Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The definitive, fully illustrated official companion to Stranger Things, detailing every aspect of the show’s development from page to screen. PLEASE NOTE: The distressed look of the cover is intentio

Funny and totally true childhood biographies and full-color illustrations tell tales from the challenging yet defining growing-up years of Albert Einstein, Jane Goodall, Marie Curie, and 12 other brilliant scientists.Every great scientist started out as a kid. Before their experiments, inventions, and discoveries that changed the world, the world's most celebrated scientists had regular-kid problems just like you.*Stephen Hawking hated school, and preferred to spend his free time building model airplanes, inventing board games, and even building his own computer.*Jane Goodall got in trouble for bringing worms and snails into her house.*And Neil deGrasse Tyson had to start a dog-walking business to save up money to buy a telescope.Readers ages 8 to 12 years old will learn all the stories of a diverse and inclusive group—also including Temple Grandin, Nikola Tesla, Ada Lovelace, Benjamin Franklin, Isaac Newton, Rosalind Franklin, Sally Ride, Rachel Carson, George Washington Carver, and V

Izzy and friends are excited! The snow is falling fast and they’re hoping they’ll all be sent home early. But then they hear weird noises in the playground, and find a big footprint in the snow… And that’s when they know! There’s a YETI in the playground and it’s HUNGRY!Laugh-out-loud fun from Blue Peter Award winners Pamela Butchart and Thomas Flintham.Read more of Izzy’s adventures!Baby Aliens Got My TeacherThe Spy Who Loved School DinnersMy Headteacher Is a Vampire RatThe Demon Dinner LadiesThere’s a Werewolf in my TentTo Wee or Not to WeeThe Phantom Lollipop ManIcarus Was Ridiculous

The figure of the young American poet living in Paris is familiar from Paul Auster's celebrated novels; here that character is realised in Auster's own stunningly accomplished verse. His penetrating and charged poetry resembles little else in recent American literature. This collection of his poems, translations, and composition notes from early in his career furnish yet further evidence of his literary mastery.Taut, densely lyrical and everywhere informed by a powerful and subtle music, this selection begins with the compact verse fragments of Spokes (written when Auster was in his early twenties) and Unearth, continues on through the more ample meditations of Wall Writing, Disappearances, Effigies, Fragments From the Cold, Facing the Music, and White Spaces, then moves further back in time to include Auster's revealing translations of many of the French poets who influenced his own writing - including Paul Eluard, Andre Breton, Tristan Tzara, Philippe Soupault, Robert Desnos and Rene

Both Watcher, the young NPC leading the villager army, and Krael, King of the Withers, have taken magical weapons from the ancient Vault of Weapons. Watcher is now able to raise a powerful army using

Diego is under Maldred's dark spell!Pick a book. Grow a Reader!This series is part of Scholastic's early chapter book line, Branches, aimed at newly independent readers. With easy-to-read text, high-interest content, fast-paced plots, and illustrations on every page, these books will boost reading confidence and stamina. Branches books help readers grow!In the eleventh book in this fantasy series, the wizard Maldred is back! And Diego is under his dark spell! Drake learns that Maldred wants to control the Naga -- an enormous dragon that lives deep within the Earth. Two keys are needed to control the Naga. The first key is guarded by a Silver Dragon named Argent. Drake, Bo, and Carlos must find Argent and stop Diego before it's too late. But will Argent's powerful Dragon Master Jean get in their way? The action is nonstop in this exciting, heavily illustrated early chapter book series!

This book tells the fascinating story of the development of medical and sanitation services in Hong Kong during the first century of British rule and how changing political values and directions of th

A Step 3 BIOGRAPHY READER about the unsung historical figure and Founding Mother Elizabeth Schuyler Hamilton.Hamilton, the musical, is igniting American history fever in adults and kids--especially about the central figures of the play. Kids clearly want to know more, and this companion to early reader Alexander Hamilton: From Orphan to Founding Father will fill the void. Eliza Hamilton was so much more than just Alexander Hamilton's wife. She was a spirited girl who grew up to be a strong woman with a big heart and amazing strength of character. She rescued many children in need during her life. In fact, she and others established New York City's first orphanage--which became a place that is still helping needy children to this day. She lived for 50 years after Hamilton's death in the infamous duel, and she preserved his historical legacy and contributed to American history with other Founding Mothers in ways that will finally be shared widely with those newly interested in Colonial a

The Fashion Business Manual is everything you need to start building your fashion brand. It takes you step by step through building a brand from startup to retailing, using illustrations to break dow

Batter up! It's an NYC-themed Super Special! Ballpark Mysteries are fun, accessible early chapter books that cross baseball action with puzzling whodunits!Catch a baseball mystery--in New York City! M

Whizzing Through The Woods Deep in the woods where people seldom go live The Butterfly Children. It was early morning and The Butterfly Children were asleep. All of a sudden DC was woken up by a loud

Create a thinking classroom that helps students move from the factual to the conceptual Concept-Based Inquiry is a framework for inquiry that promotes deep understanding. The key is using guiding

Learn about dinosaurs with Big Stickers for Little Hands Dinosaur Island. This early learning sticker activity book introduces children aged 3+ to roar-some dinos through simple activities, big stickers and card press-outs. This 16-page sticker book for kids is full of fun, early learning activities that are perfect for young animal lovers.Includes 2 sheets of big stickersWith 2 sheets of awesome card press-outs16 pages of simple, early learning activities

35 step-by-step art projects using paint and paper, for children aged 7+.35 step-by-step art projects using paint and paper, for children aged 7+. My First Painting and Collage Book shows you differen

Understanding the concept of time in relation to routine activities is a vital pre-school skill, and this interactive book is an engaging introduction to daily routines, ordering events and describing your day. A fun introduction to a key early learning concept, with over 60 flaps to lift.商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

Facebook and Conversation Analysis investigates the structure and organization of comments on a major social media platform, Facebook, using applied conversation analysis methods. Providing previously

This updated DK classic includes sixteen colorful flashcards with tactile elements that are perfect for giving toddlers a head start in developing early language skills.Each 17-card pack contains 16 touch-and-feel picture cards and 1 card of parent guidance notes to help both parents and little ones get the most from the collection. My First Touch and Feel Picture Colors and Shapes features colorful squares, circles, triangles, and more! On the reverse of most cards, there are a series of engaging questions, in addition to word translations for Spanish, French, German, Chinese, and phonetic spellings to help develop early language skills. Sturdy cards and fun tactile images make these packs ideal for preschool play.

Radar Meteorology: A First Course introduces undergraduate and graduate students to the technology and application of radar in 21st century meteorology and atmospheric sciences. The book, designed to accompany university courses in radar meteorology, will have three distinct parts. In the first part, the reader will be introduced to electromagnetic wave propagation and radar design considerations. This part will then develop the techniques used to retrieve the key quantities central to radar meteorology: the effective radar reflectivity factor, the Doppler radial velocity and spectral width, and polarization variables. The second part will focus on operational meteorological applications, including data quality control, precipitation estimation and hydrometeorological applications, warm season mid-latitude severe weather, cold season hazardous weather, and tropical cyclones. The third part of the book will focus on research applications, including research

Narwhal's obsession with his new favorite food leads him into hijinks and hilarity in the third book of this all-star early graphic novel series!Narwhal and Jelly are back and Narwhal has a new obsess

This exciting new strand of Charlie and Lola activity books provides fun and accessiblity across key early years learning topics. From Children's Laureate Lauren Child.

The rules for finding professional work once seemed clear and unwavering: capture career highlights in a resume, practice answers to standard interview questions, and do lots of face-to-face networking. Cracking the New Job Market shows how these rules have changed and delivers new job-hunting strategies that actually work. The key, rather than to emphasize past accomplishments, is to sell your self on the value you can create for an employer. This new approach to getting hired requires new skills. Author R. Willam Holland, a human resources insider, shows job seekers how to: * Gather information on what a prospective employer finds important * Emphasize those skills, accom plish ments, and qualities in tailored resumes and interview answers * Identify the intersection between personal talents and what the marketplace needs * Unlock the networking power of social media * Negotiate the best possible offer Enlightening and practical, this myth-busting book delivers seven powerful rules f

A picture book biography of Ada Lovelace, the woman recognized today as history’s first computer programmer—she imagined them 100 years before they existed!In the early nineteenth century lived Ada By

A practical, dip-in guide, packed with over 100 outdoor activities for children.In an era when the iPad is often more appealing than the park, it can be difficult to encourage kids to get off the couch and spend time outside. In this inspirational book, with ideas for children of all ages, there are over 100 imaginative ways for children to keep busy and have fun outdoors. They can enjoy outdoor crafts such as making leaf art bunting, a dream catcher, or their own toy raft, or get physical and burn off some energy with beach hopscotch, animal tracking, and developing their hunting and gathering skills. Or perhaps they would like to relax and enjoy some star-gazing or pond-dipping instead. There are fun activities to help kids get up close and personal with nature by making a wormery and a bug attractor, doing some investigative ant experiments, and putting on their own gastropod race! The book includes handy reference pics to help children identify plants, flowers, and wildlife, so as

How good are YOUR table manners? Do you eat with your mouth open like cow, or gulp your food like duck? Do you dribble like anteater or do you burp like pig?Wiggle the sliding tabs and giggle as the r

Updated and revised to meet all current standardsThis is a concise step-by-step guide for novice nurse educators on the development of new programs and curricula or the revision of existing ones that

Teach yourself more than 3,000 of the most common and essential English words and phrases using illustrations, a free audio app, and hundreds of practice exercises.Expand your English vocabulary with

Scholastic Decodable Readers is a 4-level learing program which helps accelerate children’s word identification skills and achieve greater mastery in early reading skills. Each level has 20 sequenced

The 80 books in this series (20 per level) cover the full range of phonics skills---from short vowels (Level A), to short vowels with blends and digraphs (Level B), to long vowels and diphthongs (Leverl C), to complex vowels and multisyllabic words (Level D).These books provide highly-controlled phonics practice and offer a complete basic course in decoding. They can also serve as supplemental reading texts when using other programs such as Phonics Readers as the scope and sequence of each series correlates.Level B features+ Short Vowels+ Consonant Vowel Consonant+ Digraphs+ Blends* Introduces intermediate vowels and consonants.* Help children understand letter-pairing and how sounds can be blended to form words.* Repetitive sentence pattern provides extensive practices.

The Evan-Moor Smart Start STEM Grade 1 Activity Book introduces scientific concepts to first graders using a mixture of hands-on activities, stories and problem solving tasks that are sure to keep kids entertained while theyre gaining invaluable skills. When working on physical science concepts, gr. 1 students will focus on the differences between solids, liquids and gases. The life science sections discuss the things animals eat and how they take care of their babies, all in language that grade one kids can comprehend. And, in the earth science lessons, well introduce concepts about the moon, bodies of water and weather.

The Evan-Moor Smart Start STEM Grade 1 Activity Book introduces scientific concepts to first graders using a mixture of hands-on activities, stories and problem solving tasks that are sure to keep kid

These books are aimed at children who can read a little, but who need lively but structured books to help them develop their skills further, focusing particularly on phonics. Using a familiar tale, th

After a few early glitches in their relationship, Sammy and his 'bro-bot' E are now best friends. In fact, E is such a valued member of the family that the other electronic members of the House of Rob

黑暗勢力正籠罩大地 Perodia，禿鷲 Thorn 帶領間諜大軍，企圖以黑魔法毀滅世界。小貓頭鷹 Tag 雖渴望成為勇敢的戰士，卻還太稚嫩。與他的好友松鼠 Skyla，以及最後一隻火鷹攜手，他們踏上尋找魔法石的旅程。故事節奏明快，人物討喜，是孩子接觸奇幻與任務冒險的絕佳入門。Pick a book. Grow a Reader!This series is part of Scholastic's early chapter book line Branches, aimed at newly independent readers. With easy-to-read text, high-interest content, fast-paced plots, and illustrations on every page, these books will boost reading confidence and stamina. Branches books help readers grow!A terrible darkness is spreading across Perodia. Thorn, a powerful vulture, is using dark magic (and his dark army of spies!) to destroy the magical land. A young owl named Tag may be the only one who can save it! Tag dreams of one day becoming a brave warrior, but he is small... In this first book, Tag and his best friend -- a squirrel named Skyla -- meet the last firehawk. Together, the three friends learn about a magical stone. Could this stone be powerful enough to defeat Thorn? This action-packed series makes a great introduction t

Six little fish in the sea can be seen, but can you find the fish with scales that are green? Gentle rhyming text combines with a fun spotting activity to present early concepts in a fun new way. Can

Let's say hello to the animals at the zoo. One is tall and spotty, can you see who? Gentle rhyming text combines with a fun spotting activity to present early concepts in a fun new way. Explore famili

New in the Little People, Big Dreams series, this inspiring and informative little biography follows the colourful life of iconic actress Audrey Hepburn, from her early life during World War Two, to b

The wacky robots from the award-winning StoryBots apps, videos, and Netflix show now star in their own early readers. This one is about everyone’s favorite dinosaur!Fans of the StoryBots will recogniz

★ 前華爾街量化分析師揭露：演算法如何操控你的未來★ 大數據黑暗面全面曝光：看不見的歧視與不公平我們以為世界正變得更公平——由機器取代人類做決策，似乎能消除偏見。但真相，可能正好相反。在這個「演算法主宰」的時代，你能否錄取學校、拿到工作、申請貸款，甚至保險費率高低，都悄悄被一套看不見的數學模型決定。這些系統看似客觀，卻無法被檢驗，也無從質疑，一旦出錯，影響卻會層層放大。數學家暨資料科學家凱西．歐尼爾，以親身經驗揭開大數據的陰暗面：這些模型不只沒有消除不平等，反而強化既有的階級與歧視，讓弱勢更難翻身。本書如同一場警醒之旅，帶你看見科技背後不為人知的權力運作。NEW YORK TIMES BESTSELLER • A former Wall Street quant sounds the alarm on Big Data and the mathematical models that threaten to rip apart our social fabric—with a new afterword“A manual for the twenty-first-century citizen . . . relevant and urgent.”—Financial TimesNATIONAL BOOK AWARD LONGLIST • NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • The Boston Globe • Wired • Fortune • Kirkus Reviews • The Guardian • Nature • On PointWe live in the age of the algorithm. Increasingly, the decisions that affect our lives—where we go to school, whether we can get a job or a loan, how much we pay for health insurance—are being made not by humans, but by machines. In theory, this should lead t

#1 The Crooked Sixpence (THE UNCOMMONERS)#2 The Smoking Hourglass (THE UNCOMMONERS)#3 Jennifer Bell, Karl James Mountford (THE UNCOMMONERS)★ 英倫奇幻冒險《The Uncommoners》三部曲★ 魔法城市 × 神祕交易市場 × 世界級奇幻冒險★ 從倫敦地下城市到紐約神祕市場，魔法世界全面擴張★ 《哈利波特》《善惡學院》讀者必讀的奇幻系列在倫敦地下，藏著一座神祕城市——Lundinor。這裡的世界與眾不同：普通物品可能擁有不可思議的魔法力量，各式奇妙物件在祕密市場流通。當艾薇與哥哥賽布意外闖入這個世界，他們被捲入一場危險冒險，必須解開家族祕密、尋找失蹤的人，並阻止黑暗勢力奪取強大的魔法物品。《The Uncommoners》三部曲帶來充滿想像力的奇幻冒險。*]:pointer-events-auto scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]" data-turn="assistant" data-scroll-anchor="true" data-testid="conversation-turn-16" data-turn-id="request-WEB:62142b30-ffda-462a-bca8-86a529fefff7-78">Hidden beneath the streets of London lies the extraordinary city of Lundinor — a secret world where ordinary objects possess extraordinary powers.In this hidden city, mysterious traders deal in magical items: enchanted feathers that write messages, coins with strange abilities, and countless uncommon objects whose powers are yet to be discovered.When Ivy S

Chosen as one of The New York Times Best Illustrated Children's Books 2016 Little Red Riding Hood meets a wolf on her way through the woods to visit her sick grandmother. The wolf is hungry, and Red R