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Are you frustrated by the lack of lack of quality, up-to-date revision material for the Primary FRCA OSCE examination? The answer is here. Primary FRCA: OSCEs in Anaesthesia provides candidates with over 80 practice OSCE stations presented in the style of the Royal College exam. Covering the main OCSE categories such as physical examination, resuscitation and simulation, anaesthetic hazards, and equipment, this book will help candidates prepare for the exam and test their knowledge. Each station is constructed in clear and logical fashion to make the revision of individual topics more accessible. The sample questions and answers allow self-testing and are complemented by discussions, numerous illustrations and up-to-date clinical guidelines which follow modern-day anaesthetic practice. With more candidates now failing the OSCE component of the exam, Primary FRCA: OSCEs in Anaesthesia is a must-have for trainees and tutors preparing for the primary FRCA.

Despite its position at the heart of Europe and its quintessentially European nature, Switzerland's history is often overlooked within the English-speaking world. This comprehensive and engaging history of Switzerland traces the historical and cultural development of this fascinating but neglected European country from the end of the Dark Ages up to the present. The authors focus on the initial Confederacy of the Middle Ages; the religious divisions which threatened it after 1500 and its surprising survival amongst Europe's monarchies; the turmoil following the French Revolution and conquest, which continued until the Federal Constitution of 1848; the testing of the Swiss nation through the late nineteenth century and then two World Wars and the Depression of the 1930s; and the unparalleled economic and social growth and political success of the post-war era. The book concludes with a discussion of the contemporary challenges, often shared with neighbours, that shape the country today.

This is the first book to explore the concept of 'Grotian Moments'. Named for Hugo Grotius, whose masterpiece De jure belli ac pacis helped marshal in the modern system of international law, Grotian Moments are transformative developments that generate the unique conditions for accelerated formation of customary international law. In periods of fundamental change, whether by technological advances, the commission of new forms of crimes against humanity, or the development of new means of warfare or terrorism, customary international law may form much more rapidly and with less state practice than is normally the case to keep up with the pace of developments. The book examines the historic underpinnings of the Grotian Moment concept, provides a theoretical framework for testing its existence and application, and analyzes six case studies of potential Grotian Moments: Nuremberg, the continental shelf, space law, the Yugoslavia Tribunal's Tadic decision, the 1999 NATO intervention in Serb

This is the first book to explore the concept of 'Grotian Moments'. Named for Hugo Grotius, whose masterpiece De jure belli ac pacis helped marshal in the modern system of international law, Grotian Moments are transformative developments that generate the unique conditions for accelerated formation of customary international law. In periods of fundamental change, whether by technological advances, the commission of new forms of crimes against humanity, or the development of new means of warfare or terrorism, customary international law may form much more rapidly and with less state practice than is normally the case to keep up with the pace of developments. The book examines the historic underpinnings of the Grotian Moment concept, provides a theoretical framework for testing its existence and application, and analyzes six case studies of potential Grotian Moments: Nuremberg, the continental shelf, space law, the Yugoslavia Tribunal's Tadic decision, the 1999 NATO intervention in Serb

Political behavior is the result of innumerable unnoticed forces and conscious deliberation is often a rationalization of automatically triggered feelings and thoughts. Citizens are very sensitive to environmental contextual factors such as the title 'President' preceding 'Obama' in a newspaper headline, upbeat music or patriotic symbols accompanying a campaign ad, or question wording and order in a survey, all of which have their greatest influence when citizens are unaware. This book develops and tests a dual-process theory of political beliefs, attitudes and behavior, claiming that all thinking, feeling, reasoning and doing have an automatic component as well as a conscious deliberative component. The authors are especially interested in the impact of automatic feelings on political judgments and evaluations. This research is based on laboratory experiments, which allow the testing of five basic hypotheses: hot cognition, automaticity, affect transfer, affect contagion and motivated

Some of the most brutal and long-lasting civil wars of our time involve the rapid formation and disintegration of alliances among warring groups, as well as fractionalization within them. It would be natural to suppose that warring groups form alliances based on shared identity considerations - such as Christian groups allying with Christian groups - but this is not what we see. Two groups that identify themselves as bitter foes one day, on the basis of some identity narrative, might be allies the next day and vice versa. Nor is any group, however homogeneous, safe from internal fractionalization. Rather, looking closely at the civil wars in Afghanistan and Bosnia and testing against the broader universe of fifty-three cases of multiparty civil wars, Fotini Christia finds that the relative power distribution between and within various warring groups is the primary driving force behind alliance formation, alliance changes, group splits and internal group takeovers.

Some of the most brutal and long-lasting civil wars of our time involve the rapid formation and disintegration of alliances among warring groups, as well as fractionalization within them. It would be natural to suppose that warring groups form alliances based on shared identity considerations - such as Christian groups allying with Christian groups - but this is not what we see. Two groups that identify themselves as bitter foes one day, on the basis of some identity narrative, might be allies the next day and vice versa. Nor is any group, however homogeneous, safe from internal fractionalization. Rather, looking closely at the civil wars in Afghanistan and Bosnia and testing against the broader universe of fifty-three cases of multiparty civil wars, Fotini Christia finds that the relative power distribution between and within various warring groups is the primary driving force behind alliance formation, alliance changes, group splits and internal group takeovers.

An understanding of statistical thermodynamic molecular theory is fundamental to the appreciation of molecular solutions. This complex subject has been simplified by the authors with down-to-earth presentations of molecular theory. Using the potential distribution theorem (PDT) as the basis, the text provides a discussion of practical theories in conjunction with simulation results. The authors discuss the field in a concise and simple manner, illustrating the text with useful models of solution thermodynamics and numerous exercises. Modern quasi-chemical theories that permit statistical thermodynamic properties to be studied on the basis of electronic structure calculations are given extended development, as is the testing of those theoretical results with ab initio molecular dynamics simulations. The book is intended for students taking up research problems of molecular science in chemistry, chemical engineering, biochemistry, pharmaceutical chemistry, nanotechnology and biotechnolog

Developed from the author's popular text, A Concise Introduction to the Theory of Numbers, this book provides a comprehensive initiation to all the major branches of number theory. Beginning with the rudiments of the subject, the author proceeds to more advanced topics, including elements of cryptography and primality testing, an account of number fields in the classical vein including properties of their units, ideals and ideal classes, aspects of analytic number theory including studies of the Riemann zeta-function, the prime-number theorem and primes in arithmetical progressions, a description of the Hardy–Littlewood and sieve methods from respectively additive and multiplicative number theory and an exposition of the arithmetic of elliptic curves. The book includes many worked examples, exercises and further reading. Its wider coverage and versatility make this book suitable for courses extending from the elementary to beginning graduate studies.

The fundamental principles of the scientific method are essential for enhancing perspective, increasing productivity, and stimulating innovation. These principles include deductive and inductive logic, probability, parsimony and hypothesis testing, as well as science's presuppositions, limitations, ethics and bold claims of rationality and truth. The examples and case studies drawn upon in this book span the physical, biological and social sciences; include applications in agriculture, engineering and medicine; and also explore science's interrelationships with disciplines in the humanities such as philosophy and law. Informed by position papers on science from the American Association for the Advancement of Science, National Academy of Sciences and National Science Foundation, this book aligns with a distinctively mainstream vision of science. It is an ideal resource for anyone undertaking a systematic study of scientific method for the first time, from undergraduates to professionals

Developed from the author's popular text, A Concise Introduction to the Theory of Numbers, this book provides a comprehensive initiation to all the major branches of number theory. Beginning with the rudiments of the subject, the author proceeds to more advanced topics, including elements of cryptography and primality testing, an account of number fields in the classical vein including properties of their units, ideals and ideal classes, aspects of analytic number theory including studies of the Riemann zeta-function, the prime-number theorem and primes in arithmetical progressions, a description of the Hardy–Littlewood and sieve methods from respectively additive and multiplicative number theory and an exposition of the arithmetic of elliptic curves. The book includes many worked examples, exercises and further reading. Its wider coverage and versatility make this book suitable for courses extending from the elementary to beginning graduate studies.

Modern astronomical research is beset with a vast range of statistical challenges, ranging from reducing data from megadatasets to characterizing an amazing variety of variable celestial objects or testing astrophysical theory. Linking astronomy to the world of modern statistics, this volume is a unique resource, introducing astronomers to advanced statistics through ready-to-use code in the public domain R statistical software environment. The book presents fundamental results of probability theory and statistical inference, before exploring several fields of applied statistics, such as data smoothing, regression, multivariate analysis and classification, treatment of nondetections, time series analysis, and spatial point processes. It applies the methods discussed to contemporary astronomical research datasets using the R statistical software, making it invaluable for graduate students and researchers facing complex data analysis tasks. A link to the author's website for this book ca

George Levine is one of the world's leading scholars of Victorian literature and culture. This collection of his essays develops the key themes of his work: the intersection of nineteenth-century British literature, culture and science and the relation of knowledge and truth to ethics. The essays offer perspectives on George Eliot, Thackeray, the Positivists, and the Scientific Naturalists, and reassess the complex relationship between Ruskin and Darwin. In readings of Lawrence and Coetzee, Levine addresses Victorian and modern efforts to push beyond the limits of realist art by testing its aesthetic and epistemological limits in engagement with the self and the other. Some of Levine's most important contributions to the field are reprinted, in revised and updated form, alongside previously unpublished material. Together, these essays cohere into an exploration both of Victorian literature and culture and of ethical, epistemological, and aesthetic problems fundamental to our own times.

This book presents a comprehensive and consistent theory of estimation. The framework described leads naturally to a generalized maximum capacity estimator. This approach allows the optimal estimation of real-valued parameters, their number and intervals, as well as providing common ground for explaining the power of these estimators. Beginning with a review of coding and the key properties of information, the author goes on to discuss the techniques of estimation and develops the generalized maximum capacity estimator, based on a new form of Shannon's mutual information and channel capacity. Applications of this powerful technique in hypothesis testing and denoising are described in detail. Offering an original and thought-provoking perspective on estimation theory, Jorma Rissanen's book is of interest to graduate students and researchers in the fields of information theory, probability and statistics, econometrics and finance.

This book, first published in 2005, develops a comparative model of intergovernmental bargaining to account for variation in the capacity of federations in the developing world to undertake economic policy reform, suggesting that many market reform policies are a function of a constant process of bargaining between national and regional leaders struggling for political survival. As the degree of national-regional disagreement mounts, collective action on reforms that require implementation at multiple levels of government becomes more difficult. The degree to which the two factors conflict depends on four factors: the individual electoral interests, a shared intergovernmental fiscal system, the manner in which regional interests are represented in national policy making and the levers of partisan influence national leaders have over subnational politicians. In testing the argument with a combination of cross-sectional time-series and case study analysis, this book contributes to the br

Game theory is concerned with strategic interaction among several decision-makers. In such strategic encounters, all players are aware of the fact that their actions affect the other players. Game theory analyzes how these strategic, interactive considerations may affect the players' decisions and influence the final outcome. This textbook focuses on applications of complete-information games in economics and management, as well as in other fields such as political science, law and biology. It guides students through the fundamentals of game theory by letting examples lead the way to the concepts needed to solve them. It provides opportunities for self-study and self-testing through an extensive pedagogical apparatus of examples, questions and answers. The book also includes more advanced material suitable as a basis for seminar papers or elective topics, including rationalizability, stability of equilibria (with discrete-time dynamics), games and evolution, equilibrium selection and g

An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely comprehensive account of intra-familial marriage. Detailed information on past and present religious, social and legal practices and prohibitions is presented as a backdrop to the preferences and beliefs of the 1100+ million people in consanguineous unions. Chapters on population genetics, and the role of consanguinity in reproductive behaviour and genetic variation, set the scene for critical analyses of the influence of consanguinity on health in the early years of life. The discussion on consanguinity and disorders of adulthood is the first review of its kind and is particularly relevant given the ageing of the global population. Incest is treated as a separate issue, with historical and present-day examples examined. The final three chapters deal in detail with practical issues, including genetic testing, education and counselling, national and international legislation and imperatives, and

Ideology and Spatial Voting in American Elections addresses two core issues related to the foundations of democratic governance: how the political views of Americans are structured and how citizens' voting decisions relate to their ideological proximity to the candidates. Focusing on testing the assumptions and implications of spatial voting, this book connects the theory with empirical analysis of voter preferences and behavior, showing Americans cast their ballots largely in accordance with spatial voting theory. Stephen A. Jessee's research shows voters possess meaningful ideologies that structure their policy beliefs, moderated by partisanship and differing levels of political information. Jessee finds that while voters with lower levels of political information are more influenced by partisanship, independents and better informed partisans are able to form reasonably accurate perceptions of candidates' ideologies. His findings should reaffirm citizens' faith in the broad functioni

Ideology and Spatial Voting in American Elections addresses two core issues related to the foundations of democratic governance: how the political views of Americans are structured and how citizens' voting decisions relate to their ideological proximity to the candidates. Focusing on testing the assumptions and implications of spatial voting, this book connects the theory with empirical analysis of voter preferences and behavior, showing Americans cast their ballots largely in accordance with spatial voting theory. Stephen A. Jessee's research shows voters possess meaningful ideologies that structure their policy beliefs, moderated by partisanship and differing levels of political information. Jessee finds that while voters with lower levels of political information are more influenced by partisanship, independents and better informed partisans are able to form reasonably accurate perceptions of candidates' ideologies. His findings should reaffirm citizens' faith in the broad functioni

Progress in genetic knowledge is profoundly affecting medical practice, and no clinical specialty has more diseases associated with genetic mutations than neurology. As a more complete picture of the genes which give rise to neurological disease is obtained, trainee and practising neurologists need a guide to basic principles and the more important clinical entities with a genetic component. It is against this background that Neurogenetics: A Guide for Clinicians has been written. The book opens with coverage of genetic testing and counselling. Subsequent chapters discuss genetic factors for all the major neurological diseases, including epilepsy, Alzheimer's disease, Parkinsonism and muscular dystrophies. No book in this field can hope to be fully up to date with the latest research; rather this work provides a framework on which to add new genetic discoveries. Neurogenetics: A Guide for Clinicians provides a synoptic overview for neurologists, medical geneticists and scientists worki

Astronomy needs statistical methods to interpret data, but statistics is a many-faceted subject that is difficult for non-specialists to access. This handbook helps astronomers analyze the complex data and models of modern astronomy. This second edition has been revised to feature many more examples using Monte Carlo simulations, and now also includes Bayesian inference, Bayes factors and Markov chain Monte Carlo integration. Chapters cover basic probability, correlation analysis, hypothesis testing, Bayesian modelling, time series analysis, luminosity functions and clustering. Exercises at the end of each chapter guide readers through the techniques and tests necessary for most observational investigations. The data tables, solutions to problems, and other resources are available online at www.cambridge.org/9780521732499. Bringing together the most relevant statistical and probabilistic techniques for use in observational astronomy, this handbook is a practical manual for advanced und

Each volume in this richly illustrated series, sponsored by the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytological and histological diagnosis of small tissue samples. Benign, pre-malignant and malignant entities are presented in a well-organized and standardized format, with high-resolution color photomicrographs, tables, tabulated specific morphologic criteria and appropriate ancillary testing algorithms. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This volume provides comprehensive coverage of lung and mediastinal cytopathology. It presents a correlation of findings from fine-needle aspiration and exfoliative cytology and histologic findings obtained via core needle biopsies and surgical specimens. With a focus on malignant tumors, the full spectrum of inflammatory disorders, infectious diseases, hyperplasias and benign tumor or tumor-like lesions are also covered in detail. With over 500 p

Asia, the Pacific Islands and the coasts of the Americas have long been studied separately. This essential single-volume history of the Pacific traces the global interactions and remarkable peoples that have connected these regions with each other and with Europe and the Indian Ocean, for millennia. From ancient canoe navigators, monumental civilisations, pirates and seaborne empires, to the rise of nuclear testing and global warming, Matt Matsuda ranges across the frontiers of colonial history, anthropology and Pacific Rim economics and politics, piecing together a history of the region. The book identifies and draws together the defining threads and extraordinary personal narratives which have contributed to this history, showing how localised contacts and contests have often blossomed into global struggles over colonialism, tourism and the rise of Asian economies. Drawing on Asian, Oceanian, European, American, ancient and modern narratives, the author assembles a fascinating Pacifi

Asia, the Pacific Islands and the coasts of the Americas have long been studied separately. This essential single-volume history of the Pacific traces the global interactions and remarkable peoples that have connected these regions with each other and with Europe and the Indian Ocean, for millennia. From ancient canoe navigators, monumental civilisations, pirates and seaborne empires, to the rise of nuclear testing and global warming, Matt Matsuda ranges across the frontiers of colonial history, anthropology and Pacific Rim economics and politics, piecing together a history of the region. The book identifies and draws together the defining threads and extraordinary personal narratives which have contributed to this history, showing how localised contacts and contests have often blossomed into global struggles over colonialism, tourism and the rise of Asian economies. Drawing on Asian, Oceanian, European, American, ancient and modern narratives, the author assembles a fascinating Pacifi

African states have become testing grounds for Western conflict-resolution experiments, particularly power-sharing agreements, supposedly intended to end deadly conflict, secure peace and build democracy in divided societies. This volume examines the legal and political efficacy of transitional political power-sharing between democratically constituted governments and the African warlords, rebels, or junta that seek to violently unseat them. What role does law indicate for itself to play in informing, shaping and regulating peace agreements? This book addresses this question and others through the prism of three West African case studies: Liberia, Sierra Leone and Guinea-Bissau. It applies the neo-Kadeshean model of analysis and offers a framework for a 'Law on Power-sharing'. In a field dominated by political scientists, and drawing from ancient and contemporary international law, this book represents the first substantive legal critique of the law, practice and politics of power-shar

Breast MRI is no longer the domain of specialised centres; it is now a mainstream diagnostic technique, and an understanding of its applications is essential for any clinician involved with breast imaging. The Handbook of Breast MRI provides core knowledge and clinical guidelines for performing breast MRI in everyday practice. Introductory chapters on breast MRI basics, anatomy and pathology are followed by detailed chapters on the use of MRI in screening, staging, problem-solving and MRI-guided interventions, each containing diagnostic algorithms, tables and lists for quick access to key diagnostic information. Each chapter also contains a selection of self testing questions, and numerous Appendices concisely summarise tumour classification and current breast cancer treatment options. The Handbook of Breast MRI is an invaluable practical diagnostic resource for radiologists, surgeons, oncologists and all clinicians involved in breast cancer management.

An understanding of statistics and experimental design is essential for life science studies, but many students lack a mathematical background and some even dread taking an introductory statistics course. Using a refreshingly clear and encouraging reader-friendly approach, this book helps students understand how to choose, carry out, interpret and report the results of complex statistical analyses, critically evaluate the design of experiments and proceed to more advanced material. Taking a straightforward conceptual approach, it is specifically designed to foster understanding, demystify difficult concepts and encourage the unsure. Even complex topics are explained clearly, using a pictorial approach with a minimum of formulae and terminology. Examples of tests included throughout are kept simple by using small data sets. In addition, end-of-chapter exercises, new to this edition, allow self-testing. Handy diagnostic tables help students choose the right test for their work and remain

An understanding of statistics and experimental design is essential for life science studies, but many students lack a mathematical background and some even dread taking an introductory statistics course. Using a refreshingly clear and encouraging reader-friendly approach, this book helps students understand how to choose, carry out, interpret and report the results of complex statistical analyses, critically evaluate the design of experiments and proceed to more advanced material. Taking a straightforward conceptual approach, it is specifically designed to foster understanding, demystify difficult concepts and encourage the unsure. Even complex topics are explained clearly, using a pictorial approach with a minimum of formulae and terminology. Examples of tests included throughout are kept simple by using small data sets. In addition, end-of-chapter exercises, new to this edition, allow self-testing. Handy diagnostic tables help students choose the right test for their work and remain

The renewed interest in high-speed propulsion has led to increased activity in the development of the supersonic combustion ramjet engine for hypersonic flight applications. In the hypersonic regime the scramjet engine's specific thrust exceeds that of other propulsion systems. This book, written by a leading researcher, describes the processes and characteristics of the scramjet engine in a unified manner, reviewing both theoretical and experimental research. The focus is on the phenomena that dictate the thermo-aerodynamic processes encountered in the scramjet engine, including component analyses and flowpath considerations; fundamental theoretical topics related to internal flow with chemical reactions and non-equilibrium effects, high-temperature gas dynamics, and hypersonic effects are included. Cycle and component analyses are further described, followed by flowpath examination. Finally, the book reviews experimental and theoretical capabilities and describes ground testing facil

In psychiatry, as in many other medical disciplines, training is shifting from an emphasis on testing factual knowledge towards a system based on continuing assessment and the acquisition of practical skills and competencies. Workplace Based Assessments in Psychiatric Training describes current approaches to these new assessment systems around the world, provides practical advice regarding their implementation and makes recommendations for future developments. The book opens with an overview and analysis of methods of workplace based assessments, followed by a review of the trainee assessment from the patient perspective. Chapters contain in-depth, detailed discussion of recent developments in Canada, Denmark, India, the UK and the USA. The book reviews both technical developments in assessment tools and techniques and the socio-political context within which these have taken place. With a practical focus and unique global perspective, this is a 'must buy' for anyone responsible for th

An Introduction to Male Reproductive Medicine is written specifically for readers seeking entry into this fast-moving, complex specialty with a solid understanding of the subject. The first chapters cover the anatomy and physiology, clinical evaluation, surgery, medicine, genetics and laboratory testing involved in the current evaluation and treatment of the infertile male, and the final chapter describes the interaction of the field with female reproductive medicine. Throughout the book, references are directly made to the fourth edition of the major text in the specialty, Infertility in the Male, edited by Larry Lipshultz, Stuart Howards and Craig Niederberger, allowing readers to expand their understanding of specific areas where desired. Each chapter is written by a well-renowned expert in an easy to follow, informal style, making the text ideal for students, residents and general physicians who are seeking to increase their general knowledge of the field.

A practical and systematic overview of the design, fabrication and test of MEMS-based inertial sensors, this comprehensive and rigorous guide shows you how to analyze and transform application requirements into practical designs, and helps you to avoid potential pitfalls and to cut design time. With this book you'll soon be up to speed on the relevant basics, including MEMS technologies, packaging, kinematics and mechanics, and transducers. You'll also get a thorough evaluation of different approaches and architectures for design and an overview of key aspects of testing and calibration. Unique insights into the practical difficulties of making sensors for real-world applications make this up-to-date description of the state of the art in inertial MEMS an ideal resource for professional engineers in industry as well as students looking for a complete introduction to the area.

Games provide mathematical models for interaction. Numerous tasks in computer science can be formulated in game-theoretic terms. This fresh and intuitive way of thinking through complex issues reveals underlying algorithmic questions and clarifies the relationships between different domains. This collection of lectures, by specialists in the field, provides an excellent introduction to various aspects of game theory relevant for applications in computer science that concern program design, synthesis, verification, testing and design of multi-agent or distributed systems. Originally devised for a Spring School organised by the GAMES Networking Programme in 2009, these lectures have since been revised and expanded, and range from tutorials concerning fundamental notions and methods to more advanced presentations of current research topics. This volume is a valuable guide to current research on game-based methods in computer science for undergraduate and graduate students. It will also in

Written and edited by leading clinicians and researchers in sleep medicine, this is the first book to focus on the causes, consequences and treatment of disorders of excessive sleepiness. Extensive coverage is provided for all known causes of sleepiness, including sleep deprivation, obstructive sleep apnea syndrome, narcolepsy and other hypersomnias of central origin, shift work, and medical and psychiatric disorders. Since many causes of sleepiness are difficult to differentiate from each other, and treatment modalities can vary greatly from one disorder to another, this book helps the clinician to formulate a differential diagnosis that will ultimately lead to the correct diagnosis. Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also discussed in detail. This is an essential resource for

The Elements of MATLAB Style is a guide for both new and experienced MATLAB programmers. It provides a comprehensive collection of standards and guidelines for creating solid MATLAB code that will be easy to understand, enhance, and maintain. It is written for both individuals and those working in teams in which consistency is critical. This is the only book devoted to MATLAB style and best programming practices, focusing on how MATLAB code can be written in order to maximize its effectiveness. Just as Strunk and White's The Elements of Style provides rules for writing in the English language, this book provides conventions for formatting, naming, documentation, programming and testing. It includes many concise examples of correct and incorrect usage, as well as coverage of the latest language features. The author also provides recommendations on use of the integrated development environment features that help produce better, more consistent software.

Cancer Symptom Science is the first interdisciplinary compilation of research on the mechanisms underlying the expression of cancer-related symptoms. It presents innovations in clinical, animal and in vitro research, research methods in brain imaging, and statistical-descriptive approaches to understanding the mechanistic basis of symptom expression. This volume also provides perspectives from patients, government and industry. By collecting and synthesizing the developing threads of new approaches to understanding cancer-related symptoms, the book promotes a pioneering framework for merging behavioral and biological disciplines to clarify mechanisms of symptom evolution, incorporating new technologies, testing novel agents for symptom control, and improving patient functioning and quality of life both during and after cancer treatment. With an expert editorial team led by Charles S. Cleeland, an internationally-recognized leader in cancer pain assessment and treatment, this is essenti

Bringing together a collection of previously published work, this book provides a discussion of major considerations relating to the construction of econometric models that work well to explain economic phenomena, predict future outcomes and be useful for policy-making. Analytical relations between dynamic econometric structural models and empirical time series MVARMA, VAR, transfer function, and univariate ARIMA models are established with important application for model-checking and model construction. The theory and applications of these procedures to a variety of econometric modeling and forecasting problems as well as Bayesian and non-Bayesian testing, shrinkage estimation and forecasting procedures are also presented and applied. Finally, attention is focused on the effects of disaggregation on forecasting precision and the Marshallian Macroeconomic Model that features demand, supply and entry equations for major sectors of economies is analysed and described. This volume will pr

Kinks and domain walls are the simplest kind of solitons and are invaluable for testing various ideas and for learning about non-perturbative aspects of field theories. They are the subject of research in essentially every branch of physics, ranging from condensed matter to cosmology. This book is an introduction to kinks and domain walls and their principal classical and quantum properties. The book examines classical solitons, building from examples in elementary systems to more complicated settings. The formation of solitons in phase transitions, their dynamics and their cosmological consequences are further discussed. The book closes with an explicit description of a few laboratory systems containing solitons. Kinks and Domain Walls includes several state-of-the-art results, some previously unpublished. Each chapter closes with open questions and research problems and will be of great interest to both graduate students and academic researchers in theoretical physics, particle physi

Do intertidal organisms simply respond to the rise and fall of tides, or do they possess biological timing and navigation mechanisms that allow them to anticipate when conditions are most favourable? How are the patterns of growth, development and reproduction of some marine plants and animals related to changes in day-length or to phases of the moon? The author describes how marine organisms, from single cells to vertebrates, on sea shores, in estuaries and in the open ocean, have evolved inbuilt biological clockwork and synchronisation mechanisms which control rhythmic processes and navigational behaviour, permitting successful exploitation of highly variable and often hostile environments. Adopting a hypothesis-testing and experimental approach, the book is intended for undergraduate and postgraduate students of marine biology, marine ecology, animal behaviour, oceanography and other biological sciences and also as an introduction for researchers, including physiologists, biochemist

Originally published in 1976, this book introduced a series of mathematical models of urban phenomena relevant to scientists and planners attempting to understand and predict the form of cities and regions. Dr Batty organises the book around the main theme of designing and using such models in practical situations and develops a family of static and dynamic models dealing with the location of land use and economic activities. He describes the models both as urban theories and as computer algorithms, and thoroughly explores the process of calibrating or 'tuning' the models to reflect reality. Problems concerning the definition of the spatial systems to which these models refer are examined, as are other practical difficulties such as data organisation. The quasi-experimental approach which characterises this style of computer model-building extends to using the models in conditional prediction and Dr Batty discusses their role in the planning process, with their use in testing the impac