Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

On the eve of becoming a married man, the Counselor makes a risky entree into the drug trade—and gambles that the consequences won’t catch up to him.Along the gritty terrain of the Texas–Mexico border

The kingdom has been breached. Beware The Griefer! Four friends must defend their shared world in this official Minecraft novel.With middle school starting, Lam Đặng is officially ready for a change. He loves to play Minecraft, embarking on epic builds with his crew—Jazz, Elias, and Britt—in their beloved shared world, the Kingdom of the Killer Bunnies. But Lam also wants to try new things and meet new people. So maybe going into sixth grade with a little distance from his old friends wouldn’t be such a bad thing. . . .Lam’s plans change, though, when mysterious letters show up in the gang’s lockers. Someone calling themselves The Griefer is threatening to destroy everything the Killer Bunnies worked so hard to build in the Overworld, from their magnificent castle to the surrounding village. If they don’t play The Griefer’s twisted game, everything will be lost. Lam may be ready for something new, but he’s not prepared to give up the old just yet.Following clues in both the real world

本書是 Geisel 獎得主 Greg Pizzoli 的全新橋樑書系列，以輕快幽默的節奏，描寫兩位性格南轅北轍的鄰居──樂天的鳥兒 Earl 和喜歡安靜閱讀的 Worm。他們的友誼一開始並不順利：一方熱愛清晨的音樂，另一方則嚮往寧靜。但透過一杯檸檬水、一面牆的顏色、一首尚未寫完的詩，以及願意分享彼此的小故事，他們慢慢建立起難得的情誼。全書收錄三個短篇故事，節奏輕快，文字簡潔，特別適合剛從《Elephant and Piggie》畢業的初階讀者，笑聲與溫度兼具，是閱讀橋接期的理想選擇This giggle-inducing early reader kicks off a brand-new series featuring two unlikely friends, for fans of Frog and Toad, from beloved Geisel Award-winning author of The Watermelon Seed.Earl and Worm have been friends for a very, very long time, but their friendship had a rocky start. Earl is a happy go-lucky bird who plays saxophone to his plants because they love music in the morning. His neighbor Worm, on the other hand...well, Worm is the exact opposite. She would rather read in silence.How will these very different neighbors become the very best of friends? With some sweet lemonade, the right shade of paint, and an unfinished poem, and most of all, sharing a little bit about themselves.Award-winning creator Greg Pizzoli delivers three funny

PULITZER PRIZE WINNER • #1 NEW YORK TIMES BESTSELLER • NATIONAL BOOK AWARD WINNER • A brilliant, action-packed reimagining of Adventures of Huckleberry Finn, both harrowing and darkly humorous, told from the enslaved Jim's point of viewNATIONAL BOOK CRITICS CIRCLE AWARD FINALIST • ONE OF THE NEW YORK TIMES BOOK REVIEW'S 10 BEST BOOKS OF THE YEAR • SHORTLISTED FOR THE BOOKER PRIZE • KIRKUS PRIZE WINNER • A LOS ANGELES TIMES BEST FICTION BOOK OF THE LAST 30 YEARSIn development as a feature film to be produced by Steven Spielberg • A Best Book of the Year: The New York Times Book Review, LA Times, The New Yorker, The Atlantic, The Economist, TIME, and more."Genius"—The Atlantic • "A masterpiece that will help redefine one of the classics of American literature, while also being a major achievement on its own."—Chicago Tribune • "A provocative, enlightening literary work of art."—The Boston Globe • "Everett’s most thrilling novel, but also his most soulful."—The New York TimesWhen Jim over

An outrageously stylish, wickedly funny novel of fashion in the digital age, The Knockoff is the story of Imogen Tate, editor in chief of Glossy magazine, who finds her twentysomething former assistan

A GoodReads Reader's ChoiceBridget Jones—one of the most beloved characters in modern literature (v.g.)—is back! In Helen Fielding's wildly funny, hotly anticipated new novel, Bridget faces a few rath

Colorful illustrations help demonstrate the sound of each letter in the alphabet.

The next blockbuster from the bestselling publishing program--now with over five million books in print!Amy and her brother Marc used to be best friends. But after Marc left home to become an adventurer, Amy has missed her daredevil brother. Meanwhile, Amy has settled into a quiet life, mining close to home. All that changes when Amy receives news that Marc has been trapped in a mysterious haunted mansion. Determined to save her brother, Amy must embark on an epic adventure into a scary house of traps and horrors--with only her brave cat Tuna by her side.

NEW YORK TIMES BESTSELLER • An unforgettable cast of small-town characters copes with love and loss in this new work of fiction by #1 bestselling author and Pulitzer Prize winner Elizabeth Strout

A new book by Pulitzer Prize winner Elizabeth Strout is cause for celebration. Her bestselling novels, includingOlive Kitteridge and The Burgess Boys,have illuminated our most tender relationships. Now, inMy Name Is Lucy Barton, this extraordinary writer shows how a simple hospital visit becomes a portal to the most tender relationship of all—the one between mother and daughter.Lucy Barton is recovering slowly from what should have been a simple operation. Her mother, to whom she hasn’t spoken for many years, comes to see her. Gentle gossip about people from Lucy’s childhood in Amgash, Illinois, seems to reconnect them, but just below the surface lie the tension and longing that have informed every aspect of Lucy’s life: her escape from her troubled family, her desire to become a writer, her marriage, her love for her two daughters. Knitting this powerful narrative together is the brilliant storytelling voice of Lucy herself: keenly observant, deeply human, and truly unforgettable.Prai

Written and drawn by the team behind the best-selling books, Avatar: The Promise and Avatar: The Search, Gene Luen Yang and Gurihiru, in collaboration with the Avatar: The Last Airbender and Legend of

When Gleesome Goodday crash-lands on a beautiful island on a planet with no adults, he promises wonderful things in exchange for a bit of youth, but best friends Brimir and Hulda see that Goodday is n

"Another Angry Birds National Geographic mash-up! This fun, engaging paperback uses Angry Birds to explain the physics at work in the world--and behind the popular game. National Geographic's tradema

A NEW YORK TIMES NOTABLE BOOK“Part love story, part history, this novel is a tour de force [told] in language that soars and sears.”—More? St. Petersburg, 1917. After Rasputin’s body is pulled from th

In S.E.C.R.E.T there are…No Judgments. No limits. No shame.Cassie Robichaud’s life is filled with regret and loneliness after the sudden death of her husband. She waits tables at the rundown Cafe Rose

Now a Major Motion Picture Starring Brad PittJackie Cogan is an enforcer for the mob. When a high-stakes card game is heisted by unknown hoodlums, Cogan is called in to “handle” the problem. Moving ex

Christians were never meant to “just get by.” You were created to rise above adversity and display greatness! In this compelling book, best-selling author John Bevere explores what it takes to finish

Thomas被送入一處神祕封閉的空間，只知道自己的名字。和他一樣的少年們都忘了過去，只能靠自己在未知中尋找生機。環繞著他們的是一座不斷變動的迷宮，而當唯一的女孩出現並帶來詭異訊息，一切開始急轉直下。《The Maze Runner》開啟了一段驚險求生之路，充滿心理壓力、團隊衝突與謎團，是一部結合《飢餓遊戲》與《蒼蠅王》風格的末日小說系列。THE #1 NEW YORK TIMES BESTSELLING MAZE RUNNER SERIES • A teenager with no memory must navigate a deadly maze to survive in book one of this post-apocalyptic phenomenon.“[A] mysterious survival saga that passionate fans describe as a fusion of Lord of the Flies [and] The Hunger Games” (Entertainment Weekly)When Thomas wakes up in the lift, the only thing he can remember is his name. He’s surrounded by strangers—boys whose memories are also gone.Outside the towering stone walls that surround them is a limitless, ever-changing maze. It’s the only way out—and no one’s ever made it through alive.Then a girl arrives. The first girl ever. And the message she delivers is terrifying: Remember. Survive. Run.Look for more books in the blockbuster Maze Runner series:THE MAZE RUNNER • THE SCORCH TRIALS • THE DEATH CURE • THE KILL O

Now in paperback! Fifteen-year-old Eragon believes that he is merely a poor farm boy—until his destiny as a Dragon Rider is revealed. Gifted with only an ancient sword, a loyal dragon, and sage advice

Break through writer's block using your five senses!The sensory details that infuse our everyday experience—the smell of a favorite dish cooking, the texture of a well-worn coat, hearing a song that r

The Cassel sisters have little in common besides a pair of wacky parents and a maddening knack for eluding happily-ever-after endings. But when their lives require damage control, only a dose of siste

SOON TO BE A NETFLIX LIMITED SERIES. The origin of the opioid epidemic from the Pulitzer Prize-winning journalist who first broke the story: A searing account of this country's greatest health crisis that implicates OxyContin's maker and the U.S. governmentBetween 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by the aggressive marketing of OxyContin by its maker, Purdue Pharma. Purdue, owned by a wealthy and secretive family--the Sacklers--knew early on that teenagers and others were abusing its billion dollar "wonder" drug. But Justice Department officials balked a decade ago when it came to meting out justice, allowing an opioid crisis to evolve into a catastrophe. Meier reveals new and shocking information about how long the drug maker knew about OxyContin's abuse, even as it marketed it aggressively, and the way government officials passed up opportunities to protect tens of thousands of lives. Equal

IDENTIFYING THE ENIGMATIC HERO In this volume of Ghost in the Shell, Marcelo Jarty, the hero of a democratic revolution, and South American drug dealer, has been coming to Japan periodically and no

Twelve-year-old Toulouse “Tull” Trotter lives on his grandfather’s vast Bel-Air parkland estate with his mother, the beautiful, drug-addicted Katrina—a landscape artist who specializes in topiary lab

In one of his beloved early bestsellers, Pulitzer Prize–winning author James A. Michener crafts a tale of the American men who fought the Korean War, detailing their exploits in the air as well as the

“A throwback Southern California mystery in modern pinstripes . . . A treat for readers of mystery or baseball novels.” —KIRKUS REVIEWSJohnny Adcock is an aging Major League pitcher with the perfect r

Accidentally spilling some of the Moon Drip intended to unfreeze the village, Natsu and his friends follow a familiar voice and battle against wizards and demons in order to find the spirit that can r

A brilliant and moving coming-of-age story in the tradition of Wonder by R. J. Palacio and The Curious Incident of the Dog in the Night-Time by Mark Haddon—this debut novel is written with tremendous

A DEADLY VIRUS UNLEASHED!In a vile attempt to collect their original computer data, J and his fellow terrorists have unleashed the BLOODY-X virus in the basement of Third-i. Fujimaru now finds himself

How did a charismatic young president elected in an atmosphere of optimism and expectation lead the United States to the brink of revolution? From a chance encounter in the early 1980s to the Democrat

"Early in Proud Beggars, a brutal and motiveless murder is committed in a Cairo brothel. But the real mystery at the heart of Albert Cossery's wry black comedy is not the cause of this death, but the

GUILD WARFairy Tail's rival guild, Phantom Lord, has taken the competition to dangerous levels by smashing the Fairy Tail building and nearly killing three wizards. What is Fairy Tail's response? F

Filled with exciting games, curious projects, magic tricks, simple science experiments, artsy craft projects, and more, this deck will help parents, grandparents, and childcare providers keep kids amu

A young man writes letters in the voice of his dead father. A young woman is shot at by a hunter in the field. An early-twentieth-century idyll is destroyed by infidelity. A schoolgirl dies in an expl

In this brilliantly imagined book, author Danell Jones mines the diaries, essays, correspondence, and fiction of a literary legend to create an unforgettable master class in the art of writing. Using

Alice and Nanny have never met before, but they have one thing in common: their late friend Roberta. Alice is the prim proprietor of a chic Madison Avenue shop, while Nanny is a sharp-eyed Manhattan r

There are many well-established scientific reasons that the HIV/AIDS hypothesis is highly doubtful. In Science Sold Out, Rebecca Culshaw describes her slow uncovering of these reasons over her years r

Three months ago, Juliette D’Alisa’s world changed.In a bittersweet series of events, her mother’s health took a turn for the worse. Juliette and her brother opened their restaurant together to rave r

This groundbreaking book explains how to practise mindfulness, using step-by-step exercises to help the reader understand key techniques such as breathing, relaxation, body scanning and concentration

Every day is an opportunity to engage your persistence, patience, imagination, and daring as you stretch the boundaries of your creativity: draw a round figure using only lines, coin a new word, creat