Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Traditionally in China and Japan, drinking a cup of tea was an opportunity for contemplation, meditation, and an elevation of mind and spirit. Here, renowned translator William Scott Wilson distills w

IN COUNTLESS STUDIES, PSYCHOLOGISTS HAVE DISCOVERED A SURPRISING FACT:For decades they assumed that people who face adversity—a difficult childhood, career turbulence, sudden bouts of bad luck—will su

The newest Oprah's Book Club 2.0 selection. The arrival of a major new voice in contemporary fiction. A debut of extraordinary distinction: Ayana Mathis tells the story of the children of the Great

Now a Major Motion Picture Starring Brad PittJackie Cogan is an enforcer for the mob. When a high-stakes card game is heisted by unknown hoodlums, Cogan is called in to “handle” the problem. Moving ex

Christians were never meant to “just get by.” You were created to rise above adversity and display greatness! In this compelling book, best-selling author John Bevere explores what it takes to finish

Pilgrimage took Annie Leibovitz to places that she could explore with no agenda. She wasn’t on assignment. She chose the subjects simply because they meant something to her. The first place was Emily Dickinson’s house in Amherst, Massachusetts, which Leibovitz visited with a small digital camera. A few months later, she went with her three young children to Niagara Falls. “That’s when I started making lists,” she says. She added the houses of Virginia Woolf and Charles Darwin in the English countryside and Sigmund Freud’s final home, in London, but most of the places on the lists were American. The work became more ambitious as Leibovitz discovered that she wanted to photograph objects as well as rooms and landscapes. She began to use more sophisticated cameras and a tripod and to travel with an assistant, but the project remained personal. Leibovitz went to Concord to photograph the site of Thoreau’s cabin at Walden Pond. Once she got there, she was drawn into the wider world of the C

The smell of a pie baking in the kitchen immediately conjures up feelings of comfort, nostalgia, and love. Michele Stuart vividly remembers standing at her grandmother’s apron hem as a child, as she f

Since its hardcover publication in August of 1995, Buffett has appeared on the Wall Street Journal, New York Times, San Francisco Chronicle, Los Angeles Times, Seattle Times, Newsday and Business Week

"Something close to magic." The Los Angeles TimesThe astonishing novel of a young boy's life in the New York City of the 1930s, a stunning recreation of the sights, sounds, aromas and emotions of a ti

Walter Farley's tales of bravery, instinct, and survival have been captivating readers for almost 65 years. Here, in a handsome gift set, are four of the best, starting with The Black Stallion, where

Most readers know Truman Capote as the author of Breakfast at Tiffany’s and In Cold Blood; or they remember his notorious social life and wild and witty public appearances. But he was also the author

為什麼聰明人也會做出愚蠢行為？從比爾‧柯林頓的醜聞到休‧葛蘭特的荒唐事件，再到不合理的怒吼、扭曲的自我認知，《與內在白癡共處》以幽默又犀利的筆觸，揭露人類潛意識中那個叫作「Inner Dummy」的原始衝動！心理作家大衛‧魏納融合佛洛伊德理論與演化心理學，解析我們腦中那渴望性、地位與生存的原始本能。讀者不僅能笑看社會奇聞，更能學會如何駕馭內心的白癡衝動，避免讓生活陷入災難。From the sexcapades of Bill Clinton to the unbelievable story of Hugh Grant and the prostitute; from the 15-year-old who weighs only 82 pounds but believes she's obese, to the professor who screams profanities at other drivers in snarled traffic--we wonder out loud, "What are they thinking?!" What drives so many apparently normal, intelligent people to act irrationally, harming themselves and others?According to Sigmund Freud, such behavior may be caused by the "id," our built-in mental invitation to everything from dangerous fun to horrendous acts of irrationality. For popular psychology writer David Weiner, "id" stands for "Inner Dummy," the part of the brain that we must come to understand if we are ever to know why we do foolish, irrational, and compulsive things. Drawing on the groundbreaking the

This successor volume to The Hidden Origins of Islam (edited by Karl-Heinz Ohlig and Gerd-R. Puin) continues the pioneering research begun in the first volume into the earliest development of Islam. U

This graphic novel adaptation contains more than fifty pages of exclusive content not available in the original comic books, including‧ a new Preface by George R. R. Martin‧ early renderings of key sc

In a handful of years between the development of electrical recording in 1925 and the outset of the Great Depression in the early 1930s, the soundscape of modern music unfolded in a series of relative

A hands-on science book packed with fun experiments from rockstar science educator Carmelo the Science Fellow! Designed to encourage kids' natural love of science from an early age, this book promotes

A unique approach to the history of science using do-it-yourself experiments along with brief historical profiles to demonstrate how the ancient alchemists stumbled upon the science of chemistry.Be th

A stand-alone entry in the Shannara series finds Paxon Leah attempting to rescue his kidnapped sister using a seemingly insignificant family sword only to uncover a plot to overthrow the Druids, who r

Developed in Japan in the early 1990s, metal clay represents a dramatic development in the handling of precious metals for jewelrymaking. Metal clay consists of microscopic particles of silver or gold

This is a no-holds-barred response to the liberal and conservative retreat from an assertive, activist, and socially transformative civil rights agenda of recent years--using a black feminist lens and

A New York Times BestsellerAn audacious, irreverent investigation of human behavior—and a first look at a revolution in the makingOur personal data has been used to spy on us, hire and fire us, and sell us stuff we don’t need. InDataclysm, Christian Rudder uses it to show us who we truly are. For centuries, we’ve relied on polling or small-scale lab experiments to study human behavior. Today, a new approach is possible. As we live more of our lives online, researchers can finally observe us directly, in vast numbers, and without filters. Data scientists have become the new demographers.In this daring and original book, Rudder explains how Facebook "likes" can predict, with surprising accuracy, a person’s sexual orientation and even intelligence; how attractive women receive exponentially more interview requests; and why you must have haters to be hot. He charts the rise and fall of America’s most reviled word through Google Search and examines the new dynamics of coll

The Mindful Mother offers you unparalleled support and nurturing throughout pregnancy, labour and early motherhood. Author Naomi Chunilal shows you how clear and simple meditation and self-development

Drawing from five years' worth of investigative reporting, presents the history of Latin American drug cartels, revealing how Mexico became their base and the extent of corruption within the country's

Break through writer's block using your five senses!The sensory details that infuse our everyday experience—the smell of a favorite dish cooking, the texture of a well-worn coat, hearing a song that r

Entheogens and the Development of Culture makes the radical proposition that mind-altering substances have played a major part not only in cultural development but also in human brain development. Res

In this joyous and whimsical holiday novel, Debbie Macomber rings in the season with the return of Shirley, Goodness, and Mercy, delivering laughs, love, and a charming dose of angelic intervention.

What happens when two cartoonists for The New Yorker fall in love and marry? Lots of witty wordplay, skewering drawings, and a healthy dose of illustrative competition. For twenty years, veteran carto

The Cassel sisters have little in common besides a pair of wacky parents and a maddening knack for eluding happily-ever-after endings. But when their lives require damage control, only a dose of siste

Using both canonical and noncanonical primary texts, Ludemann (history and literature of early Christianity, U. of Gottingen) presents evidence that the resurrection was not a historical event and arg

Millions of people already live their lives in accordance with Rob Brezsny's "Real Astrology" prophecies. But the time has come for a deeper dose of Brezsny's brain. The Televisionary Oracle is an arc

SOON TO BE A NETFLIX LIMITED SERIES. The origin of the opioid epidemic from the Pulitzer Prize-winning journalist who first broke the story: A searing account of this country's greatest health crisis that implicates OxyContin's maker and the U.S. governmentBetween 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by the aggressive marketing of OxyContin by its maker, Purdue Pharma. Purdue, owned by a wealthy and secretive family--the Sacklers--knew early on that teenagers and others were abusing its billion dollar "wonder" drug. But Justice Department officials balked a decade ago when it came to meting out justice, allowing an opioid crisis to evolve into a catastrophe. Meier reveals new and shocking information about how long the drug maker knew about OxyContin's abuse, even as it marketed it aggressively, and the way government officials passed up opportunities to protect tens of thousands of lives. Equal

Yoga has never been more popular. Throughout the United States, people are turning to this ancient practice as a response to the pressures of today’s hectic world. In Meditations on Intention

The early fiction of one of the nation’s most celebrated writers, Truman Capote, as he takes his first bold steps into the canon of American literatureRecently discovered as manuscript pages in the ar

From the twisted imagination of creator Michael Dougherty (director of the upcomingKrampus and Trick ‘r Treat, screenwriter of X-Men 2 and Superman Returns) and a top-notch team of artists includingFi

New York Times bestselling author Joe Abercrombie’s thrilling new series continues in the follow-up toHalf a King, which George R. R. Martin hailed as “a fast-paced tale of betrayal and revenge that g

In the grand tradition of George R. R. Martin, Terry Brooks, David Eddings, and Robert Jordan, New York Times bestselling author Peter V. Brett continues his critically acclaimed Demon Cycle, which la

Joe Abercrombie’s Best Served Cold meets George R. R. Martin’s A Game of Thrones in the final novel in Richard K. Morgan’s epic A Land Fit for Heroes trilogy, which burst onto the fantasy scene with T

"Richard McGuire's Here is the story of a corner of a room and the events that happened in that space while moving forward and backward in time. The book experiments with formal properties of comics,

Drawing on both their own fieldwork from 1991 to 1999 and older written sources, Stewart and Strathern explore how the Duna have remade their rituals and associated myths in response to the outside in

March, 1944: US Army Lieutenant Billy Boyle, back in England after a dangerous mission in Italy, is due for a little R&R, and also a promotion. But the now-Captain Boyle doesn't get to kick back a