Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Featuring twenty-two easy craft projects using natural and recycled materials, The Big Book of Nature Art is a fun and eco-friendly way for young children to connect creatively with nature.Featuring twenty-two easy craft projects using natural and recycled materials, The Big Book of Nature Art is a fun and eco way for young children to connect creatively with nature.From bestselling author Yuval Zommer, The Big Book of Nature Art is packed with twenty-two easy art activities inspired by nature. Each of the activities can be achieved in four simple steps using natural materials combined with recycled or found materials from around the home. Drawing on Zommer's years of experience running art workshops for children, The Big Book of Nature Art includes his tips for stress-free ways to get creative with kids.Each nature art activity requires no more than five minutes set-up and five minutes clean-up, making them easy to achieve and fun for everyone involved. The book also encourages childr

From the Amazon rainforest in South America to the Congo in Central Africa, find the animals hidden in each scene using the special "flashlight" included in the book. Who's hiding in the grass? And what about the shadow in the branches of that tree? Thanks to the magic flashlight in this book, children will be entertained looking for more than 60 animals hidden in the wonderfully illustrated pages. Each spread highlights a different part of the world and provides bite-sized facts about the creatures found in that jungle.

Sir Ladybug (Book 1)(graphic novel)Sir Ladybug and the Queen Bee (Book 2)(graphic novel)Sir Ladybug and the Bookworms (Book 3)(graphic novel)The debut of a clever and humorous young graphic novel series about the adventures of a valiant ladybug and his friends, from Geisel Award–winning author-illustrator Corey R. Tabor.Ladies and gentlebugs, presenting the duke of the dandelion patch, champion of truth and justice, the one, the only—Sir Ladybug!Sir Ladybug never shies away from a quest, even when he’d rather be playing a video game or baking a cake. So when a caterpillar needs rescuing from a “monster” (a hungry chickadee), Sir Ladybug and his trusty friends—his herald, a roly-poly named Pell, and his squire, a snail named Sterling—hatch the perfect (delicious) plan.From Geisel Award–winning author-illustrator Corey R. Tabor comes a fresh and funny young graphic novel series sure to delight readers. Perfect for fans of Catwad, Bird & Squirrel, and Narwhal & Jelly.

This new series of little books builds children's confidence with mathematical vocabulary and ideas and provides a foundation for learning in a way that feels good. Using carefully chosen words in relatable settings from the world around them, this book creates a moment for children and adults to discover first sorting words through dressing up and having fun. The engaging art style, fun characters and hardback picture book feel make this series accessible and perfect to share.Written and illustrated by the same winning team as 'Big Words for Little People', this series is special not only because it focuses on maths in a child-friendly way, but also because it's from Oxford, it's packed with educational goodness that helps children develop and grow.

This new series of little books builds children's confidence with mathematical vocabulary and ideas and provides a foundation for learning in a way that feels good. Using carefully chosen words in relatable settings from the world around them, this book creates a moment for children and adults to discover first counting words at a pizza party. The engaging art style, fun characters and hardback picture book feel make this series accessible and perfect to share.Written and illustrated by the same winning team as 'Big Words for Little People', this series is special not only because it focuses on maths in a child-friendly way, but also because it's from Oxford, it's packed with educational goodness that helps children develop and grow.

Boom! Crash! Crumble! A wrecking ball smashes into the side of a building, sending pieces flying. It’s an awe-inspiring sight. It’s also science!This book explores how things break down, crack, explode, crumple, and shatter. This fun, unique take on a how-things-work book explores the world through the lens of what it takes for things to, well, not work. In these vibrantly illustrated pages, you’ll peer through the smoke and rubble of controlled demolitions to discover the properties of building materials. Then get a glimpse of the inner workings of a cracked cell phone screen, peek carefully at mega-avalanches and sinkholes, and hold on tight as wrecking balls swing and car crushers crunch metal. Buckle up with crash-test dummies and travel back in time to explore the world’s most famous failures (looking at you, Leaning Tower of Pisa).Featuring hands-on activities that walk kids through their own experiments in destruction, Break Down! will change the way you look at the world.Topics

This visually extraordinary book presents the history of medicine as it has never been seen before... perfect for readers aged 9+. From potions and ointments to modern day bionics, the journey through medicine has been one full of experiments, trials and breakthroughs.Humankind's battle to stay alive has been horrifying, bizarre and exhilarating, and there is still a long way to go. Uniquely presented through a series of posters, comic-strip retellings, timelines, newspaper articles and much more, this strikingly illustrated book charts the history of medicine in engaging and unusual ways - guaranteed to keep children gripped. With expert text written by pharmacy historian, Briony Hudson and stunning graphic artwork by Nick Taylor.

Go back in time to when everyone's favorite Catstronaut, Waffles, was a kitten! Fans of Narwhal and Jelly will love this fun, cat-tastic early graphic novel series. It's time to visit Gramps and Grammers and that means Waffles, Pancake, and Mom-Cat are taking a very early flight to get to maximize the fun-times! This is the kittens' first airplane ride and while Pancake is excited to get on board, Waffles is a little more nervous: an airplane has wings, but airplane wings don't flap! How does it stay up in the air? With a little bit of science and a whole lot of imagination, the kittens are able to understand the mechanics of flight andenjoy the ride. Come fly the feline skies!

Your all-access pass to spectacular space stations. Step inside one of humanity's greatest achievements with a behind-the-scenes guide to space exploration. Revealing a new perspective into the world of space exploration and the daring astronauts who make it possible, Behind the Scenes at the Space Station takes you on a once-in-a-lifetime tour of the space station. Learn what the astronauts do once they make it to the space station, from experiments to repairs and so much more! Have you ever wondered if plants can grow in outer space? Or how the space station doesn't break down in outer space? Or how astronauts go to the toilet in zero gravity? Behind the Scenes at the Space Station is a treasure trove of information. Did you know that during a 24-hour period, the space station completes 16 orbits of Earth and the astronauts on board see 16 sunrises and sunsets everyday? Or that the International Space Station is so enormous that it was launched in pieces and constructed in orbit? Bri

Studies in Colloquial Chinese and Its History: Dialect and Text presents cutting-edge research into issues regarding prestige colloquial languages in China in their spoken forms and as well as their relationship to written forms and the colloquial literary language. These include the standard regional languages and prestige dialects of the past, the influence of historical forms of spoken Chinese on written Chinese, the history of guānhuà and the history of báihuà, proto-dialects and supra-regional common languages (koines), and their relationship to spoken dialects. The various studies in this collection focus on the dialect groups with the most substantial written tradition, including Mandarin, Wu, Min, and Cantonese, in north, central and eastern coastal, and southern China respectively. The contributors explore the histories of these dialects in their written and spoken forms, presenting a variegated view of the history and development of the regional forms, including their evoluti

繼《Lion Needs a Haircut》知名童書作家Hyewon Yum再次帶來溫馨的兒童生活教養繪本。看醫生一點都不可怕，讓勇敢的獅子哥哥為第一次看診的妹妹當個好模範吧！A lion family navigates their fears of going to the doctor in this adorable, hilariously relatable companion to Lion Needs a HaircutLittle lion Luka is NOT worried about a visit to the doctor. He’s NOT scared of getting a shot. And he’s definitely NOT a little lion anymore. R-O-A-R!His younger sister, Lulu, might be nervous for her first checkup―but no need to worry, big brother is here to set a brave example. Step by step, he walks her through what will happen, offering encouragement and holding her hand. But when it’s his turn, on second thought, maybe he doesn’t need to see Dr. Brown today; he’s feeling perfectly fine, after all.This witty, tender story follows two siblings sharing a universal experience together, giving each other courage and realizing that a trip to the doctor’s office isn’t so bad.

A proposal that we think about digital technologies such as machine learning not in terms of artificial intelligence but as artificial communication.Algorithms that work with deep learning and big data are getting so much better at doing so many things that it makes us uncomfortable. How can a device know what our favorite songs are, or what we should write in an email? Have machines become too smart? In Artificial Communication, Elena Esposito argues that drawing this sort of analogy between algorithms and human intelligence is misleading. If machines contribute to social intelligence, it will not be because they have learned how to think like us but because we have learned how to communicate with them. Esposito proposes that we think of “smart” machines not in terms of artificial intelligence but in terms of artificial communication.To do this, we need a concept of communication that can take into account the possibility that a communication partner may be not a human being but an al

The fact that Snow did not sneak into “red China” to gather information constituting the basis of his Red Start over China all alone is in many instances isunderstood even by scholars.Mao Zedong’s biography has been the subject of an international mountain of commentary in China and elsewhere. Biographies praising Mao and those slandering him are all based on the American journalist Edgar Snow’s (1905–1972) account in Red Star over China for the route Mao traveled from early childhood through his youth.How the “Red Star” Rose introduces the image of Mao and the biographical information made known to the world through the publication of Red Star, and with its publication the circumstances which they fundamentally undermined. Ishikawa Yoshihiro uses Mao Zedong as raw material to examine from whence and how ordinary historical information and images which we habitually use unconsciously come into being.He desires to help readers to reconsider the historicity of the generation of not only

What does it mean to be queer in a Confucian society in which kinship roles, ties, and ideologies are of such great importance? This book makes sense of queer cultures in China—a country with one of the largest queer populations in the world—and offers an alternative to Euro-American blueprints of queer individual identity. This book contends that kinship relations must be understood as central to any expression of queer selfhood and culture in contemporary cultural production in China. Using a critical approach—“queering Chinese kinship”—Lin Song scrutinizes the relationship between queerness and family relations, and questions Eurocentric queer culture’s frequent assumption of the separation of queerness from blood family.Offering five case studies of queer representations across a range of media genres, this book also challenges the tendency in current scholarship on Chinese and East Asian queerness to understand queer cultures as predominantly counter-mainstream, marginal, and unde

Inspired by his beloved CatStronauts series, Drew Brockington is going back in time to when everyone's favorite Catstronaut, Waffles, was a kitten! Fans of Narwhal and Jelly and Elephant & Piggie will love this fun, cat-tastic early graphic novel series.One very special Saturday, Dad-Cat decides to take Waffles and his sister Pancake to the big city to go to the science museum! While they're there, the kittens see extraordinary things, like dino-cats, hairballs in 4D, and even the planetarium. But as the kittens learn about constellations and Neil Pawstrong, they get separated from Dad-Cat. Oh no!Will the kittens be able to find their (possibly invisible) Dad-Cat? Or will they get stuck living in the museum and eating star tots and tuna melts fur-ever?! This early graphic novel series is chock-full of educational facts about space―perfect for young readers.

Charise Mericle Harper (Crafty Cat, Just Grace, Fashion Kitty) delivers another hilarious and charming early graphic novel series starring Pepper and Boo, two darling dogs, and their suspicious housem

A stunning guide to growing, harvesting, and arranging gorgeous dahlia blooms from celebrated farmer-florist and New York Times bestselling author Erin Benzakein, founder of Floret Flower Farm.World-r

A brand-new early reader graphic novel series about finding friendship in unexpected places! This fun and funny buddy comedy is perfect for fans of Narwhal & Jelly, emerging readers, and all kids

In the West, love occupies center stage in the modern age, whether in art, intellectual life, or the economic life. We may observe a similar development in China, on its own impetus, which has resulted in this characteristic of modernity—this feature of modern life has been securely and unambiguously established, not the least facilitated by the thriving of literature about qing, whether in traditional or modern forms.Qiancheng Li concentrates on the nuances of a similar trend manifested in the Chinese context. The emphasis is on critical readings of the texts that have shaped this trend, including important Ming- and Qing-dynasty works of drama, Buddhist texts and other religious/philosophical works, in all their subtlety and evocative power.

A concise, brilliant, and trenchant examination of Democratic Nominee Joseph R. Biden Jr.'s lifelong quest for the presidency by National Book Award winner Evan Osnos, adapted from nearly a decade of

Charise Mericle Harper (Crafty Cat, Just Grace, Fashion Kitty) delivers another hilarious and charming early graphic novel series starring Pepper and Boo, two darling dogs, and their suspicious housem

The true tale of Irena Sendlerowa, a social worker in the Warsaw ghetto in the early 1940s, during the early days of German occupation. She is credited for saving the lives of 2500 Jewish children by gradually and quietly smuggling them to safety in small groups. While she is eventually arrested by Gestapo, imprisoned, and tortured for her actions, she refuses to reveal her network and is condemned to death. She is ultimately saved from death by other members of her organization.This second volume focuses on Irena's activities following her incarceration, and her years long mission to locate and reunite the rescued children with their families, which led decades later to her ultimate recognition. Her attempts to locate each of their natural parents for reunion were as often heartbreaking as fulfilling. And while most of the parents had been gassed in the Holocaust, she made it her mission to help those orphaned find new homes.

Move over, Spot…. Spoofing classic primers, Max the Dog talks back to the book in a twist that will have fans of funny early readers howling.See Max. Max is not a cat—Max is a dog. But much to Max’s d

From early times, Daoist writers claimed to receive scriptures via revelation from heavenly beings. In numerous cases, these writings were composed over the course of many nights and by different medi

In the Ruins of the Japanese Empire concludes that early East Asian Cold War history needs to be studied within the framework of post-imperial history. Japan’s surrender did not mean that the Japanese

A coming-of-age story about learning to celebrate yourself -- and teaching the world to recognize you, too -- perfect for fans of R. J. Palacio's Wonder!"This glimpse into the world of a young autisti

Join two bug friends as they learn about the science of the world around them and the meaning of friendship in this early graphic novel series perfect for fans of Narwhal and Jelly!Rhino-B is a brash,

The Ultimate series is a worldwide success because it offers readers an intriguing close-up view of their subject, with lots of opportunity for hands-on interaction using flaps, tabs, pop-ups and more

Based on rare first-hand historical data, Wang Ke presents the analysis of the East Turkestan from the perspective of Islamic social structure, the origin and evolution of thoughts on national revolut

Funny and totally true childhood biographies and full-color illustrations tell tales from the challenging yet defining growing-up years of Albert Einstein, Jane Goodall, Marie Curie, and 12 other brilliant scientists.Every great scientist started out as a kid. Before their experiments, inventions, and discoveries that changed the world, the world's most celebrated scientists had regular-kid problems just like you.*Stephen Hawking hated school, and preferred to spend his free time building model airplanes, inventing board games, and even building his own computer.*Jane Goodall got in trouble for bringing worms and snails into her house.*And Neil deGrasse Tyson had to start a dog-walking business to save up money to buy a telescope.Readers ages 8 to 12 years old will learn all the stories of a diverse and inclusive group—also including Temple Grandin, Nikola Tesla, Ada Lovelace, Benjamin Franklin, Isaac Newton, Rosalind Franklin, Sally Ride, Rachel Carson, George Washington Carver, and V

This book tells the fascinating story of the development of medical and sanitation services in Hong Kong during the first century of British rule and how changing political values and directions of th

Whizzing Through The Woods Deep in the woods where people seldom go live The Butterfly Children. It was early morning and The Butterfly Children were asleep. All of a sudden DC was woken up by a loud

Facebook and Conversation Analysis investigates the structure and organization of comments on a major social media platform, Facebook, using applied conversation analysis methods. Providing previously

Radar Meteorology: A First Course introduces undergraduate and graduate students to the technology and application of radar in 21st century meteorology and atmospheric sciences. The book, designed to accompany university courses in radar meteorology, will have three distinct parts. In the first part, the reader will be introduced to electromagnetic wave propagation and radar design considerations. This part will then develop the techniques used to retrieve the key quantities central to radar meteorology: the effective radar reflectivity factor, the Doppler radial velocity and spectral width, and polarization variables. The second part will focus on operational meteorological applications, including data quality control, precipitation estimation and hydrometeorological applications, warm season mid-latitude severe weather, cold season hazardous weather, and tropical cyclones. The third part of the book will focus on research applications, including research

Narwhal's obsession with his new favorite food leads him into hijinks and hilarity in the third book of this all-star early graphic novel series!Narwhal and Jelly are back and Narwhal has a new obsess

A picture book biography of Ada Lovelace, the woman recognized today as history’s first computer programmer—she imagined them 100 years before they existed!In the early nineteenth century lived Ada By

Teach yourself more than 3,000 of the most common and essential English words and phrases using illustrations, a free audio app, and hundreds of practice exercises.Expand your English vocabulary with

These books are aimed at children who can read a little, but who need lively but structured books to help them develop their skills further, focusing particularly on phonics. Using a familiar tale, th

New in the Little People, Big Dreams series, this inspiring and informative little biography follows the colourful life of iconic actress Audrey Hepburn, from her early life during World War Two, to b

This book explores the development of late 19th century study societies in China against the context of the decline of the imperial Qing government and its control on ideological production, widesprea