Dr Paul Wyatt, School of Chemistry, University of Bristol, Bristol
Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning.
Dr Stuart Warren, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge
Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley) and Organic Synthesis (OUP)
A: Introduction: Selectivity.
1. Planning Organic Syntheses: Tactics, Strategy and Control.
2. Chemoselectivity.
3. Regioselectivity: Controlled Aldol Reactions.
4. Stereoselectivity: Stereoselective Aldol Reactions.
5. Alternative Strategies for Enone Synthesis.
6. Choosing a Strategy: The Synthesis of Cyclopentenones.
B: Making Carbon-Carbon Bonds.
7. The Ortho Strategy for Aromatic Compounds.
8. δ-Complexes of Metals.
9. Controlling the Michael Reaction.
10. Specific Enol Equivalents.
11. Extended Enolates.
12. Allyl Anions.
13. Homoenolates.
14. Acyl Anion Equivalents.
C: Carbon–Carbon Double Bonds.
15. Synthesis of Double Bonds of Defined Stereochemistry.
16. Vinyl Anions.
17. Electrophilic Attack on Alkenes.
18. Vinyl Cations.
19. Allyl Alcohols: Allyl Cation Equivalents (and More).
D: Stereochemistry.
20. Control of Stereochemistry — Introduction.
21. Diastereoselectivity.
22. Resolution .
23. The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials.
24. Asymmetric Induction I: Reagent-Based Strategy.
25. Asymmetric Induction II: Asymmetric Catalysis: Formation of C–O and C–N Bonds.
26. Asymmetric Induction III: Asymmetric Catalysis: Formation of C–H and C–C Bonds.
27. Asymmetric Induction IV: Substrate-Based Strategy.
28. Kinetic Resolution.
29. Enzymes: Biological Methods in Asymmetric Synthesis.
30. New Chiral Centres from Old: Enantiomerically Pure Compounds & Sophisticated Syntheses.
31. Strategy of Asymmetric Synthesis.
E: Functional Group Strategy.
32. Functionalisation of Pyridine.
33. Oxidation of Aromatic Rings and of Enol(ate)s.
34. Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements.
35. Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms.
36. Tandem Organic Reactions.
Index.
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