Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This book takes an in-depth look at the development of the private education sector in modern China. Readers will find valuable data and materials never before presented in such an accessible and tran

This monograph provides a new perspective on business modeling in small and medium-sized enterprises (SMEs). It builds on the theoretical framework on innovation and revisits the Zahra and George (200

Modeling and Control of Power Electronics Converter Systems for Power Quality Improvements provides grounded theory for the modeling, analysis and control of different converter topologies that improv

This book explains the development of theoretical computer science in its early stages, specifically from 1965 to 1990. The author is among the pioneers of theoretical computer science, and he guides

The fate of the world is in the hands of detective of the supernatural R. F. Jackaby and his intrepid assistant, Abigail Rook. An evil king is turning ancient tensions into modern strife, using a blen

This book discusses the fusion of mobile and WiFi network data with semantic technologies and diverse context sources for offering semantically enriched context-aware services in the telecommunication

Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues,

Dosage Form Design Parameters, Volume II, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues,

The drug control regime established by the international community has not succeeded in curbing either the demand for, or the offer of, narcotics. But, despite a series of developments in the Americas

Chemometrics in Spectroscopy, Second Edition, provides the reader with the methodology crucial to apply chemometrics to real world data. It allows scientists using spectroscopic instruments to find ex

Medicine in Modern Britain 1780-1950, provides an introduction to the development of medicine – scientific and heterodox, domestic and professional – in Britain from the end of the early modern period

Medicine in Modern Britain 1780-1950, provides an introduction to the development of medicine – scientific and heterodox, domestic and professional – in Britain from the end of the early modern period

The primary goal of AutoCAD 2019 Tutorial Second Level 3D Modeling is to introduce the aspects of computer based three dimensional modeling. This text is intended to be used as a training guide for bo

Anisotropic Particle Assemblies: Synthesis, Assembly, Modeling, and Applications covers the synthesis, assembly, modeling, and applications of various types of anisotropic particles. Topics such as ch

Microeconomic Modeling in Urban Science proposes an interdisciplinary framework for the analysis of urban systems. It portrays agents as rational beings modeled under the framework of random utility b

What are the factors that determine how central governments respond to demands for independence? Secessionist movements are numerous and quite varied in form, but the chief obstacle to their ambitions is the state itself, which can deny independence demands, deploy force if need be, and request that the international community respect its territorial integrity by not recognizing the breakaway region. Age of Secession focuses on this crucial but neglected moment in the life of a secessionist movement. Griffiths offers a novel theory using original data on secessionist movements between 1816 and 2011. He explains how state response is shaped by international and domestic factors, when conflict is likely, and why states have proliferated since 1945. He mixes quantitative methods with case studies of secessionist movements in the United Kingdom, Russia/Soviet Union, and India. This is an important book for anyone who wants to understand the phenomenon of secession.

This open access book examines more than two centuries of societal development using novel historical and statistical approaches. It applies the well-being monitor developed by Statistics Netherlands

Doug Hall shares data-proven methods that can make sales, marketing, and business development measurably more effective.

The gothic novel in Ireland, c. 1760-1829 offers a compelling account of the development of gothic literature in late-eighteenth and early-nineteenth century Ireland. Countering traditional scholarly

The processes of gemination, lenition, and vowel lengthening are central to the study of phonology, as they reveal much about the treatment of quantity in a given language. Using data from older language stages, modern dialects and standard languages, this study examines the interdependence of vowel and consonant quantity in the history of the Germanic branch of Indo-European. Kurt Goblirsch focusses on the various geminations in Old Germanic languages (West Germanic gemination, glide strengthening, and expressive gemination), open syllable lengthening in German, Dutch, Frisian, English, and Scandinavian languages, and the major lenitions in High German, Low German, and Danish, as well as minor lenitions in Bavarian, Franconian, and Frisian dialects. All of these changes are related to the development of the Germanic languages from distinctive segmental length to complementary length to syllable cut. The discussion challenges traditional theoretical assumptions about quantity change in

This overview of prescription drug abuse includes historical background, key concepts, and discussion of the prevalence of drug abuse, treatments, and policy issues implicated in ending the epidemic.?

The world is becoming increasingly complex, with larger quantities of data available to be analyzed. It so happens that much of these "big data" that are available are spatio-temporal in nature, meani

Adaptive Learning Methods for Nonlinear System Modeling presents some of the recent advances on adaptive algorithms and machine learning methods designed for nonlinear system modeling and identificati

Global Flood Hazard Flooding is a costly natural disaster in terms of damage to land, property and infrastructure. This volume describes the latest tools and technologies for modeling, mapping, and pr

"By examining the history of universal history from the late Middle Ages until the early nineteenth century we trace the making of the global. Early modern universal history can be seen as a response

Using longitudinal data from the Swiss Household Panel to zoom in on continuity and change in the life course, this open access book describes how the lives of the Swiss population have changed in ter

Learning Spaces in Africa traces the development of school building design in Western and Southern Africa from the mid-19th to the early 21st century. In doing so, Uduku explores the architecture, soc

This distinctive and enlightening book explores the development of tea drinking in China, using tea culture to explore the profound question of how Chinese have traditionally expressed individuality.

This book explores the development of territorial identity in the late prehistoric, Roman, and early medieval periods. Over the course of the Iron Age, a series of marked regional variations in materi

The most devastating attacks against the Jews of medieval Christian Europe took place during the riots that erupted, in 1391 and 1392, in the lands of Castile and Aragon. For ten horrific months, hundreds if not thousands of Jews were killed, numerous Jewish institutions destroyed, and many Jews forcibly converted to Christianity. Benjamin R. Gampel explores why the famed convivencia of medieval Iberian society - in which Christians, Muslims and Jews seemingly lived together in relative harmony - was conspicuously absent. Using extensive archival evidence, this critical volume explores the social, religious, political, and economic tensions at play in each affected town. The relationships, biographies and personal dispositions of the royal family are explored to understand why monarchic authority failed to protect the Jews during these violent months. Gampel's extensive study is essential for scholars and graduate students of medieval Iberian and Jewish history.

This edited volume presents current archaeological research and data from the major early Acheulean sites in East Africa, and addresses three main areas of focus; 1) the tempo and mode of technologica

This book describes the development of systems of magnetic resonance imaging using the higher magnetic field strength of 3 tesla, in comparison to the current gold standard of 1.5 tesla. These new sys

The idea that international development aid needs to be better managed and coordinated gained currency in the early 1990s. The increasing emphasis on management has resulted in the present vogue of ‘m

To analyze complex situations we use everyday analogies that allow us to invest in an unknown domain knowledge we have acquired in a known field. In this work the author proposes a modeling and analys

As society changes, so do the demands of urban development - these themes are discussed using examples from all over Europe. In certain parts of the world, the founding of new towns and extensive urb

The guide pharmacists and students turn to first for cutting-edge coverage of drug informationThe goal of Drug Information: A Guide for Pharmacists, Sixth Edition is to teach students and practitioner

This is an introductory game theory book that quickly moves readers through the fundamental ideas of game theory to enable them to engage in creative modeling projects based on game theoretic concepts

Early on a cold Somerset morning, ten year old Alesha Daniels is reported missing by her father, a violent alcoholic. Her mother, a known drug addict, is found unconscious, but it’s her mother’s boyfr

This book fills the gap in research of the early stages of literary Gothicism and examines its transfer from England, via French, to Poland-Lithuania in the late eighteenth and early nineteenth centur

There continues to be a vigorous public debate in our society about the status of climate science. Much of the skepticism voiced in this debate suffers from a lack of understanding of how the science works - in particular the complex interdisciplinary scientific modeling activities such as those which are at the heart of climate science. In this book Eric Winsberg shows clearly and accessibly how philosophy of science can contribute to our understanding of climate science, and how it can also shape climate policy debates and provide a starting point for research. Covering a wide range of topics including the nature of scientific data, modeling, and simulation, his book provides a detailed guide for those willing to look beyond ideological proclamations, and enriches our understanding of how climate science relates to important concepts such as chaos, unpredictability, and the extent of what we know.