!" Feeling that this was an important moment in his life, he took hold of the handgrips. They felt good and solid bene

Speaking Clearly aims to help intermediate and advanced learners of English overcome problems of understanding and being understood by other speakers of English. It integrates pronunciation and listening; provides systematic ear-training and practice from individual words and sounds to longer stretches of speech; contains diagnostic tests and explains phonological features in clear, non-technical terms.

A celebration of a child's growing self awareness, and a prime example of how books can contribute to this. Whether brave or shy, strong or weak, in the end the young boy celebrates all different, app

Two centuries after they were published, Kant's ethical writings are as much admired and imitated as they have ever been, yet serious and long-standing accusations of internal incoherence remain unresolved. Onora O'Neill traces the alleged incoherences to attempt to assimilate Kant's ethical writings to modern conceptions of rationality, action and rights. When the temptation to assimilate is resisted, a strikingly different and more cohesive account of reason and morality emerges. Kant offers a `constructivist' vindication of reason and a moral vision in which obligations are prior to rights and in which justice and virtue are linked. O'Neill begins by reconsidering Kant's conceptions of philosophical method, reason, freedom, automony and action. She then moves on to the more familiar terrain of interpretation of the Categorical Imperative, while in the last section she emphasises differences between Kant's ethics and recent 'Kantian' ethics, including the work of John Rawls and othe

The four Alden children and their new friend Lars uncover a mystery during a trip to an island in the South Seas

A friendly writer with a metal detector, the mysterious inhabitants of a tower house, and the discovery of a locket in the sand are ingredients for the Aldens' latest mystery.

The Alder and Beach children see a strange window in the old beach home from their tree house, and they set out to solve the puzzles it presents

Grandpa Alden and the Alden children encounter danger, excitement, adventure, and mystery in a quiet island fishing village

There was once a little raccoon who wanted to go out in the night -- to know an owl, to see if the moon is a rabbit, and to find out how dark is the dark. But his mother said, "Wait. Wait till the moo

SnakesSlithering, scaly, and sly -- snakes are fascinating reptiles. They are also hunters. Find out how snakes survive in the wild, and how they capture their prey.

Filled with sex and violence--in and out of time and space--the three books of The Illuminatus are only partly works of the imagination. They tackle all the coverups of our time--from who really shot the Kennedys to why there's a pyramid on a one-dollar bill.

In this allegory, the author's reaction to the Holocaust, the animals of the forest are carried away, one type after another, by the Terrible Things, not realizing that if perhaps they would all stick

Francisco is a lonely boy. Amigo is a prairie dog. They both live in the desert, and both want someone to play with. Francisco thinks that he's "taming" Amigo, his pet -- but Amigo knows better.

Analyzes novels by Stendhal, Dostoevsky, Eliot, Flaubert, Mann, Woolf, and Gadolis in terms of their historical context

A Novel of the life of the tormented genius who put so much of himself into his art that he found it difficult to maintain himself in ordinary society.