Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Landslides have geological causes but can be triggered by natural processes (rainfall, snowmelt, erosion and earthquakes) or by human actions such as agriculture and construction. Research aimed at better understanding slope stability and failure has accelerated in recent years, accompanied by basic field research and numerical modeling of slope failure processes, mechanisms of debris movement, and landslide causes and triggers. Written by seventy-five world-leading researchers and practitioners, this book provides a state-of-the-art summary of landslide science. It features both field geology and engineering approaches, as well as modeling of slope failure and run-out using a variety of numerical codes. It is illustrated with international case studies integrating geological, geotechnical and remote sensing studies, and includes recent slope investigations in North America, Europe and Asia. This is an essential reference for researchers and graduate students in geomorphology, engineer

Predictive Analytics has revolutionised marketing practice. It involves using many techniques from data mining, statistics, modelling, machine learning and artificial intelligence, to analyse current

For courses in Introductory Statistics (algebra-based). Gets students thinking statistically from the start Stats: Modeling the World by Bock, Velleman, DeVeaux, and Bullard engages students by opening with practical data analysis and graphics. Chapters begin with new, motivating examples and follow through with analyses of the data; then, real-world examples provide a basis for sample problems and exercises.The authors’ colloquial, approachable writing style reads unlike any other other statistics text. Their signature Think, Show, and Tell problem-solving method guides students through learning what we can find in data, why we find it interesting, and how to report it to others. Focused lessons are shorter than in most other texts, and are more manageable for both students and instructors. The 5th Edition extends the innovations of this acclaimed text, with important revisions and additions that support the teaching of Statistics and statistical thinking as it is practiced toda

In this work, Carol V.A. Quinn considers survivors’ arguments in the debate concerning the ethics of using Nazi medical data, showing what it would mean to take their claims seriously. Her approach is

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodolo

This book presents an overview of the technical underpinnings in the field of digital media. This includes theory, imaging, big data, interaction, and the research and development that is needed in or

This book forwards the hypothesis on dis-utility of using military force/militarism as a counter-terrorism measure by states. Drawing on data on terrorism and world development indicators it advocates

This book describes the dynamic collisions between baseballs, softballs, and bats, and the intricate modeling of these interactions, using only Newton’s basic principles and the conservation laws of p

For courses in Beginning Algebra. Modeling authentic data through curve-fitting gives students new meaning to the math Seeking the answer to students’ perennial question “But what is

Nonlinear Time Series Analysis with R provides a practical guide to emerging empirical techniques allowing practitioners to diagnose whether highly fluctuating and random appearing data are most likel

Written for computer programming students, hobbyists, and professionals, FUNDAMENTALS OF PYTHON: DATA STRUCTURES is an introduction to object-oriented design and data structures using the popular Pyth

Responding to the developments of the past twenty years, Les Kirkup has thoroughly updated his popular book on experimental methods, while retaining the extensive coverage and practical advice from the first edition. Many topics from that edition remain, including keeping a record of work, how to deal with measurement uncertainties, understanding the statistical basis of data analysis and reporting the results of experiments. However, with new technologies influencing how experiments are devised, carried out, analyzed, presented and reported, this new edition reflects the digital changes which have taken place and the increased emphasis on the importance of communication skills in reporting results. Bringing together key elements of experimental methods into one coherent book, it is perfect for students seeking guidance with their experimental work, including how to acquire, analyse and present data. Exercises, worked examples and end-of-chapter problems are provided throughout the boo

Societal transformations are needed across the globe in light of pressing environmental issues. This need to transform is increasingly acknowledged in policy, planning, academic debate, and media, whether it is to achieve decarbonization, resilience, national development plans, or sustainability objectives. This volume provides the first comprehensive comparison of how sustainability transformations are understood across societies. It contains historical analogies and concrete examples from around the world to show how societal transformations could achieve the Paris Agreement and the United Nations Sustainable Development Goals through governance, innovations, lifestyle changes, education and new narratives. It examines how societal actors in different geographical, political and cultural contexts understand the agents and drivers of societal change towards sustainability, using data from the academic literature, international news media, lay people's focus groups across five continen

Societal transformations are needed across the globe in light of pressing environmental issues. This need to transform is increasingly acknowledged in policy, planning, academic debate, and media, whether it is to achieve decarbonization, resilience, national development plans, or sustainability objectives. This volume provides the first comprehensive comparison of how sustainability transformations are understood across societies. It contains historical analogies and concrete examples from around the world to show how societal transformations could achieve the Paris Agreement and the United Nations Sustainable Development Goals through governance, innovations, lifestyle changes, education and new narratives. It examines how societal actors in different geographical, political and cultural contexts understand the agents and drivers of societal change towards sustainability, using data from the academic literature, international news media, lay people's focus groups across five continen

Does religion influence political participation? This book takes up this pressing debate using Christianity in sub-Saharan Africa as its empirical base to demonstrate that religious teachings communicated in sermons can influence both the degree and the form of citizens' political participation. McClendon and Riedl document some of the current diversity of sermon content in contemporary Christian houses of worship and then use a combination of laboratory experiments, observational survey data, focus groups, and case comparisons in Zambia, Uganda, and Kenya to interrogate the impact of sermon exposure on political participation and the longevity of that impact. Pews to Politics in Africa leverages the pluralism of sermons in sub-Saharan Africa to gain insight into the content of cultural influences and their consequences for how ordinary citizens participate in politics.

Although the archaeological evidence indicates a prosperous and thriving Galilee in the early first century CE, the Gospel texts suggest a society under stress, where the rich were flourishing at the expense of the poor. In this multi-disciplinary study, Rosemary Margaret Luff contributes to current debates concerning the pressures on early first-century Palestinian Jews, particularly with reference to socio-economic and religious issues. She examines Jesus within his Jewish environment in order to understand why he rose to prominence when he did, and what motivated him to persevere with his mission. Luff's study includes six carefully-constructed essays that examine Early Christian texts against the wider background of late Second Temple Judaic literature, together with the material evidence of Galilee and Judea (Jerusalem). Synthesizing a wide range of archaeological and textual data for the first time, she offers new insights into the depth of social discontent and its role in the r

Evaluation for Health Policy and Health Care: A Contemporary Data-Driven Approach explores the best practices and applications for producing, synthesizing, visualizing, using, and disseminating health

Qualitative and Mixed Methods Data Analysis Using Dedoose®: A Practical Approach for Research Across the Social Sciences provides both new and experienced researchers with a guided introduction to dea

World War II played an important role in the trajectory of race and American political development, but the War's effects were much more complex than many assume. Steven White offers an extensive analysis of rarely utilized survey data and archival evidence to assess white racial attitudes and the executive branch response to civil rights advocacy. He finds that, contrary to conventional wisdom, the white mass public's racial policy attitudes largely did not liberalize during the war against Nazi Germany. In this context, advocates turned their attention to the possibility of unilateral action by the president, emphasizing a wartime civil rights agenda focused on discrimination in the defense industry and segregation in the military. This book offers a reinterpretation of this critical period in American political development, as well as implications for the theoretical relationship between war and the inclusion of marginalized groups in democratic societies.

The bestselling author of All the Shah’s Men and The Brothers tells the astonishing story of the man who oversaw the CIA’s secret drug and mind-control experiments of the 1950s and ’60s.The visionary

In this book, Sabine R. Huebner explores the world of the protagonists of the New Testament and the early Christians using the rich papyrological evidence from Roman Egypt. This gives us unparalleled insights into the everyday lives of the non-elite population in an area quite similar to neighboring Judaea-Palestine. What were the daily concerns and difficulties experienced by a carpenter's family or by a shepherd looking after his flocks? How did the average man or woman experience a Roman census? What obstacles did women living in a patriarchal society face in private, in public, and in the early Church? Given the flight of Jesus' family into Egypt, how mobile were the lower classes, what was their understanding of geography, and what costs and dangers were associated with travel? This volume gives a better understanding of the structural, social, and cultural conditions under which figures from the New Testament lived.

In this book, Sabine R. Huebner explores the world of the protagonists of the New Testament and the early Christians using the rich papyrological evidence from Roman Egypt. This gives us unparalleled insights into the everyday lives of the non-elite population in an area quite similar to neighboring Judaea-Palestine. What were the daily concerns and difficulties experienced by a carpenter's family or by a shepherd looking after his flocks? How did the average man or woman experience a Roman census? What obstacles did women living in a patriarchal society face in private, in public, and in the early Church? Given the flight of Jesus' family into Egypt, how mobile were the lower classes, what was their understanding of geography, and what costs and dangers were associated with travel? This volume gives a better understanding of the structural, social, and cultural conditions under which figures from the New Testament lived.

This book takes a unique look at visual character development in motion pictures and television by using famous works of art combined with modern works of film and television to demonstrate how to wea

Building information modeling (BIM) is rapidly replacing AutoCAD as the digital drawing tool of choice for architects and interior designers-and Revit (R) Architecture is the leading software package

This third edition volume expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathec

Organizations and businesses strive toward excellence, and solutions to problems are based mostly on judgment and experience. However, increased competition and consumer demands require that the solutions be optimum and not just feasible. Theory leads to algorithms. Algorithms need to be translated into computer codes. Engineering problems need to be modeled. Optimum solutions are obtained using theory and computers, and then interpreted. Revised and expanded in its third edition, this textbook integrates theory, modeling, development of numerical methods, and problem solving, thus preparing students to apply optimization to real-world problems. This text covers a broad variety of optimization problems using: unconstrained, constrained, gradient, and non-gradient techniques; duality concepts; multi-objective optimization; linear, integer, geometric, and dynamic programming with applications; and finite element-based optimization. It is ideal for advanced undergraduate or graduate cours

Film stars are central to today's celebrity-obsessed culture. Yet, in the early decades of cinema, the industry faced disincentives to using the identities of performers for publicity. For over 12 yea

Provides fully updated coverage of new experiments in quantum optics This fully revised and expanded edition of a well-established textbook on experiments on quantum optics covers new concepts, res

The development industry is worth billions. International non-governmental organizations (INGOs) have become an integral component in international development and humanitarian response. Yet as recent

In the late 1980s and early 1990s, the Bronx had one of the highest per capita murder rates in the country. The use of crack cocaine surged, replacing heroin as the high of choice. Drug dealers claime

This book presents a comprehensive introduction to the design of compact and broadband fiber and waveguide devices using active-ion-doped photonic glasses. Combining cutting-edge theory with new applications, it shows how the complementarity of emission spectra of different active ions can be used in broadband fiber amplifiers and optical fiber communication, and describes how the quantum cutting of active ions can improve the match between the solar spectrum and the responsiveness of silicon cells. Mathematical modeling is used to predict the performance of photonic fiber and waveguide devices, and experimental data from glass doped with rare-earth ions is included. Offering unique insights into the state-of-the-art of the field, this is an ideal reference for researchers and practitioners, and invaluable reading for students in optoelectronics, electrical engineering, and materials science.

Engaging and accessible, this book offers students a complete guide to using NVivo for qualitative data analysis. Drawing on their wealth of expertise, the authors offer detailed, practical advice tha

Engaging and accessible, this book offers students a complete guide to using NVivo for qualitative data analysis. Drawing on their wealth of expertise, the authors offer detailed, practical advice tha

Multilevel Structural Equation Modeling, by Silva, Bosancianu, and Littvay focuses on the confluence of two fields in applied statistics: multilevel modeling (MLM) and structural equation mo

This volume describes how controlled-source electromagnetic (CSEM) methods are used to determine the electrical conductivity and hydrocarbon content of the upper few kilometres of the Earth, on land and at sea. The authors show how the signal-to-noise ratio of the measured data may be maximised via suitable choice of acquisition and processing parameters and selection of subsequent data analysis procedures. Complete impulse responses for every electric and magnetic source and receiver configuration are derived, providing a guide to the expected response for real data. 1-D, 2-D and 3-D modelling and inversion procedures for recovery of Earth conductivity are presented, emphasising the importance of updating model parameters using complementary geophysical data and rock physics relations. Requiring no specialist prior knowledge of electromagnetic theory, and providing a step-by-step guide through the necessary mathematics, this book provides an accessible introduction for advanced studen

The increased and widespread availability of large network data resources in recent years has resulted in a growing need for effective methods for their analysis. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straightforward task because of the size of the data sets and the computer power required for the analysis. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this text provides an ideal introduction to and insight into the interdisciplinary field of network da

The Educational Leader’s Guide to Improvement Science: Data, Design and Cases for Reflection is a collection illustrating applied organizational problem-solving using methods of Improvement Scien

Statistics for Engineers and Scientists stands out for its crystal clear presentation of applied statistics. The book takes a practical approach to methods of statistical modeling and data analysis th

Paleozoology and Paleoenvironments outlines the reconstruction of ancient climates, floras, and habitats on the basis of animal fossil remains recovered from archaeological and paleontological sites. In addition to outlining the ecological fundamentals and analytical assumptions attending such analyzes, J. Tyler Faith and R. Lee Lyman describe and critically evaluate many of the varied analytical techniques that have been applied to paleozoological remains for the purpose of paleoenvironmental reconstruction. These techniques range from analyses based on the presence or abundance of species in a fossil assemblage to those based on taxon-free ecological characterizations. All techniques are illustrated using faunal data from archaeological or paleontological contexts. Aimed at students and professionals, this volume will serve as fundamental resource for courses in zooarchaeology, paleontology, and paleoecology.

Paleozoology and Paleoenvironments outlines the reconstruction of ancient climates, floras, and habitats on the basis of animal fossil remains recovered from archaeological and paleontological sites. In addition to outlining the ecological fundamentals and analytical assumptions attending such analyzes, J. Tyler Faith and R. Lee Lyman describe and critically evaluate many of the varied analytical techniques that have been applied to paleozoological remains for the purpose of paleoenvironmental reconstruction. These techniques range from analyses based on the presence or abundance of species in a fossil assemblage to those based on taxon-free ecological characterizations. All techniques are illustrated using faunal data from archaeological or paleontological contexts. Aimed at students and professionals, this volume will serve as fundamental resource for courses in zooarchaeology, paleontology, and paleoecology.