A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design.The first part of this
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader
This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope bring
This book examines the principles and practice of authentic assessment. It seeks to answer the following questions. What is authentic assessment? How is authentic assessment different from 'performanc
This book examines the principles and practice of authentic assessment. It seeks to answer the following questions. What is authentic assessment? How is authentic assessment different from 'performanc
In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the developmen
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with d
Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized la
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed.
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future.Divided in
Tailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessm
After thirty five years, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing a
The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists.The authors provide more than a systematic overview of computational tools and kn
How can animal models contribute to the early drug development process, from target validation to lead profiling? Pharmaceutical industry experts discuss the opportunities for novel drug development a
Researchers in pharmacy, medical information, and other biological and medical specialties explore how therapeutic strategies are now targeting interactions between proteins, rather than just small mo
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first cha
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles a
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.The first part provides a basic understanding
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessmentand prediction of ADMET properties. Although the p
DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology has been acclaimed by the worldwide medical community as the standard-setting oncology reference. Its primary goal is to pr
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel thera
A comprehensive and up-to-date overview, this is both a desktop reference and practical guide for virtual screening applications in drug discovery. Clearly divided into three major sections, the first
If we want all our students to become better thinkers and learners, we must design rigorous learning experiences that go beyond helping them simply master standards.In this guide, Robyn R. Jackson ta
Opening with a general introduction on chemokine function and chemokine receptor biology, the handbook goes on to cover the known implications of these signaling molecules in human diseases, such as c
Thoroughly updated for its Sixth Edition, Principles and Practice of Pediatric Oncology provides a comprehensive review of the multiple disciplines that make up the care and research agendas for chil
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of asp
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit
Comprised of chapters carefully selected from CRC’s best-selling engineering handbooks, volumes in the Principles and Applications in Engineering series provide convenient, economical references sharp
A concrete approach to assessing patients and situations in the field that presents the relationship between assessment findings and pathology in an informal yet informative manner. Includes detailed
Fundamentals of Marital Therapy serves as an authoritative introduction to the field, making clear just how different it is to intervene within a marital context than it is to work with an individual.
The revised and expanded third edition of the Manual for Clinical Psychology Trainees is directed primarily to graduate psychology students - although it will prove valuable for everyone involved in p
An overview of child abuse looking at the historical aspects of the problem, incidence, epidemiology, contributing factors, assessment, treatment and prevention. Oates (pediatrics, U. of Sydney) reali
Dr. Dorfman begins by placing social work in a historical setting. She introduces the social reformers and settlement workers who inaugurated many aspects of the field, and then moves on to today's mo
Exceedingly clear, concise, and comprehensive, this volume sets forth the essential fundamentals of both the practice and theoretical underpinnings of clinical hypnosis. It will acquaint readers with
Forde (fomerly Preservation Services, UK National Archives, and educator) and Rhys-Lewis (preservation and collections management consultant, and curation and stewardship, U. College London, UK) provi
Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment plannin
