Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

An introduction to Jesus for very young children -- a perfect gift for the holiday season! A gentle look at Jesus's birth, childhood, teachings, crucifixion, and resurrection. Written in a simple, warm style, with colorful illustrations that will captivate and inspire.

This Big Golden Book edition of the best-selling Little Golden Book is the perfect way to share the true meaning of Easter with the whole family. This beautifully illustrated introduction to the biblical account of Jesus's final days on earth--including the Last Supper, the Resurrection, and the Ascension--is now available as a Big Golden Book. This bigger format makes for a better read-aloud for families and in Sunday School classrooms, encouraging more participation from young readers and students. It's a great way to teach children why Easter is a religous Holy Day and how Christians celebrate today.

“Darkly addictive with a blistering pace and puzzle-box structure” —Katy Hays, New York Times bestselling author of The CloistersA page-turning suspense debut about a woman infamous for escaping a cult as a teenager, who finds her future threatened when dangerous secrets come back to haunt her—perfect for fans of Jessica Knoll and The Girls.Everybody knows the story. Nobody knows the truth…Lucy Golden is a true-crime icon, infamous for the murder she committed while escaping a California cult twenty years ago. But as everyone in Los Angeles knows, fame is fleeting, and Lucy and her story are always just one news cycle away from obscurity. Not to mention, she’s fending off a stalker and moderating an icy feud between her acclaimed photographer mother and her scandalous rock star sister. Worst of all, online trolls are asking increasingly threatening questions about the legendary crime. Questions that could tear her life apart.So when a hotshot documentarian makes her case the subject of

In the explosive first novel of an epic dark academia fantasy series, a young woman enters a gothic academy in the wilderness of upstate New York and uncovers the mysteries of a secret order of witches on the brink of war.Vic Wood knows her priorities: scrape by on her waitressing wages, take care of her younger brother Henry, and forget their mother ever existed. But Vic’s careful life crumbles when Henry reveals that their long-missing mother belonged to the Acheron Order—a secret society of witches tasked with keeping the dead at bay. What’s worse, Henry inherited their mother’s magical abilities while Vic did not, and Henry has been chosen as the Order's newest recruit.Determined to keep him safe, Vic accompanies him to the isolated woods in upstate New York that host to the Order’s academy, the sprawling and eerie Avalon Castle. As she joins the academy despite not having manifested powers, she risks not only the Order’s wrath, but also her brother’s. And then there is Xan, the he

Come along on a side-splittingly funny adventure and meet the tractors with a big secret ... they're going to space! Life on the farm doesn't change much for tractors, so when an out-of-this-world adventure is suggested, they rustle up a spaceship and strap in for takeoff, ready to take on space! Battle weightlessness, navigate around black holes, and explore the wonders of our universe with these silly farmyard machines. With lots of heart and hilarious illustrations by award-winning artist Alex Willmore, budding astronauts and tractor lovers will delight in getting to know their new tractor friends while exploring space and our solar system. Why chug around the farm when you could go on a cosmic adventure with the spectacularly silly space tractors?!

"Paisley Hope is a masterful storyteller, with plenty of heat and so much heart-wrenching romance." --Kristen Proby, New York Times, USA Today, and Wall Street Journal bestselling authorThe Hounds of Hell motorcycle club takes care of their own...and every once in a while another rebellious soul catches their eye.Sean "Ax" Hunter is both a former marine and Sergeant at Arms for the Hounds of Hell MC. His mind works like a twisted hamster wheel. Dates, facts, faces, memories, are all vivid and constant. Nothing holds his attention long, until the night a Georgia storm forces him into an upscale club and suddenly his attention belongs solely to her. Layla Monroe, the rebel without a cause, just trying to stay afloat after her parents' tragic death. A death that is surrounded by both unanswered mystery and shocking truth. The sins her parents kept covered up ran deep enough for Layla to question everything she's ever been taught, but they also keep her fighting her attraction to this mon

A fearless eight-year-old runs his own ghost patrol in this graphic novel based on the first book of the Desmond Cole Ghost Patrol chapter book series! Andres Miedoso just wants everything to be normal-boring. But after moving to a new town called Kersville, it quickly becomes clear that this place is anything but ordinary. His new neighbor, Desmond Cole, runs a Ghost Patrol, taking on any monster-catching job no matter how spooky, icky, or risky it might be. Grown-ups always have a lot of advice for new kids in town. But they never say what to do when the house--no, the entire town--is haunted! Perfect for emerging readers, this full-color graphic novel tells the spooky story better than ever before.

From New York Times bestselling author L.J. Shen comes a gorgeous collector's edition of The Kiss Thief, an enemies-to-lovers romance with a twist...They say your first kiss should be earned.Mine was stolen by a devil in a masquerade mask under the black Chicago sky.They say the vows you take on your wedding day are sacred.Mine were broken before we left church.They say your heart only beats for one man.Mine split and bled for two rivals who fought for it until the bitter end.I was promised to Angelo Bandini, the heir to one of the most powerful families in the Chicago Outfit.Then taken by Senator Wolfe Keaton, who held my father's sins over his head to force me into marriage.They say that all great love stories have a happy ending.I, Francesca Rossi, found myself erasing and rewriting mine until the very last chapter.One kiss.Two men.Three lives.Entwined together.And somewhere between these two men, I had to find my forever.

A thrilling, heartfelt, and magical companion to The Daggers of Ire from J. C. Cervantes, New York Times bestselling author of the Storm Runner series. Perfect for fans of Witchlings and Amari and the Night Brothers!Fetch the fox is on his own.Fetch is a weaver of magic, gifted with immense powers—but there is no one left to teach him how to master them. And no one to share his life with since the cruel Winter Queen, Celeste, cursed Fetch into a fox and abducted his beloved younger sister, Violet.As Celeste awakens from her slumber to usher in Winter once more, she makes a stunning announcement: the Winter Palace—the very place where Violet is being held captive--will host a festival. With the palace's spelled protections down for just one evening, the opportunity to save his sister might finally be in Fetch's grasp. And so, with only Beckblade, a tiny yet fierce bone dragon, for company, he sets off on a treacherous rescue mission.But what Fetch doesn't realize is that a dark and myst

日本兩個半月熱賣10萬冊！ X（推特）上一年獲得93萬人次按讚的超強英文學習法！ ◎see、watch、look都是「看」；speak、say、talk都是「說」，差在哪裡？ ◎開心可以用happy，也可以用glad、pleased、joyful……怎麼正確使用？ ◎story是故事也是建築物樓層；capital是首都也是資金，一字多意怎麼背？ ◎上班是go to work？回家卻是go home，為何不用加to？ ◎desert（沙漠）跟dessert（甜點），你到現在還是常搞混？ 本書作者Mark（村木幸司），是日本英文教練協會認證教練， 初入職場時他為了工作需要，特別找母語人士補習英文， 補了幾年，多益（TOEIC）還是只有三百多分。 後來他靠「看圖像」學英文，能力大幅提升，甚至被公司派駐海外。 這套「圖像英文學習法」一發布到網路上，網友直呼：「應該收錄在教科書！」 目前追蹤人數已超過6萬。 ◎國中程度就卡關？用圖像克服！ ．做和製造的多重宇宙 do、act、execute……都是「做」； make、create、generate……都能翻成「製造」， 用法差在哪？答案藏在語感裡。 ．時態好難？看圖，就變得超簡單！ 現在式和進行式有什麼不同？過去式和完成式差在哪？ 畫一條「時間線」你就能瞬間搞懂。 usually、often、sometimes，中文都是「有時候」，怎麼判斷程度高低？ 作者教你「百分比」記憶法，輕鬆判斷好簡單。 in Sunday、on Sunday、at Sunday哪個對？ on a bus、in a bus，還是by a bus，超困擾！ 善用「空間圖」，讓你記一輩子。 ◎開口說，先從日常生活練起！ 起床用get up（從醒來到起身）， 如果還躺在床上就是wake up（從睡眠狀態睜開眼）； 上學用go to school，回家用go home，go後面加不加to，怎麼判斷？ ◎多益（TOEIC）測驗常考字，靠圖表搞懂！ story是「故事」也是「建築物樓層」； capital是「首都」也是「資金」； book除

An Indie Next Pick!Written by the author of the Caldecott-winning FIREWORKS!A young fox learns the joys - and surprises - of being independent in this lush new story from award-winning children's book author, Matthew Burgess and rising-star illustrator, Julie Benbassat. One cold November evening, young Mungo ventures into the forest to find the sweet, red berries he's been dreaming about. But he soon finds that foraging alone can be hard for a kit like him, and Mungo gets lost. Very lost! Will he find the berries--and his way back home--all on his own? With suspense, daring, and foxy resolve, here is a story for all readers who wish to strike out on their own before returning to the cozy warmth of home. ★ "A comforting lap time or cozy winter storytime read." - Booklist (starred review)"Kids looking to go a bit feral after snack time will appreciate Mungo’s success as an argument for their own independence, and helicopter parents might take a lesson or two from mom’s free-range approac

"Mercedes Ron does the forbidden love trope in such a fresh and incredibly emotional way. This series is an addicting gem and reminds us of the power of second chances and redemption. I loved it!" - NYT Bestselling Author, Anna Todd, for the Culpables seriesFrom New York Times bestselling author and Wattpad sensation Mercedes Ron comes the English translation of the second in the Tell Me series, where Kamila Hamilton is caught between the two Di Bianco brothers after they burst back into her life.

An incredible picture book biography about how the trailblazing astronomer found her people--and figured out what stars are made of. Cecilia Payne loved learning to see nature's wonders, even things other people called impossible. While studying at Cambridge, she dreamed of becoming a great astronomer like the ones she read about in the library. But too many people thought women didn't belong among stars or atoms. So, Cecilia packed her bags for Harvard, where she could surround herself with women who also loved astronomy and physics. These "Harvard Computers" shared their treasures with her--thousands of photographs of starlight. Cecilia found a way to read the patterns in these photos and started asking big questions. Could these photos show her what stars are made of? What if they showed Cecilia something all the great astronomers called impossible?With stellar gouache and watercolor art and thrilling scientific details, this biography is a loving tribute to the joy of curiosity, th

This Little Golden Book is based on Disney and Pixar's Hoppers, releasing in theaters Spring 2026! What if you could talk to animals and understand what they're saying? In Disney and Pixar's all-new feature film Hoppers, scientists have discovered how to "hop" human consciousness into lifelike robotic animals, allowing people to communicate with animals as animals! The adventure introduces Mabel, an animal lover who seizes an opportunity to use the technology, uncovering mysteries within the animal world that are beyond anything she could have imagined. This Little Golden Book retelling of the film is perfect for children ages 2 to 5, as well as Disney Little Golden Book collectors of all ages! Little Golden Books enjoy nearly 100% consumer recognition. They feature beloved classics, hot licenses, and new original stories . . . the classics of tomorrow.

【2026 年度選書】《Black Cake》暢銷作家 夏梅．威克森 震撼續作：《Good Dirt》這不只是一本懸疑小說，更是一場關於如何與「喪親之痛」和解的深度旅程。《TIME》、《NPR》年度選書，亞馬遜讀者 4.5 顆星好評盛讚。如果破碎的陶罐能說話，它會訴說這家人隱瞞了多少年的秘密？當十歲的艾比目睹哥哥倒在血泊中，身旁散落著碎成千萬片的百年傳家陶罐時，她的人生也隨之粉碎。十八年後，一場意外的媒體風暴將她逼回法國的家族古宅，她被迫重新拾起那些碎片——不僅是陶器的，更是家族歷史中那些被刻意抹去的黑暗與光榮。這是一部寫給所有曾感到迷失、渴望尋找根源之人的文學傑作。From the New York Times bestselling author of Black Cake comes a stunningly beautiful tale about love, family and seeking a new life in the aftermath of tragedyTHE GRIPPING TALE OF LOVE, FAMILY, AND THE SEARCH FOR A NEW BEGINNING,FROM THE NEW YORK TIMES BESTSELLING AUTHOR OF BLACK CAKE'A beautifully imagined family saga, with a moving and hopeful ending’ NEW YORK TIMES'This novel solidifies Wilkerson's place as one of the great multi-generational storytellers of our time' ABI DARE'A sensational story about hidden heartbreak, hope, and the power of embracing one's ancestry' JESSICA GEORGE, author of MAAME'Will be every reader's highlight of 2025' ETHAN JOELLA, author of THE SAME BRIGHT STARS'Glittering an

2012 marks 110 years since Warne published The Tale of Peter Rabbit. In celebration, we are publishing limited editions of twelve classic tales with colorful covers, special endpapers, and notes explaining the history behind each book. The Tale of Peter Rabbit is the tale of a mischievous rabbit and his nerve-wracking encounter with Mr. McGregor.

This storybook is based on Disney and Pixar's Hoppers, releasing in theaters Spring 2026! What if you could talk to animals and understand what they're saying? In Disney and Pixar's all-new feature film Hoppers, scientists have discovered how to "hop" human consciousness into lifelike robotic animals, allowing people to communicate with animals as animals! The adventure introduces Mabel, an animal lover who seizes an opportunity to use the technology, uncovering mysteries within the animal world that are beyond anything she could have imagined. Children ages 3 to 7 will love this paperback storybook based on the animated feature film.

《A Hymn to Life》是 Gisèle Pelicot 首度完整敘述自身經歷的回憶錄。2024年，她在法國 Avignon 的審判中公開身分，控告前夫 Dominique Pelicot 及數十名涉案男子。這場歷時數月的審理，引發全球媒體關注與社會討論，她所說的「Shame must change sides」更成為支持受害者的重要聲音。本書從警方來電揭開序幕，循序鋪陳她過往五十年的生命軌跡，以及婚姻後期不為人知的真相。The sexual assault that stunned the world. A courageous woman’s rallying call for shame to "change sides." For the very first time, Gisèle Pelicot tells her story.In 2024, Gisèle Pelicot waived her right to anonymity in her legal fight against her ex-husband and the fifty men accused of sexually assaulting her, a courageous decision that inspired millions of people around the world. Only four years prior, Gisèle had made the shattering discovery that her partner, Dominique Pelicot, had been secretly drugging and raping her, and inviting strangers to also abuse her in their home for nearly a decade. “Shame must change sides,” Gisèle bravely declared at the opening of the trial in Avignon, France, and the dictum soon became an international rallying cry to radically transfor

Late Heaney is a book about poetry, landscape and experience, exploring how Seamus Heaney's sense of belonging evolved over time. It visits the places and people that were important to Heaney in the l

A comprehensive survey of the evolution of market design over the past three decades. In the mid-1990s, the first Federal Communications Commission spectrum auction and the redesign of the National Residency Matching Program collectively helped to jumpstart the field of market design. Since then, extensive research has improved auction design and broken new conceptual ground in addressing multi-agent matching problems. This volume summarizes key discoveries and advances in market design over the past three decades and explores contemporary challenges--from climate policy and electricity markets to AI-mediated exchanges and hospital resource allocation. Contributors examine how to design efficient, incentive-compatible mechanisms that are robust to shifting conditions and increasing complexity. They consider a wide variety of applications that could benefit from the market design viewpoint, such as environmental markets, school choice, and organ exchange. Together, the chapters illustr

The Bhagavad Gita is a philosophical and spiritual poem about truth, duty, good actions and the purpose of life. This book collates the wisdom it offers and applies it to contemporary life and work offering lessons on how to foster excellence and fulfilment in today's competitive world. The corporate world and the contemporary society focus on winning, per□forming and developing a competitive edge. Gita for Work and Life offers readers a deeper philosophical understanding of the interconnectedness of all beings, the importance of self-reflection and improvement, purpose, duty, morality, equanimity and peace. These guiding principles provided by Krishna to Arjuna in the Bhagavad Gita are meant to rekindle the dormant human spirit and inspire the reader to elevate their understanding of the mind and soul and how these relate to their work. The book explores themes such as depression management, realised action, knowing oneself, work and fulfilment, balance and discipline, material

This book explores governance challenges in India through the public finance lens, providing insights for policymakers, academics, and administrators. It is a timely contribution to the ongoing dialog

A Harvard professor shows how we can become better talkers - and why effective conversation will help us all thriveYou might already consider yourself a stellar conversationalist, but could you be even better? This book will help enrich your life, one conversation at a time.'Reading TALK is like having a conversation with the world's best conversationalist' Angela Duckworth_________Conversation is at the heart of our relationships and decision-making - but the science behind our everyday interactions, and how to improve them, is little known.In Talk, Harvard Professor Alison Wood Brooks provides fascinating insights into the power of effective communication. She gives you the tools that her MBA students say transform their lives, bringing together psychology, linguistics, sociology and neuroscience in her original framework:T – Topics – including the surprising impact of preparing topics before a conversationA – Asking – why we need to do more (and why we do less than we think)L – Levi

Discover the joy of drawing in a sketchbook as a way of looking, reflecting and relaxing.We draw with joy and without inhibitions when we are young children, but there often comes a point where we become self-conscious and self-critical of our drawings, a belief that sadly often continues into adulthood. As often is the case, learning to draw “properly” leads to comparing ourselves with truly professional artists with years of experience, and we end up copying instead of finding our own unique creative style and expression.This book aims to be inclusive and features not only Sam’s beautiful drawings, but that of many of her students – people of all ages, all abilities and from all walks of life. Along with photographs of the students’ work, there will also be written segments that share the students’ experiences of the exercises and of the process of completing their drawings.This is an inspirational guide that encourages you to discover the joy of drawing in a sketchbook as a way of l

This book provides an overview of the European energy law, laying the groundwork for understanding the energy industry. The book explains private and public law aspects of the energy industry and energy environment law. Starting from the internal energy market, current energy law and regulatory issues are explored, from the Energy Union to the globalisation of energy trading.In order to grasp the breadth of energy law, it is important to understand the European and international framework conditions. This knowledge is a prerequisite for successful work in the energy industry, politics, administration and associations. Last but not least, it is also the basis for understanding the energy transition.

Percy Jackson meets Diary of a Wimpy Kid in this exciting adventure from No.1 Sunday Times bestselling author James Patterson, where Greek gods task an ordinary twelve-year-old with a big mission. Nick Andino isn’t exactly 'hero' material. He’s perfectly happy working at his family’s Greek diner, pining over his crush, and avoiding his bully.His life isn’t very exciting… until destiny comes calling. Dr. Zeus, the over-the-top king of the gods, zooms into town with a quest that Nick must complete to save the Andino family's past and present from being erased from history.Accompanied by a fast-talking Hermes, Nick journeys back to ancient Greece, where his ancestors await - along with new friends and a whole host of Greek gods and monsters. Can Nick be the hero the Andinos need, or will his story be another Greek tragedy?This fast-paced, feel-good adventure from the world’s favourite storyteller has black-and-white illustrations throughout, and amphitheatres full of humour and heart.

This new edition of Indian Fiscal Federalism offers a timely and comprehensive analysis of federalism in India, examining the evolving roles of Finance Commissions and institutional changes since 2015

An insightful, wide-ranging analysis of the economic hurdles facing America's higher education system. The US higher education sector faces numerous economic challenges, including the stagnating number of college-age domestic students, geographic mismatch between population growth and the location of colleges and universities, financial pressures, including cutbacks in government support, growing student debt burdens, sticker prices that deter prospective applicants, and the risk of low capital market returns on endowment portfolios. This volume analyzes the responses of students, families, and the financial managers of higher education institutions to these challenges. It presents new insights into the substantial disparities in the financial structure of, and the financial challenges facing, different types of institutions. The volume draws together contributions from financial economics, public finance, and industrial organization, as well as the economics of education.