Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This book introduces the main theoretical findings related to copulas and shows how statistical modeling of multivariate continuous distributions using copulas can be carried out in the R statistical

Spatial Modeling in GIS and R for Earth and Environmental Sciences offers an integrated approach to spatial modelling using both GIS and R. Given the importance of Geographical Information Systems and

This book is a comprehensive introduction to financial modeling that teaches advanced undergraduate and graduate students in finance and economics how to use R to analyze financial data and implement

The Oracle Press Guide to Big Data Analytics using RCowritten by members of the Big Data team at Oracle, this Oracle Press book focuses on analyzing data with R while making it scalable using Oracle’s

Fox--the beloved and popular trickster character featured in the Geisel Award-winning books Fox Has a Problem, Fox at Night, and Fox the Tiger--is on the move! But Fox knows that life is about the journey, not the destination, and if his untraditional transportation methods get him in a bit of trouble, he can always try again tomorrow. Kirkus Reviews calls Corey R. Tabor "a master of the early reader."Where is Fox going? But more importantly, how is he getting there?A train? A bus? A surfboard? A waterfall? Fox's travel methods may be a bit unusual, but we would expect nothing less from our terrific, trickster friend.Wry, repetitive text with carefully chosen language and a limited vocabulary allows for an accessible read while charming illustrations provide context and comedy in Corey R. Tabor's award-winning Fox series, making it a perfect choice for emerging readers and their caretakers. The Fox series, which is comprised of both picture books and beginning readers, has received thr

全方位重點 ALL IN ONE鞏固基礎｜課文結構、寫作手法以表格統整延伸知識｜彙整必讀、必考語文知識強化閱讀｜每課一組閱讀題，練習統測題型

《圓覺經》全名《大方廣圓覺修多羅了義經》，透過文殊師利等十二位菩薩與佛陀的問答，宣說如來圓覺妙理，揭櫫一切眾生具足圓覺妙心，是指引如何修行成佛的經典。《圓覺經》廣受唐代天台、華嚴、禪宗、密宗重視，北宋郭印提出佛教四書，清末吳坤修甄選釋氏十三經，它從未缺席，又早早流布高麗與鎌倉時代的朝鮮、日本。該經一卷之薄，允為東亞漢傳佛教「經中之睛」。是次新注新譯，深度利用東亞文獻以校勘、輯佚，紹述唐僧玄奘忠於原典及思想、語言原貌之傳統，從佛學乃至文學角度，予以精當闡釋，化深奧為易懂，內容至簡至要。〈導讀〉一文更明析該經結構、善本、善注、文體，乃至東亞古典時代地位諸議題。研讀佛教經典者，切莫錯過。The Sūtra of Perfect Englightenment 圓覺經, whose full title is The Nītârtha Sūtra on the canon of the great and expansive Perfect Enlightenment (Dà fāngguăng yuánjué xiūduōluó liǎoyì jīng) 大方廣圓覺修多羅了義經, uses a conversation between the Buddha and twelve Bodhisattvas, led by Mañjuśrī, to promulgate the wondrous doctrine of perfect enlightenment. It discloses that all sentient beings have an innate mind of perfect enlightenment, and guides them on how to train to attain Buddhahood. In the Tang dynasty, the Sūtra of Perfect Enlightenment was held in high esteem by the Tiantai, Huayan, Chan, and Vajrayāna (Esoteric) schools. And it was listed in the four Buddhist classics proposed by the Northern Song’s G

Izzy the Inventor has HAD ENOUGH. Bad Fairy Brenda has turned VERY BAD indeed, and Izzy wants to find a way to make her good. Unfortunately, this involves climbing up a beanstalk to the Land of the Giants, along with her sister and Henry the Unicorn. This journey will put Izzy's science skills to the test - she'll need catapults, light experiments and a pair of giant flying underpants...Every book contains ideas for science experiments and a QR code with links for more to try at home.Collect all the books in the series!

全方位重點 ALL IN ONE鞏固基礎｜課文結構、寫作手法以表格統整延伸知識｜彙整必讀、必考語文知識強化閱讀｜每課一組閱讀題，練習統測題型

⊙系統性內容編排：章節難度由淺至深安排，循序漸進建構知識。⊙實務應用導向：透過案例，學習運用各種統計方法分析問題，並以R語言的統計程式套件，解決不同的統計模式，達到做中學的學習效果。⊙提供習題演練：各章節皆附有習題，學習成效輕鬆驗收。【以R語言學習統計，邊做邊學好懂易上手】本書以R語言作為統計學教學的嚮導，運用R語言之程式套件中世界各地實際的研究個案與資料，讓學習者認識各種統計方法，解決不同的統計模式，也能了解統計在各方面的應用。書中章節安排難度由淺至深，循序漸進帶領學習者一一攻克各種統計方法，內容包含：R語言基礎指令操作、單變數資料、兩個與多個變數資料、機率、離散型機率分配、連續型機率分配、抽樣分配、常態近似與自助抽樣法、估計、統計假說檢定、變異數分析：多個母體平均數比較、簡單線性迴歸分析、多元線性迴歸分析、適合度檢定：類別資料分析、無母數統計等。各章節最末提供習題，讓學習者可透過演練驗收學習成效，加深記憶、鞏固知識。

適合程式設計新手，迅速進入資料科學領域。資料匯入、整理、變換、視覺化與模型建立。使用R和RStudio進行資料科學研究，利用tidyverse套件使工作更高效、流暢。這一版介紹Tidyverse的最新功能和最佳實務做法，並新增章節介紹從不同來源獲取資料，進一步實踐所學。「這本書更新了世界首屈一指的R資料科學實務指南，優秀程度令人驚歎，凡是與資料打交道的人都應該閱讀此書！」—Emma RandUniversity of York, UK運用R將資料轉化為洞察力、知識和理解。透過這本實用的書籍，有志於成為資料科學家的讀者將學會如何使用R和RStudio進行資料科學研究，並利用tidyverse這組專為協同工作而設計的套件，讓資料科學實務變得更快速、流暢且有趣。即使沒有程式設計的經驗，本書最新版也能幫助你迅速進入資料科學的領域。你將學會如何匯入、變換和視覺化資料，並傳達結果。你還將獲得資料科學流程的整體理解，以及管理細節所需的基本工具。這一版針對最新的tidyverse功能和最佳實務做法進行了更新，有新的章節示範如何從試算表、資料庫和網站獲取資料。其中的習題也將幫助你實踐所學。你將學到如何：‧視覺化：為資料探索和結果的交流創建圖表‧變換：找出變數型別及處理它們的工具‧匯入：將資料匯入R並轉換為方便分析的形式‧程式設計：學習R語言的工具，以更清晰的方式輕鬆解決資料問題‧溝通：使用Quarto整合說明、程式碼和分析結果

本書針對在行為科學界中，想以 R 著手進階統計分析的讀者而撰寫。第二版大幅改寫 R 程式，採用整齊資料（tidy）有關的資料整理套件與繪圖，並搭配管線運算子（pipe operator）。本書每一章皆以真實的案例為資料來源，實際演示資料分析一系列的歷程，使讀者更容易熟悉資料分析與 R 程式的使用。• 全部以精選之臺灣實際資料示範。• 分析流程完整，包括探索資料、設定模型分析與診斷模型三個步驟。• 所有分析可以完全重製。適用課程︰「統計軟體應用」、「統計模型應用」、「資料分析」等相關課程。適用對象︰大學、技專校院相關學系大學部、研究所之學生，亦適合實務工作者。

如何運用資料說故事？資料科學最重要的功能在於解讀與呈現其意義。將資料產生的意義加以串接與形成更多理解世界的線索，並且讓他們的讀者更快、更精準地理解現象背後的真相。自周敦頤說「文，所以載道也」，後有「文以載道」一說。對資料科學家，「文以載道」就是資料寫作學：讓資料分析成為書寫。如果文件需要對資料作圖表處理和統計分析，用R Markdown 製作文件就是最佳選擇。編輯R Markdown可以直接在R Studio當中進行，在寫R Code分析數據的同時，同時撰寫分析報告，不需要在不同的軟體中進行切換，上手相當容易。在本書中，將使用RStudio的免費平台，建立好讀者製表、製圖與繪製地圖的基本功，以及運用Markdown語法，將R語法及結果直接與你的解讀編織(knit) 在一起，進而轉為簡報檔或一本線上圖書。分享、讓大眾理解數據資料蘊含的脈絡與現象，是資料寫作最大的價值。

«每個人的故事都有它的意義——透過挖掘劉宰的生命故事，探索南宋士人的崇高使命感 «不再侷限皇帝達官顯要的歷史——重新建構南宋基層社會樣貌 ◎「與士大夫共治天下」不是說說而已——致仕歸鄉仍有志於社會 劉宰是何許人也？劉宰並非南宋重臣名宦，身分僅為地方士人官僚，他在官途順遂且尚處壯年之時，毅然辭官返鄉。由於他過往擔任地方基層官的種種經驗，加之家鄉鎮江府金壇縣位處南宋與金的邊境，是當時南宋政局動盪的首衝之地，於是他選擇「退而不休」，不只積極號召、凝聚鄉親人力，更多次推動大型社會公益活動。 ◎小人物立大功——誰說只有權有勢的官宦才能影響政局及社會 縱然劉宰不似同時代的史彌遠、韓侂冑等人威名赫赫，劉宰雖已脫離官場，他仍時常與當權者通信，並且依據自己在地方地所聞所見，提供政策解決方案，同時對時局提出建言。他作為政府官方與地方士人的中介，促使南宋地方政府與基層社會緊密連結，展現南宋時代的獨特士人社會力。 作者結合地理環境和時代政局的變動，描繪劉宰一生所關注、推動以及與時代環境緊密連結的家國事業，藉由認識劉宰他的人格特質以及他所代表的南宋時代的士人社會力微觀研究出發，剖析環境與資源對區域的發展影響，建構出更完整的南宋社會樣貌，試圖從與過往不同的視角理解南宋在中國歷史轉型期的關鍵地位。 Huang Kuanchung is a social historian, political historian, cultural historian, and intellectual historian all at once. All his talents are in apparent in this fascinating and important study of Liu Zai 劉宰in Southern Song local society and national politics. 黃寬重同時是社會、政治、文化和思想史學家。他所有的才能，在這部精彩且重要的關於南宋地方社會和國家政治的劉宰研究中，顯露無遺。——Peter Bol（

«每個人的故事都有它的意義——透過挖掘劉宰的生命故事，探索南宋士人的崇高使命感 «不再侷限皇帝達官顯要的歷史——重新建構南宋基層社會樣貌 ◎「與士大夫共治天下」不是說說而已——致仕歸鄉仍有志於社會 劉宰是何許人也？劉宰並非南宋重臣名宦，身分僅為地方士人官僚，他在官途順遂且尚處壯年之時，毅然辭官返鄉。由於他過往擔任地方基層官的種種經驗，加之家鄉鎮江府金壇縣位處南宋與金的邊境，是當時南宋政局動盪的首衝之地，於是他選擇「退而不休」，不只積極號召、凝聚鄉親人力，更多次推動大型社會公益活動。 ◎小人物立大功——誰說只有權有勢的官宦才能影響政局及社會 縱然劉宰不似同時代的史彌遠、韓侂冑等人威名赫赫，劉宰雖已脫離官場，他仍時常與當權者通信，並且依據自己在地方地所聞所見，提供政策解決方案，同時對時局提出建言。他作為政府官方與地方士人的中介，促使南宋地方政府與基層社會緊密連結，展現南宋時代的獨特士人社會力。 作者結合地理環境和時代政局的變動，描繪劉宰一生所關注、推動以及與時代環境緊密連結的家國事業，藉由認識劉宰他的人格特質以及他所代表的南宋時代的士人社會力微觀研究出發，剖析環境與資源對區域的發展影響，建構出更完整的南宋社會樣貌，試圖從與過往不同的視角理解南宋在中國歷史轉型期的關鍵地位。 Huang Kuanchung is a social historian, political historian, cultural historian, and intellectual historian all at once. All his talents are in apparent in this fascinating and important study of Liu Zai 劉宰in Southern Song local society and national politics. 黃寬重同時是社會、政治、文化和思想史學家。他所有的才能，在這部精彩且重要的關於南宋地方社會和國家政治的劉宰研究中，顯露無遺。——Peter Bol（包弼德）&n

Welcome to the LEGO (R) Dreamzzz (TM) universe! Build your Mateo minifigure before joining him on an epic adventure to protect the dream world from the evil Nightmare King.

第一本結合管理數學和Python、R應用的工具書，輕鬆獲得雙倍效果！管理的問題，就用數學來解決吧！令人驚呼的超強特色：1.淺顯易懂的口吻加上超豐富內容，一本掌握管理數學！2.附有精彩的範例、習題與解析，滿足所有練習慾望！3.用Python、R簡單搞定繁雜的數學計算，手把手跟著步驟走！讓數據分析成為管理的後盾，成就更無懈可擊的經營決策！管理數學為一門重要的基礎，不只是為了商業管理和決策，也是學習資料科學的第一步。現今不論是商管領域的學生或是從業人員，為了跟上世界的腳步，都必須學習程式語言，如果能在學習管理數學時搭配Python、R做使用，不只符合世界潮流，也等同開啓資料分析的大門。本書作者投入融合「計量經濟學和資料科學」的計量資料科學 (Econometric Data Science) 多年，對於以計量經濟學為基礎的資料科學猶有心得，本書由淺入深地介紹微分、積分、矩陣代數和數學規劃等管理數學必需的基礎與商管應用，此外，為達到與程式學習相輔相成之效，作者編排章節亦十分用心，在管理數學的16堂課中，穿插步驟式的Python、R教學單元，讓讀者學完數學原理和計算之後，能立刻熟悉Python與R的應用方式，學習效率更加倍！輕鬆就學會管理數學！

Learn through play in this exciting expansion of the groundbreaking TinkerActive series, with format innovations perfect for learners ages 3 and up!TinkerActive Early Skills workbooks are curriculum-based hands-on fun, perfect for your littlest learners! Each Early Skills workbook is:Created with AWARD-WINNING TEACHERSPacked with STEM ACTIVITIESFilled with TINKERING, CRAFTING, & ENGINEERING projectsLoaded with STICKERS and a FOLD-OUT REWARD POSTERComplete with a WRITE-AND-WIPE game board and activities, so kids can PRACTICE AND PLAY AGAIN AND AGAIN.And even includes EASY AND PRACTICAL TIPS on how to engage your little tinkerer in learning.For ages 3 and up, this workbook covers: Same & Different, Sorting, Counting to 20, Quantities, Writing Numbers, Addition & Subtraction Fundamentals, Measurement, Spatial Reasoning, and Shapes.

Learn through play with TinkerActive Early Skills Workbooks―an exciting expansion of the groundbreaking TinkerActive workbook series, with format innovations perfect for learners ages 3 and up!TinkerActive Early Skills workbooks are curriculum-based hands-on fun, perfect for your littlest learners! Each Early Skills workbook is:Created with AWARD-WINNING TEACHERSPacked with STEM ACTIVITIESFilled with TINKERING, CRAFTING, & ENGINEERING projectsLoaded with STICKERS and a FOLD-OUT REWARD POSTERComplete with a WRITE-AND-WIPE game board and activities, so kids can PRACTICE AND PLAY AGAIN AND AGAIN.And even includes EASY AND PRACTICAL TIPS on how to engage your little tinkerer in learning.For ages 3 and up, this workbook covers: Pencil Control, Crayon Control, Letter Recognition, Tracing Uppercase Letters, Alphabetical Order, Letter Sounds, Early Vocabulary

Test Prep Books' CSCS Exam Prep 2022 - 2023: Study Guide Book with Practice Tests for the NSCA Certified Strength and Conditioning Specialist Assessment [5th Edition]Taking the CSCS test? Want to get a good score?Written by Test Prep Books, this comprehensive study guide includes: Quick OverviewTest-Taking StrategiesIntroductionStudy Prep Plan for the CSCS ExamExercise SciencesSport PsychologyNutritionExercise TechniqueProgram DesignOrganization and AdministrationTesting, Ongoing Monitoring, and Data EvaluationPractice QuestionsDetailed Answer ExplanationsDisclaimer: *CSCS(R) and Certified Strength and Conditioning Specialist(R) are registered trademarks of the National Strength and Conditioning Association. Neither this publication nor the publisher have any affiliation with, or any recognition, sponsorship, or endorsement by, the NSCA.Studying is hard. We know. We want to help. You can ace your test.Each part of the test has a full review. This study guide covers everything likely to

Oh dear . . . when Pip shows up with a new look that's just as much of a surprise to him as to Zoey and Sassafras, the trio knows something strange is happening in the forest. They retrace Pip's steps only to see another magical friend change right before their eyes It's up to the team to figure out what is happening and how to change the magical animals back before things get any more serious . . .Each story in the Zoey and Sassafras series features a new magical animal with a problem that must be solved using science. There isn't a set formula for each book; Zoey sometimes needs to run experiments, while other times she needs to investigate a mystery, and yet other times she needs to do research. Zoey models how to keep a science journal through her handwritten entries in each story. Each story is complete with a glossary of the kid-friendly definitions for scientific terms used. The series highlights child-led inquiry science and the topics covered align with both Common Core and Ne

※本書版稅全數捐贈社團法人中華民國肯愛社會服務協會場上的拚搏，是他賭上青春的印記「球沒落地，絕不放棄」李洋自述成長故事！「正因為我普通，所以才更努力去做我想做的！」2024年8月4日巴黎，在眾人屏息期待下，李洋與王齊麟摘下運動最高殿堂羽球男雙金牌，創下史上首次羽球項目男子雙打連續奪得金牌的紀錄。2021年7月31日東京，羽球男雙金牌戰，決勝點的一記壓線球「IN」，李洋成功守住了前場。「我喜歡打球，所以我也會繼續開心地、努力地在球場上追逐我的夢想。」他始終不忘喜愛羽球的初心，但曾經，他也想過要放棄……李洋的羽球生涯起步較晚，從乙組晉升甲組，足足熬了八年。父親說他「你不是這塊料」，讓他徹夜痛哭，掙扎是否該放下手上的球拍。最後，他擦乾淚水，踏實地一步步走上運動最高殿堂，「逐夢路上艱辛難免，但並不孤單」。想知道李洋是如何堅定目標，勇敢逐夢嗎？想知道燦爛笑容之下，有多少酸甜苦辣的故事嗎？想知道面對人生選擇時，他是如何取捨嗎？讓李洋親自告訴你，他是誰。專文推薦陳宏麟（中華隊羽球雙打教練、土地銀行羽球隊教練）王齊麟（中華隊羽球男子雙打選手）李峻淯（李洋父親、中央銀行羽球社主力球員）「競技運動場上永遠不會有終點，每天都是新的起點，唯有不斷突破、堅持，才能享受最後甜美的果實。」──陳宏麟（中華隊羽球雙打教練、土地銀行羽球隊教練）「希望我們在接下來的比賽都能有不錯的成績，可以一起站上更多重要比賽的領獎臺，一起搭配，打到不能動為止。」──王齊麟（中華隊羽球男子雙打選手）「志在峰巔的攀登者，不會陶醉在沿途的某個腳印之中，激情過後，我告訴李洋：當更謙卑、更努力，以不負自我期許，以及國家所託、同胞所望！」──李峻淯（李洋父親、中央銀行羽球社主力球員）

Steve Spangler’s Super-Cool Science Experiments for Kids is a collection of 50 startling projects that encourage kids to question the world around them and how it works.This book presents the most ama

有效的資料分析、統計與繪圖實用錦囊 “和其它的程式語言書籍相比，我從這本書中學到更多。” ―David Curran Cognitive Engineer at OpenJaw Technologies 本書是《R錦囊妙計》第二版，擴展了更多的內容，使用R快速有效地執行超過275種實用資料分析。R語言提供了統計分析工作所需要的一切工具，但是它的結構可能有點難以掌握。本書彙整精簡、任務導向的錦囊，能

"Let's practice! helps you build confidence and credibility to create graphs and visualizations that make sense and weave them into action-inspiring stories. Expanding upon ... Storytelling With Data'

Plant remains can preserve a critical part of history of life on Earth. While telling the fascinating evolutionary story of plants and vegetation across the last 500 million years, this book also crucially offers non-specialists a practical guide to studying, dealing with and interpreting plant fossils. It shows how various techniques can be used to reveal the secrets of plant fossils and how to identify common types, such as compressions and impressions. Incorporating the concepts of evolutionary floras, this second edition includes revised data on all main plant groups, the latest approaches to naming plant fossils using fossil-taxa and techniques such as tomography. With extensive illustrations of plant fossils and living plants, the book encourages readers to think of fossils as once-living organisms. It is written for students on introductory or intermediate courses in palaeobotany, palaeontology, plant evolutionary biology and plant science, and for amateurs interested in studyin

If you think of science as a puzzle, you’ll see that data is a key to unlocking it. Exemplary Evidence: Scientists and Their Data touches on the world’s many riddles—from how we see to what’s at the b

Livvy and Jayden are the stars of their school's robotics team. Livvy is especially enthusiastic because her own mother works in a robotics lab and experiments with Artificial Intelligence. To impress

本書《R語言與資料分析實戰》以R語言的「程式設計屬性」為中心，內容涵蓋R語言基礎理論到實際資料分析，透過分析模型和演算法等更實用的範例，講解了資料視覺化、統計分析、資料採擷、機器學習等常用的方法。同時書中還收錄了作者的實戰經驗和學習體會，可以解決資料統計分析過程中出現的各種問題。如果你是一名資料統計分析的研究人員，本書將是一本不可多得的參考書，能夠深化理解與認識R軟體的應用，進一步提高資料統計分析

‧本書主要針對人文社科學子，以及有興趣以R分析民意調查資料的學習者所打造。以多種民意調查進行資料分析實作，包含大型面訪調查資料、電話調查資料及網路調查資料，從資料描述到報表輸出，都能用R輕鬆完成。•提供清楚的學習路徑圖，幫助三種學習者快速上手：無論如何都想入門R，卻苦無任何程式訓練背景的學習者、正在不同資料分析工具之間評估R的學習者，以及準備好要用R處理民意調查資料的學生、從業人員或是學者。•提供

Now in its fifth edition, this invaluable handbook provides a complete guide to the practical application of data protection law. It is fully updated and expanded to include coverage of significant de

Soccer is the most mathematical of sports--riddled with numbers, patterns, and shapes. How to make sense of them? The answer lies in mathematical modeling, a science with applications in a host of bio

Due to the increasing demand for career guidance in recent years, career counsellors have been challenged to modernise their practice. As a response to the rapidly changing world of work, with more di

NEW YORK TIMES BESTSELLERRanking alongside George R. R. Martin as a groundbreaking master of fantasy, Robin Hobb delivers the second book in her long-awaited Fitz and the Fool trilogy. The harrow

Classic Grounded Theory: Applications with Qualitative and Quantitative Data is unique in its presentation of classic grounded theory, from its historical origins to step-by-step guidance on how to ca

David Card and Alan B. Krueger have already made national news with their pathbreaking research on the minimum wage. Here they present a powerful new challenge to the conventional view that higher minimum wages reduce jobs for low-wage workers. In a work that has important implications for public policy as well as for the direction of economic research, the authors put standard economic theory to the test, using data from a series of recent episodes, including the 1992 increase in New Jersey's minimum wage, the 1988 rise in California's minimum wage, and the 1990-91 increases in the federal minimum wage. In each case they present a battery of evidence showing that increases in the minimum wage lead to increases in pay, but no loss in jobs.A distinctive feature of Card and Krueger's research is the use of empirical methods borrowed from the natural sciences, including comparisons between the "treatment" and "control" groups formed when the minimum wag

Aasif Mandvi—best known for his work as a correspondent on The Daily Show with Jon Stewart—has been dealing with identity issues across three continents and 30 years. With wit, smarts, and a good dose

Globalization and the professionalization of Corporate Social Responsibility (CSR) have led to a surge of CSR activities claiming to support development across the globe. In this two volume series, th

本書經作者10年重修及5次精心撰述 本書適合作為想擔任公司總經理或集團企業總裁的實用工具書，是追求「民富國強」的企業大軍出將入相術，所以稱為「有效總經理──企業將帥術」。 公司總經理就是將軍、軍長(General)；集團總裁就是軍團司令、統帥(Commander in chief)，凡是「將」、「帥」都要學會企業管理之道──由「雙重五指山」構成的「管理科學矩陣」。第一重五指山是

Panel Data是一個越來越受到重視的資料型態，除了財經會計之外，一般社會科學對於分析Panel Data的需要也日益增加。本書除了介紹標準個體計量使用的Panel Data分析之外，也包括非定態Panel Data的分析，以及近年來相當引人注意的 Large Panel問題。►以資料分析的角度結合Panel Data的理論和實做：本書多以敘述方式講述理論，另外再輔以簡單的代數，讀者可以很快地