Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

阿西姆的朋友馬克斯處於危險之中！阿西姆確信某種超自然存在——也許是女巫？——在追捕馬克斯。羅克夏爾，這個小組中的理性者，認為這位女士是一位利用孩子進行實驗的科學家！無論哪種情況，馬克斯都處於危險之中，阿西姆和羅克夏爾負責保護他。但是當他們接近找到答案時，阿西姆和他的朋友遭到火球的襲擊。是科學解釋了這些飛來的火球？還是來自圭亞那民間傳說的女巫？如果你敢的話，找出答案吧！不要錯過基於圭亞那鬼故事的《神秘偵探》系列。There are mysterious explosions near the old abandoned houses in town. Is it science . . . or is it something strange and ghostly? Find out in the latest installment to the spooky chapter book series Spooky Sleuths.Asim’s friend Max is in danger! Asim is sure some sort of supernatural being—a witch, maybe?—is after Max. Rokshar, the levelheaded one of the group, thinks the woman is a scientist using kids for her experiments! Either way, Max is in trouble, and it’s up to Asim and Rokshar to keep him safe.But when they get close to finding answers, Asim and his friends are attacked by fireballs. Is science behind the flying fire? Or is it a witch from Guyanese folklore?Find out . . . if you dare!Don't miss the Spooky Sleuths series based on ghost stories from Guyana.Spooky Sleuth

From BIG BANGS to tiny atoms SCIENCE tells us why things happen. Explore the whys, whats and hows of science and answer all the really BIG questions that curious kids are keen to ask. This playful rhyming book bubbles and bursts with all things scientific, from technology and space to experiments, inventions and the natural world.

Aspiring astronauts will be ready for liftoff with this thrilling guide to preparing for and doing a real spacewalk with the first American woman to walk in space as their partner.What is it like to walk in space—to use cutting-edge equipment and conduct experiments in a 280-pound space suit? How do you get there in the first place? Would-be spacewalkers will find enthusiasm, vibrant encouragement, and a host of amazing facts, photos, drawings, and descriptions in this engaging guide cowritten by three-time shuttle astronaut Kathryn D. Sullivan and children’s book author Michael J. Rosen (who also provides illustrations). From detailed info about how to train (sometimes underwater!) to descriptions of the emotions spurred by seeing Earth from above, this guide will leave readers inspired and excited to start their own journeys into space.

It’s fun to be smart! These two illustration-based card decks are packed with early learning questions that promote language development, cognitive growth, and social skills for fifth graders.Loved by kids, teacher approved, and trusted by parents, Brain Quest For Twos question-and-answer cards help children explore and talk about daily routines, seasonal activities, and outings as they identify objects, shapes, colors, and more! In a set of two decks, Brain Quest For Twos features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and funOver 300 questions covering colors, counting, object identification, shapes, and moreWhat’s New?New content: Twenty-two brand-new cards added!Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and int

It’s fun to be smart! Packed with early learning questions that promote language development, cognitive growth, and social skills, these illustration-based card decks are the key to making Pre-K fun.Loved by kids, teacher approved, and trusted by parents, Brain Quest Pre-Kindergarten question-and-answer cards help children explore and learn about phonics, word study, counting, matching, sequencing, and more! In a set of two decks, Brain Quest Pre-Kindergarten features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and fun300 questions that set the foundation for learningWhat’s New?Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and interactions with peersUpdated content: Fresh and relevant to today’s familiesBrain Quest decks ar

Discover how space is part of our daily lives with Everyday STEM Science - Space, filled with facts, stories and experiments to try at home!Everyone knows there are planets and stars and space rocks, but how do these, and everything else in space, affect us on Earth? From the beginning of the universe and the origins of the planets, to the latest research and space missions, journey through space and uncover what is really out there . . .Discover how we're made of stars, find out how old you would be if you lived on Mars, and how time travel can happen in space. Plus, meet the explorers, astronomers and scientists whose discoveries have given us this fascinating space knowledge, including Mae Jemison, Stephen Hawking and Cecilia Payne-Gaposchkin. Readers can also carry out cool astronomical experiments at home.With easy-to-understand text written by science communicator and podcaster Izzie Clarke, and lots of colourful artworks, photos and diagrams, readers can best explore where we en

Brain Quest, America's #1 educational brand with more than 57 million copies in print, is now for babies! My First Brain Quest board books introduce essential early learning concepts and foundational vocabulary using engaging visuals and Brain Quest's signature question and answer format.From the rain in the sky to the grass at their feet, help your child understand the world around them with the guidance of this fun and exciting introduction to science!My First Brain Quest: First Words: Science Around Us introduces babies and toddlers to more than 100 STEM-related vocabulary words in their world—in the backyard, at the doctor's office, at the beach. Each scene features labeled illustrated objects as well as brief captions that help to introduce STEM concepts and help put into context, alongside questions that encourage conversation between reader and child. Children have fun naming, counting, and comparing.

Ages: 7–11Level: KS2Subject: MathsPower Maths is a leading primary maths mastery scheme, developed in partnership with White Rose Maths.This edition is fully aligned with the new White Rose Maths schemes of learning (version 3.0) and has been updated in response to current mastery best practice and feedback from teachers.For children who are following either the Power Maths or White Rose Maths scheme, the Practice Books provide additional practice for each lesson that children can complete independently.

During the early stages of its development, Taiwan’s New Literature was intimately connected with realism.The year 2022 is the one-hundredth anniversary of fiction writing in Taiwan, and also the one-hundredth anniversary of modernist literature in the English-speaking world. For the former, this is the one-hundredth anniversary of the publication of Chui Feng’s “Where Will She Go?” For the latter, it is the one-hundredth anniversary of the publication of James Joyce’s (1882–1941) novel Ulysses, and Anglo-American writer T. S. Eliot’s (1888–1965) poem The Waste Land. When the Alphabet Lab was first established, it also paid tribute to the contribution of modernism in the development of post-war Taiwan literature. In this special fiftieth issue on “Taiwan Fiction and ‘Realism,’” we once again identify and trace out the pathways and objectives of Taiwan’s writer apostles over the past one-hundred years.台灣新文學的發展，以追風的〈她要往何處去〉為濫觴，發表於1922年，至今剛好一百年。台灣新文學發軔時，歐美現代主義發展已達到高峰，台灣必然受到影響，可見現代主義與現實主義，

Hello, USA! This delightful board book from Hello, World creator Ashley Evanson pairs early learning concepts with colorful, stylish illustrations of the iconic art, architecture, food, and culture from all 50 US states.In Hello, USA! A Book of Beginner Concepts, readers learn all about the 50 states through five sections of early reading concepts (numbers, months, colors, shapes, and opposites): from the eight iconic stripes on Maine's Acadia Lighthouse to four purple wildflowers in Montana's Glacier National Park to the colorful rectangle houses in South Carolina's Charleston, and more -- all in Ashley Evanson's dynamic Hello, World style.

This lavish visual history—featuring over 150 new, full-colour illustrations—is a stunning introduction to House Targaryen, the iconic family at the heart of HBO’s Game of Thrones prequel series, House of the Dragon.For hundreds of years, the Targaryens sat the Iron Throne of Westeros while their dragons ruled the skies. The story of the only family of dragonlords to survive Valyria’s Doom is a tale of twisty politics, alliances and betrayals, and acts both noble and craven. The Rise of the Dragon chronicles the creation and rise of Targaryen power in Westeros, covering the history first told in George R. R. Martin’s epic Fire & Blood, from Aegon Targaryen’s conquest of Westeros through to the infamous Dance of the Dragons—the bloody civil war that nearly undid Targaryen rule for good.Packed with all-new artwork, the Targaryens—and their dragons—come vividly to life in this deluxe reference book. Perfect for fans steeped in the lore of Westeros, as well as those who first meet the

The This is line of World of Reading early readers is designed to offer reluctant readers books they will want to read by featuring the origin stories of characters they love.Learn how Kamala Khan finds out that she's an Inhuman with super powers and becomes Ms. Marvel, how Peter Parker puts his powers to good use and becomes the friendly neighborhood Spider-Man, how Jane Foster becomes The Mighty Thor, how Shang-Chi uses his martial arts skills to becomes an Avenger, and how Kate trains to be the ultimate super hero.Discover how Marvel's most popular characters became the Super Heroes they are today in this bind-up of 5 stories perfect for reluctant readers.Features:large, easy-to-read printshort, simple sentencesfun illustrations Complete your Marvel World of Reading collection and get to know the origin stories for each of your favorite heroes!This is Black PantherThis is Miles MoralesThis is Captain MarvelThis is Black WidowThis is ThorThis is Doctor StrangeThis is FalconFor r

吉翁公國之寶――「光塔」的全貌逐步明朗，《機動戰士鋼彈 MSV-R 強尼．萊汀的歸來》最新刊第22集登場！ ©Ark Performance 2021 ©SOTSU・SUNRISE KADOKAWA CORPORATION ★寫實風格的作戰場面！大魄力的MSV機體激鬥！ ★本作品是以「強尼．萊汀」的人物形象為中心主軸， 加上豐富MSV機體的原創漫畫。

From the multi-award winning author of The Bridge (BBC) and Marcella (Netflix, ITV) comes a blockbuster new thriller… A DEAD WOLFA DRUG DEAL GONE WRONGA LETHAL FEMALE ASSASSINHannah Wester, a detective in the remote northern Swedish town of Haparanda, finds herself on the precipice of chaos.When human remains are found in the stomach of a dead wolf, Hannah knows that this summer won’t be like any other. The remains are soon linked to a bloody drug deal that went down just across the border in Finland. But how did the victim end up in the woods outside Haparanda? And where have the drugs and money gone?Hannah and her colleagues are soon caught up in an increasingly complex investigation. But time is scarce and they aren’t the only ones looking.When the secretive and deadly Katja shows up, unexpected and brutal events start to pile up. In just a few days, life in the border town is turned upside down. Not least for Hannah, who is finally forced to confront her own past.

Take a large group of kids in puberty, send them to a new school, and add a generous dose of tests, homework, and hormones, not to mention diverse personalities, bland food, and unpleasant odors. That’s middle school, and it can be a little . . . weird.Yes, there are cool things about middle school, like more independence, new friends, and new activities. But there’s baffling stuff too, like harsh judgment, the whole “popularity” thing, and, of course, drama. With insights from hundreds of students, this guidebook explores the halls of middle school, especially the odd behaviors that lurk in the shadows. Slip-on your lab coats, because we’re going to dissect these behaviors one by one to understand what’s really going on. With fun illustrations and choose-your-own-adventure-style scenarios, Middle School: Safety Goggles Advised will help you deal with the drama and define who you are and how to navigate life when things get, well, weird.

This is Slappy's world -- You only scream in it!Space-obsessed Murphy Shannon is pumped that his 6th grade class is visiting the Rayburne Observatory. Except, being a know-it-all means he's totally bored with the lectures he has to sit through. So when classmates Orly and Cleo say they should explore on their own, Murphy sneaks out with them. But when they come face-to-face with the strange Dr. Rayburne and his experiments, they realize they may be way in-over-their heads. A grand adventure in space may be in store for them, if they can survive...

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Waves and Wiggles little ones can become familiar with letter shapes: W, M, N, U and V. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Swirls and Squiggles

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Swirls and Squiggles little ones can become familiar with letter shapes: S, C, Z, E and O. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Waves and Wiggles

Learn about football in this early learning activity book. Big Stickers for Little Hands Football introduces children to the world of football through simple activities, big stickers and card press-outs. Each page is full of fun, early learning activities that are perfect for young children. FUN ACTIVITY BOOK WITH BIG STICKERS FOR LITTLE HANDS, COLOURING AND CARD PRESS-OUT PAGESIncludes 2 sheets of big stickersWith 2 sheets of fun card press-outs16 pages of simple, early learning activities

The Buddhist Maritime Silk Road recounts the magnificent history of the world of Maritime Buddhism from a diverse range of aspects―the various Buddhist traditions, pilgrims and monks, causes and conditions, norms and rituals, cross-cultural relations between East and West, as well as the intricacies of navigation technology, and migrations of the Austronesian peoples―all remarkable and crucial elements of the transmission of Buddhism brought to new heights of importance.In this book, Dr. Lewis R. Lancaster innovatively shifts the focus to documenting the dynamic networks and systems of interchange in Eurasia, instead of the common approach of historical, event-structured analysis. The fascinating history of the spread of Buddhism begins in the early years of the Common Era, when animal caravans began treading across the inland routes between India and China, evolving as sea routes flourished over centuries. It emerges that Buddhism flowed and thrived along with the beating pulse of the

How did Bitcoin price increase 1,200 times in only a decade? Why can a virtual image be sold for as high as HK$500 million? How did Dogecoin once become the fourth largest digital asset in terms of market cap, after being created for fun? Understanding the development of blockchain and crypto assets and how to make good use of its decentralized technology can protect individual wealth effectively and be an edge against the inflation caused by central banks, and sometimes also be a shortcut to get rich. Cryptocurrencies, including Bitcoin, Ethereum, and many others, have been mushrooming in recent years. Blockchain technology has also evolved from 1.0 to 3.0. How can you identify and seize these new opportunities? This book gives a brief explanation of the development course of blockchain and crypto assets, an analysis of the industry ecosystem, a framework for institutional investors to manage their portfolios, and an outlook on the development direction of this industry in the coming

Favorite stories from Robert Munsch in an early reader format kids will love! Adapted from the originals so beginner readers can proudly say "I read this myself!"Mortimer will not be quiet and go to sleep. Not for his mother, or his father, or his seventeen sisters and brothers, not even for the police.Colorful and fun, Robert Munsch's zany stories and Michael Martchenko's illustrations will grab kids' attention and keep them interested as they practice their reading skills.Tips for supporting emerging readers are in the back for parents.

Favorite stories from Robert Munsch in an early reader format kids will love! Adapted from the originals so beginner readers can proudly say "I read this myself!"Pigs are smarter than you think! When Megan's dad tells her not to let the pigs out of their pen, curiosity gets the better of her. Why not? Pigs are too dumb to do anything anyway . . . or are they? Before she knows it, the pigs are wreaking havoc all over her house, all over her school, and all over town. It's up to her to fgure out how to get them back home. To Megan's surprise, she discovers the animals are much smarter than she realized.Colorful and fun, Robert Munsch's zany stories and Michael Martchenko's illustrations will grab kids' attention and keep them interested as they practice their reading skills.Tips for supporting emerging readers are in the back for parents.

模糊統計遇上R語言，激盪出美麗的火花，成為您統計之路最好運用的工具！本書在模糊統計導論的基礎上，針對每種模糊統計分析方法提供R語言的撰寫語法，讓讀者更容易應用與計算。「當有人說他今天感到很快樂時，究竟他對於快樂的認知為何呢？什麼樣的測量標準可以稱得上快樂呢？或是這樣的感覺持續多久的時間以上才能算是快樂呢？」模糊理論是一種定量化處理人類語言、思維的新興學門。模糊邏輯並非如字面上意思那樣的馬虎、不精確，而是面對生活上各種的不確定性，以更合理的規則去分析及管理控制，以期得到更有效率、更合乎人性與智慧的結果。模糊統計並不模糊，它是處理不確定事件的新技術，帶領我們從古典的統計估計與檢定研究計算，進入一個需要軟計算、穩健性的高科技e世代。原本模糊統計導論就已經建構了相當完整的定義與計算公式，但苦於沒有容易操作使用的統計軟體平台，所幸R語言的成熟，提供了一個便於計算與理解模糊統計方法的平台，透過程式語言的撰寫，更能印證模糊統計方法的各種設想，而且也能由讀者自行撰寫更彈性與多元的語法，讓模糊統計的應用更為廣泛與深入。

There are all sorts of early years activities shown in this delightfully illustrated sticker book, including going to a birthday party, visiting a farm and playing in the playground. There's plenty of

'I want to be me! The glorious glittering me . . .People like me here Celestine! They adore me!'Victoria Stitch has escaped from the confines of Wiskling Wood and flown into the human world. Here, she breaks the most sacred of all wiskling laws and speaks to a human. Where she is feared and disgraced in Wiskling Wood, she is adored and revered in the human world.But the net is closing in. There are wisklings who would like to end Victoria Stitch's famous reign in the human world for good. Will her beloved twin, Celestine, be able to warn her in time? And even if she can, will Victoria Stitch listen?Review of Victoria Stitch: Bad and Glittering. This absorbing miniature melodrama is full of fraught sibling fondness between sweet, gentle Celestine and the marvellously ambitious and snooty Victoria, with Muncaster's own enticing illustrations. - The GuardianReview of Victoria Stitch: Bad and Glittering. Packed full of gothic glam and with a hefty dose of sparkles and glitter, Victoria Sti

資料分析聽起來很難，但只要你會用Excel，其實就不難上手了。透過這本實作指南，能夠幫助你更進一步地理解資料分析與處理，並瞭解如何藉助程式語言進行資料分析與假說檢定。 資料分析的重點是找出關聯性，本書可以引導你學到更進階的資料分析技術。本書運用試算表作為練習基礎統計學概念的範例，並告訴你如何運用Python與R進行更有效率的資料分析。 這本實用指南可以幫助你： ．了解如何利用Excel進行資料分析：透過Excel來測試變數之間的關係，並運用統計學製作令人信服的分析 ．從Excel到R：學會如何使用R進行原本利用Excel所進行的資料分析工作 ．從Excel到Python：學會如何應用Python進行原本利用Excel所進行的資料分析工作 ________________________________________ 專家推薦 「本書精確地說明如何運用Excel進行資料科學與分析的工作」--Jordan Goldmeier, 微軟Excel MVP 「這本書不僅可以作為商業和資料分析的參考資料，也可以作為入門教材」--Aiden Johnson, 資料科學家

Physics is intended for a two-semester college course in introductory physics using algebra and trigonometry.

Travel to a magical moonlit party with fairy friends Ruby, Iris, and Pip in this wondrous early reader series!Pick a Book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, a

Princess Truly is not afraid of anything, in these rhyming stories perfect for early readers!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children

A beautifully illustrated and insightful anthology to return to time and again. We all have days when we find ourselves in need of some positivity. In difficult times, the words of others can lift us up. Bright, joyful art to inspire hopefulness is combined with carefully curated poems, chosen to lift the spirits through the healing power of words. The book is divided into eight sections on the themes of Joy, Hope, Resilience, Nature, Tranquillity, Gratitude, Escape and Love. Featuring a diverse range of writers from Maya Angelou to Oscar Wilde, Pablo Neruda to Rupi Kaur, the selections are accompanied by explanations and illuminating context that reinforces the positive mental health message. Combining uplifting lines of verse and joyful illustrations, this unique book provides a much-needed dose of hopefulness and happiness in turbulent times, whether as a thoughtful gift for someone in need of solace or a resource that can be turned to whenever we need to.

The only official Minecraft English book for children aged 5-6! Children embark on a Minecraft adventure in each English topic, using their skills and knowledge to complete the tasks and earn

Eva Wingdale is getting a new pet, in this bestselling early chapter book series just-right for emerging readers Pick a book. Grow a Reader This series is part of Scholastic's early chapter book line,

The groundbreaking feminist and socialist writings of Puerto Rican author and activist Luisa Capetillo A Penguin Classic In 1915, Puerto Rican activist Luisa Capetillo was arrested and acquitted in 1915 for being the first woman to wear men's trousers publicly. While this act of gender-nonconforming rebellion elevated her to feminist icon status in modern pop culture, it also overshadowed the significant contributions she made to both the women's movement and anarchist labor movements of the early twentieth century--both in her native Puerto Rico and in the migrant labor belt in the eastern United States. With the volume A Nation of Women, Capetillo's socialist and feminist activism is given the spotlight it deserves with its inclusion of the first English translation of Capetillo's landmark Mi opini n sobre las libertades, derechos y deberes de la mujer. Originally published in Spanish in 1911, Mi opini n is considered by many to be the first feminist treatise in Puerto Rico and one o

With over 20 million copies sold in the US and Canada, and translated into more than 34 languages, Orson Scott Card's Ender series is one of Tor's all-time bestselling series, now repackaged for new r

運用R和Python學習50+個必學統計概念 「這本書並非是另一本統計學教科書，也不是機器學習手冊。本書透過清楚的解釋和豐富範例，將實用的統計術語及原理和當今資料探勘的行話及實務聯繫起來。對資料科學的初學者和老手來說，這都是一本非常出色的參考書。」 ―Galit Shmueli, 暢銷書《Data Mining for Business Analytics》主要作者，台灣清華大學特聘教授 統計方法

It's play time! Can you play on the swings and jump on the trampoline?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread in

Imperial Japan's campaigns of conquest in late 1941/early 1942 were launched in order to achieve self-sufficiency for the Japanese people, chiefly in the precious commodity of oil. The Netherlands (or

◎詳細說明量化研究中資料處理。◎扎實的統計方法說明，提供不同情境的分析範例。◎以圖片詳實說明操作流程，同時輔助學習R語言。◎書中範例資料檔案請至五南網站https://www.wunan.com.tw，輸入書號1H0T下載。本書介紹R語言在量化資料分析上的應用，並從量化資料的各種分析方法中，以理論配合實例分析加以說明。內容共分為11章，分別是R語言簡介、量表題目分析、量表信度與效度分析、平均數差異

It's a dark and stormy night and Toby cannot sleep. The whole house seems to be tossing and turning like a ship in the middle of the ocean...and soon Toby enters a fantasy world where he is indeed at sea, caught up in a strange and wild adventure. Luckily, Toby's cat makes up the crew of his ship, and together they chart a course through the storm and fend off a giant sea monster - with the last minute help of a mystery submarine which comes to their aid.But hang on, the submarine is manned by his Grandma and Grandpa! Soon they are back in the safety of the harbour, ready for breakfast - but lift the flap for one last surprise! Dramatic and surreal, there is danger and bravery with a large dose of the surreal, and lots more to notice on every re-read.