Preparative Enantioselective Chromatography

The development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale.

• Brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeric mixtures on a range of process scales
  
• Presents case studies drawn from within the pharmaceutical industry to clearly illustrate the utility and value of preparative scale enantioselective chromatography in chemical research, development and production
  
• Key reference source and entry to the literature so the reader does not have to engage in expensive and time consuming literature searching

Dr Geoffrey B Cox

(Editor)VP & General Manager, Separation Solutions

Contributors.

Preface.

1. Chiral Chromatography in Support of Pharmaceutical Process Research (Christopher J. Welch).

2. Introduction to Preparative Chromatography (Geoffrey B. Cox).

3. Chiral Stationary Phases for Preparative Enantioselective Chromatography (Eric Francotte).

4. Method Development for Preparative Enantioselective Chromatography (Christina Suteu).

5. Scaling-Up of Preparative Chromatographic Enantiomer Separations (Jules Dingenen).

6. Steady-State Recycling and Its use in Chiral Separations (Charles M. Grill and Laurence M. Miller).

7. Simulated Moving Bed and Related Techniques (Luís S. Pais, Vera G. Mata and Alírio E. Rodrigues).

8. Preparative-Scale Supercritical Fluid Chromatography (Manon S. Villeneuve and Luke A. Miller).

9. Equipment for Preparative and Large Size Enantioselective Chromatography (Henri Colin, Olivier Ludemann-Hombourger and Félicie Denet).

10. Case Study in Production-Scale Multicolumn Continuous Chromatography (Michel Hamende).

11. Contract Manufacturing and Outsourcing Considerations (Olivier Dapremont).

Appendix: Advanced Concepts.

Index.