Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Mehar, a young bride in rural 1929 Punjab, is trying to discover the identity of her new husband. She and her sisters-in-law, married to three brothers in a single ceremony, spend their days hard at work in the family's 'china room', sequestered from contact with the men. When Mehar develops a theory as to which of them is hers, a passion is ignited that will put more than one life at risk.Spiralling around Mehar's story is that of a young man who in 1999 travels from England to the now-deserted farm, its 'china room' locked and barred.In enforced flight from the traumas of his adolescence - his experiences of addiction, racism, and estrangement from the culture of his birth - he spends a summer in painful contemplation and recovery, before finally finding the strength to return 'home'.

Twelve-year-old Mallie knows better than to dream. In Coal Top, you live the story you're given: boys toil in the mines and girls work as servants. Mallie can't bear the idea of that kind of life, but

Explore the connections found in nature in this simply stunning picture book that explores the idea of change, both big and small. This sky isthe same sky that was blue, and now isspilling down in dri

In the third installment of the exciting Dragon Kingdom of Wrenly graphic novel series, Ruskin and his friends compete in the legendary Night Hunt.Ruskin is excited to visit Crestwood to witness a ver

The #1 bestselling chapter book is now a graphic novel Magic. Mystery. Time-travel. Get whisked back in time in the magic tree house with Jack and Annie Where did the tree house come from? Before Jack

Discover the hilarious schooltime companion to the beloved, bestselling, and Caldecott Honor-winning classic, No, David!David's teacher has her hands full. From running in the halls to chewing gum in

The third adventure in this much-loved classic series is re-published for a new audience. 'There was once ONE Happy Lion who lived in the zoo of a little French town. Then there were TWO Happy Lions,

This book adds richly not only to understanding of the unique form of Daoism in Central Hunan today, but to the entire fashi tradition that rose to prominence in the Song–Yuan. In the h

Join the the fairies and pixies as they splash in rainbow puddles, paint rainbows in the sky, play withunicorns, prepare for a rainbow party and snuggle up in rainbow beds at the end of the day. There

Little bee is hiding! Children will love peeping through the holes in the pages of this charmingly illustrated book in search of the elusive bee. With fingertrails to touch and details to talk about,

The essential companion to every train journey. This write-in book is easy to dip in and out of on short trips, again and again, or distract and entertain you on long journeys for hours and hours. It’

Every veggie needs their shuteye in this restful, charming story set in a community garden, illustrated by New York Times best-selling artist Zachariah OHora. Perfect for fans of the Llama Llama serie

TheBig Fat Notebooks' big step up to high school continues! Announcing Biology,the third in the high schoolseries. With over 5 million copies in print since 2016, and sales escalating every year, theB

The first book in the Bevelstoke series: witty, irresistibly romantic and by the bestselling author of the global phenomenon Bridgerton'2nd March 1810 . . .Today, I fell in love'At the age of ten, Mis

From the Emmy-nominated TV writer and New Yorker contributor, a totally new, virtuosic form of memoir: a reconstruction of a beloved grandmother's words and wisdom to tell her family's story with equal parts poignancy and hilarity Bess Kalb saved every voicemail her grandmother Bobby Bell ever left her. Bobby was a force--irrepressible, glamorous, unapologetically opinionated. Bobby doted on Bess; Bess adored Bobby. Then, at ninety, Bobby died. But in this debut memoir, Bobby is speaking to Bess once more, in a voice as passionate as it ever was in life. Recounting both family lore and family secrets, Bobby brings us four generations of indomitable women and the men who loved them. There's Bobby's mother, who traveled solo from Belarus to America in the 1880s to escape the pogroms, and Bess's mother, a 1970s rebel who always fought against convention. But it was Bobby and Bess who always had the fiercest bond: Bobby her granddaughter's fiercest supporter, giving Bess unequivocal love,

This new title in the Who HQ Now format for trending topics details superstar Dwayne “The Rock” Johnson’s legendary career from the ring to the big screen.This new title in the Who HQ Now format for t

Look up! From the Caldecott Medal-winning creator of the Hat trilogy comes a new deadpan gem. Turtle really likes standing in his favourite spot. He likes it so much that he asks his friend Armadillo to come over and stand in it, too.But now that Armadillo is standing in that spot, he has a bad feeling about it... A hilarious meditation on the workings of friendship, fate, shared futuristic visions, and that funny feeling you get that there''s something off somewhere, but you just can''t put your finger on it. Merging broad visual suspense with wry wit and existential silliness, celebrated picture-book creator Jon Klassen gives us a wholly original comedy for the ages.

初學者能夠輕鬆學習實作Android的過程 精選5大主題循序漸進讓你簡單操作 詳盡的步驟圖文解說內容快速上手 本書內容改編自第11屆iT邦幫忙鐵人賽Mobile Development組佳作，以「iOS的角度」去撰寫，用筆記的形式做紀錄，並輔以獨立的小範例做說明。書中的程式語言是使用Java進行開發，重點在Android的畫面與功能上的應用。 【本書精彩內容】 入門篇：介紹開發環境、專案設定、基本

Historical monarchs are interviewed from the grave in this hilarious children’s graphic novel.Discover the incredible stories of rulers throughout history in this hilarious graphic novel that brings t

Critically acclaimed author Emma Otheguy joins Newbery Honor-winning Adam Gidwitz as co-author as the kids travel to Cuba to help the legendary Madre de aguas, now in paperback. In Cuba, it is believe

Who HQ brings you the stories behind the most beloved characters of our time.Find out how Alice in Wonderland became a children's classic.Published in 1865 by British author Lewis Carroll, this fantas

In his penultimate adventure, now in paperback, a devastated but determined Apollo travels to Camp Jupiter, where he must learn what it is to be a hero, or die trying."A clash of mythic intrigues and

A Newbery Honor Book and Walter Honor Book for Younger ReadersOne of the most acclaimed middle grade books of last year is now coming out in paperback. This is a gorgeously written, hopeful novel in v

Now in its second edition, Forensic DNA Evidence Interpretation is the most comprehensive resource for DNA casework available today. Written by leaders in the fields of biology and statistics, including a contribution from Peter Gill, the father of DNA analysis, the book emphasizes the interpretation of test results and provides the necessary formulae in an easily accessible manner. This latest edition is fully updated and includes current and emerging techniques in this fast-moving field. The book begins by reviewing all pertinent biology, and then provides information on every aspect of DNA analysis. This includes modern interpretation methods and contemporary population genetic models available for estimating DNA frequencies or likelihood ratios. Following a chapter on procedures for validating databases, the text presents overviews and performance assessments of both modern sampling uncertainty methods and current paternity testing techniques, including new guidelines on paternity

Get ready for action, adrenaline and adventure in the latest explosive Alex Rider mission by bestselling author Anthony Horowitz, now in paperback. In this adrenaline-fuelled adventure in the number o

A funny story, all about wee, packed full of animal facts! The follow-up to the hilarious Poo! Is That You?Lenny the lemur is on holiday in Alaska. He's skipping across the snow, when he slips in a pu

Orangutans are swinging in trees, tigers are prowling stealthily amonst the foliage, Elephants are walking across the savannah, a green turtle is gliding through the coral and pandas are eating and sleeping. Watch them all come to life in this beautiful Pop-up book by Usborne.

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A brilliantly fun search-and-find puzzle book for children from 6+, developed in consultation with the British Museum. Tom's not only lost in time, he's lost his cat, too! Can you find Tom and his n

A boy who accidentally bonds with a magical Beast must set off on an adventure in the mysterious Woods in this whimsical and cheeky middle grade fantasy debutperfect for fans of Nevermoor and How to T

Now in hardcover for the first time, featuring new illustrations Return to the world of the Wingfeather Saga with Andrew Peterson and his all-star author friends. Immerse yourself in a land of bomnubb

The bestselling paranormal action adventure manga series Bleach continues in novel form as an all-new threat arises!The Quincies' Thousand Year Blood War is over, but the embers of turmoil still smolder in the Soul Society.... Hikone Ubugino and Tokinada Tsunayashiro's combined powers make a mockery of the strongest of the Soul Reapers, Arrancars, Quincies, and Fullbringers in this epic conclusion to the Can't Fear Your Own World arc! As the Soul Society's secrets are brought to light, the full terror of Tokinada's plan is revealed. In the midst of this, Shuhei Hisagi discovers the true ability of his zanpaku-to and the meaning of its name.Can a blade that controls death also sever the consequences of death? A host of powerful characters-including Kenpachi Zaraki and Grimmjow Zaraki Jeagerjaques-make an appearance in the decisive battle, and the volume is complemented by a generous selection of Tite Kubo illustrations!

A brand new title from award-winning Marta Altes. This dog may be alone and without a home, but he's excited and ready to embrace a new life in a new town - and EVERYONE in it! This town is a busy, vi

Learning while playing is the name of the game: Parents are forever looking for things to keep children entertained while on a road trip-whether it's a 10-minute ride to Grandma's house or a flight across the country They'll find the perfect solution in Twirl's Matching Game Books.- Four activities in one Slide the panels to find matching pairs; spot the creatures in the big picture; identify them by their characteristics; play hide-and seek with the matching pairs, or even come up with games of their own- An interactive game book that trains visual memory, increases attention to detail, and builds vocabulary too- Colorful and whimsical illustrations of a wide variety of bugs and little creaturesFans of Matching Game Book: Bugs will also enjoy the interactive learning in other books in the Matching Game Book series, including Animals, Zoom , and Colors.- Ideal for travelling and learning on the go- Books for 3-5 years old- Books for preschool and kindergarten learning

How did an immigrant who sold sewing supplies in New York City reinvent himself in the American West by creating the most iconic pair of pants in the world? Find out in this addition to the Who HQ lib

Acclaimed author Kate Messner blends a hijinks-filled mystery with the timely #MeToo movement in a heartfelt and important novel.When Mia moves to Vermont the summer after seventh grade, she’s recovering from the broken arm she got falling off a balance beam. Packed away in the moving boxes under her clothes and gymnastics trophies is a secret she’d rather forget.Mia’s change in scenery brings day camps, new friends, and time with her beloved grandmother. But Gram is convinced someone is out to destroy her cricket farm. Is it sabotage or is Gram’s thinking impaired from the stroke she suffered months ago? Mia and her friends set out to investigate, but can they uncover the truth in time to save the farm? And will solving one mystery empower Mia to confront the secret she’s been hiding?In a compelling story rich with friendship, science, and summer fun, a girl finds her voice while navigating the joys and challenges of growing up.

Three BFFs take a stand against gender bias in the sixth book in this POB friendship series told entirely in text messages, emojis, and passed notes.TBH, sometimes boys say dumb things about girls. An

The last great master of the ukiyo-e tradition, Hiroshige produced works of subtle yet intense color. This collection of prints, first published in the 1850s, contains images of each of Japan’s provinces. Created during Hiroshige’s highly productive later years, this series was an ambitious project that captured a crucial moment in Japan’s history, a decade before the Meiji Restoration would open the doors to industrialization and Western influence.One of its most striking characteristics is the vertical presentation, which allowed Hiroshige to experiment with perspective. His sweeping panoramas of the beautiful countryside combine the illusion of distance with a depth of detail that draws the viewer in. In addition to these glorious landscapes, Hiroshige’s depictions of busy urban centers provide a rare insight into daily life in the Edo era.This beautiful slip- cased edition includes two volumes: a complete set of seventy prints and a separate booklet that provides an introduction to

Winnie and Wilbur are visiting the wild animals from their library book in real life. It's exciting to journey by magic all around the world, but there is trouble for our travellers when the animals get hungry! A whistle-stop tour full of hilarious slapstick fun, with plenty of details to pore over in Korky Paul's intricate and spellbinding artwork. The best-selling Winnie and Wilbur series has been delighting readers both young and old since 1987 and Winnie and Wilbur have become favourite characters in homes and schools all over the world.

The dolls love travelling the world in their girl band. Use the stickers to dress them for a dance rehearsal, a day in the recording studio, a big performance and their jet-setting world tour. With ov