商品簡介
Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studies, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation.
Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders.
From the Contents:
- Interactions of alpha-Synuclein with Lipids
- Interaction of hIAPP and its Precursors with Membranes
- Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine
- The Role of Lipid Rafts in Alzheimer?s Disease
- Alzheimer's Disease as a Membrane-Associated Enzymopathy of beta-Amyloid Precursor Protein (APP) Secretases
- Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by beta-Amyloid in Alzheimer?s Disease
- Membrane Changes in BSE and Scrapie
- Experimental Approaches and Technical Challenges for Studying Amyloid?Membrane Interactions
and more
作者簡介
Currently at the department of Chemistry at Ben Gurion University, Israel, Raz Jelinek obtained his BSc in chemistry from the Hebrew University of Jerusalem, Israel, and his PhD from the University of California, Berkeley. He was a Cancer Research Institute post-doctoral fellow at the University of Pennsylvania and a Visiting Professor at the Department of Chemical and Biomolecular Engineering at Johns Hopkins University. Professor Jelinek has over 90 scientific publications and 10 patents to his name, and has received several scientific awards, including the Roger-Siegel-Brown Award of the Israeli Academy of Science and the Ruth L. Kirschstein National Research Service Award of the National Institutes of Health, USA.
目次
Interactions of Alpha-Synuclein with Lipids and Artificial Membranes Monitored by ESPIT Probes
Structural and Functional Insights Into Alpha-Synuclein Lipid Interactions
Surfactants and Alcohols as Inducers of Protein Amyloid: Aggregation Chaperones or Membrane Simulators?
Interaction of hIAPP and its Precursors with Model and Biological Membranes
Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine
Intracellular Amyloid Beta: A Modification to Amyloid Hypothesis in Alzheimer's Disease
Lipid Rafts Play a Crucial Role in Protein Interactions and Intracellular Signaling Involved in Neuronal Preservation Against Alzheimer's Disease
Alzheimer's Disease as Membrane-Associated Enzymopathies of APP Secretases
Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease
Membrane Changes in BSE and Scapie
Interaction of Alzheimer Amyloid Peptide with Cell Surfaces and Artificial Membranes
Experimental Approach and Technical Challenges for Studying Amyloid-Membrane Interactions
