Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

本書以井然有序、簡明扼要的方式呈現了一個高度複雜的主題，為當今的學生提供了易於閱讀、全面涵蓋人類胚胎發育的內容。它將解剖學和組織學與細胞和分子機制相結合，重點關注正常發育和先天性異常。該書配有精美的插圖和照片，並且基於最新科學發現和理解，具有強烈的臨床應用導向。a)本書作者是國際上從事人類胚胎學研究的著名專家，作者本身具有國際影響力；b)本書內容上，結合了人類三維描述性胚胎學、動物模型實驗胚胎學和人類先天缺陷三方面的內容，是當前國際上最權威的人類胚胎學著作；c)本書圖文並茂，有多達541幅插圖，文字內容反映了最新研究進展及其臨床相關性，直觀的插圖幫助學習，有助於提供更好的學習效果；d)本書在線資源豐富，包括圖像、動畫和視頻，提供更生動的學習體驗；e)本書巧妙地使用陰影文本框等創新方式來提供詳細信息，以便理解正常和異常人類胚胎發育的臨床意義；f)本書每個部分的內容都可以獨立成章，讀者可根據自己的需求和興趣予以學習，或者輕鬆省略不感興趣的部分；g)本書關注出生缺陷對兒童及其家庭生活的影響，且為從事該職業者提供了“Clinical Taster” 和 “Embryology in Practice”兩個部分。

As people get older, they become more likely to have hearing difficulties in certain situations; for example, having conversations in public settings where there is naturally more noise. This can sometimes lead to isolation, depression, or even fatigue from the effort needed to communicate with others. Clinicians and researchers often do not use standardized outcome measures for hearing interventions that reflect patients' perceptions of real-life improvements. The National Academies of Sciences, Engineering, and Medicine convened a committee of experts to identify a core set of outcomes and corresponding measures that researchers and clinicians should use each time they assess the effectiveness of hearing aids and other treatments in addressing hearing difficulties. The resulting report, Measuring Meaningful Outcomes for Adult Hearing Health Interventions, presents those outcomes and measures, as well as recommendations for promoting their use within the hearing health community.

The classic work that has shaped the field of biomedical ethics, fully updated to include cutting-edge approaches and research. Principles of Biomedical Ethics provides a highly original, insightful, and practical guide to morality in the health professions, health policy, and public health. Acclaimed authors Tom L. Beauchamp and James F. Childress thoroughly develop and advocate for four principles that lie at the core of moral reasoning in health care: respect for autonomy, nonmaleficence, beneficence, and justice. Drawing from contemporary research - and integrating detailed case studies and vivid real-life examples and scenarios - they demonstrate how these prima facie principles can be used to address various conflicts and dilemmas, from how to deliver bad news to the decision to withhold or withdraw life-sustaining treatments.Ideal for courses in biomedical ethics, bioethics, and health care ethics, the text is enhanced by hundreds of annotated citations, along with key terms and

The origins of the legendary Black Axe and its first mouse wielder revealed for the first time! Eisner Award-winning creator David Petersen joins forces with Eisner-nominated artist Gabriel Rodr璲uez to bring a brand new prequel chapter in the epic Mouse Guard saga to life--just in time to celebrate the series 20th anniversary! Set at the earliest point in the series' timeline, this epic reveals the origin of the legendary weapon and the courageous mouse to first wield it--Bardrick. As darkness encroaches and monstrous serpents threaten the fragile peace of the Territories, Bardrick must rise to a duty greater than himself and embark on a perilous journey of sacrifice, bravery, and legacy. But with such immense stakes at hand, can the first Black Axe survive the toll of his quest? Featuring stunning sequential art from Rodr璲uez paired with colors by Petersen himself, this hardcover volume beautifully expands the Mouse Guard mythos with the untold history of its earliest heroes. Collects

Federated Learning for the Metaverse: Applications in Virtual Environments provides readers with insights into how federated learning, a decentralized machine learning paradigm, can be strategically applied to address critical aspects of the metaverse. The book covers a wide range of topics, including privacy-preserving personalization, security, collaboration, adaptive learning environments, real-time communication, decentralized governance, language understanding, immersive learning experiences, avatar customization, and dynamic scene rendering.

Additive manufacturing (AM), also known as three-dimensional (3D) printing, is a relatively new manufacturing technique that has gained significant industrial interest. AM is a key low-carbon manufacturing technology incorporating net-shaping whilst avoiding complex process chains. This manufacturing technique is appealing for a variety of applications, including aerospace, oil, gas, marine, automotive, biomedical, and nuclear, due to advantages such as component design freedom, component complexity, light weighting, toolless nature, part consolidation, and decreased material waste. To overcome the performance limitations and to take advantage of the alloy design opportunities provided by AM technology, a new generation of alloys suitable for AM is needed. In addition to this, optimising process parameters and microstructure evolution during AM can lead to improved mechanical, corrosion, fatigue, irradiation, and wear properties, amongst other benefits. With a view to select the best a

Award-winning author/illustrator Don Brown explores the history of rocket building in this installment of the Big Ideas That Changed the World graphic novel series. "That's one small step for man, one giant leap for mankind." On July 20, 1969, Neil Armstrong said those iconic words when Apollo 11 landed on the moon. But it wasn't just one man who got us to the moon--there was a whole team of people, plus centuries of discoveries and technologies that came before that made it possible. From ancient Chinese rockets to the first steps on the moon, Rocket to the Moon! Reveals which "bombs bursting in air" inspired the writer of "The Star-Spangled Banner," why the Russians wanted to launch a dog into Earth's atmosphere, and how exactly astronauts are able to go to the bathroom while in a rocket far off in space! Big Ideas That Changed the World is a graphic novel series that celebrates the hard-won succession of ideas that ultimately changed the world. Humor, drama, and art unite to tell th

Padawan Reath Silas is being sent from the cosmopolitan galactic capital of Coruscant to the undeveloped frontier―and he couldn’t be less happy about it. He’d rather stay at the Jedi Temple, studying the archives. But when the ship he’s traveling on is knocked out of hyperspace in a galactic-wide disaster, Reath finds himself at the center of the action.The Jedi and their traveling companions find refuge on what appears to be an abandoned space station. But then strange things start happening, leading the Jedi to investigate the truth behind the mysterious station, a truth that could end in tragedy...“Claudia Gray created an absolute masterpiece with incredible depth. This is a must-read for any Star Wars fan in 2021.” - Cultress“The most fun entry of The High Republic line yet.” – ComicBook.com"An emotionally resonant Star Wars adventure like you've never seen before." -- CinelinxEnjoy more adventures from the all-new era of storytelling of the glorious High Republic:Star Wars: Light

Sylvestri Yarrow is on a streak of bad luck with no end of sight. She’s been doing her best to keep the family cargo business going after her mom’s death, but between mounting debt and increasing attacks by the Nihil on unsuspecting ships, Syl is in danger of losing all she has left of her mother. She heads to the galactic capital of Coruscant for help, but gets sidetracked when she’s drawn into a squabble between two of the Republic’s most powerful families over a patch of space on the frontier. Tangled up in familial politics is the last place Syl wants to be, but the promise of a big payoff is enough to keep her interested…Meanwhile, Jedi Knight Vernestra Rwoh has been summoned to Coruscant, but with no idea of why or by whom. She and her Padawan Imri Cantaros arrive at the capital along with Jedi Master Cohmac Vitus and his Padawan, Reath Silas―and are asked to assist with the property dispute on the frontier. But why? What is so important about an empty patch of space? The answer

Playing is an essential part of psychotherapy, and sandplay in particular allows for the development of an active tie between the therapist and the patient. This book analyses the elements that are introduced into therapy through sandplay: implicit memory, the embodied self and empathy, as well as the relationship that is created through the process of this type of therapy. Napoliello focuses on sandplay, but the use of the ideas here extends to the importance of activating a dimension of play in a patient as a way to bridge a link between the conscious and subconscious, on the importance of body language and using past experience to decipher the meaning of physical movements.