Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The Bhagavad Gita is a philosophical and spiritual poem about truth, duty, good actions and the purpose of life. This book collates the wisdom it offers and applies it to contemporary life and work offering lessons on how to foster excellence and fulfilment in today's competitive world. The corporate world and the contemporary society focus on winning, per□forming and developing a competitive edge. Gita for Work and Life offers readers a deeper philosophical understanding of the interconnectedness of all beings, the importance of self-reflection and improvement, purpose, duty, morality, equanimity and peace. These guiding principles provided by Krishna to Arjuna in the Bhagavad Gita are meant to rekindle the dormant human spirit and inspire the reader to elevate their understanding of the mind and soul and how these relate to their work. The book explores themes such as depression management, realised action, knowing oneself, work and fulfilment, balance and discipline, material

This book explores governance challenges in India through the public finance lens, providing insights for policymakers, academics, and administrators. It is a timely contribution to the ongoing dialog

A Harvard professor shows how we can become better talkers - and why effective conversation will help us all thriveYou might already consider yourself a stellar conversationalist, but could you be even better? This book will help enrich your life, one conversation at a time.'Reading TALK is like having a conversation with the world's best conversationalist' Angela Duckworth_________Conversation is at the heart of our relationships and decision-making - but the science behind our everyday interactions, and how to improve them, is little known.In Talk, Harvard Professor Alison Wood Brooks provides fascinating insights into the power of effective communication. She gives you the tools that her MBA students say transform their lives, bringing together psychology, linguistics, sociology and neuroscience in her original framework:T – Topics – including the surprising impact of preparing topics before a conversationA – Asking – why we need to do more (and why we do less than we think)L – Levi

Discover the joy of drawing in a sketchbook as a way of looking, reflecting and relaxing.We draw with joy and without inhibitions when we are young children, but there often comes a point where we become self-conscious and self-critical of our drawings, a belief that sadly often continues into adulthood. As often is the case, learning to draw “properly” leads to comparing ourselves with truly professional artists with years of experience, and we end up copying instead of finding our own unique creative style and expression.This book aims to be inclusive and features not only Sam’s beautiful drawings, but that of many of her students – people of all ages, all abilities and from all walks of life. Along with photographs of the students’ work, there will also be written segments that share the students’ experiences of the exercises and of the process of completing their drawings.This is an inspirational guide that encourages you to discover the joy of drawing in a sketchbook as a way of l

This book provides an overview of the European energy law, laying the groundwork for understanding the energy industry. The book explains private and public law aspects of the energy industry and energy environment law. Starting from the internal energy market, current energy law and regulatory issues are explored, from the Energy Union to the globalisation of energy trading.In order to grasp the breadth of energy law, it is important to understand the European and international framework conditions. This knowledge is a prerequisite for successful work in the energy industry, politics, administration and associations. Last but not least, it is also the basis for understanding the energy transition.

Percy Jackson meets Diary of a Wimpy Kid in this exciting adventure from No.1 Sunday Times bestselling author James Patterson, where Greek gods task an ordinary twelve-year-old with a big mission. Nick Andino isn’t exactly 'hero' material. He’s perfectly happy working at his family’s Greek diner, pining over his crush, and avoiding his bully.His life isn’t very exciting… until destiny comes calling. Dr. Zeus, the over-the-top king of the gods, zooms into town with a quest that Nick must complete to save the Andino family's past and present from being erased from history.Accompanied by a fast-talking Hermes, Nick journeys back to ancient Greece, where his ancestors await - along with new friends and a whole host of Greek gods and monsters. Can Nick be the hero the Andinos need, or will his story be another Greek tragedy?This fast-paced, feel-good adventure from the world’s favourite storyteller has black-and-white illustrations throughout, and amphitheatres full of humour and heart.

This new edition of Indian Fiscal Federalism offers a timely and comprehensive analysis of federalism in India, examining the evolving roles of Finance Commissions and institutional changes since 2015

An insightful, wide-ranging analysis of the economic hurdles facing America's higher education system. The US higher education sector faces numerous economic challenges, including the stagnating number of college-age domestic students, geographic mismatch between population growth and the location of colleges and universities, financial pressures, including cutbacks in government support, growing student debt burdens, sticker prices that deter prospective applicants, and the risk of low capital market returns on endowment portfolios. This volume analyzes the responses of students, families, and the financial managers of higher education institutions to these challenges. It presents new insights into the substantial disparities in the financial structure of, and the financial challenges facing, different types of institutions. The volume draws together contributions from financial economics, public finance, and industrial organization, as well as the economics of education.

AN INSTANT #1 NEW YORK TIMES BESTSELLERAN INSTANT USA TODAY AND INDIE BESTSELLERHarry Dresden, Chicago’s only professional wizard, has always managed to save the day—but, in this powerful entry in the #1 New York Times bestselling Dresden Files, can he save himself?One year. 365 days. Twelve months.Harry Dresden has been through a lot, and so has his city. After Harry and his allies narrowly managed to save Chicago from being razed to the ground, everything is different—and it’s not just the current lack of electricity.In the battle, Harry lost people he cared about. And that's the kind of loss that takes a toll. Harry being Harry, he’s doing his level best to help the city and his friends recover and rebuild. But it’s a heavy load, and he needs time. But time is one thing Harry doesn’t have. Ghouls are prowling Chicago and taking out innocent civilians. Harry’s brother is dying, and Harry doesn’t know how to help him. And last but certainly not least, the Winter Queen of the Fae has a

Inspired by a virtual hangout with Pope Francis and children around the world, Our Treasures Within brings together Pope Francis and New York Times bestselling author and illustrator Peter H. Reynolds in an empowering picture book that encourages young readers to discover, and then share with the world, their own unique gifts.

From spectacular storyteller Buck Turner comes a southern paranormal romance to transcend timeCole Mercer is a young man angry at the world... and for good reason. After the sudden loss of his father, Cole's mother moves them to the small town of Evergreen, North Carolina. Between difficult classmates, the beautiful girl next door, and the forest on the outskirts of town that always seems to have more of a presence than it should, nothing in Evergreen is quite what it seems.From the author of the sensational The Keeper of Stars comes a paranormal YA coming-of-age story with a twist. Perfect for readers of Sarah Addison Allen, readers will fall in love with the sleepy town of Evergreen with its southern charm, love story that transcends time, and many secrets lurking in the shadows.

★ 《紐約時報》暢銷作家Jennette McCurdy，萬眾矚目首部長篇小說！★ 席捲 2026 歐美文壇，最具爭議、最赤裸的「少女慾望」剖析。主角Waldo是一名17歲的少女。她飢渴、衝動、孤獨、充滿憤怒，卻也無比敏銳。她最渴望的目標，是她的寫作老師—柯基先生 (Mr. Korgy)。柯基先生是一個有妻小、有貸款、夢想早已萎縮、挺著小腹的中年男人。沃多不知道自己為何想要他。是因為他的熱情？人生經驗？還是因為他懂那些她不懂的書與電影？或者更單純：在所有人都無視她的世界裡，柯基先生是唯一「看見」她的人。如果你也曾在愛中迷失，如果你也曾為了被看見而付出昂貴代價，這本書寫給每一個受過傷、卻依然渴望著什麼的靈魂。From the #1 New York Times bestselling author of I'm Glad My Mom Died comes a sad, funny, thrilling novel about sex, consumerism, class, desire, loneliness, the internet, rage, intimacy, power, and the (oftentimes misguided) lengths we'll go to in order to get what we want.Waldo is ravenous. Horny. Blunt. Naive. Wise. Impulsive. Lonely. Angry. Forceful. Hurting. Perceptive. Endlessly wanting. And the thing she wants most of all: Mr. Korgy, her creative writing teacher with the wife and the kid and the mortgage and the growing paunch. She doesn't know why she wants him. Is it his passion? His life experience? The fact that he knows books and films and things that she doesn't? Or is it

★ 《紐約時報》暢銷作家Jennette McCurdy，萬眾矚目首部長篇小說！★ 席捲 2026 歐美文壇，最具爭議、最赤裸的「少女慾望」剖析。主角Waldo是一名17歲的少女。她飢渴、衝動、孤獨、充滿憤怒，卻也無比敏銳。她最渴望的目標，是她的寫作老師—柯基先生 (Mr. Korgy)。柯基先生是一個有妻小、有貸款、夢想早已萎縮、挺著小腹的中年男人。沃多不知道自己為何想要他。是因為他的熱情？人生經驗？還是因為他懂那些她不懂的書與電影？或者更單純：在所有人都無視她的世界裡，柯基先生是唯一「看見」她的人。如果你也曾在愛中迷失，如果你也曾為了被看見而付出昂貴代價，這本書寫給每一個受過傷、卻依然渴望著什麼的靈魂。From the #1 New York Times bestselling author of I'm Glad My Mom Died comes a sad, funny, thrilling novel about sex, consumerism, class, desire, loneliness, the internet, rage, intimacy, power, and the (oftentimes misguided) lengths we'll go to in order to get what we want.Waldo is ravenous. Horny. Blunt. Naive. Wise. Impulsive. Lonely. Angry. Forceful. Hurting. Perceptive. Endlessly wanting. And the thing she wants most of all: Mr. Korgy, her creative writing teacher with the wife and the kid and the mortgage and the growing paunch. She doesn't know why she wants him. Is it his passion? His life experience? The fact that he knows books and films and things that she doesn't? Or is it

本書結合亞美尼亞與波斯神話，以圖像小說形式描繪家族、料理與魔法交織的故事。十七歲的 Katah Fustukian 在三兄妹中總覺得格格不入，既不擅長廚藝，也未曾親身認識那位在 Pars Empire 聲名顯赫的名廚父親。隨著母親病情惡化，他開始注意到自己夢境中的異象，或許那正是魔力甦醒的跡象。夢境引領他遇見 div Az──與他家族似乎有著神祕關聯的存在。為了拯救母親，兄妹三人與 Az 達成協議：以一道能媲美父親手藝的料理換取協助。然而在決定要做什麼菜時，他們意見分歧，Katah 也被迫面對自己的魔法與家族過往，並做出不只牽涉一頓佳餚的抉擇。Inspired by Armenian and Persian mythology, this delectable YA graphic novel debut follows the youngest of three dysfunctional siblings who strike a magical deal to save their mother's life--perfect for fans of The Magic Fish! Seventeen-year-old Katah Fustukian has always felt like the odd one out in his family of chefs. Unlike his older siblings, he is useless in the kitchen, and too young to have known their late father--a legendary Hye chef who'd made a name for himself in the Pars Empire. But with his mom's illness worsening, Katah hopes that his vision-like dreams are a sign of magic stirring within him--especially after they lead him to Az, a powerful div with some mysterious connection to his family. In an at

A searing YA dystopian fantasy for fans of Arcane and Iron Widow! When a girl with the ability to conduct electricity discovers that the powerful House of Industry is not the benevolent organization they present to be, she teams up with two boys--former lovers--who are standing against the harm the House has caused in the name of progress. Josephine Haven's outbursts are infamous at the House of Industry, the secretive school for children who can wield Radiance, an electricity-like magic. She's tried to follow the rules, but her fiery nature is at odds with the core tenant of the House: never form attachments to others. How is she meant to feel nothing when her classmates are maddening? No one is surprised when upon graduation, Josephine is banished to the Mission farthest from Sterling City. In Frostbrook, she must work under the authority of standoffish Julian, the former golden boy of the House of Industry. Rather than being helpful, he seems determined to watch her fail. And then t

★《第四翼》作者──全球暢銷女王Rebecca Yarros經典愛情代表作★雙時間線交織，跨越戰火與世代的命定之戀★BookTok破2億觀看，讀者一致淚推★無書衣燙金硬殼＋書口噴繪＋專屬彩繪蝴蝶頁，夢幻收藏級典藏本有些愛，沒有結局。有些故事，註定無法完成。二十八歲的喬治亞在一場殘酷離婚後失去幾乎一切，只能回到科羅拉多外曾祖母的莊園重新開始。沒想到，她必須與傲慢又迷人的暢銷作家諾亞．哈里森合作，替外曾祖母未完成的最後一部小說寫下結局。然而，當他們翻閱手稿與塵封的信件，才發現那本小說其實源自一段二戰飛行員的真實愛情——而結局，並不幸福。當愛情與現實交錯，當命運逼你直視心中最深的傷痕——你，還敢再愛一次嗎？Told in alternating timelines, THE THINGS WE LEAVE UNFINISHED examines the risks we take for love, the scars too deep to heal, and the endings we can't bring ourselves to see coming. Twenty-eight-year-old Georgia Stanton has to start over after she gave up almost everything in a brutal divorce―the New York house, the friends, and her pride. Now back home at her late great-grandmother's estate in Colorado, she finds herself face-to-face with Noah Harrison, the bestselling author of a million books where the cover is always people nearly kissing. He's just as arrogant in person as in interviews, and she'll be damned if the good-looking writer of love stories thinks he's the one to finish h

When you lose your way in life, the Elsewhere Express just might find you. Step on board the train that can take you to your life’s purpose, in this cozy and inspiring fantasy from the author of Water Moon.What happens when you lose your way in life? The Elsewhere Express finds you. It's a magical train carrying very rare and special cargo: a sense of purpose, peace, and belonging.Raya is one of those lost souls. She dreamed of being a songwriter, but when her brother died, she gave up on her dream and started living his instead.One day, as her thoughts wander while on the subway, she's swept off to the Elsewhere Express. There she also meets Q, a charming, handsome artist who, like her, has lost his place in the world.Together they find a train full of wonders, from a boarding car that's also a meadow to a dining car where passengers can picnic on lilypads to a bar where jellyfish and whales swim through pink clouds.But they also discover that the train harbors secrets--and danger: a

DELUXE EDITION―featuring gorgeous gilded edges, detailed endpapers, and beautiful case art under the book jacket! Debut author Shen Tao introduces readers to the lush, deadly world of The Poet Empress, a sweeping, epic and intimate fantasy perfect for fans of The Serpent & the Wings of Night, The Song of Achilles and She Who Became the Sun. In the waning years of the Azalea Dynasty, the emperor is dying, the land consumed by famine, and poetry magic has been lost to all except the most powerful. Wei Yin is desperate. After the death of her sister, with her family and village on the brink of starvation, she will do anything to save those she loves. Even offer herself as concubine to the cruel, dissolute heir of the blood-glutted Azalea House. But in a twist of fate, the inner court stands on the knife-edge of civil war with Wei now at the center...as the prince's chosen. To survive, Wei must harden her heart, rely on her wit, and become dangerous herself, even if it means learning t

'An incredible read. I laughed, I cried and my heart was truly touched by this beautifully written true story of hope and humanity at its best.' Rosemary Conley CBE'An extraordinary story. Truly Inspirational' Tim Vine An astonishing story of kindness, self-learning, pain, unbelievable hope and the sheer power of love to change a life. Christmas 1975 and Queen's 'Bohemian Rhapsody' is riding high in the charts. In a residential street just outside Cardiff, a persistent knocking breaks the stillness of the evening ... When Rob Parsons, a young lawyer, opens his door he finds a man standing before him clutching a bag of belongings and a frozen chicken. Rob and his wife, Dianne, invite him into their home, cook his chicken and offer him shelter for the night. What happens next is an astonishing story of human kindness, self-learning, incredible pain, unbelievable hope and the sheer power of love to change a life. A Knock at the Door is the true story of Ronnie Lockwood, a homeless man

A young girl spends a magical day in her grandad's painting studio, discovering the joy of art, music, and the special bond they share. By the granddaughter of legendary Caldecott Medal-winning children's book illustrator Jerry Pinkney. Step into the warm, jazz-filled world of a young girl and her artist grandad, as she learns about her grandad's paintings and discovers the joy of creating her own art. In this inspiring story, a very young painter learns there is no right way to be an artist, and that every brushstroke and every sketch is a unique expression of her imagination. With Grandad's gentle guidance, she draws, dreams, and lets her creativity flow, filling the studio with memories and masterpieces. As the day fades, the young artist realizes that time spent with Grandad is a treasure to carry in her heart forever. Based on her memories of time with her grandfather--beloved children's book creator Jerry Pinkney--Charnelle Pinkney Barlow's beautifully illustrated picture book wi

A betrayal. A deception. A tragedy. A murder.Charity has a past full of dark secrets that she keeps buried deep inside her cold heart. Samantha didn't used to have any secrets, but that's all about to change. And Roy, who seems to be caught in the middle, may have a haunting past of his own. All three of them were never supposed to survive.But when the small town they live in is hit with a devastating flood, the isolation and danger of the rising waters will lead the three of them down a path they can never return from. How long will it take the three of them to realize that one will have to go, for the others to survive?

★ 《紐約時報》暢銷作家Jennette McCurdy，萬眾矚目首部長篇小說！★ 席捲 2026 歐美文壇，最具爭議、最赤裸的「少女慾望」剖析。主角Waldo是一名17歲的少女。她飢渴、衝動、孤獨、充滿憤怒，卻也無比敏銳。她最渴望的目標，是她的寫作老師—柯基先生 (Mr. Korgy)。柯基先生是一個有妻小、有貸款、夢想早已萎縮、挺著小腹的中年男人。沃多不知道自己為何想要他。是因為他的熱情？人生經驗？還是因為他懂那些她不懂的書與電影？或者更單純：在所有人都無視她的世界裡，柯基先生是唯一「看見」她的人。如果你也曾在愛中迷失，如果你也曾為了被看見而付出昂貴代價，這本書寫給每一個受過傷、卻依然渴望著什麼的靈魂。From the #1 New York Times bestselling author of I'm Glad My Mom Died comes a sad, funny, thrilling novel about sex, consumerism, class, desire, loneliness, the internet, rage, intimacy, power, and the (oftentimes misguided) lengths we'll go to in order to get what we want.Waldo is ravenous. Horny. Blunt. Naive. Wise. Impulsive. Lonely. Angry. Forceful. Hurting. Perceptive. Endlessly wanting. And the thing she wants most of all: Mr. Korgy, her creative writing teacher with the wife and the kid and the mortgage and the growing paunch. She doesn't know why she wants him. Is it his passion? His life experience? The fact that he knows books and films and things that she doesn't? Or is it