Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Illustrated in full color and packed with character and humor, this is the fifth whodunnit mystery in the awardwinning Detective Gordon series, fun to read alone or aloud.A Case with a Bang is the final book in the series of funny detective stories for early readers set in a friendly forest in which two determinedly fair police—retired-toad Gordon and the indefatigable mouse Buffy—solve the mystery and stop regularly to eat cake.Night brings a horrible humming, scraping sound in the forest. Someone has wrecked the badger’s trash can. Later, three large creatures are spotted up on the mountain.Detective Buffy discovers this seemingly small case really is a dangerous mystery—she comes back from her first investigation flat as a gingerbread, rolled over by something huge and terrifying.Back at the station, retired Detective Gordon is training a new young police assistant, and the cakes have run out in the forest bakery!While all the animals cower at the police station, Buffy remembers Gor

我分類故我在！大數據也要大思維！思維革新比數據技術更重要！在商業分析和商業智慧的脈絡下，建構大數據，而不是從巨量資料當中大海撈針。在未來，容易上手的程式只會越來越普及，唯有絕佳的資料素養，和更有價值的決策能力才能讓你不同凡響。如果只是把資料變大，認知學習能力的維度卻沒有變大，接下來會如何？從少量數據都學習不到的價值，大數據只是讓它更遙不可及。作者鑽研R語言多年、擁有資深學界經驗，貢獻良多。本書內容豐富，以十個面向切入，探討大數據所必備的工具，例如R-Commander、決策樹、隨機森林與R語言強大的視覺化功能。除了概念解析之外，作者更逐行解析專業程式語言，再加碼實際操作與應用功能說明，在每講的最後，還能領略作者獨到的觀念釐清，讓你不會迷失在大數據的眉角中。非常適合做為R語言的基礎自學書，對於初入大數據領域的讀者如同暮鼓晨鐘、醍醐灌頂，對已入行的數據分析師而言，更是當頭棒喝、突破盲點。

Women Talking is a profound, unsettling novel from the award-winning author of Fight Night and All My Puny Sorrows.In a remote Mennonite colony, over a hundred girls and women were knocked unconscious and violated-by what many thought were ghosts or demons-aspunishment for their sins. Their accounts were chalked up to 'wild female imagination.'Women Talking is an imagined response to these real events. When the women learn that they were in fact drugged and attacked by men in their community, they hold a secret meeting in a hayloft. They have two days to make a plan before the rapists are bailed out and brought home: will they dare to escape?'Don't miss this.' MARGARET ATWOOD'Beautiful. . . a novel for the times.' LISA McINERNEY'Tender, enraging and brimming with a bitter wit.' The Times'An astonishment, a volcano of a novel.' LAUREN GROFF'Profound, affecting stuff.' Sunday Telegraph'Brave and thoughtful.' Observer

From the New York Times bestselling author of Girl in Pieces comes a stunning novel that Vanity Fair calls "impossibly moving" and "suffused with light". In this raw, deeply personal story, a teenaged girl struggles to find herself amidst the fallout of her brother's addiction in a town ravaged by the opioid crisis. For all of Emory's life she's been told who she is. In town she's the rich one--the great-great-granddaughter of the mill's founder. At school she's hot Maddie Ward's younger sister. And at home, she's the good one, her stoner older brother Joey's babysitter. Everything was turned on its head, though, when she and Joey were in the car accident that killed Candy MontClaire. The car accident that revealed just how bad Joey's drug habit was. Four months later, Emmy's junior year is starting, Joey is home from rehab, and the entire town of Mill Haven is still reeling from the accident. Everyone's telling Emmy who she is, but so much has changed, how can she be the same person?

This book examines Hong Kong foodways in different periods of social development and hopes to advance anthropological inquiries by addressing issues concerning identity, migration, consumerism, globalization, and the invention of local cuisines in the context of Hong Kong as a fast-changing society in East Asia.

It’s eat or be eaten...literally!Locked in battle with the Lunatic Magician, Laios is the last man standing against an array of the dungeon’s deadliest dragons. Using his extensive monster knowledge to his advantage, Laios manages to defy the odds of almost certain death―at least until Sissel devises an even more terrible plan! Will Laios’s love of dungeon dining prove to be his downfall?

Go back in time to when everyone's favorite Catstronaut, Waffles, was a kitten! Fans of Narwhal and Jelly will love this fun, cat-tastic early graphic novel series. It's time to visit Gramps and Grammers and that means Waffles, Pancake, and Mom-Cat are taking a very early flight to get to maximize the fun-times! This is the kittens' first airplane ride and while Pancake is excited to get on board, Waffles is a little more nervous: an airplane has wings, but airplane wings don't flap! How does it stay up in the air? With a little bit of science and a whole lot of imagination, the kittens are able to understand the mechanics of flight andenjoy the ride. Come fly the feline skies!

《遊戲人生》進階版！ 「教學現場的魔法師」莊越翔老師首本遊戲寶典。陪你一起善用遊戲，活化人生，遊戲成精。 《遊戲人生》作者楊田林老師喻為「帶領遊戲的奇才」──莊越翔老師，演講場次逾千場，近15,000讚友推薦。進階玩法，靈活應用，讓教學現場好好玩！ 遊戲專業想‧活動專業想‧創意專業想 全書共8大主題，吸睛活動72變──R促進人際互動 R體驗遊戲樂趣 R現場引導反思R實體課程說明 R線上帶動分享 R延伸活動變化 從人間四季春夏秋冬，隱喻遊戲帶動熱身、激發學員熱情、建立共識、安頓整理四大節奏。這本書，教的不只是遊戲，是人生！ 傳承推薦____《遊戲人生》作者楊田林 企業人文講師專文推薦（依筆畫序）____張志成 中華康輔教育推廣協會創會理事長｜張忘形 溝通表達培訓師｜黃同慶 世界五百強企業顧問／職業企管講師｜葉丙成 臺大教授｜歐耶 起初文創表達訓練總監／即興脫口秀演員｜歐陽立中 暢銷作家／Super教師｜蔡居澤 師範大學公民教育與活動領導學系副教授暨系主任 名人推薦（依筆畫序）____阿滴 百萬Youtuber／阿滴英文創辦人｜王漢克 實境解謎培訓師｜曲智鑛 陶璽工作室創辦人｜李姵儀 育圃教育執行長｜林佳諭 中興國中教師｜邱建智 中華康輔教育推廣協會副理事長｜南瓜妹 共玩創新共同創辦人｜洪瑞聲 遊戲學習設計師｜連育仁 中原大學應用華語文學系副教授｜陳志恆 諮商心理師｜趙胤丞 專職講師｜黎孔平 玩轉學校共同創辦人｜賴以威 師範大學電機工程學系副教授

From Geisel Award-winning author-illustrator Corey R. Tabor comes a fresh and funny young graphic novel series sure to delight readers. Perfect for fans of Catwad, Bird & Squirrel, and Narwhal & Jelly.Ladies and gentlebugs, presenting the duke of the dandelion patch, champion of truth and justice, the one, the only--Sir Ladybug!Sir Ladybug never shies away from a quest, even when he'd rather be playing a video game or baking a cake. So when a caterpillar needs rescuing from a "monster" (a hungry chickadee), Sir Ladybug and his trusty friends--his herald, a roly-poly named Pell, and his squire, a snail named Sterling--hatch the perfect (delicious) plan.This is the first in a new graphic novel series for newly independent readers, following the adventures of a ladybug knight and his pals in the dandelion patch.Woven seamlessly into this funny and surprising story are the themes of friendship, bravery, teamwork, creative thinking, and helping others. With warmth and heart, surpris

Wry, witty and very funny diary-style story packed with doodles and comic strips about the frustration trickster god Loki feels at having to live trapped in the body of a weedy eleven-year-old boy. After one trick too many, Loki is banished to live on Earth as a "normal" school boy. Forbidden from using his AWESOME godly powers, Loki must show moral improvement.As he records his lies THE TRUTH in his magical (judgemental) diary, it becomes clear Loki hasn't a clue how to tell good from evil, trust from tricks, or friends from enemies.

Discover how geology is part of our daily lives with Everyday STEM Science: Geology. Explore the wonders of Earth and see how geology is all around us, from natures materials that are used to build roads and buildings to the minerals found in your mobile phone and drinks can. Witness a volcanic eruption, find out if there is water on Mars, unearth a dinosaur and meet the geologists and scientists who brought geology to life. Readers can also carry out geology experiments at home. With easy-to-understand text written by Emily Dodd, fun callouts and lots of colourful artworks, photos, and diagrams, readers can best explore where we encounter geology and why it’s even important at all. The Everyday STEM series makes STEM relevant to tweens. Instead of telling kids STEM is important and is the key to their “future success,” these books, including Everyday STEM Science – Physics, show readers how we use science, technology, engineering and maths in our everyday lives. While the topics sound

Give your first grader a strong computer science foundation with Smart Start: Beginning Coding Stories and Activities. Children will learn important coding concepts with engaging stories and practice activities. Based on the K-12 Computer Science Framework, this dynamic early learning series helps children understand coding concepts to develop a strong foundation in computer science, including computational thinking, problem solving, and critical thinking. Each full-color activity book is organized into eight themed units around one coding concept and includes: - Coding stories that demonstrate what coders do and include an audio read-aloud feature - Concept pages that connect coding concepts to real-world situations - Practice activities that reinforce important coding rules - Review pages for every coding concept practiced - Coding projects with print-based games and puzzles - Mini coding handbook with key terms Computer science concepts and skills help early learners become critical

Introducing My First Brain Quest for babies! These chunky board books introduce early learning concepts - like first words - with bright images, simple vocabulary, and signature Brain Quest Q&A fun.It

Inspired by his beloved CatStronauts series, Drew Brockington is going back in time to when everyone's favorite Catstronaut, Waffles, was a kitten! Fans of Narwhal and Jelly and Elephant & Piggie will love this fun, cat-tastic early graphic novel series.One very special Saturday, Dad-Cat decides to take Waffles and his sister Pancake to the big city to go to the science museum! While they're there, the kittens see extraordinary things, like dino-cats, hairballs in 4D, and even the planetarium. But as the kittens learn about constellations and Neil Pawstrong, they get separated from Dad-Cat. Oh no!Will the kittens be able to find their (possibly invisible) Dad-Cat? Or will they get stuck living in the museum and eating star tots and tuna melts fur-ever?! This early graphic novel series is chock-full of educational facts about space―perfect for young readers.

Charise Mericle Harper (Crafty Cat, Just Grace, Fashion Kitty) delivers another hilarious and charming early graphic novel series starring Pepper and Boo, two darling dogs, and their suspicious housem

Packed with tips and examples of how to make a successful and effective presentation, Get Ready for Your Presentation provides ways for students to prepare, practice and perform English presentations as well as practice in the use of the most commonly used language patterns.Get Ready for Your Presentation includes: Systematic development of key language and powerful presentation techniquesA step-by-step approach to structuring your presentation and then delivering your presentationUp-to-date principles for designing effective visuals and slidesVivid illustrations of how to master body languageCommon business language structures

In this charming trip of the imagination, a little girl delights in experiencing life at a slower pace as she shares her day with a sleepy sloth who moves so slowly, moss grows in his fur! This sloth may be sleepy but it's a champion on the jungle gym, thanks to its super gripping skills. And climbing trees has never been so easy! But the little girl's hairdresser is less than impressed to find not just moss but also moths in its fur - and by the time our sleepy sloth has finished its morning walk, the day is almost done. Through rollicking rhymes and bold, graphic illustrations, If I had a sleepy sloth imagines the positives and negatives of having a sloth for a pet and provides a welcome alternative to the fast pace of modern life by creating the time for readers to simply b-r-e-a-t-h-e.

這是一本前沿的定性比較分析（QCA）方法工具書，是通過R語言實現定性比較分析的一個全面指南。QCA方法的獨特之處在於結合了定性方法與定量方法的特點，已成為近年來國外社會學、管理學、營銷學、政治學、傳播學等領域的學者進行開創性研究的“第三條道路”。QCA方法適用範圍廣泛，既可以用於小樣本的案例研究（彌補案例研究的外部推廣性差的缺陷），也可以用於大樣本的數據分析（彌補大樣本研究缺乏定性判斷和對於複雜因

*series focuses on positive social development of young children*books offer support through a variety of childhood experiences*sharing theme*pull tabs show a resolution that is reassuring to children and affirms positive behavior*pull tabs also provide encouragement and remind chidlren that they can control what happens in differet situations

After breaking a curse on the imperial heirs, a palace servant with training in herbal medicine is promoted up the ranks to food taster...and right into the thick of palace intrigue in this lushly illustrated period mystery series Maomao, a young woman trained in the art of herbal medicine, is forced to work as a lowly servant in the inner palace. Though she yearns for life outside its perfumed halls, she isn't long for a life of drudgery Using her wits to break a curse afflicting the imperial heirs, Maomao attracts the attentions of the handsome eunuch Jinshi and is promoted to attendant food taster. But Jinshi has other plans for the erstwhile apothecary, and soon Maomao is back to brewing potions and...solving mysteries?

A brand-new early reader graphic novel series about finding friendship in unexpected places! This fun and funny buddy comedy is perfect for fans of Narwhal & Jelly, emerging readers, and all kids

Give your child positive math experiences and strong math foundations with Smart Start: Math Stories and Activities. The colorful activities introduce math concepts in creative ways using math stories to help children recognize number relationships in the world around them.Smart Start: Math Stories and Activities workbooks provide structured weekly activities to help children practice and learn numbers, counting, measurement, addition and subtraction, shape recognition, and graphing. Audio story read-alouds with colorful illustrations help students learn math concepts and make connections to the real world. Illustrated activities provide meaningful practice in a variety of formats, giving children multiple opportunities to achieve understanding.Math activities:Provide strong math foundations that teach the most important math skills.Include creative and fun lessons thathelp children create positive math connections.Provide reward stickers to motivate children to complete the activities

A New York Times bestseller!“Smart and funny…warm and rewarding.” ―Booklist (starred review)“A compelling and quirky tale of love and negotiating early adulthood in New York City.” ―School Library Jou

A beautiful and gentle look at the circle of life, using Christine Pym's gorgeous animals characters to explore the emotions and facts around death, with questions such as Is it ok to talk about dying

Are the answers to these ancient secrets worth your soul?Vathek, the ninth caliph of the Abassides in Arabia, ascends to the throne at an early age and reigns with an iron fist, inspiring terror and u

Tells the whole story using excerpts from the original text-not just a primer!What fools these mortals be!?―Puck, Act III, Scene 2, 115Join Bottom the Weaver, Oberon and Titania, and the confused love

Using the incredible Anatomicum as inspiration, this activity book is bursting with fascinating facts and puzzles, perfect for budding artists and science enthusiasts. Activities include amazing mazes

Join two bug friends as they learn about the science of the world around them and the meaning of friendship in this early graphic novel series perfect for fans of Narwhal and Jelly!Rhino-B is a brash,

This beautiful boxed set contains three simple nine-piece jigsaws and a beautifully illustrated board book. Little children will enjoy looking at the colourful scenes in the book, filled with garden animals including a fox, hedgehog, birds and snails, and then using the jigsaw pieces to recreate three scenes. 3款9片大拼圖+1本小書 拼圖完成尺寸19*19公分

Olivia really doesn t like her nickname mostly because it gets her into some sticky situations! How can she persuade her mum to stop using it? A hilarious look at the affectionate names we give the on

《帝國戰記──意志者W I L L T E R》是一部引人入勝精采絕倫的科幻冒險故事，講述一群使用「源」能力的超能力者「意志者」，穿梭近未來雙世界觀，往復來去「雅思」「阿特蘭提斯」異次元世界，具雙重世界觀概念，有悠遊浩瀚時空宇宙的磅薄氣勢。故事主角─光野遼介，出身自武道流派名家，來到位於「阿特蘭提斯」界的學校─聖光學園（聖斐勒斯嘟學園）與女主角之一的神崎希邂逅，故事從這裡開始發展。面對遭遇帝國暗黑

This revised and updated guide to baby massage enables parents to readily bond with their baby and promote his or her development, uncover potential problems and treat minor ailments. Being massaged m

It's never too early to encourage children to talk about how they feel. This newest title in the Pull and Play BooksTM series provides reassurance and support through gently humorous situations. Child

Izzy and friends are excited! The snow is falling fast and they’re hoping they’ll all be sent home early. But then they hear weird noises in the playground, and find a big footprint in the snow… And that’s when they know! There’s a YETI in the playground and it’s HUNGRY!Laugh-out-loud fun from Blue Peter Award winners Pamela Butchart and Thomas Flintham.Read more of Izzy’s adventures!Baby Aliens Got My TeacherThe Spy Who Loved School DinnersMy Headteacher Is a Vampire RatThe Demon Dinner LadiesThere’s a Werewolf in my TentTo Wee or Not to WeeThe Phantom Lollipop ManIcarus Was Ridiculous

35 step-by-step art projects using paint and paper, for children aged 7+.35 step-by-step art projects using paint and paper, for children aged 7+. My First Painting and Collage Book shows you differen

Understanding the concept of time in relation to routine activities is a vital pre-school skill, and this interactive book is an engaging introduction to daily routines, ordering events and describing your day. A fun introduction to a key early learning concept, with over 60 flaps to lift.商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

This updated DK classic includes sixteen colorful flashcards with tactile elements that are perfect for giving toddlers a head start in developing early language skills.Each 17-card pack contains 16 touch-and-feel picture cards and 1 card of parent guidance notes to help both parents and little ones get the most from the collection. My First Touch and Feel Picture Colors and Shapes features colorful squares, circles, triangles, and more! On the reverse of most cards, there are a series of engaging questions, in addition to word translations for Spanish, French, German, Chinese, and phonetic spellings to help develop early language skills. Sturdy cards and fun tactile images make these packs ideal for preschool play.

Narwhal's obsession with his new favorite food leads him into hijinks and hilarity in the third book of this all-star early graphic novel series!Narwhal and Jelly are back and Narwhal has a new obsess

BabyLit® Storybooks give classics new life for the next generation of early readers.In The Jungle Book, preschoolers can tag along on Mowgli’s thrilling adventure, meeting wolves, elephants, and even

A practical, dip-in guide, packed with over 100 outdoor activities for children.In an era when the iPad is often more appealing than the park, it can be difficult to encourage kids to get off the couch and spend time outside. In this inspirational book, with ideas for children of all ages, there are over 100 imaginative ways for children to keep busy and have fun outdoors. They can enjoy outdoor crafts such as making leaf art bunting, a dream catcher, or their own toy raft, or get physical and burn off some energy with beach hopscotch, animal tracking, and developing their hunting and gathering skills. Or perhaps they would like to relax and enjoy some star-gazing or pond-dipping instead. There are fun activities to help kids get up close and personal with nature by making a wormery and a bug attractor, doing some investigative ant experiments, and putting on their own gastropod race! The book includes handy reference pics to help children identify plants, flowers, and wildlife, so as