Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The death was an odd one, it was true; but there was after all no very clear reason to assume it was anything but natural.' In the winter of 1942, England lies cold and dark in the wartime blackout. O

'I started to write short pieces when I was living in a room too small to write a novel in.' So says Angela Carter of this collection, written during a period living in Toyko. These exotic, sensuous stories represent Carter's first major achievement in the short story form. Lush imaginary forests, a murderous puppet show and an expressionistic vision of Japan: each one instantly conjures an atmosphere, dark and luminous in turn, and from the recognisably daring imagination of one of the great twentieth-century stylists.

The fourth book in the Anne Shirley series.'Gilbert, I'm afraid I'm scandalously in love with you'Anne Shirley and Gilbert Blythe are at last engaged, but still they are apart: for three years Gilbert

A baby is found by wood nymphs in the forest of Burzee. They raise him as their own and give him the name Neclaus. When he grows up, Neclaus has to leave the forest so he makes a home for himself in t

English gentleman, Rupert Rassendyll, arrives in the kingdom of Ruritania on the eve of King Rudolf’s coronation. That night the king is abducted and held prisoner in a castle in the small town of Zen

This attractive First 100 box set contains five of Priddy's bestselling word books, published in paperback for the first time, with a sticker sheet in each. Full of big, bright photographs and bold wo

Whether she’s a leading lady, loyal spouse, or lightning rod for scandal, the First Lady of the United States has always been in the spotlight—and in 2017 that’s truer than ever. This revised and expa

It's time for the Halloween pumpkin competition at playgroup and Grandpa Pig has grown Peppa a really special pumpkin. The trouble is, it's a little bit too big to fit in the car. . . In fact, i

Meet the Flying Doctors: Princess Pearl, Sir Gadabout and, of course, their trusty 'air ambulance', Zog the dragon, in this fabulously original sequel to the bestselling ZOG, now available in paperbac

Calling all Raina Telgemeier fans! The Newbery Honor-winning author of Roller Girl is back with a heartwarming graphic novel about starting middle school, surviving your embarrassing family, and the Renaissance Faire.Eleven-year-old Imogene (Impy) has grown up with two parents working at the Renaissance Faire, and she's eager to begin her own training as a squire. First, though, she'll need to prove her bravery. Luckily Impy has just the quest in mind—she'll go to public school after a life of being homeschooled! But it's not easy to act like a noble knight-in-training in middle school. Impy falls in with a group of girls who seem really nice (until they don't) and starts to be embarrassed of her thrift shop apparel, her family's unusual lifestyle, and their small, messy apartment. Impy has always thought of herself as a heroic knight, but when she does something really mean in order to fit in, she begins to wonder whether she might be more of a dragon after all. As she did in Ro

After being cast as the Ninja Master in his school's Halloween play, a boy decides it is time to catch the monster in his closet.

THE #1 NEW YORK TIMES BESTSELLING SEQUEL TO AN EMBER IN THE ASHESA USA TODAY BESTSELLERA WALL STREET JOURNAL BESTSELLER“Spectacular.”—Entertainment Weekly“Fresh and exciting...Tahir has shown a remarkable talent for penning complex villains.”—A.V. Club"Even higher stakes than its predecessor… thrilling." —Publishers Weekly, starred review“[An] action-packed, breathlessly paced story.” —Booklist, starred reviewSet in a rich, high-fantasy world inspired by ancient Rome, Sabaa Tahir's AN EMBER IN THE ASHES told the story of Laia, a slave fighting for her family, and Elias, a young soldier fighting for his freedom. Now, in A TORCH AGAINST THE NIGHT, Elias and Laia are running for their lives.After the events of the Fourth Trial, Martial soldiers hunt the two fugitives as they flee the city of Serra and undertake a perilous journey through the heart of the Empire. Laia is determined to break into Kauf—the Empire’s most secure and dangerous prison—to save her brother, who is the ke

The fourth in Luke Pearson's acclaimed series of magical adventures starring Hilda, our favorite blue-haired heroine--now in paperback!Hilda stumbles upon Tontu, a lost house spirit. Plunged into the

In his 1997 work Guns, Germs and Steel, Jared Diamond marshals evidence from five continents and across 13,000 years of human history in an attempt to answer the question of why that history unfolded

Small hostilities were growing; vague jealousies were gaining strength; and far off, wasn't there a nebulous hint of approaching tragedy in the air?' Welworth Garden City in the 1940s is a forward-thi

A man is forbidden to uncover the secret of the tower in a fairy-tale castle by the Rhine. A headless corpse is found in a secret garden in Paris - belonging to the city's chief of police. And a drown

How is it possible to live free and joyful in this world of domination? The key idea Nietzsche offers us is this: don't hide from struggle in fantasy worlds or imaginary futures, but affirm life, say

Take to the skies with Flying Machines!Follow the famous aviators from their bicycle shop in Dayton, Ohio, to the fields of North Carolina where they were to make their famous flights. In an era of di

The Sunday Times Top Ten BestsellerShe will change your life forever… In the south-west of Ireland, rugged mountains meet bright blue lakes and thick forests. Deep in the woods, a young woman lives al

The wonder of being a dad is on display in this touching tribute to fathers. After all, the connection between a father and child yields a lifetime of learning and love. In You and Me, Me and You, tha

Prepare to be Bewitched!Makoto Kowata, a novice witch, packs up her belongings (including her black cat familiar) and moves in with her distant cousins in rural Aomori Prefecture, in the far north rea

Delight in a beautifully realised and very funny exploration of colour, the relationship between different objects and the power of the imagination in this sturdy board book version of the classic. Or

Revisit one of the most beloved books in Laura Ingalls Wilder’s classic Little House series with this gorgeous hardcover, unjacketed edition of Little House in the Big Woods, featuring a special forew

It's been a long, crazy trip around the world. Now the duo is back in their beloved forest, and Bird wants to throw a party! But Squirrel isn't in the mood to celebrate. His house needs a good cleanin

推薦序：Creating a refreshing blend of realities, author Daniel Chuang evinces a keen sense of imagination in Game Terror, his second novel. In Craven's Arcade, the players and the arcade's eponymous owne

Silver award winner in the MadeForMums Awards 2017 children's books series category. DKfindout! Stone Age takes kids back in time to discover what life was like in the Stone Ages. The most popular topic on www.dkfindout.com, Stone Ages was added to the national curriculum in 2014.With beautiful photography, lively illustrations, and key curriculum information, the DKfindout! series will satisfy any child who is eager to learn and acquire facts - and keep them coming back for more! For any kid that can't get enough of Stone Age facts, DKfindout! Stone Age is packed with up-to-date information, fun quizzes and incredible images of every aspect of Stone Age life. Discover what Stone Age people wore, sample some of their favourite foods and spot the Stone Age animal. DKfindout! Stone Age will surprise and delight young readers.

In 1960, Lin published the collection of stories Memories of Peking: South Side Stories and established her name in Taiwan's literary circle. Based on five sequential stories of a Taiwanese family liv

The third book in the heart-stopping The Darkest Minds trilogy, by New York Times bestselling author of Passenger, for fans of Divergent and The Hunger Games. The fate of a generation lies in Ruby's h

From the legendary New York Times bestselling author of The Flowers in the Attic and My Sweet Audrina series comes the first book in a new series featuring identical twin sisters made to act, look, an

Get ready to explore the depths of the ocean, the farthest reaches of space, and everything in between! Volcanic eruptions, vampire bats, feathered velociraptors, and more await you in SCIENCE COMICS.

Jacqueline Woodson's National Book Award and Newbery Honor winner, now available in paperback with 6 all new poems.Raised in South Carolina and New York, Woodson always felt halfway home in each place

A follow-up to the best-selling The Storm Whale, winner of the 2014 inaugural Oscar's First Book Prize in association with the Evening Standard. It’s winter time and Noi’s island is covered in a blank

This was the motto of Chang Kuo-sin, and the ideal which he inspired generations of students of communication to follow. He proved his own dedication to this when, in 1949, he found himself in Nanking

Sunny the meerkat lives with his enormous family in the Kalahari desert. They are all very close ...so close, in fact, that one day Sunny decides it's just too crowded and packs his bags. He's off to

In the seeming tranquility of Regency Square in Cheltenham live the diverse inhabitants of its ten houses. One summer's evening, the square's rivalries and allegiances are disrupted by a sudden and un

The Sunday Times Top Ten Bestseller, available as a Penguin Essential for the first time. A castle at the foot of the Carpathian mountains in the 1930s. Two men, inseparable in their youth, meet for t

Seek and ye shall find. With these words echoing in his head, eminent Harvard symbologist Robert Langdon awakes in a hospital bed with no recollection of where he is or how he got there. Nor can he ex

In this second book in the Tiny Travellers series, Jack, Ella, Noah, Izzy and Lucky the cat are setting off on a new adventure: to help Aboki the lost alien find his way back home! Young readers can j

Daisy's getting into double the trouble in this fantastic collection! Whether she's making lots of furry friends on her summer holiday in Spain, or trying to win a coconut at the fair, one thing's for

Shifty McGifty and Slippery Sam have swapped their life of crime for a career in cupcakes. But when they're asked to bake for a seriously swanky party, Shifty and Sam find themselves caught up in the