Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Ranking alongside George R. R. Martin as a groundbreaking master of fantasy,New York Times bestselling author Robin Hobb delivers the second book in her long-awaited Fitz and the Fool trilogy.The harr

GAME OF THRONES: A NEW ORIGINAL SERIES, NOW ON HBO.Few books have captivated the imagination and won the devotion and praise of readers and critics everywhere as has George R. R. Martin’s monumental e

"California, Labor Day weekend . . . early, with ocean fog still in the streets, outlaw motorcyclists wearing chains, shades and greasy Levis roll out from damp garages, all-night diners and cast-off

"Grace's father believes in science and builds his daughter a dollhouse with lights that really work. Grace's mother takes her skinny-dipping in the lake and teaches her about African hyena men who de

"The newest installment in the beloved and best-selling series. In this delightful fifteenth installment, Mma Ramotswe has her hands full both at home and in the office. To add to her current challeng

A sophisticated vegetarian cookbook with all the tools you need to be at home in your kitchen, cooking in the most nourishing and delicious ways--from the foundations of stocking a pantry and under

Truman Capote’s masterpiece, In Cold Blood, created a sensation when it was first published, serially, in The New Yorker in 1965. The intensively researched, atmospheric narrative of the lives of the

From the Modern Library’s new set of beautifully repackaged hardcover classics by Truman Capote—also available are In Cold Blood, Portraits and Observations, and The Complete StoriesTogether in one vo

In time for the one year anniversary of the 2011 earthquake in Japan, a collection of essays and stories by Japanese writers on the devastating disaster, its aftermath, and the resolve of a people to

NATIONAL BESTSELLER • Most fairytales end with a wedding and a happily-ever-after—but this is no fairytale. The updated and official translation ofUnder the Oak Tree, the #1 webnovel on MANTA, continues in this second volume.The gorgeous first edition hardcover ofUnder the Oak Tree: Volume 2 (The Novel)will feature designed sprayed page edges, full-color patterned endpapers, foil stamping on the cover, and a ribbon bookmark!As her first winter in Anatol turns to spring, Lady Maximilian finds herself confronting an unfamiliar feeling: hope. Her voice and her magic strengthen every day; the only parts of Calypse Castle left to refurbish are its gardens, which she plans to fill with blooming flowers; and the way her husband, the recalcitrant war hero Sir Riftan, looks at her from across their bedroom makes her feel, for the first time in her life, that she might be worthy of love and affection.However, Maxi's life is never that easy. Just as she begins to feel at home with Riftan, Maxi re

The incredible true story of the card-counting mathematics professor who taught the world how to beat the dealer and, as the first of the great quantitative investors, ushered in a revolution on Wall

"Milo Andret, the genius who solved the Malosz Conjecture and won the Fields Medal for mathematics, had an unusual, even eerie mind from birth, but not until he moves to Berkeley in the 1970s to pursu

Give your child a smart start with the revised and updatedWhat Your Second Grader Needs to KnowWhat will your child be expected to learn in the second grade? How can you help him or her at home? This

The highly anticipated new standalone full-color graphic novel from Bryan Lee O’Malley, author and artist of the hugely bestselling Scott Pilgrim graphic novel series.Advance praise for Seconds “In S

Expanded and updated exclusively for graduates just entering the workforce, this extraordinary edition of Lean In includes a letter to graduates from Sheryl Sandberg and six additional chapters from e

An intimate, voyeuristic exploration into the private landscape of the unconscious from the Muybridge of sleep. In 1975, Ted Spagna began his voyeuristic venture into "inner space," exposing the se

This movie tie-in edition for the upcoming documentary feature, which is based on the author's book Aftershock, offers an eye-opening and original analysis of the causes of our current recession and p

#1 NEW YORK TIMES BESTSELLER A SONG OF ICE AND FIRE: BOOK FIVE In the aftermath of a colossal battle, Daenerys Targaryen rules with her three dragons as queen of a city built on dust and death. Bu

An instant American icon--the first Hispanic on the U.S. Supreme Court--tells the story of her life before becoming a judge in an inspiring, surprisingly personal memoir.With startling candor and inti

Pilgrimage took Annie Leibovitz to places that she could explore with no agenda. She wasn’t on assignment. She chose the subjects simply because they meant something to her. The first place was Emily Dickinson’s house in Amherst, Massachusetts, which Leibovitz visited with a small digital camera. A few months later, she went with her three young children to Niagara Falls. “That’s when I started making lists,” she says. She added the houses of Virginia Woolf and Charles Darwin in the English countryside and Sigmund Freud’s final home, in London, but most of the places on the lists were American. The work became more ambitious as Leibovitz discovered that she wanted to photograph objects as well as rooms and landscapes. She began to use more sophisticated cameras and a tripod and to travel with an assistant, but the project remained personal. Leibovitz went to Concord to photograph the site of Thoreau’s cabin at Walden Pond. Once she got there, she was drawn into the wider world of the C

The smell of a pie baking in the kitchen immediately conjures up feelings of comfort, nostalgia, and love. Michele Stuart vividly remembers standing at her grandmother’s apron hem as a child, as she f

Since its hardcover publication in August of 1995, Buffett has appeared on the Wall Street Journal, New York Times, San Francisco Chronicle, Los Angeles Times, Seattle Times, Newsday and Business Week

"Something close to magic." The Los Angeles TimesThe astonishing novel of a young boy's life in the New York City of the 1930s, a stunning recreation of the sights, sounds, aromas and emotions of a ti

Walter Farley's tales of bravery, instinct, and survival have been captivating readers for almost 65 years. Here, in a handsome gift set, are four of the best, starting with The Black Stallion, where

Most readers know Truman Capote as the author of Breakfast at Tiffany’s and In Cold Blood; or they remember his notorious social life and wild and witty public appearances. But he was also the author

為什麼聰明人也會做出愚蠢行為？從比爾‧柯林頓的醜聞到休‧葛蘭特的荒唐事件，再到不合理的怒吼、扭曲的自我認知，《與內在白癡共處》以幽默又犀利的筆觸，揭露人類潛意識中那個叫作「Inner Dummy」的原始衝動！心理作家大衛‧魏納融合佛洛伊德理論與演化心理學，解析我們腦中那渴望性、地位與生存的原始本能。讀者不僅能笑看社會奇聞，更能學會如何駕馭內心的白癡衝動，避免讓生活陷入災難。From the sexcapades of Bill Clinton to the unbelievable story of Hugh Grant and the prostitute; from the 15-year-old who weighs only 82 pounds but believes she's obese, to the professor who screams profanities at other drivers in snarled traffic--we wonder out loud, "What are they thinking?!" What drives so many apparently normal, intelligent people to act irrationally, harming themselves and others?According to Sigmund Freud, such behavior may be caused by the "id," our built-in mental invitation to everything from dangerous fun to horrendous acts of irrationality. For popular psychology writer David Weiner, "id" stands for "Inner Dummy," the part of the brain that we must come to understand if we are ever to know why we do foolish, irrational, and compulsive things. Drawing on the groundbreaking the

This successor volume to The Hidden Origins of Islam (edited by Karl-Heinz Ohlig and Gerd-R. Puin) continues the pioneering research begun in the first volume into the earliest development of Islam. U

This graphic novel adaptation contains more than fifty pages of exclusive content not available in the original comic books, including‧ a new Preface by George R. R. Martin‧ early renderings of key sc

In a handful of years between the development of electrical recording in 1925 and the outset of the Great Depression in the early 1930s, the soundscape of modern music unfolded in a series of relative

A unique approach to the history of science using do-it-yourself experiments along with brief historical profiles to demonstrate how the ancient alchemists stumbled upon the science of chemistry.Be th

A stand-alone entry in the Shannara series finds Paxon Leah attempting to rescue his kidnapped sister using a seemingly insignificant family sword only to uncover a plot to overthrow the Druids, who r

In this joyous and whimsical holiday novel, Debbie Macomber rings in the season with the return of Shirley, Goodness, and Mercy, delivering laughs, love, and a charming dose of angelic intervention.

Developed in Japan in the early 1990s, metal clay represents a dramatic development in the handling of precious metals for jewelrymaking. Metal clay consists of microscopic particles of silver or gold

The Mindful Mother offers you unparalleled support and nurturing throughout pregnancy, labour and early motherhood. Author Naomi Chunilal shows you how clear and simple meditation and self-development

Drawing from five years' worth of investigative reporting, presents the history of Latin American drug cartels, revealing how Mexico became their base and the extent of corruption within the country's

Entheogens and the Development of Culture makes the radical proposition that mind-altering substances have played a major part not only in cultural development but also in human brain development. Res

What happens when two cartoonists for The New Yorker fall in love and marry? Lots of witty wordplay, skewering drawings, and a healthy dose of illustrative competition. For twenty years, veteran carto

Using both canonical and noncanonical primary texts, Ludemann (history and literature of early Christianity, U. of Gottingen) presents evidence that the resurrection was not a historical event and arg

Millions of people already live their lives in accordance with Rob Brezsny's "Real Astrology" prophecies. But the time has come for a deeper dose of Brezsny's brain. The Televisionary Oracle is an arc

The early fiction of one of the nation’s most celebrated writers, Truman Capote, as he takes his first bold steps into the canon of American literatureRecently discovered as manuscript pages in the ar