Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Learn to live in the moment in this magical fantasy adventure that teaches us to leave behind the mundane and delight in imagination and play! After Daddy has finished working from home for the day, his daughter takes him out on a walk that soon turns into an epic journey across enchanting landscapes. Along the way, they encounter magical creatures like trolls and pixies, yetis and giants, but Daddy doesn’t believe in any of them! Will she convince her dad to put away the distraction of his work crisis, and finally see the magic all around them? Learn to let go of the day-to-day and enjoy magical moments with our loved ones.

Build new cars in the factory, put speedy trains on the tracks and stick enormous planes on the runway in this exciting book. There are all sorts of vehicles to spot and talk about on every page. With over 450 stickers to add to the charmingly illustrated scenes.

Ancient Greek classic about the amazing adventures of Odysseus, in graphic novel form.Greek warrior Odysseus is desperate to make his way home to the island of Ithaca. But giants, sirens and many-headed serpents are just some of the obstacles that stand in his way. Join him on his amazing adventures in this dynamic graphic novel.

An easy-to-read introduction to world history for young children.A bright, lively introduction to world history - from the dinosaurs to the Civil Rights Movement - with simple text, amazing photographs and detailed illustrations. Provides clear explanations to questions such as "Who lived in the Forbidden City?", "Where did the Vikings come from?" and "What was the Industrial Revolution?"- Includes acomprehensive index, plusQR linksto selected websites and videos atUsborne Quicklinks.- An idealstarting pointandreference bookfor any child with questions about history.Chapters in this book include:- Dinosaur world- The first people- The first farmers- The first cities- Ancient Egypt- Celtic warriors- Ancient Greece- Ancient China- Ancient Rome- Viking raiders- African kingdoms- Living in a castle- Living in a village- Inca cities- Aztec life- Italian ideas- Exploring the world- Tudor England- Ming China- Russian rulers- Living in Japan- Living in America- Mogul India- Dutch traders- Fren

Can two very different women put aside their differences to save the bookstore they love? The Japanese bestseller that kicked off a seven-book series – adapted for TV and 200,000 copies soldRiko Nishioka is assistant manager of the flagship Pegasus bookstore in Kichijoji. After working her way up from a part-time position, she is now, aged forty, a respected figure in the Japanese publishing industry. But she has a nemesis.Aki Kitamura, twenty-seven, has waltzed in as a full-time employee thanks to her family connections. A free spirit with a rebellious streak and a silver spoon in her mouth, she’s anything but a team player.The two are always clashing – both at work and over their personal lives. But when Riko is given notice that the store will be closing in six months’ time, they face a stark choice.Can they put their petty enmities aside to boost sales and save their livelihoods or will they go down fighting . . . each other?Translated from the Japanese by Haydn Trowell

Help the baby sea animals find their way home in this fun sliding counter board book series!Meet baby turtle, baby dolphin, baby clownfish and baby whale - four adorable animals who are lost in the waves!With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby animals home in this robust board book.Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Other titles in the Let's Go Home series include:*Baby Tiger*Baby Shark*Baby T-Rex*Let's Go Home, Baby Panda

Explore the big outdoors in these action-packed animal board books with sliders on every page.This series of board books will inspire a love of nature in even the littlest of animal lovers. With vibrant artwork printed on white board, robust easy-to-use mechanisms for tiny hands and a rhyming text with friendly animal facts, these are the perfect books to captivate curious little explorers time and time again.In this first minibeasts book, there are earthworms tunnelling underground, spiders spinning webs, butterflies flitting around and many more bugs to discover and bring to life with the moving parts.Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Other titles in the series include:*Countryside*Seaside*Woods*Farm*River*Snow*Jungle*Safari*Birds

Stunning, large-format board book with flaps on every page and lots of dinosaurs to meet!A brand-new title in this best-selling gift format from award-winning illustrator and homeware and stationery designer, Edward Underwood.The perfect gift book for dinosaur fans of all ages, with bold colours and big flaps that will catch a child's attention on every page as they learn all about dinosaurs with over 100 words and pictures to spot. This book will help develop vocabulary, encourage speech and promote book confidence in an interactive way, as well as introduce first words from the world of dinosaurs.Other books in the 100 First Words series include: First Words, First Words: City, First Words Nature, My First ABC and My First 123

Dream big with bestselling author Rob Biddulph in this wonderful exploration of jobs and the world of work Sailor, dancer, teacher, vet – explore all the many things you can be when you’re older in this beautiful and heartfelt text from bestselling author Rob Biddulph. Full of hope and childhood ambition, and with glorious illustrations throughout, be introduced to the world of work in this inspiring picture book, perfect for little dreamers.

Experience the world of fashion in a whole new way with Fashion Unfolded – an enthralling pop-up book series bringing stories of legendary brands to life in three-dimension. Fashion Unfolded is a series that renders fashion history in three dimensions—where popups reveal iconic moments, timeless designs, and lasting legacies in an engaging exploration of style and history across celebrated houses. Following on from the success of Chanel and Dior, the third title in this captivating pop-up book series delves into the history, legacy and iconic creations of the world renowned fashion brand Louis Vuitton.Each pop-up spread showcases legendary designs and celebrated pieces, from the iconic Speedy bag to the signature trunks, brought to life with intricate paper engineering and illustrations. With its hardcover design and matching slipcase, Fashion Unfolded is both a charming gift and timeless collectable for fashion enthusiasts.

'A master class in human behavior from someone who’s lived it at the highest level.' – Steven Bartlett, author of The Diary of a CEO Simple but powerful body language skills to connect instantly with anyone and build rapport, from the international bestselling author of What Every Body is Saying, Joe Navarro. Over his twenty-five-year career as an FBI counterintelligence officer, Joe Navarro had to read people in an instant, build trust in the most reluctant of people and nurture life-long relationships. The key to achieving it was simple but powerful: body language. In Mastering Connections, Navarro draws on his unique experiences and shows readers how to apply these skills to their everyday lives. In this book, you will discover how to: Master the art of the first impressionBuild trust and rapport with someone newHandle workplace negotiationsDefuse tension and conflictBe prepared for a first dateFoster life-long relationships.

Wiska Wildflower is back! From the creator of Isadora Moon, Harriet Muncaster. Told in diary format and packed with beautiful full-colour illustrations, this is the enchanting story of Wiska Wildflower's first school expedition-to one of the most dangerous places in all of Wiskling Wood! We're going on a school trip to Wiskling Mountain! We have to read a map and make our own camp and find and cook our own food-it's a BIG deal. Wiska is excited to be paired with Citrine for the school trip, but when Citirne persuades her to join her on a secret mission to find a rare starflower, she begins to have doubts.After disaster strikes, the friends seek sanctuary in a hidden spot in Wiskling Wood. What they find there is incredible and life-changing. But will their friendship survive this dangerous adventure? Book 2 following the Children's bestseller The Diary of Wiska Wildflower: The New School.

The Meanest Goose on Earth is back! Honkingly funny storytelling from bestselling author Alex Latimer-highly illustrated and full of laughs, this is the perfect series for emerging readers. Gordon is THE MEANEST GOOSE ON EARTH. Well .. . he used to be, but now he's trying to change his ways and be a GOOD GOOSE.The trouble is, it's really tricky to be kind and patient and good, especially when you've always been mean. In Gordon Saves the Day, there's a new goose in town! Unfortunately for Gordon, it's Captain Quack-the superhero. The whole town's excited about having another 'good goose' around, but Gordon can't help but wonder .. . is Grover Gardens big enough for the both of them? For more mean goose antics read Gordon in the City.

From Jarvis, author-illustrator of the award-winning The Boy with Flowers in His Hair, comes a picture book that explores joyful, pure and wind-swept memories on a pebble beach between a grandad and grandson.A gorgeous book for children to share with grandad, Jarvis captures the kind of golden childhood memory that you carry with you, as comforting as holding a warm, smooth pebble in your hand. And when life changes, and people change, these pebbles stay with you always.With sweets stuffed in their pockets, a boy and his grandad take the trip down to the beach: through the wonky woods, across the railway track – stopping for a chat with the spotty dogs! – over the stile, and there ... peeking out beyond the dunes, the sea and "their" beach. They pick pebbles, wash them clean in the waves and paint their memories from the day, placing them in a special place – a secret place.

This beautifully illustrated flap book transports the reader back in time to the amazing world of the dinosaurs. From fearsome meat-eaters to giant herbivores, readers can lift the different flaps to discover the very different world these big beasts lived in. Discover the strange, feathery dinosaurs who lived in deserts, what a T.Rex had for lunch, the massive reptiles who soared in the sky and swam in the sea, before finding out why dinosaurs no longer live with us. Or do they...?

專為設計師、創作者與初學者打造的實戰指南 用好上手的方式學遊戲開發，不只是學習Unity，而是真正學會如何做出一款遊戲 【內容簡介】 ♚完整學習路徑：Unity知識深入淺出，從做中學、學中做 ♚Unity實戰：從角色控制、UI、動畫到任務系統完整實作 ♚輕鬆上手開發：簡單的語法就能夠完成遊戲主程式 ♚理解開發思維：不需要資訊背景，一步步完成遊戲作品 本書內容改編自第16屆iThome鐵人賽Software Development 組系列文章《初心者限定！設計師帶你學Unity 3D遊戲程式設計》。本書專為初學者、設計師與創作者打造，從Unity最基礎的操作開始，一步步帶你理解遊戲世界背後的「互動邏輯」。 不同於傳統偏工程導向的教學，本書更重視「設計思維」與「遊戲體驗」，你將學會如何從一個想法出發，逐步建立角色控制、場景互動、UI系統、動畫、任務機制與遊戲流程，最終完成自己的第一款3D遊戲。書中結合大量圖解、實作案例，即使沒有程式基礎，也能循序漸進完成真正能操作的互動作品，這不只是一本Unity教學書，更是一本讓創作者真正踏入遊戲世界的實戰指南。 【目標讀者】 ✪沒有程式基礎，但想做遊戲的人。 ✪設計、動畫、多媒體相關科系學生。 ✪想學Unity的創作者與獨立開發者。 ✪對互動設計、AR / VR有興趣的學習者。 ✪想把自己的創意真正做成作品的人。 【本書特色】 ✪認識Unity開發流程與核心觀念。 ✪學習遊戲設計中的互動邏輯。 ✪建立C#程式基礎與實際應用。 ✪了解3D場景與角色控制。 ✪使用UI介面與互動系統設計。 ✪整合動畫、音效與遊戲演出。 ✪從零完成第一款3D遊戲。 本書內容改編自第16屆iThome鐵人賽Software Development 組系列文章《初心者限定！設計師帶你學Unity 3D遊戲程式設計》。本書專為初學者、設計師與創作者打造，從Unity最基礎的操作開始，一步步帶你理解遊戲世界背後的「互動邏輯」。不同於傳統偏工程導向的教學，本書更重視「設計思維」與「遊戲體驗」，你將學會如何從一個想法出發，逐步建立角色控制、場景互動、UI系統、動畫、任務機制與遊戲流程，最終完成自己的第一款3D遊戲。書中結合大量圖解、實作案例，即使沒有程式基礎，也能循序漸進完成真正能操作的互動作品，這不只是一本Unity教學書，更是一本讓創作者真正踏入遊戲世界的實戰指南