Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

In most non-democratic countries, today governing forty-four percent of the world population, the power of the regime rests upon a ruling party. Contrasting with conventional notions that authoritarian regime parties serve to contain elite conflict and manipulate electoral-legislative processes, this book presents the case of China and shows that rank and-file members of the Communist Party allow the state to penetrate local communities. Subnational comparative analysis demonstrates that in 'red areas' with high party saturation, the state is most effectively enforcing policy and collecting taxes. Because party membership patterns are extremely enduring, they must be explained by events prior to the Communist takeover in 1949. Frontlines during the anti-colonial Sino-Japanese War (1937–1945) continue to shape China's political map even today. Newly available evidence from the Great Leap Forward (1958–1961) and the Cultural Revolution (1966–1976) shows how a strong local party basis sus

The Thea Sisters are learning cool survival techniques, but will that be enough to get them through a perilous night in the woods?

I've landed -- along with my brother, Jonah, and our dog, Prince -- in the fairy tale of The Princess and the Pea! When I can't fall asleep on top of a hundred mattresses, the kingdom decides I must be the princess they're looking for. Talk about royal treatment -- I'm suddenly being waited on hand and foot. Plus, I get unlimited ball gowns, sparkly jewelry, and ice cream. But can we find a REAL princess to run the kingdom?Now we have to:- Hold a princess contest- Defeat an obnoxious prince- Escape hungry alligators- Make it back home There's no time to snooze -- may the best princess win!

Buzz is making a movie about aliens from outer space. When the action begins, superheroes Fly Guy and Buzz Boy are protecting a secret fort in the sky when an alien ship captures them! The duo must ou

The biggest movie of 1985 is now the wildest and wackiest picture book of 2018! Even 30 years after its theatrical debut, BACK TO THE FUTURE is a perennial favorite in classrooms and family movie nigh

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。 施德樓 防乾

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。施德樓 防乾油性麥克筆(圓頭)．超強韌抗壓筆尖，筆頭不內縮．卓越的防抹及防水性．耐候性超強，黑色與綠色可保證10年不褪色．油性墨水，無毒、無臭，顏色清晰亮麗．快乾-保持文件、物品表面清潔．48小時離蓋防乾．PP製筆桿及筆蓋，確保筆具有較長的書寫壽命．機艙適用-自動壓力平衡，不會因飛機上氣壓轉變引致漏墨成份：專利無毒無臭酒精性墨水、PP無孔隙防乾筆蓋商品規格：H140xW17xD17mm(測量有±2cm誤差值)筆尖：圓頭約2mm數量：1入顏色：棕產地：德國保存期限：妥善保存五年適用年齡：九歲以上用途：一般書寫使用使用方法：拆封即可使用注意事項：●請勿將筆尖對準他人及眼睛，以免發生危險●用畢請蓋緊筆帽●請勿放置於潮濕處或高溫日照下●請勿放置於幼兒易取處●請勿接近火源以及腐蝕性溶劑●內有細小配件，請勿放入口中，以免誤食●九歲以下兒童請在成人監護下使用●三歲以下兒童不宜商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

One of today's most widely read philosophers considers the shift in violence from visible to invisible, from negativity to excess of positivity.Some things never disappear -- violence, for example. Vi

這本書是作者Adam Kay 的親身經歷，記錄了他在英國國家醫療服務體系 (NHS) 擔任婦產科住院醫師時的日記 。他以一種極其幽默、尖銳且時而令人心碎的方式，揭露了醫生這個職業不為人知的一面 。書中充滿了各種令人捧腹大笑的荒謬日常，例如：處理病人塞進體內的各種奇葩物品、應對高壓高工時下扭曲的心態（像是聽到病人威脅要打斷他的腿時，第一個念頭竟是「太好了可以休假了」） 。然而，在這些爆笑故事的背後，卻是血淋淋的現實：每週工作97小時、薪資微薄、永無止盡的瘋狂白晝與睡眠不足的夜晚，以及那些永遠失蹤的週末假期 。​這本書不僅僅是一本搞笑的醫生日記，它更深刻地揭示了醫療體系前線人員所面臨的巨大壓力、官僚體制的荒謬，以及那些在生死一線間的驚恐與心碎時刻 。書名《This is Going to Hurt》不僅是醫生對病人說的話，也像是作者對讀者打的一劑預防針——在爆笑之後，隨之而來的是對醫療人員處境的深刻反思與不捨 。Read by the author, Adam Kay.The multi-million copy bestsellerBook of the Year at The National Book Awards‘Painfully funny. The pain and the funniness somehow add up to something entirely good, entirely noble and entirely loveable.' - Stephen FryWelcome to the life of a junior doctor: 97-hour weeks, life and death decisions, a constant tsunami of bodily fluids, and the hospital parking meter earns more than you.Scribbled in secret after endless days, sleepless nights and missed weekends, Adam Kay's This is Going to Hurt provides a no-holds-barred account of his time on the NHS front

Two greedy squirrels learn to share in the third hilarious rhyming adventure from the bestselling creators of THE LION INSIDE. Greedy squirrels Cyril and Bruce both have their sights on a very special

The incredible true story of the card-counting mathematics professor who taught the world how to beat the dealer and, as the first of the great quantitative investors, ushered in a revolution on Wall

Why Enlightenment culture sparked the Industrial RevolutionDuring the late eighteenth century, innovations in Europe triggered the Industrial Revolution and the sustained economic progress that spread

On the last day of a family vacation, a little girl is as blue as the sea, and her shoes are filled with sand. What should she do with all of this sand? Together, she and her brother decide to plant the grains of sand, and imagine what will grow. A field of beach umbrellas, to wave hello to the sun? Or a forest of windmills, to fill the sails of a boat? Before drifting off to sleep, the girl has her dad promise they’ll go back for new grains of sand next year.Spare text will prompt readers to wonder and imagine their own possibilities, while illustrations in a palette of yellows and grays convey the sun-soaked joy and the lingering nostalgia of family vacations well remembered.

A sensitive and multidimensional portrait of what it means to live with mental illness in contemporary Japan.

It's her funniest adventure yet! A few sessions with a college-age math tutor turn Judy into a jargon-spouting polygon princess. Crucial!Judy Moody is in a mood. Not a good mood. And definitely NOT a

Winner of the Scott O'Dell Award Five Starred Reviews!A New York Public Library Best Book for Kids, 2016Grown-ups lie. That’s one truth Beans knows for sure. He and his gang know how to spot a whopper a mile away, because they are the savviest bunch of barefoot conchs (that means “locals”) in all of Key West. Not that Beans really minds; it’s 1934, the middle of the Great Depression. With no jobs on the island, and no money anywhere, who can really blame the grown-ups for telling a few tales? Besides, Beans isn’t anyone’s fool. In fact, he has plans. Big plans. And the consequences might surprise even Beans himself.Return to the wonderful world of Newbery Honor Book Turtle in Paradise through the eyes of Turtle’s cousin Beans!"A surprising coming-of-age story with a remarkably honest message." —The New York Times"[Holm] captures this colorful slice of Depression history with her usual vivacious wit. . . . Children will love Beans." —Shelf Awareness, Starred"A novel as en

Erin Hunter’s #1 bestselling Warriors series continues with the third book in the Vision of Shadows arc! ShadowClan has fallen. A group of rogues now rules the pine forest, and their cruel leader, Dar

“Sweetly funny.” —Entertainment WeeklyNew York Times bestselling authorLara Jean’s letter-writing days aren’t over in this surprise follow-up to the bestselling To All the Boys I’ve Loved Before and P

Fans of Girl, Interrupted, Thirteen Reasons Why, and All the Bright Places will love the New York Times bestselling novel Girl in Pieces."A haunting, beautiful, and necessary book that will stay with

It’s Backwards Day, so Judy Moody double-dares herself to become Queen of the Good Mood for one whole week. Can she do it?Will the real Judy Moody please stand up? In honor of Backwards Day, Jud

The Fairytale Hairdresser meets Narnia in this magical new picture book series about a girl and her enchanted dressing-up wardrobe! Join Molly on her first magical adventure as she discovers an encha

準備好了嗎？Bizzy Bear 要出發比賽囉！快幫他按下起跑燈、開動賽車、繞過彎道，最後舉旗衝向終點！這本書讓孩子親手操作五個機關，參與整場刺激的比賽過程。畫面色彩明亮、情境節奏明快，就像一場賽道上的小冒險。全書搭配輕快押韻的敘事節奏，讓孩子在操作中自然而然開口說、認識情境與語彙。操作簡單、安全耐翻，是學齡前孩子的閱讀啟蒙好選擇。Five easy to move sliders, a rhyming story and lots to spot and say in this series of bright, interactive board books for toddlers!Today, Bizzy Bear is taking part in a big race – ready, steady, go! Turn the lights on to signal the start, help him speed along in his racing car and zoom around the track. Then lift the flag as he crosses the finish line! But will he get there first? A funny little story with loads of details to spot and chat about.This story needs YOU! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life! The high level of interaction builds confidence and engagement with books, which is a key stepping-stone to reading for toddlers.Illustrated by multi-award-winning Benji Davies, illustrator of The Storm Whale, and Grandad’s I

First Stories: Sleeping Beauty is the perfect introduction for young children to this classic fairy tale. Push, pull and turn mechanisms bring the story to life and introduce the main characters: the sleeping princess and the prince who wakes her. This well-loved fairy tale is beautifully imagined for a new generation by children's illustrator Dan Taylor. Titles to collect: Snow White, Alice in Wonderland, Cinderella, Rapunzel, The Jungle Book, Little Red Riding Hood, Jack and the Beanstalk, The Nutcracker, Beauty and the Beast, The Little Mermaid, Peter Pan, Goldilocks and the Three Bears, The Three Little Pigs and Hansel and Gretel.商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

The perfect picture book for children who have discovered the power of the word "NO"!Ned the knight ALWAYS does exactly what he's told. When his parents ask him to pick up his toys, dig up the cabbages or go to bed on time, he does it all with a smile. And when the dragon swoops into town every night, he always runs inside just as he's asked.But one morning, instead of saying,"yes," he says, "NO!" He will NOT help his dad find his shield, his arrow or his bow, and he will certainly NOT let the butcher go past. That night, he refuses to go inside, and in doing so he confronts the dragon, making a very unlikely friend . .. This rambunctious, rhyming picture book is a brilliantly observed portrait of children's behaviour, with vibrant, detailed illustrations by the enormously talented Kate Hindley. Children and adults alike will fall in love with little crosspatch knight Ned and the very cute and lonely dragon he befriends.Lucy Rowland is a children's speech and language therapist has wri

The Lumberjanes short stories collected for the first time in paperback! Join April, Jo, Mal, Molly and Ripley as they explore their all-girls camp. From ghost ponies to strange plants, these Lum

Shoyo Hinata is out to prove that in volleyball you don't need to be tall to fly!Ever since he saw the legendary player known as “the Little Giant” compete at the national volleyball final

This story follows a little boy named Raphael, whose daily rhythm is steeped in his immense affection for his friend Jerome. The two boys share jokes and snacks and plan future adventures to the Himal

It’s the series that could! Built for the way babies read, INDESTRUCTIBLES are now selling 400,000 copies a year, and the series has over 3 million copies in print. Sweet, soothing books, uniquely des

It’s the series that could! Built for the way babies read, INDESTRUCTIBLES are now selling 400,000 copies a year, and the series has over 3 million copies in print. Sweet, soothing books, uniquely des

Thor's hammer is missing again. The thunder god has a disturbing habit of misplacing his weapon--the mightiest force in the Nine Worlds. But this time the hammer isn't just lost, it has fallen into enemy hands. If Magnus Chase and his friends can't retrieve the hammer quickly, the mortal worlds will be defenseless against an onslaught of giants. Ragnarok will begin. The Nine Worlds will burn. Unfortunately, the only person who can broker a deal for the hammer's return is the gods' worst enemy, Loki--and the price he wants is very high. Bonus content includes a chapter from Magnus Chase Book 3: SHIP OF THE DEAD and a chapter from the first Rick Riordan Presents book, ARU SHAH AND THE END OF TIME by Roshani Chokshi.

The #1 New York Times bestselling series! The electrifying second installment in the Red Queen series has all the drama, intrigue, and steamy romance that made it a #1 New York Times bestseller. Mare

水戶岡銳治是以設計JR九州的超豪華臥鋪列車“七星in九州”而聞名于世的設計師，本書講述了他在設計列車和車站時，經歷的各種“戰斗”。作者堅持站在用戶角度，說服了自己的客戶—鐵道公司、車輛制造商和國土交通省，通過不斷改進自己的想法，最終完成了設計。書中采用大量篇幅，講述作者如何與其他負責設計列車配件的專業人士共同工作，如設計洗臉池的第14代井田柿右衛門。通過閱讀本書，不僅能看到大量作者工作時的心境和訣

Who's fallen asleep? Lots to look at and talk about in this colorful new title from Usborne. Babies will marvel at the colourful pictures and the fun rhyming questions and will share a delightful mome

Everimal is an ingenious interactive book for young readers with a powerful message: everything that is can be held in the palm of your hand.Beginning with a human hand, this tale follows a charming b

For so many around the world, it was in the cinema that they saw their first glimpse of martial arts. Through the films of Lau Kar Leung, among others, they came to appreciate the power and skill of m

Who's the smarty pants in your family? Packed with number and logic puzzles, riddles, dingbats, codes and much more, this fun and challenging travel-themed activity book is perfect for car journeys, h

本書分為上下兩冊。下冊內容為：「河洛語的『是非問句』與『正反問句』」、「華語的正反問句：華語與河洛語的比較分析」、「河洛語的動後成分：結構與功能」、「台灣河洛語的『限定子句』與『非限定子句』」、「On the kam-question in Holo」、「On Reduplication of Adjectives in Chinese: A Comparative Study of Mandar

The book provides the reader with a multifaceted picture of mathematics education in Israel, put into an international perspective where relevant. It is intended to give an overview of a wide range of

In this book, the Zhou-Yi and its Divination Process are reviewed from mathematical perspectives which provide a completely new understanding of its meaning and operation features. The highlights are:

O’Neil所著《高等工程數學》第八版包括下列幾個特點，旨在使學生更容易接近數學以及對數學產生興趣： 一、新增「數往知來」（Math in Context），是由工程師為工程學生編寫的短文，從他們的角度提供洞察力，了解數學如何在各種現實世界的工程項目和設置中出現。 二、本書的組織已重新設計，以便更有效地關注特定主題。例如，增加了史特姆―李奧維里問題、波動和熱方程式的解法包括處理驅動函數的技術，以及