Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Hot off his star-making appearance in MARVEL RIVALS, everyone’s favorite walking fish boy stars in his first series!Join Jeff the Land Shark as he teams up with many of the friends he’s made over the years and outsmarts more than a few rivals along the way. And this time, he’s got some all-new abilities on his side! But a malevolent force has been set upon the world — a being of pure darkness who wants nothing more than dismay and destruction. Beware the evil known as…Shadow Jeff! Plus: Our selachian sensation stalks the dangerous corridors of Madripoor alongside Wolverine and Psylocke! Jeff co-creator Kelly Thompson and artist Tokitokoro sharpen the teeth of the undeniable star of the entire Marvel Universe!COLLECTING: Jeff the Land Shark (2025) #1-5

From the brains behind Brain Quest comes Puzzletopia, an interactive new series chock-full of mind-bending logic puzzles! Grab a pencil and get ready to solve fun, adventurous brain teasers for kids ages 8 & up. Embark on a perfectly puzzling journey full of over 100 brain twisters that strengthen problem-solving skills, increase concentration and attention span, and enhance memory and processing--all while having fun with puzzles! Puzzletopia: 100 Perfectly Puzzling Adventures! is packed with a huge variety of kid-friendly, highly visual logic puzzles, critical thinking activities, picture puzzles, and more. Every activity is introduced with a unique, engaging narrative based on a quest, adventure, or mission--featuring aliens, magical creatures, scalawag pirates, and other colorful characters! Full of helpful hints and annotations, and featuring an illustrated answer key in the back, Puzzletopia provides both a challenge and ample support to the reader. And as kids' skills get be

Hunting for a book all about KPop? Look no further! Read all about the music, the movies, the fandoms, and the history that made KPop a global sensation in this beautifully illustrated, star-studded Little Golden Book!Learn about the pop cultural phenomenon that is KPop--one of the most beloved music genres worldwide today! Featuring fun facts and colorful illustrations of favorite KPop performers--including bands like BTS, BLACKPINK, Twice, Stray Kids, and Red Velvet--this book is a celebration of all things KPop!

One of CBC Books' 20 Canadian children's books to read this summer (2025)A Canadian Children's Book Centre Best Book for Kids and Teens, Fall 2025A 2026 Saskatchewan Young Readers Choice Diamond Willow Award NomineeA stubborn young girl named Fiona stumbles upon an abandoned house full of stray cats, just as it is threatened by a demolition team, a leadership crisis, and two potentially malicious parakeets. Can Fiona save the house and all its inhabitants? A middle-grade novel, now available in paperback, by critically acclaimed author Tanya Lloyd Kyi.When Fiona wanders into an abandoned mansion down by the harbor, she discovers the house is full of stray cats (and two chaotic parakeets). Fiona feels a great deal of sympathy for the animals; she understands what it's like to need a safe home. Ever since her parents died, she's been struggling to adjust to the tiny apartment where she and her Aunt Tanis, who has little time to spare for Fiona, now live.When the mansion is threatened by

在本書中，古老的妖精王國以交換護符維繫和平：鹿王的鹿角碎片、鴞王的羽毛、銀鱗女王的鱗片。然而鱞王野心漸盛，以他人魔法維生，並不斷尋找新娘。當姊妹 Ilsette 與 Lyla 被召入宮廷，Lyla 成為鱞王的目標。為救姊姊，Ilsette 踏上尋找羽毛的旅程，來到雙月與赤星交映的國度，試圖竊取改變權力平衡的關鍵。Bex Hogan 以濃烈而細緻的筆觸，構築危險又迷人的妖精世界。本書為《Nettle》同宇宙作品，可獨立閱讀，靈感取自威爾斯傳說，融合黑暗氣息與節制情感。獲《Kirkus Reviews》讚譽為引人入勝、節奏明快的民間奇幻。這是一則關於姊妹情誼、故事力量與代價抉擇的青少年小說。A dark, captivating YA tale of deception and survival, set in the same faery world as Nettle. Long ago, kings and queens of the faery realms exchanged talismans with one another to maintain harmony in their world. The Stag King gave up a shard of antler, the Owl King a feather, and the Minnow Queen a shimmering, silver scale. But the Owl King has grown restless, and his kingdom has become dangerous as he feeds off the magic of others. Always he hunts for a new bride to sustain him. When devoted sisters Ilsette and Lyla are summoned to court, the Owl King's eye soon falls on the beautiful Lyla. Determined to save her sister from a terrible fate, Ilsette sets out on a quest to find the prized fea

Riley Vasquez is haunted by the brutal murder of the couple she was babysitting for.Max Cross is suffering under the shadow of a life-altering diagnosis he doesn't dare reveal. The last thing either of them wants is to spend a weekend away at a therapy camp alongside five other teens with "issues." But that's exactly where they are when three masked men burst in to take the group hostage. The building has no windows. The exits are sealed shut. Their phones are gone. And their captors are on a killing spree. Riley and Max know that if they can't get out, they'll be next--but they're about to discover that even escape doesn't equal freedom.

在本書中，時間回到1960年代的夏令營。Bee 因母親赴紐約工作，被送往營地度夏。她不擅社交，不會划獨木舟，也害怕夜裡的森林。更詭異的是，她總在遠方聽見若有似無的音樂，像從幽暗深處飄來。直到古怪卻自信的 Zippy 出現，兩人發現「Hawks」小屋的高年級女孩夜夜外出，卻總在查房時安然躺在床上。隨著調查展開，神祕男孩、沉默的營地主人與鬧鬼傳聞交織成層層謎團。Charis Cotter 以從容筆調鋪陳氛圍，營造既陰森又溫柔的成長故事。《Kirkus Reviews》與《Publishers Weekly》給予星級好評，並入選 Canadian Children’s Book Centre 2025 秋季推薦。這是一部關於友情、勇氣與夏夜祕密的中階小說。Set in the '60s at a summer camp, The Mystery of the Haunted Dance Hall is a spooky, atmospheric middle-grade story for fans of classic ghost stories, unlikely friendships and intriguing mysteries. Now available in paperback! Bee's mom has a job in New York City for the summer, so Bee is being sent to summer camp. She's not excited about it. Being around other people is hard for her, plus she knows nothing about campfires, she's not a good swimmer and she's never even been in a canoe. When she first arrives, things go pretty much as she expected. The other girls either make fun of her or ignore her, and the woods surrounding the camp give her the creeps: she keep

Based on the wildly popular four-part series on Andrew Huberman's podcast, this affirming book from world-renowned and celebrity-endorsed psychiatrist, Dr. Paul Conti, offers a paradigm-shifting approach to optimizing mental health -- offering readers a proven way towards a joyful life. More than one in five US adults are living with a mental illness. Since 2010, adults ages eighteen to twenty-five have experienced a 139 percent increase in anxiety. For all of the increasing and well-intended mental health resources at our immediate disposal, we could easily ask where we are going wrong. Yet, Dr. Paul Conti wants to know, "what's going right?" Backed by celebrities and esteemed colleagues such as Lady GaGa, Peter Attia, and Kim Kardashian, Dr. Conti poses that the best place to start addressing our mental health isn't in focusing on what's going wrong, but rather what's going right. And the key to embracing this new narrative is tapping into our often ignored and long over-looked gener

"Alexandra Andrews is monied Manhattan's very own Agatha Christie."--Ada CalhounFrom the critically acclaimed author of Who is Maud Dixon? comes a riveting new novel about a young wife and mother in a world of wealth and privilege, whose rash mistake sets off a domino effect of murder and betrayal.In the beginning, there was art.It was Clare Bast's love of art that saved her from a bleak, predictable life in upstate New York, and drew her to the cultured world of Manhattan's Upper East Side where she met Jed, her doting, affluent husband.Despite her best efforts--including a half-finished PhD, abandoned when her daughter Sadie was born--Clare secretly can't help but feel like an imposter in Jed's one-percent, Park-Avenue life. When the well-connected wife of Jed's new boss introduces her to influential friends--a curator here, a gallerist there, an aficionado abroad--Clare feels an essential part of herself coming alive again. And when she discovers that an important work painted by th

Fun how to draw sports drawing book for kids--5-minute lessons great for young artists, holiday gifts, birthday gifts, homeschool art lessons, and elementary art classes! Perfect for budding artists and kids who have never drawn before, this beginner drawing book will teach your kid how to draw fun sports-themed pictures in no time! Author and professional artist Alli Koch's kid-friendly, mini drawing lessons will help your child practice their basic art skills and teach them how to draw with confidence. This book is perfect for kids 7-12, but kids as young as 5 with an interest in art will be able to easily follow along as well. No experience required! Easy-to-Follow Instructions: Simple steps and diagrams from start to finish40+ Cool Projects: Learn to draw fun sports things, from baseball bats to football helmets to pickleball paddles and moreLayflat Binding: Making it easier for kids to keep the book open as they follow alongPerforated Pages and Premium Paper: Easily removable page

This Step 2 Step into Reading leveled reader is based on Disney and Pixar's Toy Story 5, releasing in theaters June 19, 2026! The toys are back in Disney and Pixar's Toy Story 5, and this time, it's Toy meets Tech. Buzz, Woody, Jessie, and the rest of the gang's jobs are challenged when they're introduced to what kids are obsessed with today . . . electronics! Directed by Andrew Stanton, co-directed by McKenna Harris, and produced by Jessica Choi, Toy Story 5 opens only in theaters on June 19, 2026. Kids will love this Step 2 leveled reader based on the film! Step 2 readers use basic vocabulary and short sentences to tell simple stories. They are for children who recognize familiar words and can sound out new words with help.

【尋找名字，是為了找回活下去的姿態】「我是誰？我從哪裡來？如果切斷了根，靈魂該如何開花？」這不只是一個關於尋根的故事，更是一場橫跨大陸、跨越時代的女性覺醒史詩。在舊金山的迷霧中，Emilia 擁有看似完美的人生。然而，血液裡那股來自智利的呼喚，卻讓她決定拋下一切，跨越海洋回到那個被火焰與戰火洗禮的家鄉。當代文學大師 伊莎貝·阿言德 (Isabel Allende) 再次以她如絲綢般優美、如烈火般熾熱的筆觸，帶領讀者走進智利那段動盪的歲月。在 Emilia 的名字背後，隱藏著的是家族的流亡、禁忌的愛情，以及在政治巨輪碾壓下，依然堅韌不拔的人性光輝。NATIONAL BESTSELLER • In this “stunning” (People), “riveting” (Entertainment Weekly) historical novel,a young writer journeys to South America to uncover the truth about her father—and herself.“All of Allende’s books,My Name Is Emilia del Valleincluded, have the epic feel of a major Hollywood film.”—Associated PressAN NPR ANDNEW YORKERBEST BOOK OF THE YEARIn San Francisco in 1866, an Irish nun, abandoned following a torrid relationship with a Chilean aristocrat, gives birth to a daughter named Emilia del Valle. Raised by a loving stepfather, Emilia grows into an independent thinker and a self-sufficient young woman.To pursue her passion for writing, she is willing to defy societal norms. At the age of seventeen, sh

From New York Times bestselling author and Wattpad sensation Mercedes Ron comes the English translation of the third in the Tell Me series, where Kamila Hamilton is caught between the two Di Bianco brothers after they burst back into her life.Kamila Hamilton must decide between the two Di Bianco brothers: Thiago or Taylor... Taylor or Thiago. Choosing one means giving up the other, but how can she leave a part of herself behind?Thiago makes her feel like she holds the sky in her hands.Taylor knows he will never let go of Kami's hand.But just when Kami believes that his heart has finally decided, the real nightmare is about to begin.Can Taylor and Thiago face it with her? Can Kami prevent love from destroying everything? What will happen when life decides their fates for them once again?Filled with angst, danger, and electric attraction, Tell Me with Kisses is perfect for readers looking for: Contemporary teen romance booksUnputdownable & bingeworthy novelsTikTok booksColleen Hoover

Dark, seductive, and utterly enchanting, this fae romance follows a human heroine who defies the shadows--and the fae prince destined to claim her. **DELUXE LIMITED EDITION FIRST PRINT RUN--featuring beautiful sprayed edges. Special edition features only available for a limited time and while supplies last.** A defiant human woman. A dark fae Prince. Two enemies bound to a marriage that could destroy their world. Reyna was born a valuable slave to the Gold Court, imprisoned her whole life in a glittering palace by sadistic, greedy fae. When the palace is raided, she takes her opportunity to escape. But the raid is led by her worst nightmare. The Prince of the most feared fae of all; the Shadow Court. And he wants one thing. Her. The copper-haired, rune-marked human. Reyna doesn't know why the Prince has kidnapped her. But when he announces her as his betrothed, she knows that she must escape before she is eternally bound to the monster behind the mask. Only, when he takes the mask off,

Cindersmella is the fifth installment of the Stinky’s Stories series, a hilarious and highly illustrated chapter book set from New York Times bestselling author Chris Grabenstein and J.J. Grabenstein!It’s story time again at Hickleberry Elementary with Stinky the stuffed skunk. This time, the kids are reading Cinderella! Everyone knows the story ends with Cinderella marrying the prince, but only Stinky knows what happened after they got engaged! In Cindersmella, Stinky tells the story of the disgusting mess that became of the evil stepsisters’ house, why you shouldn’t eat a poison apple pie, and just how stinky a pair of glass slippers can get.Filled with sweaty feet, sabotage, and a lot of bad apples, Cindersmella is the latest offering in the hilarious chapter book series from New York Times bestselling authors Chris and J.J. Grabenstein, with illustrations in every chapter from Alex Patrick. Reading has never been so much stinkin' fun!

Join the entire gang of mer-friends--along with Neptune, king of the ocean, and Viking god Thor--in this epic and masterfully crafted adventure by New York Times best-selling author Liz Kessler. Adventure always seems to find Emily Windsnap! So when she discovers a bangle with a unique crystal under Rainbow Rocks, she and her friends are soon unraveling a whole new mystery. After learning that the crystal originally came from a familiar place--Halflight Castle!--Shona and Emily reunite there with Aaron . . . and none other than Neptune, king of the oceans. The bangle leads the mermaids to a cave full of crystals, and, with Mandy's help, they discover the truth about the jewel's origin--and what's at stake if they don't make things right. Unfortunately, the only solution involves getting the sea and sky's most powerful (and notoriously selfish) rulers to put their own interests aside for the greater good. Will the quartet find a way to convince the imperious Neptune and the Viking god T

YA犯罪推理 × 流行偶像 × 姊妹祕密 × 爆笑偵探搭檔。推薦給喜歡 Holly Jackson、Karen M. McManus、流行文化懸疑與青少年推理的讀者。A Junior Library Guild Gold Standard Selection!An investigation turns into an obsession when the younger sister of a slain pop starlet is determined to uncover her sister's killer, no matter what it costs, in this "tense and intricately plotted thriller...[that] achieves high marks across the board" (Publishers Weekly, starred review). When superstar Blair Baker is murdered moments before her triumphant homecoming concert, her younger sister, Stevie, knows she has one chance to find out who's responsible. The thing is, Stevie's been here before, desperately searching for clues that might reveal who hurt someone she loves...but Stevie was younger then, just a kid. This time, she won't let the truth slip through her fingers. What begins as a search for answers about Blair's death turns into a dangerous journey through the darker side of global fame. Soon, Stevie begins to uncover dark secrets closer to hom

Welcome to Briar U!Get ready for your newest obsession . . . Discover the addictive world of the Off-Campus series from The Queen of Hockey Romance, Elle Kennedy!ReadThe Dealnow for the perfect fake-dating romance!She's about to make a deal with the college bad boy . . .Hannah Wells has finally found someone who turns her on. But while she might be confident in every other area of her life, she's carting around a full set of baggage when it comes to sex and seduction. If she wants to get her crush's attention, she'll have to step out of her comfort zone andmakehim take notice . . . even if it means tutoring the annoying, childish,cockycaptain of the hockey team in exchange for a pretend date. . . and it's going to be oh so goodAll Garrett Graham has ever wanted is to play professional hockey after graduation, but his plummeting GPA is threatening everything he's worked so hard for. If helping a sarcastic brunette make another guy jealous will help him secure his position on the team, h

From the #1 bestselling author of RESTART, the story of a family of liars... and the son who wants to break the family tradition.Trey knows the drill: His dad gets him into a school full of kids with rich parents. Trey makes friends, and his dad makes connections. Soon, there's the con, where Trey's dad suckers the other parents into investing in one of his schemes. Once the money's in the bank, Trey, his sister, and their dad are on the run... until they set up somewhere else and start again.Trey believes his father when he says no one's getting hurt. After all, these parents have money to spare.But Trey's starting to get tired of running... and lying... and never having a friend for longer than a few months. But how do you get your family to stop lying when your lives depend on it?

向死而生，功力全開只有劉梓潔能超越劉梓潔以小說技藝衝撞生死邊界，不只是哀悼，更是探問：你想要怎麼活？收錄2025葉石濤短篇小說文學獎首獎作▍死亡隊伍如一列龍陣，▍柔美流暢地起伏翻躍過她身旁。余柏衡變成幽靈四處逍遙了，這次的熱海之旅只剩自己。詹天明按了遙控器上的「再生」鍵，竟聽到余柏衡的聲音。──你不就是因為覺得我在「這裡」才來的嗎？──〈再生，涼子，以及與幽靈共度的熱海〉品儀偶爾會在聖明入睡後來找我，在聖明起床前回到家裡。我從未感到罪惡，看到不倫師生戀的新聞也都覺得與我無關。但聽到聖明在沉睡中死去的消息，我卻對她升起巨大的愧疚。──〈晚安，再見〉阿公負責翻譯神諭，沒見過的老爸是一代名乩。少爺邱鵬佑是帝爺公的義子，卻什麼都感應不到。少爺長大也學翻譯，感應到語言文字像水流，像氣息。為阿公奔喪回到老家，他卻始終無法對媽媽翻譯自己和那位威廉哥的關係。──〈少爺〉巧宜獲得前夫送的高級住宅那天，也同時得知自己只剩六個月壽命。最高樓住戶珊卓既是地藏菩薩的使者，也是議長的膨床。她邀巧宜參加百日誦《地藏經》法會，如果把人生最後的一百天都獻給地藏菩薩，沒理由死後不會到天上，對吧？──〈無主〉▍有過再見才能再生，暌違12年，劉梓潔全新短篇小說集要怎麼寫才不會辜負、才匹配得上、才對得起如是我聞？寫作者得到珍貴寶石了，要如何端出來？讓它用什麼姿態呈現？與當初全程參與完父親葬禮一樣，這些問題再度如法鼓梵鐘般在我腦中、心中、手中來回撞擊。心裡有個強烈直覺，絕不可寫一篇「阿公後七日」之類的散文就把它「用」掉了⋯⋯──劉梓潔▍9篇關於人生的check out與check in，她舉起筆尖，扎進我們的心送別舊時光與老地方，送別所有「不是我的」，送別那些愛過的。用晚安代替再見，或說聲旅途愉快，想像某些離開，只是因為這裡不夠好玩。約好的旅途就照常成行，有些旅程卻只能屬於自己。再見到再生，死亡在她筆下荒誕幽默，卻讓我們在不禁一笑的同時，又刺痛非常。▍書封設計概念回憶如絲，纏繞成圓，一圈未盡，一圈又起，成為時間的漩，也成為心中的繭；亦成生者與逝者之間攪動的、覆寫的、難解的、未境的情節。──書封設計師．吳佳璘▍眾名家一再推薦　●按姓氏筆畫序排列小說是怎麼回事呢？你走在路邊，偶然發現一個被丟棄的布偶，又醜又髒的，你把它拿起來，覺得好像在哪裡見過。你忽然想起一些過去的事情，有著奇怪數字的店名、熟悉的人名，或許有

You can’t always get what you want…. unless you have a magic wand!“I WANT!” shouts Baby.“Do you want this rice cake?” asks Witch.“I WANT COOOOKIIIEEE!” Baby screams.With a sigh, Witch waves her wand and conjures a cookie. But Baby’s wants don’t stop there. He demands a balloon, a ball… and then the wand itself.Once armed with magic, Baby’s demands spiral out of control: Witch ends up teetering on a tiger, a dinosaur, a pirate ship, a fire engine, an elephant and a castle. But still, Baby isn’t satisfied. He wants the clouds. The moon. The stars. And unless Witch reclaims that wand, she may never get what she wants again.I Want is a gloriously hilarious caper wrapped around a sharp truth: the endless appetites of toddlers and the impossible balance between giving in and holding firm. Written in punchy comic-book dialogue and brought to life with Charlotte Ager’s warm, sketchy lines, this book will delight children and strike a knowing chord with every parent.

This is the first comprehensive book on the creative universe of NIGO (Tomoaki Nagao) – charting his journey from Toyko in the 1980s to global tastemaker, via a career as influential fashion designer, DJ and record producer.With contributions from NIGO, Pharrell, Yoon Ahn, Tiffany Godoy, Esme Hawes, Rachel HajekNIGO’s pioneering streetwear brand A Bathing Ape (BAPE) drew on his love of American hip-hop and pop culture; nearly 30 years later he became artistic director at luxury fashion house KENZO. He is also a collaborator on brands such as Billionaire Boys Club with Pharrell Williams, and is a member of hip-hop supergroup Teriyaki Boyz.Created in close collaboration with NIGO and his team, this richly illustrated book features texts by leading voices in fashion, design and culture, together with personal insights from three current collaborators (Pharrell Williams, TET Nishiyama and Fraser Cooke).Specially commissioned new photography focuses on objects from NIGO’s archive, published

用雙語故事看見微觀世界，帶你秒懂 DNA 轉化奧祕！ ◎用小鎮故事擬人化呈現 DNA 轉錄，讓生物學生動易懂。 ◎全書簡單易懂、插畫有趣，採雙語教學，可吸收英文資訊。 ◎冒險情節結合科學概念，輕鬆理解 DNA 轉變與專有名詞。 世界級「細胞達人」蕾妮這次將視野帶入我們體內， 從神祕的核鎮到飛速前進的 mRNA 列車。 透過精緻擬人的故事、簡練的文字與獨特的「轉錄密技」大公開， 揭開 DNA 複製與轉變的神祕面紗。 不論你是大朋友還是小朋友，不妨閉上眼睛想像、 感受身體律動，你會意外發現體內的建築家所打造的神祕家園！ English Version: Citizens in Nucleotown are finding a new place to survive. Can they move to another town without facing any danger? Come with me to explore the secrets of our body's DNA. How does it replicate and transform into different substances? Follow the journey of these citizens to discover the answers! 中文版: 核鎮的居民正在尋找新家園，希望避開所有未知的危險。 他們能順利搬遷到另一座城鎮，展開新的生活嗎？ 跟我一起探索 DNA 奧祕，看它們如何複製並轉化物質？ 加入市民們的奇幻旅程，你就能找到守護身體的答案！