Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Mac B. is back on another madcap adventure -- this time a stolen raven threatens to topple the Queen and it's up to Mac to smackdown his KGB rival once and for all!Get the latest in the New York Times

A New York Times Bestseller!While Isa is off at sleepaway orchestra camp, Jessie, Oliver, Hyacinth, and Laney are stuck at home in the brownstone with nothing to do but get on one another’s nerves. Bu

Books, books, books! Judy’s got books on the brain as she prepares for a totally RARE trivia competition. Has reading always been this exciting?Judy Moody is in it to win it. Win the Book Quiz Blowout

You've probably heard the story of Cinderella; how her father married for the second time and how his wife was a nasty, mean woman. But did you know Cinderella had a friend called Perkin who worked in

The fifteenth title in the bestselling Tom Gates series of books from the brilliantly talented Liz Pichon. What's that? A MONSTER? How has this scary beast escaped into Tom's sort-of-normal world? Is it one of his doodles? Is it Delia on the rampage? Or is it Mr Fullerman at full moon? All will be revealed in this book. According to Tom, it contains: MONSTERS - MYSTERY - A MUSIC FESTIVAL - MISSING STUFF.Oh, and also a very strict supply teacher who is every kid's nightmare. Is _that_ the monster? But you're not scared of monsters, are you? So don't let it put you off! Tom Gates is a series of books in diary form Full of Tom's doodles and pictures & his amazing sense of humour The Brilliant World of Tom Gates, was the winner of the Roald Dahl Funny Prize! Perfect gifts for boys & girls who love to laugh themselves silly The first series of The Brilliant World of Tom Gates won the Scottish BAFTA for Entertainment!

入圍 2021 Carnegie Medal，是一部揉合斯拉夫民間傳說與成長寓意的中階小說。故事中的女孩 Yanka 自幼被發現在熊穴中長大，因高大強壯而被稱為「熊女孩」。她外表堅強，內心卻始終對自身來歷感到疑惑，也承受著村人異樣的眼光。一次突如其來的變故，迫使她離開熟悉的家園，踏上一段尋找身世與自我認同的旅程。沿途，她穿越冰冷河流與熾熱山脈，結識性格各異的旅伴，也逐步理解「力量」真正的意義。本書文字帶有吟唱般的節奏，在熊、龍與公主的傳說交織下，描繪孤單、勇氣與歸屬感，並搭配 Kathrin Honesta 富含象徵意味的插畫，營造靜謐而深遠的閱讀體驗。SHORTLISTED FOR THE 2021 CARNEGIE MEDAL"Written with passion and compassion, Anderson's talent as a weaver of magic and creator of evocative landscapes is growing with every book." - The Daily Mail"Enchanting story." - The Daily TelegraphThey call me Yanka the Bear. Not because of where I was found - only a few people know about that. They call me Yanka the Bear because I am so big and strong.Found abandoned in a bear cave as a baby, Yanka has always wondered about where she is from. She tries to ignore the strange whispers and looks from the villagers, wishing she was as strong on the inside as she is on the outside. But, when she has to flee her house, looking for answers about who she really is, a journey fa

Heidi’s school is having a school spirit week in the twenty-seventh Heidi Heckelbeck adventure!It’s Spirit Week at Brewster Elementary and everyone is excited! From Crazy Hair Monday to Wacky Tacky We

Scout and Daisy are on expedition in the desert and Scout has uncovered something incredible -- a rock has told him a story! But how can a rock tell a story? Join Scout as he helps Daisy find clues to solve the Case of the Story Rock.Titles in The Gumboot Kids series:The Case of the Buzzing Honey Makers (9780228102816, paperback, 6.99)The Case of the Buzzing Honey Makers (9780228102823, hardcover, 19.95)The Case of the Singing Ocean (9780228102847, paperback, 6.99)The Case of the Singing Ocean (9780228102854, hardcover, 19.95)The Case of the Growing Bird Feeder (9780228101901, paperback, 6.99)The Case of the Growing Bird Feeder (9780228101895, hardcover, 19.95)The Case of the Story Rock (9780228101925, paperback, 6.99)The Case of the Story Rock (9780228101918, hardcover, 19.95)The Case of the Vanishing Caterpillar (9780228101949, paperback, 6.99)The Case of the Vanishing Caterpillar (9780228101932, hardcover, 19.95)The Case of the Wooden Timekeeper (9780228101963, paperback, 6.99)The C

The Bad Guys are back for the 9th installment of the New York Times bestselling series! When Mr. Wolf is blown up to Godzilla proportions, the Bad Guys find themselves in monster-sized trouble. They m

The 117-Storey Treehouse is the ninth book in Andy Griffiths and Terry Denton's wacky treehouse adventure series, with the laugh-out-loud story told through a combination of text and fantastic cartoon

A breathtaking picture book about the water cycle from Kate Greenaway Medal winner Grahame Baker-SmithIssac plays in his favorite pool on the mountainside. As rain starts to fall, he empties his littl

Much has been written about Martin Luther King, Jr. and the 1963 March on Washington. But there's little on his legendary speech and how he came to write it. Find out more in this gripping book with i

《The Last Kids on Earth》首集描繪一個「殭屍與怪物佔領小鎮」的瘋狂世界。十三歲的 Jack Sullivan 原本平凡無奇，如今卻成了末日冒險者。他住進加固的樹屋，把生活過成一場遊戲般的挑戰：與好友 Quint 一起發明裝備、想辦法營救勇敢的 June、並嘗試擊敗最可怕的怪物 Blarg。作者 Max Brallier 的敘事幽默風趣，Douglas Holgate 的插圖動態十足，讓每一頁都充滿張力。故事節奏快速，笑料與動作兼備，尤其能吸引喜歡《Diary of a Wimpy Kid》或《Dog Man》的讀者。Terrifyingly fun! Max Brallier’s The Last Kids on Earth delivers big thrills and even bigger laughs.’ Jeff Kinney, author of Diary of a Wimpy Kid.SOON TO BE A MAJOR NETFLIX SERIES!‘Forty-two days ago I was an ordinary kid, living an uneventful life. But now it’s TOTAL MONSTER ZOMBIE CHAOS and I’m battling beasts on a daily basis. Crazy, right? But I know exactly how to make it through the zombie apocalypse.’Meet Jack Sullivan, self-described as a late-blooming, slow-developing 13-year-old who has so far survived the zombie apocalypse by hiding out in his treehouse. Overnight Jack’s life has become like the plot of a video game and he has come up with his own ULTIMATE FEATS OF APOCALYPTIC SUCCESS:· Locate Quint Baker, b

Jack Sullivan 的冒險繼續展開。末日小鎮依舊充斥著殭屍與怪物，但這次 Jack 已不再孤單，他和好友 Quint、Dirk 以及 June 共同作戰，還有忠誠的寵物怪獸 Rover 相伴。樹屋經過強化，配備各種防禦裝置，彷彿一座堡壘。然而，新的威脅逐步逼近，比過去任何敵人都更龐大、更危險。作者 Max Brallier 的文字節奏明快，加上 Douglas Holgate 的插圖幽默生動，使得緊張與笑料交織，閱讀體驗輕鬆愉快Soon to be a major NETFLIX series!‘Terrifyingly fun! Max Brallier’s The Last Kids on Earth delivers big thrills and even bigger laughs.’ Jeff Kinney, author of Diary of a Wimpy KidWimpy Kid meets The Walking Dead in this hilarious post-apocalyptic graphic novel series.Jack Sullivan is back.It’s still TOTAL MONSTER ZOMBIE CHAOS on the streets, but now Jack has a gang of friends to help him through – science genius and best friend Quint, super-strong Dirk and all-round coolest girl ever, June. Not to mention Rover, Jack’s awesome monster pet! Plus the treehouse is more souped up than ever, chockablock with defensive gizmos and ready to withstand anything that the monster apocalypse can throw at it.Which is just as well, because there’s something extra-big and extra-monstr

Jack Sullivan 與好友 June、Quint、Dirk 以為自己是世界上僅存的孩子，卻意外發現或許還有其他倖存者。這個消息令大家振奮，但 Jack 卻不安——他其實很享受與朋友們住在樹屋、對抗怪物的生活，不希望改變現狀。就在此時，一個比以往更強大的怪物「Nightmare King」出現，甚至能入侵 Jack 的思緒，使他陷入矛盾與恐懼。故事延續了快節奏與幽默風格，同時加入心理層面的描寫，讓角色更立體。Soon to be a major NETFLIX series!‘Terrifyingly fun! Max Brallier’s The Last Kids on Earth delivers big thrills and even bigger laughs.’ Jeff Kinney, author of Diary of a Wimpy KidWimpy Kid meets The Walking Dead in this hilarious series packed with monsters and zombies.In their third zombie-tastic adventure, Jack Sullivan and his friends June, Quint and Dirk discover that they might not be the last kids on Earth after all . . . And everyone is thrilled – except Jack. Living in a tree house with his best friends, battling monsters and escaping certain death – he's been having the most awesome time of his life. Somehow he's got to persuade his friends that life is perfect just the way it is . . . then they won't leave him.But that's not so easy when there's a new monster hunting th

故事場景進入冬季。Jack 與好友們在怪物末日後享受滑雪彈弓與雪球大戰，甚至籌辦屬於自己的聖誕慶典。然而歡樂不久，新的威脅登場──這次的敵人竟是人類反派。她奪走 Jack 最重要的武器 Louisville Slicer，而這把武器更牽連一個足以危及世界的黑暗陰謀。為了奪回武器並阻止災難，Jack 與伙伴們展開新一輪驚險旅程。故事融合動作、笑料與友情，插圖活潑生動，讓讀者在輕鬆氛圍中體驗冬季冒險的緊張刺激。Soon to be a major NETFLIX series!‘Terrifyingly fun! Max Brallier’s The Last Kids on Earth delivers big thrills and even bigger laughs.’ Jeff Kinney, author of Diary of a Wimpy Kid.The newest installment in this New York Times bestselling series introduces new monsters, new bad guys, and tons of new laughs – Diary of a Wimpy Kid meets The Waking Dead!It's the first winter after the Monster Apocalypse. For Jack and his buddies, that means sled catapults, epic snowball battles, and one monstrous Christmas celebration. But their winter wonderland turns dark when a villainess begins hunting them. And this villainess is different - she's a human.When the villainess steals Jack's prized monster-slaying tool, the Louisville Slicer, he vows to get it back. But it won't be easy. Jack and his f

What are phantom islands? How did the Black Death cause an ice age? How could graffiti save endangered tortoises? Find the answers to these questions and 97 more in this bold, graphic and exciting boo

In a brand new original mystery from the creator of the beloved Jigsaw Jones chapter book series, Jigsaw Jones must solve find the identity of the classroom thief, before they strike again.A brand new

本書收錄 12 位迪士尼公主的全新冒險，從經典的白雪公主、仙杜瑞拉，到充滿活力的莫阿娜與梅莉達，每位公主都在故事中展現獨特的勇氣與魅力。每篇故事長度約五分鐘，適合睡前、親子共讀或繁忙日常中的小小閱讀時光。This treasury stars all 12 Disney princesses, from Snow White to Moana, and features a durable, padded cover and beautiful full-page illustrations.Each of the twelve stories in this collection is the perfect length for reading aloud in about five minutes, making them perfect for jam-packed days. The princesses' latest adventures are the royal choice before bedtime, story time, or anytime!Featuring Snow White, Cinderella, Aurora, Ariel, Belle, Jasmine, Pocahontas, Mulan, Tiana, Rapunzel, Merida, and Moana!

In this fun kids edition play bingo with a gorgeous blue bird-of-paradise, a three-banded armadillo and even the poisonous automeris moth caterpillar. Discover these and many other fascinating and bea

Mysterious, cunning, smart, and sleek, foxes are one of kids' favorite animals. Learn all about this fantastic forest canine!Packed with beautiful and engaging photos, this new leveled reader dives in

Adventure, danger, and a thrilling global mission await 12-year-old Cruz Coronado as he joins an elite school for explorers.Cruz leaves his tranquil home in Hawaii to join 23 talented kids from around

If you've never known what a wildebeest is, you'll find out now in this latest Where? Is title about the Serengeti.Each year, over 1.5 million wildebeest make a harrowing journey (more than one thousa

The first Graphic Novel in the world of Gaming Phenomenon Minecraft!Tyler is your everyday kid whose life is changed when his family has to move from the town he's always known. Thankfully, Tyler has

Shortlisted for the Waterstones Children's Book Prize 2020I'm going to tell you the word that ruins my entire life: BIG. Because my name is Jemima Small. But I am exactly the opposite.Jemima Small is funny and super smart. She knows a lot of things. Like the fact that she's made of 206 bones, over 600 muscles and trillions of cells. What she doesn't know is how that can be true and yet she can still feel like nothing... Or how being made to join the school's "special" healthy lifestyle group - A.K.A Fat Club - could feel any less special. But Jemima also knows that the biggest stars in the universe are the brightest. And maybe it's her time to shine...'An empowering story about body confidence' The Observer

This thoughtful book explores happiness, sadness, anger, fear and worry in a friendly and approachable way. Adorable animal characters experience different emotions, while imaginative flaps answer imp

Track the facts about the great printer, inventor, and Founding Father, Benjamin Franklin!When Jack and Annie came back from their adventure in Magic Tree House #32: To the Future, Ben Franklin! they

Scottish Book Trust's Book of the MonthA kid's life in ancient Greece might sound like fun, what with all that brilliant sunny weather and watching the Olympic Games, but actually life for kids could

Mr. Squirrel is back in another hilarious tale. Mr. Squirrel can’t believes his eyes—an unknown, mysterious creature is under his tree. It must be the legendary king of the forest. Will the king

Millions of young readers have loved the World’s Worst Children tales – now they will revel in this delightfully dreadful collection of the most gruesome grown-ups ever: The World’s Worst Teachers. Fr

《A Million Dots》從一棵樹、一顆點開始，每頁翻倍，直到滿頁的點點達成百萬之數。作者以圖像演繹數學概念，讓抽象的「倍數」變得具象而美麗。書頁間的變化不只是數字的增長，更是孩子對數與圖像關聯的直觀理解。這本書不需要艱深的公式，只需要一雙好奇的眼睛，就能體會數學的樂趣與壯觀，非常適合數學啟蒙與跨領域創作使用。Double the numbers from 1 to 1,000,000 in 40 pages. A stunning visualization of numbers big and small.Winner of the New York Times Top 10 Best Illustrated Children's Books of 2019.A book to promote interest in numbers and wonder at the scale they can represent, with lots to interrogate and talk about. -- School Library AssociationPotential goldmine of teaching ideas. -- School Reading ListDouble the numbers to go from 1 to 1,000,000 in 40 pages. A stunning visualization of numbers big and small.We start with a single tree; 1. As we turn the page, we are presented with a sum doubling the number on the page before it: 1+1 = 2; 2+2 = 4; 4+4 = 8. In this way, we reach a million (actually 1,048,576) within 44 pages.Each sum is brought to life with a simple graphic illustration in the distinctive style of Sven Völker. The dots form the

A fun, magical story, ideal for children practising their reading at home or in school. Manju wants to get a present for her Mum's birthday but Cumin her cat isn't sure about the toy elephant or robot

A delightful story based on the popular fairytale, ideal for children practising their reading at home or in school. Princess Imelda has come up with a way to escape from the boring old palace and see

Geronimo's adventures in a collectible slipcase!Join Geronimo as he embarks on a treasure hung, learns the secret of the Seven Wonders of the Ancient World, deals with an evil doppelganger, rescues his cousin from Transratarnia and more!本套書包含以下10本9780545835541 #61: Mouse House Hunter (Geronimo Stilton)9780545872515 #62: Mouse Overboard! (Geronimo Stilton)9780545872522 #63: The Cheese Experiment (Geronimo Stilton)9781338032871 #64: Magical Mission (Geronimo Stilton)9781338087758 #65: Bollywood Burglary (Geronimo Stilton)9781338087826 #66: Operation Secret Recipe (Geronimo Stilton)9781338159158 #67: The Chocolate Chase (Geronimo Stilton)9781338215199 #68: Cyber-thief Showdown (Geronimo Stilton)9781338215243 #69: Hug a Tree, Geronimo (Geronimo Stilton)9781338268539 #70: The Phantom Bandit (Geronimo Stilton)

The Second book in the OFFICIAL Minecraft fiction series for readers age 7+Morgan, Ash and friends are back for another adventure.Woodsword Middle has been infested by bats, bringing chaos and disorde

車子怎麼跑起來的？油門踩下去後，裡面發生了什麼事？讀者將穿越汽車的發展歷史，從蒸汽車、內燃機，到電動車的崛起，一探汽車如何改變世界！這本圖像科普漫畫不僅拆解汽車構造，也揭開動力來源的祕密，像是汽油如何燃燒驅動活塞，或電池怎麼轉換成能量驅動馬達。知識點豐富，畫風生動，滿足讀者的好奇心！Every volume of Science Comics offers a complete introduction to a particular topic—dinosaurs, the solar system, robots, and more. Whether you're a fourth grader doing a natural science unit at school or a thirty year old with a secret passion for airplanes, these books are for you!In this Science Comics: Cars, you'll learn where cars came from and how they work. When you pop the hood, what are you looking at? How does gasoline—or electric batteries, or even steam—make a car move? Rev up your motor and take look at the combustible history of the automobile and its explosive effects on our modern lives.

See if you have what it takes to survive the monster-zombie apocalypse in this interactive guided journal from the New York Times bestselling Last Kids on Earth series, soon to be a Netflix original a

Learn how the United States ended up fighting for twenty years in a remote country on the other side of the world.The Vietnam War was as much a part of the tumultuous Sixties as Flower Power and the C

When Josie goes to stay with her cousin Edith, she’s glad to be starting a new life away from the shame that has haunted her family since her brother chose not to fight in the war. But Edith’s friends

A fun, heartwarming animal story, ideal for children practising their reading at home or in school.It's Sausage's birthday and he's going to have a party with all of his friends. But the mean, jealous