Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Featured in The Times' Books of the Year 2018It's Christmas time and Pip and Posy are busy decorating the tree with candy sticks, and biscuits, and a beautiful sugar star. But the strange thing is tha

This Little Golden Book is based on Disney Frozen 2—which is in theaters November 22, 2019!Directed by Jennifer Lee and Chris Buck, and produced by Peter Del Vecho, Walt Disney Animation Studios’ feat

Little owl is hiding! Children will love peeping through the holes in this charming book to try and find the elusive owl. As they make their way through the forest they keep thinking they have found t

As they get ready for Chrsitmas Winnie and Wilbur go an epic quest to make sure Santa gets a present, too. A brand new story in a fabulous new format with stylish full colour illustrations, this is th

'The perfect mix of funny, foul and fearful' Metro'Brilliantly imagined . . .laugh-out-loud funny' Sunday ExpressThe fifth book in the bestselling, gorgeously gothic and wickedly funny Amelia Fang ser

《Allies》是Alan Gratz所著的一部多視角歷史小說，以二戰期間最著名的諾曼第登陸（D-Day，1944年6月6日）為背景。小說通過六位來自不同國家、不同年齡的青少年士兵和少年角色，展現了盟軍為打敗納粹德國而齊心協力的歷史壯舉。故事描繪這些少年在戰爭前夕及登陸作戰中的種種挑戰與抉擇，包括他們在海上與陸地面臨的生死關頭、彼此間的友情與合作，以及帶有青春氣息的內心掙扎與勇氣。每個角色的故事相互交織，形成豐富的戰爭視角和人性展現。全書節奏明快，情感真摯，既有史詩般的戰爭場面，也有細膩動人的個人故事。這本書適合中年級至青少年讀者，讓讀者更深入理解二戰歷史，並感受和平的珍貴與人類的堅韌精神。"A rousing and humane tribute to D-Day troops" - New York Times Book Review From Alan Gratz, the highly acclaimed, New York Times bestselling author of the blockbuster Refugee, comes another thrilling multi-perspective novel, this time centered around D-Day. D-Day, June 6, 1944: the most expansive military endeavor in history. No less than world cooperation would bring down Hitler and the Axis powers.And so people -- and kids -- across the globe lent their part. From the young US soldiers in the boats to spies in the French countryside, the coordination of thousands came together. Alan Gratz, author of the New York Times bestselling Refugee, explores the necessity of teamwork and heroism in d

HarperCollins is proud to present its incredible range of best-loved, essential classics.Young Charlotte Heywood arrives in Sanditon, a newly established seaside resort, with the Parkers: patrons and

From the award-winning Bethan Woollvin, creator of the iconic Little Red and Rapunzel comes Hansel and Gretel, a very funny twist on the classic fairy tale printed in vibrant pantone inks.Naughty litt

A book and CD edition of the much-loved picture book classic Giraffes Can't Dance, with audio read by Hugh Laurie.Gerald the giraffe longs to go to the great Jungle Dance, but how can he join in when

Sunday Times Culture Magazine Children’s Book of the Week, Feb 2019A foolish knight is certain that his side of the wall is the safe side in this clever, amusing and timely picture book.A little knight is very happy that his wall protects him from the dangers that are sure to lurk on the other side. However, he is too busy mending a hole in his wall to notice the mounting dangers on his own side. Luckily he is rescued by one of the ‘baddies’ on the other side, and finds out that the other side of the wall is actually a much pleasanter place to be.

The extraordinary #1 New York Times bestseller hailed as one of the best books of all time, is now the basis for an HBO original series beginning in Fall 2019, starring Dafne Keen, Ruth Wilson, James

Part of the best-selling Little People, BIG DREAMS series, Mary Shelley tells the inspiring true story of the English novelist and creator of Frankenstein.New in the critically acclaimed Little People

Prepare to be swept up by this exquisite novel that reminds us that grief and love can open the world in mystical ways.Caroline Murphy is a Hurricane Child.Being born during a hurricane is unlucky, an

The Arctic Fox’s Journey is a picture book in the award-winning Let’s-Read-and-Find-Out series about the arctic fox’s dangerous winter journey.During the winter, the arctic fox begins an incredible jo

A Sensational Encounter with High Socialist China is a recollection of the historic visit of fourteen American students (and one Canadian) to China in 1971. The visit was one of the first approved for

Four starred reviews!A Today Show Best Book of the YearAn NPR Favorite Book of 2019From E.B. White Read Aloud honor artist Matthew Forsythe comes an “extraordinary” (Publishers Weekly, starred review) picture book about a magical drum, an emerald forest, and the little frog who dares to make her own music.The biggest mistake Pokko’s parents ever made was giving her the drum. When Pokko takes the drum deep into the forest it is so quiet, so very quiet that Pokko decides to play. And before she knows it she is joined by a band of animals —first the raccoon, then the rabbit, then the wolf—and soon the entire forest is following her. Will Pokko hear her father’s voice when he calls her home?Pokko and the Drum is a story about art, persistence, and a family of frogs living in a mushroom.“In embracing one’s own beat, Pokko discovers, extraordinary things can happen.” —Publishers Weekly (starred review)“Forsythe's coy, playful writing is a wonder on its own, but the lush...illustrations beaut

紐約時報暢銷作家暨插畫家艾蜜莉‧溫菲爾德‧馬丁，以細膩筆觸重新詮釋經典童話《雪白與玫瑰紅》，打造出一個既魔幻又感人的童話世界。《雪與玫瑰》講述兩位姐妹在父親神秘失蹤、母親陷入悲傷後，踏入充滿魔法的森林，展開一場破解詛咒的冒險。全書充滿夢幻彩圖與獨特角色，在奇幻與現實交織中流露溫柔情感與深刻寓意，是一本讀者會反覆翻閱、沉醉其中的經典之作。獻給所有仍相信故事能帶來奇蹟的大小讀者。A fairy-tale reimagining of Snow White and Rose Red from the New York Times bestselling author-illustrator Emily Winfield Martin. Filled with stunning illustrations. "Emily Winfield Martin — reimagine[s] Brothers Grimm fairy tales, treating delight, with a few grisly bits folded in, as its own reward. The deeper meanings of these stories do emerge, but the pleasure they give is paramount." —The New York TimesSnow and Rose didn’t know they were in a fairy tale. People never do. . . .Once, they lived in a big house with spectacular gardens and an army of servants.Once, they had a father and mother who loved them more than the sun and moon.But that was before their father disappeared into the woods and their mother disappeared into sorrow.This is the story of two sisters and the enchanted woods that hav

Explore the animal kingdom like never before with the Animal Atlas from Lonely Planet Kids. Unfold maps to reveal animals from every continent and lift the flaps to see their unique environments and habitats. Discover a world of animal facts, life-size photos and creature features - from a bear's paw and a baby turtle to an anteater's tongue and a goliath birdeater, the world's heaviest spider. EEK! All drawn to scale so you can measure yourself against them. You'll find animals living on freezing ice caps, high on snowy mountain peaks, in parched deserts and down in the dark depths of the ocean. They fly through the air, crawl among trees, burrow into the earth, plunge through the seas, and prowl the forests - and range from the tiniest of insects too small to see without a magnifying glass to the blue whale, which is longer than three buses! The book is divided into seven sections: North America, South America, Europe, Africa, Asia, Australasia, Oceania & Antarctica - each with a

ew in the critically acclaimed Little People, BIG DREAMS series, discover the incredible life of Mary Shelley, the English novelist and creator of Frankenstein.When Mary Shelley was a little girl, she

Discover the spellbinding magic of Swan Lake in this musical retelling of the ballet – push the button on each beautiful scene to hear the vivid sound of an orchestra playing from Tchaikovsky’s score.

Discover the essential ways that we are connected to the earth in Precious Planet, and learn what you can do to take care of our planet.How amazing is the home we all share, planet Earth! It's home to

Joining bestselling Mindful Kids and Yoga Pretzels, Global Kids expands the scope of Barefoot's innovative activity card decks by inviting children to participate in 50+ crafts, food, games, festivals

Almost two dozen nations currently generate nuclear energy, and eighteen more are planning to construct reactors in the near future. This expansion increases the need for the international community t

Jennifer Giesbrecht horrifies and delights with The Monster of Elendhaven, a dark fantasia of revenge in a wholly original world“Jennifer Giesbrecht's The Monster of Elendhaven is a black tide of perv

If you have a mission, a dream to explore, but no one like you has achieved it before...Meet Dr. Ellen Ochoa—a determined space pioneer with a stellar symphony of talents.Growing up in a family of imm

Mia learns to control time in this fifth adventure of the Mia Mayhem chapter book series!When Mia first learned she had superpowers, there was one ability that always came rather naturally: freezing t

Alia Muhammad Baker's library in Basra, Iraq, has been a meeting place for those who love books for the past fourteen years. Now war has come, and Alia fears that the library--along with the thirty th

Will Franny ever prove to her dad that crows and kids can be friends?Franny has a new friend—a crow who brings her presents in its beak. Like a red button! And a silver heart! Franny’s dad doesn’t bel

Luna and her best friend, Franklin the dragon, love stories and want to visit all the places they’ve read about in books. But for all their reading they still don’t know where dragons come from. And F

Co-written with psychologists and a college student who has experienced anxiety herself, this is a relatable and straightforward guide to managing worry in emerging adulthood. As well as providing tried-and-tested advice and exercises that are proven to reduce feelings of anxiety, it includes recovery stories from people who have managed their symptoms successfully. It begins with what is difficult and challenging about young adulthood and how you can deal with uncertainty in life.It goes on to examine change and challenges, giving tips about what can help in specific scenarios such as exams, relationships, leaving home and interviews. The guide also includes strategies and techniques for coping with panic attacks; self-care; and calming your mind. The guide uses a range of evidence-based approaches, including CBT, DBT, Compassion Focused Approaches and Mindfulness so you can work out the techniques that are best for you.The signposting included throughout guides young adults towards f

Isadora Moon is special because she's different. Her mum is a fairy and her dad is a vampire and she's a bit of both. Isadora loves playing in the snow, especially when her creations come to life! But snow magic can't last forever.Will she be able to save her new friends before they melt away?With irresistible pink and black artwork throughout by author/illustrator Harriet Muncaster and a totally unique heroine with an out-of-this-world family, this is a beautiful, charming, and funny series of first chapter books. Perfect for fans of Claude, Dixie O'Day, and Squishy McFluff, Isadora Moon is the ideal choice for readers who want their magic and sparkle with a bit of bite!

Mac B. is back on another madcap adventure -- this time a stolen raven threatens to topple the Queen and it's up to Mac to smackdown his KGB rival once and for all!Get the latest in the New York Times

Two young adventure-loving and gadget-obsessed penguins dream of joining the FBI (Frosty Bureau of Investigation) in Sam Hay's hilarious new illustrated chapter book series, Spy Penguins.Adventure-lov

1. Maisy's NurseryIt’s time for school! Maisy and her friends play with building blocks, practice their counting, and sit down for storytime. A pop-up classroom scene waits at the end of the book with paper press-outs of Maisy and her pals. Kids will relish the chance to play teacher and decide the lessons, all the while putting their imaginations to the test and learning about the routines that make up a day at school.2. Maisy's FarmWhat’s more fun than a day on the farm? A day on the farm with Maisy! Maisy’s Farm is an amazing three-dimensional pop-up farm full of things to do and animals to love. The sturdy stand-up Maisy figure has arms that move and a tractor to ride in. Children will love to help Maisy milk the cow, collect the eggs, tend to the vegetable patch, and more! With twenty-six full-color press-out pieces and loads of flaps to lift and tabs to pull, there’s no end to the fun on Maisy’s farm.3. Maisy's HouseMaisy’s fans are invited to join the friendly mouse as she goes

A New York Times Bestseller!While Isa is off at sleepaway orchestra camp, Jessie, Oliver, Hyacinth, and Laney are stuck at home in the brownstone with nothing to do but get on one another’s nerves. Bu

Everyone is getting ready for a party down at No. 10 Pomegranate Street!In each apartment, someone is preparing a special dish to share with their neighbours. There’s black bean soup, meatballs, cocon

Girl, Edna O’Brien’s hotly anticipated new novel, envisages the lives of the Boko Haram girls in a masterpiece of violence and tenderness. I was a girl once, but not anymore.So begins Girl, Edna O’Br

In September, Mama Earth sighs out the first autumn frost, which crunches under children’s feet. Mama Earth looks after nature’s plants and animals throughout the year—singing lullabies to fat bears i

Books, books, books! Judy’s got books on the brain as she prepares for a totally RARE trivia competition. Has reading always been this exciting?Judy Moody is in it to win it. Win the Book Quiz Blowout

Curious minds are rewarded with curious answers in a fantastical bedtime book by Mac Barnett and Isabelle Arsenault.Why is the ocean blue? What is the rain? What happened to the dinosaurs? It might be