Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

About this BookQuirky charm infuses this tale of Old Rock's life story, which is much more exciting than you'd expect.Old Rock has been sitting in the same spot in the pine forest for as long as anyon

This paperback junior novelization retells and expands upon the exciting story of Disney/Pixar Onward—in theaters March 6, 2020!Set in a suburban fantasy world, Disney/Pixar’s Onward introduces two te

How did Jackie Chan become one of the most recognizable and beloved actors in the world? Find out in this exciting biography of this martial artist turned international film superstar.When Kong-sang w

This deluxe Step into Reading leveled reader with over 30 stickers is based on Disney Mulan—just in time for the release of the live-action in March 2020!Join Mulan and her friends Mushu, Cri-Kee, and

Batter up! Baseball action and exciting whodunits star in this chapter book series! Next up is Colorado!Mike and Kate arrive in Colorado to a ballpark covered in snow! Luckily, the stadium has a heate

Preschoolers will delight in exploring a fun-filled spring day in this sturdy board book with colorful tabs featuring everyone's favorite monkey, Curious George.It is spring and George is excited for

In January 1980, a young police officer named John MacLennan committed suicide in his Ho Man Tin flat. His death came mere hours before he was to be arrested for committing homosexual acts still, at t

"Fans of Beatrix Potter will delight in this tribute to her dedication and talent, encapsulating a legacy that reaches far beyond the pages of her beloved books."-Foreword Reviews in a STARRED REVIEW"

🍩 多元活潑的教學活動和影音輔助 🍫讓發音學習就像美味的甜點一樣 無法抗拒！ ▌本教材讓初學者從字母讀寫出發，逐漸學習混音、拼音及閱讀簡單的句子，搭配可愛又美味的甜點圖示，帶領孩子輕鬆奠定自然發音技巧。 ▌全套共五冊，每冊八個單元，每兩個單元搭配 一次複習，共四次複習，每半冊有一個桌遊複習活動。▌各冊教學重點：第一冊認識 26 個字母及發音； 第二冊認識五個短母音；第三冊介紹長母音； 第四冊認識子音群；第五冊介紹長母音、雙母 音、 母音 + r。▌每冊學生課本後附一本讀本（含兩個故事），結合簡單的句型和所學的發音單字，讓孩子可以很快地學會自己朗誦故事。▌互動 App 內容包含音檔、閃示卡、發音單字動 畫、口訣歌謠、韻文動畫及互動遊戲，鼓勵學生課後複習。（建議使用 Wi-Fi 下載大容量檔案）▌教學配件豐富：支援多元創意的教學活動，透過琅琅上口的歌謠及引人入勝的故事，搭配桌 遊海報，讓發音練習不再枯燥無趣！▌提供團訂用戶的教學資源包含教師手冊、教案範例、課本及作業本解答、單元 / 分級測驗、 課程 MP3 音檔、閃示卡電子檔。For students• Student Book+ Readers + Poster + MP3 Download QR Code + Board Games• Workbook

An ode to the girl with scrapes on her knees and flowers in her hair, and every girl in between, this exquisite treasury will appeal to readers of Dear Girl and I Am Enough and have kids poring over i

Sainsbury's Children's Book Awards 2021Lift the flaps and join in the fun with this special anniversary edition of the bestselling preschool classic, Fox's Socks by Julia Donaldson and Axel Scheffler, creators of The Gruffalo.Poor old Fox has lost his socks – can you help him find them? Are they in the kitchen or under the stairs? Are they inside the clock or hidden in a chest? Lift the flaps and find out!With sturdy flaps on every spread and rhyming stories that are a joy to read aloud, the Tales from Acorn Wood series has been delighting both parents and toddlers for over twenty years. Celebrate their unending appeal with Fox's Socks: 20th Anniversary Edition.Discover more stories in the Tales from Acorn Wood series: Rabbit's Nap: 20th Anniversary Edition, Hide-and-Seek Pig: 20th Anniversary Edition and Postman Bear: 20th Anniversary Edition.

The brilliantly funny fifth book in the SAM WU series, starring the bravest scaredy-cat in the world! Perfect for reluctant readers and fans of Tom Fletcher, Pamela Butchart and Humza Arshad's Badman.

Why is there so much plastic in the world? How does it help us? What's the problem and how can we solve it? These are just some of the 60+ questions answered in this timely and topical book. The

Cowie is a donkey who feels like a cow on the inside. Will his friends help him make his dream come true? Find out in this sweetly told story about discovering your true self.Cowie was born a donkey but he knows he’s meant to be a cow. He wants to be a cow. Cows can graze in the meadow all day long and no one asks them to carry heavy packages. So, he stands with the cows in the barn but nothing happens. Will his dream ever come true, he wonders. Can Mousie and Duckie help Cowie feel happy in his own skin?

Each of the twelve stories in this collection is the perfect length for reading aloud in about five minutes, making them perfect for jam-packed days. This treasury stars beloved characters from the Di

Colors are everywhere, and not only will children learn to spot and identify colors in familiar settings, but they will learn to name objects as well in this color-themed matching game book. They can

Learn how to analyse and manage evolutionary and sequential user behaviours in modern networks, and how to optimize network performance by using indirect reciprocity, evolutionary games, and sequential decision making. Understand the latest theory without the need to go through the details of traditional game theory. With practical management tools to regulate user behaviour, and simulations and experiments with real data sets, this is an ideal tool for graduate students and researchers working in networking, communications, and signal processing.

Both utilitarian objects and examples of textile design of wondrous beauty, Chinese rank badges were developed in the Ming and Qing dynasties to indicate the bearer’s station in the civil or military

This textbook provides future data analysts with the tools, methods, and skills needed to answer data-focused, real-life questions; to carry out data analysis; and to visualize and interpret results to support better decisions in business, economics, and public policy. Data wrangling and exploration, regression analysis, machine learning, and causal analysis are comprehensively covered, as well as when, why, and how the methods work, and how they relate to each other. As the most effective way to communicate data analysis, running case studies play a central role in this textbook. Each case starts with an industry-relevant question and answers it by using real-world data and applying the tools and methods covered in the textbook. Learning is then consolidated by 360 practice questions and 120 data exercises. Extensive online resources, including raw and cleaned data and codes for all analysis in Stata, R, and Python, can be found at www.gabors-data-analysis.com.

This textbook provides future data analysts with the tools, methods, and skills needed to answer data-focused, real-life questions; to carry out data analysis; and to visualize and interpret results to support better decisions in business, economics, and public policy. Data wrangling and exploration, regression analysis, machine learning, and causal analysis are comprehensively covered, as well as when, why, and how the methods work, and how they relate to each other. As the most effective way to communicate data analysis, running case studies play a central role in this textbook. Each case starts with an industry-relevant question and answers it by using real-world data and applying the tools and methods covered in the textbook. Learning is then consolidated by 360 practice questions and 120 data exercises. Extensive online resources, including raw and cleaned data and codes for all analysis in Stata, R, and Python, can be found at www.gabors-data-analysis.com.

Data Science for Business with R, written by Jeffrey S. Saltz and Jeffrey M. Stanton, focuses on the concepts foundational for students starting a business analytics or data science degree program. To

How organizations--including Google, StubHub, Airbnb, and Facebook--learn from experiments in a data-driven world.Have you logged into Facebook recently? Searched for something on Google? Chosen a mov

In the global race to reach the end of AIDS, why is the world slipping off track? The answer has to do with stigma, money, and data. Global funding for AIDS response is declining. Tough choices must be made: some people will win and some will lose. Global aid agencies and governments use health data to make these choices. While aid agencies prioritize a shrinking list of countries, many governments deny that sex workers, men who have sex with men, drug users, and transgender people exist. Since no data is gathered about their needs, life-saving services are not funded, and the lack of data reinforces the denial. The Uncounted cracks open this and other data paradoxes through interviews with global health leaders and activists, ethnographic research, analysis of gaps in mathematical models, and the author's experience as an activist and senior official. It shows what is counted, what is not, and why empowering communities to gather their own data could be key to ending AIDS.

Drug Development for Cancer and Diabetes: A Path to 2030 focuses on new developments in the discovery of drugs for the treatment of cancer and diabetes. This new book presents important recent advance

In the global race to reach the end of AIDS, why is the world slipping off track? The answer has to do with stigma, money, and data. Global funding for AIDS response is declining. Tough choices must be made: some people will win and some will lose. Global aid agencies and governments use health data to make these choices. While aid agencies prioritize a shrinking list of countries, many governments deny that sex workers, men who have sex with men, drug users, and transgender people exist. Since no data is gathered about their needs, life-saving services are not funded, and the lack of data reinforces the denial. The Uncounted cracks open this and other data paradoxes through interviews with global health leaders and activists, ethnographic research, analysis of gaps in mathematical models, and the author's experience as an activist and senior official. It shows what is counted, what is not, and why empowering communities to gather their own data could be key to ending AIDS.

This book introduces the field of data science in a practical and accessible manner, using a hands-on approach that assumes no prior knowledge of the subject. The foundational ideas and techniques of data science are provided independently from technology, allowing students to easily develop a firm understanding of the subject without a strong technical background, as well as being presented with material that will have continual relevance even after tools and technologies change. Using popular data science tools such as Python and R, the book offers many examples of real-life applications, with practice ranging from small to big data. A suite of online material for both instructors and students provides a strong supplement to the book, including datasets, chapter slides, solutions, sample exams and curriculum suggestions. This entry-level textbook is ideally suited to readers from a range of disciplines wishing to build a practical, working knowledge of data science.

WS Education 精心策畫World of Discovery (探索世界) 系列讀物，全套共51冊，根據不同的閱讀能力分為三個等級：A (Achieving 達成), B (Blooming 增進), C (Confident自信) ，讓孩子從有趣的閱讀體驗中認識亞洲以及探索STEM（科學、技術、工程和數學）。本系列由新加坡國立教育學院(NIE)英文系退休教授 Ruth YL Wong 博士指導，適合3至8歲及以上的孩子閱讀，書中提供說故事的指南與單詞解釋詞彙表，適合家庭、學校和公共圖書館，從有趣的閱讀中認識英文詞彙，並提升孩子對兒童對科學探索與認識全球多元文化。Level C (Confident 自信)Level C適用對閱讀有信心的小讀者，他們能夠獨立讀出書中至少90%的單詞，及閱讀較長的句子和文章。這三套的故事旨在向小讀者介紹科技，鼓勵他們想像、探索自然、科學發明。Level C 分為三套書共有12冊，本書預期可以讀者達成以下目標：• 可以指出朗讀的單詞• 讀出至少 90% 的單詞• 閱讀更長的句子和更長的文本• 享受閱讀• 獨立閱讀The World of Discovery Collection is a specially curated selection of children's books that focus on discovering Asia and discovering STEM (Science, Technology, Engineering and Maths). Under the guidance of Dr Ruth Y L Wong, these books aim to promote reading for pleasure, while exciting kids through discovery. With 51 books in this inaugural batch, and with more to come, the books are divided into three levels depending on the child's reading ability: A (Achieving), B (Blooming) and C (Confident). Level C Set 1

Discover the fascinating world of our furry companions withWoof! The Truth About DogsbyAnnette Whipple. This engaging and informative book is filled with fun facts, photographs, illustrations, and all the answers to your burning questions about man’s best friend.Amusing & Informative:Written in an engaging question-and-answer format, this book is both entertaining and educational. Readers will learn about various aspects of dogs' behavior, communication, and history.Vibrant Illustrations:Colorful photographs and illustrations bring the world of dogs to life on the pages, capturing the attention of young readers and enhancing their understanding of the topics discussed.Extra Insights:In addition to the author's informative text, readers will enjoy hearing from the dogs themselves, who provide additional insights and perspectives on their behavior and experiences.Perfect for Ages 8-12:Geared towards children aged 8-12 and grade levels 2-4,Woof! The Truth About Dogsis accessible and e

Another graphic novel in this fun series spin-off of The Baby-sitters Club, featuring Kristy's little stepsister Karen has to get glasses She doesn't want them, especially because school pictures are going to be taken soon. But she picks out some pretty pink ones and thinks she looks very grown-up.Then Yicky Ricky at school starts calling her names, like Owl Girl and Googly Eyes. If Karen wears her glasses for the school picture, Ricky will make fun of her. If she doesn't wear them, she'll feel like she's afraid to be herself. Glasses or no glasses, that Ricky is going to get it

Leigh如今事業有成，家庭美滿，似乎已擺脫23年前的陰影，直到那名神祕客戶現身。當往事的沉重後果在此時降臨，為了保護深愛的家人，她願意做到什麼地步？INSTANT NEW YORK TIMES BESTSELLER"There's deception, sabotage, violence, family secrets . . . all the stuff you could want from a fictional page-turner."— theSkimm Recommended by Washington Post • theSkimm • GMA.com • Popsugar • Bustle • Atlanta Journal-Constitution • Augusta Chronicle • Sun-Sentinel • Mystery and Suspense Magazine • and more!He saw what you did. He knows who you are…From the New York Times bestselling author of Pieces of Her and The Silent Wife, an electrifying standalone thriller.AN ORDINARY LIFE…Leigh Collier has worked hard to build what looks like a normal life. She’s an up-and-coming defense attorney at a prestigious law firm in Atlanta, would do anything for her sixteen-year-old daughter Maddy, and is managing to successfully coparent through a pandemic after an amicable separation from her husband Walter.HIDES A DEVASTATING PAST...But Leigh’s ordinary life masks a childhood no one should

Cracking the PM Interview作者又一鉅作 產品管理是很重要的角色，這本書也是非常重要的一本書。這一本為新手和有經驗的產品經理所撰寫的全方位指南，傳授優秀產品經理應具備的技能、框架和實踐法。 ‧產品技能：進行用戶研究、資料分析、雛型設計、產品文件撰寫和理解各種技術，推動更好的產品決策。 ‧執行技能：藉著進行專案管理、漸進式開發、啟動程序以及良好的時間管理，妥善地管理你的團隊，快速、順利、有效地交付專案。 ‧策略技能：為你的團隊指出更好的方向，並透過願景、戰略、路線圖和團隊目標，優化長期影響。了解「更有戰略性」意味著什麼。 ‧領導技能：藉著發展你的個人心態、協作、溝通、啟發和指導技能，更有效地領導。 ‧人員管理：學習管理者的領導技能，包括教導、招聘、面試和建立組織結構。 ‧職涯：藉著了解職業階梯、設定目標，將你的成就轉換成踏腳石，引導職業的發展。 「籠統的建議在產品管理領域需要即時做出主觀判斷的時刻根本派不上用場，Jackie和Gayle提供了實用的背景和框架，為未來的PM領導者制定概念模型，協助他們逐漸成為成功的產品領導者。」 ―STEVEN SINOFSKY，前微軟總裁和產品負責人 「這本書不但是產品管理的入門磚，甚至可以幫助最老練的產品經理成為更有效率的領導者和決策者。」 ―GIBSON BIDDLE，Netflix和Chegg前VP、產品長 「這本書提供非常實用的建議，幫助你掌控和駕馭產品管理生涯。真希望當初我入行擔任產品經理時就有這本書，它是必備的指南！」 ―YARDLEY POHL，Women In product聯合創始人和董事會成員

“Vanderbilt elegantly and persuasively tackles one of the most pernicious of the lies we tells ourselves—that the pleasures of learning are reserved for the young.” —Malcolm Gladwell, bestselling author of Outliers“Vanderbilt elegantly and persuasively tackles one of the most pernicious of the lies we tells ourselves—that the pleasures of learning are reserved for the young.” —Malcolm Gladwell, bestselling author of OutliersWhy do so many of us stop learning new skills as adults? Are we afraid to be bad at something? Have we forgotten the sheer pleasure of beginning from the ground up? Inspired by his young daughter’s insatiable curiosity, Tom Vanderbilt embarks on a yearlong quest of learning—purely for the sake of learning. Rapturously singing Spice Girls songs in an amateur choir, losing games of chess to eight-year-olds, and dodging scorpions at a surf camp in Costa Rica, Vanderbilt tackles five main skills but learns so much more. Along the way, he interviews dozens of experts abo

爺爺的記憶衰退，逐漸忘掉一個個單字，Stump努力為他拾起忘記的單詞，悉心收藏一起度過的歡樂時光。隨著癡呆日漸嚴重，爺爺甚至在大雪之中迷失方向，Stump與奶奶才終於意識到需要找出陪伴爺爺新方式。A beautiful, candid picture book for children to understand what happens when a loved one begins suffering from dementia, and how best to care for them.Stump always has a fantastic time with his grandparents, filled with flowers, puzzles, crosswords, and endless love. But one day, Stump's grandfather starts to lose his memory—and his words, which literally fall from him. Stump tries his best to keep the lost words safe, collecting them in a special box. But Grandpa seems to forget more and more everyday, and the situation comes to a head one snowy night when Stump wakes up to find Grandpa missing. Together, Stump and Grandma must find new ways to connect with Grandpa, and show him that he's not alone. This poignant, tender picture book depicts the struggle of coping with a loved one's dementia with honesty and sensitivity, with a message of hope that affirms the deep bonds of love between

Lemony Snicket meets Roald Dahl in this "wickedly funny" (James Ponti, New York Times bestselling author), deliciously macabre, and highly illustrated tale of a hungry beast, a vain immortal man, and a not-so-charming little girl who doesn't know she's about to be eaten. Beauty comes at a price. And no one knows that better than Ebenezer Tweezer, who has stayed beautiful for 511 years. How, you may wonder? Ebenezer simply has to feed the beast in the attic of his mansion. In return for meals of performing monkeys, statues of Winston Churchill, and the occasional cactus, Ebenezer gets potions that keep him young and beautiful, as well as other presents. But the beast grows ever greedier with each meal, and one day he announces that he'd like to eat a nice, juicy child next. Ebenezer has never done anything quite this terrible to hold onto his wonderful life. Still, he finds the absolutely snottiest, naughtiest, and most frankly unpleasant child he can and prepares to feed her to the bea

Grab friends, family, or dive in solo—LEGO® puzzles are a whole new way to play with LEGO bricks! Get ready LEGO® Space fans, your next jigsaw puzzle challenge is here! These 1,000 colorful pieces come together to reveal the ultimate interstellar exploration squad. Perfect for the whole family, but just as fun to take on solo, this puzzle features a team of iconic spacemen as well as vintage spaceship sets from the LEGO archives.BROAD APPEAL: This jigsaw puzzle is perfect for all types of LEGO fans—from longtime LEGO builders to casual fans to parents sharing their love of the brand with their children.CREATIVE AND CHALLENGING: This puzzle will test your skills as it showcases the creative spirit integral to the LEGO brand.LEGO SPACE THEME: This puzzle image features a colorful array of classic LEGO spacemen—some of the most beloved minifigures in history.AT-HOME ACTIVITY FOR GET-TOGETHERS: Family, friends, and LEGO fans 9 years and older will love putting this puzzle together during h

“Taiwan is not China.The Taiwanese are not the Chinese.Taiwan should be ruled by Taiwanese themselves.”This long-awaited English version will be the foundation stone on which for the peoples of the world will deepen their understanding of the Taiwan affairs and the Taiwan-China relations.The US Presidential election having turned out as it did, the world is watching Taiwan closer and harder than ever before - now what happens to Taiwan?Taiwan is no part of China. Taiwanese are not Chinese. This book tells just that.The author, Ong Iok-tek, also a linguist, wrote this book while in exile in Japan to let the world know the truth of the history of Taiwan. Ardently read and reread over half a century since its publication, this book has come to claim its due status as the most authentic historical account of Taiwan that has affected many a Taiwanese. It goes and proves then that this book so vividly portrays the realty of Taiwan based strictly on nothing but scientific, objective truths.Ch

Hilarious, poignant, utterly relatable - Confessions of a Forty-Something F*** Up is a must-read for anyone whose life isn't working out quite how they'd planned.The funniest WTF AM I DOING?! novel of the year. 'The new Bridget Jones' - Celia Walden, Telegraph'Say hello to a book that will have you laughing with every page, whether you're 20, 40 or 80' - HeatA novel for any woman who wonders how the hell she got here, and why life isn't quite how she imagined it was going to be. And who is desperately trying to figure it all out when everyone around them is making gluten-free brownies.Meet Nell. Her life is a mess. In a world of perfect Instagram lives, she feels like a f**k up.But when she starts a secret podcast and forms an unlikely friendship with Cricket, an eighty-something widow, things begin to change. Because Nell is determined. This time next year things will be very different.But first, she has a confession . . .Confessions of a Forty-Something F**k Up by Alexandra Potter wi

Return to the world of the Invisible Library for Irene's most perilous mission yet . . .Librarian Spy Irene is heading into danger. Not for the first time, but could this be her last? She's tasked with a terrifyingly dangerous solo mission to eliminate an old enemy, which must be kept secret at all costs. But even more troubling news emerges.Multiple worlds are disappearing - and the Library may have something to do with it. Determined to uncover the truth behind the vanished worlds, Irene and her friends must descend into the unplumbed depths of the Library. And what they find will change everything they know.This may be Irene's most dangerous assignment of her hazardous career. The Untold Story is the unputdownable eighth book in the Invisible Library fantasy series by Genevieve Cogman. Praise for the series: 'I absolutely loved this' - N.K. Jemisin, author of The Fifth Season 'Irene is a great heroine: fiery, resourceful and no one's fool' - Guardian 'Brilliant and so much fun. Skul

"Sholmes? Oh! I confess he is a worthy foe."When a writing desk containing a winning lottery ticket goes missing, fingers soon point to gentleman-thief Arsene Lupin. Lupin leaves the French police stumped, so famous English detective Herlock Sholmes and his friend Wilson are called upon to bring Lupin down. Will Sholmes' wits stand up against the master of disguises?Maurice Leblanc's beloved Lupin goes head-to-head in a battle of wits against his rival Sholmes in this collection of short stories.

"A tremendous treasure, belonging to the kings ..."The royal treasure hidden in the Hollow Needle is a legend; the gold of France, battlefield booty and stolen money is believed to be hidden away in a secret location. Gentleman-thief and friend to the poor, Arsene Lupin is eager to solve the mystery of the Hollow Needle and find the treasure within. Up against keen boy detective Isidore Beautrelet, has Maurice Leblanc's master of disguises finally met his match?