Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Help babies and toddlers master the building blocks of speech with this adorable, fun-to-read rhyming board book, written by an early speech expert!My First Learn-to-Talk Book is a joyful book that encourages speech development in little ones. By using adorable rhythmic rhyming text, simple exclamatory words and sounds, and engaging photographs of babies and toddlers, this book gives parents, grandparents, teachers, and therapists a new tool that does more than just entertain and engage babies and toddlers―it uses proven therapeutic techniques to help little ones think, repeat, react, and babble: the vital skills they need to talk!When I go down a slide, my mouth says "wheeee!"When I want a turn, my mouth says "me!"When I'm acting playful, my mouth says "boo!"When I hug my family, I say "I love you!"

In the ninth DATA Set adventure, the kids blast off into outer space!When Laura hears a strange but familiar buzzing coming from her radio, she instantly knows who's trying to get in touch. It's none other than Fave, the DATA Set's alien friend who crashed down on Earth! The kids excitedly decode the message but learn that Fave is in trouble! Join the kids as they suit up and blast off into the galaxy on a mission to help an old friend. With easy-to-read language and illustrations on almost every page, the DATA Set chapter books are perfect for emerging readers.

Explore the ups and downs of gravity in this introduction to physical science by a trusted nonfiction team. What happens to a ball when it rolls off a table? It falls to the floor. Why doesn't the ball keep rolling straight ahead or fly up off the table? The answer is gravity. From density to inertia to free fall, David A. Adler skillfully explains how this invisible, but all too real force operates and what it means for our daily lives. Notable science experiments by Sir Isaac Newton and astronaut David R. Scott are covered. Also included are activities for kids to test at home and in the classroom. Anna Raff's bright and humorous artwork helps breakdown the concepts in a kid-friendly way. Vetted by a physicist, this fact-filled primer includes a glossary.

Marketing Science Using R 重點探討行銷科學領域 相關統計觀念及R語言 ※內容詳解行銷科學的應用‧ ※強化解決行銷領域的問題 ※配合豐富的行銷實例說明 ※輕鬆理解並有效解決問題 本書適用於對行銷科學方法感興趣的讀者，不管是有心進入行銷領域的資訊管理背景人士，或是尋找量化分析工具的行銷從業人員，提供了理論與實務的最佳參考書籍。 【本書特色】 *直指行銷科學領域的應用層面，以解

53*36cm。以樂高人物為主角的活動書，有超過300個活動，讓小朋友腦力激盪。Join in the LEGO(R) Iconic Christmas countdown with 24 mini books to get you in the holiday spirit Let your imagination run wild as you countdown to Christmas with this advent calendar full of exciting and engaging activities Kids get one new mini winter LEGO(R) title for each day leading up to Christmas, and with 24 activity books in all, this holiday season is sure to be fun LEGO, the LEGO logo and the Brick and Knob configurations are trademarks and/or copyrights of the LEGO Group. (c)2021 The LEGO Group. All rights reserved.Manufactured by AMEET Sp. z o.o. under license from the LEGO Group.

Fairies + magic + fantasy + bestselling author Tracey West = Pixie Tricks!Pick a book. Grow a Reader!This series is part of Scholastic's early chapter book line, Branches, aimed at newly independent r

Jump-start your toddler's education with vocabulary and early language concepts using this beautiful board book set created by a speech therapist to help build your child's language skills and encourage them to explore nature.Created by licensed speech pathologist and artist Tabitha Paige, MS, CCC-SLP, the three board books in the Our Little Adventures box set take parents and toddlers or young children on trips to the farmers market, the forest, and a wildflower meadow. Each book features realistic watercolor imagery and a story carefully crafted by Tabitha, who has years of experience helping young children develop their language skills.These three timeless and durable board books feature vocabulary and early language concepts for toddlers while also teaching about friendship and kindness. Lessons include:Spatial Words: Follow along with Little Fox as he plans a surprise picnic for his friend Owl in A Trip to the Farmers Market.Quantity Words: Follow along with Little Hedgehog as he

This book introduces a new approach to embedded development, grounded in modern, industry-standard JavaScript. Using the same language that powers web browsers and Node.js, the Moddable SDK empowers IoT developers to apply many of the same tools and techniques used to build sophisticated websites and mobile apps. The Moddable SDK enables you to unlock the full potential of inexpensive microcontrollers like the ESP32 and ESP8266.Coding for these microcontrollers in C or C++ with the ESP-IDF and Arduino SDKs works for building basic products but doesn't scale to handle the increasingly complex IoT products that customers expect. The Moddable SDK adds the lightweight XS JavaScript engine to those traditional environments, accelerating development with JavaScript while keeping the performance benefits of a native SDK. Building user interfaces and communicating over the network are two areas where JavaScript really shines.IoT Development for ESP32 and ESP8266 with JavaScript shows you how t

The brand new, read-in-one-sitting mystery from the bestselling author of THE GOLDFISH BOY. When a little white lie leads to a huge dose of trouble... Cole is the odd one out at school: the other kids

A valuable new edition of a standard referenceThe use of statistical methods for categorical data has increased dramatically, particularly for applications in the biomedical and social sciences. An In

Johnson, a retired university librarian and speaker and trainer on collection development and management, explains aspects of collection development in all types of libraries, with a focus on thos

The first volume in this Early Childhood Education and Care in the 21st Century: International Teaching, Family and Policy Perspectives miniseries provides a snapshot of early childhood education and

Pro Spring Boot is your authoritative hands-on practical guide for increasing your Spring Framework-based enterprise Java and cloud application productivity while decreasing development time using the

The DATA Set find themselves stuck in the prehistoric era in the second adventure of the brand-new series!Thanks to Dr. Bunsen’s latest wacky invention, the DATA Set are blasted back to the prehistori

Best known for his epic Lord of the Rings trilogy and The Hobbit, J.R.R. Tolkien was born in British-occupied South Africa. His early life was full of action and adventure. Tolkien spent his childhood

Kung Pow Chicken is the superhero everyone has been waiting for!This series is part of Scholastic's early chapter book line called Branches, which is aimed at newly independent readers. With easy-to-r

A tummy-time, fold-out book. This first focus frieze title is aimed at children from 3 months plus. In Counting, the panels are designed to aid babie 3+ months development by using recognisable high c

Use real data, and become a pro at using Excel for statistical analysis! Designed for users already familiar with Excel and basic computer operations, this Second Edition of Neil J. Salkind’s Excel St

Within this text, the contributors provide a historical perspective on the development of anthropology and sociology since their introduction to Chinese thought and education in the early twentieth ce

Understand the role of mathematics in biology with MODELING THE DYNAMCICS OF LIFE: CALCULUS AND PROBABILTY FOR LIFE SCIENTISTS, 3E, International Edition! Designed to demonstrate the importance of mat

The R&D activity in the Information and Communication Technologies (ICT) industrial sectors is an important factor in boosting the competitiveness of the European economy, and it stands high on th

Essential Skills--Made Easy!Create dynamic Web pages complete with special effects using today's leading Web development language. JavaScript: A Beginner's Guide, Third Edition gives you step-by-step

Forword This is an abridged translation of a booklet originally written in Chinese. It is a brief account of my personal experience in educational work written in the hope that the facts related herei

Fox--the beloved and popular trickster character featured in the Geisel Award-winning books Fox Has a Problem, Fox at Night, and Fox the Tiger--is on the move! But Fox knows that life is about the journey, not the destination, and if his untraditional transportation methods get him in a bit of trouble, he can always try again tomorrow. Kirkus Reviews calls Corey R. Tabor "a master of the early reader."Where is Fox going? But more importantly, how is he getting there?A train? A bus? A surfboard? A waterfall? Fox's travel methods may be a bit unusual, but we would expect nothing less from our terrific, trickster friend.Wry, repetitive text with carefully chosen language and a limited vocabulary allows for an accessible read while charming illustrations provide context and comedy in Corey R. Tabor's award-winning Fox series, making it a perfect choice for emerging readers and their caretakers. The Fox series, which is comprised of both picture books and beginning readers, has received thr

全方位重點 ALL IN ONE鞏固基礎｜課文結構、寫作手法以表格統整延伸知識｜彙整必讀、必考語文知識強化閱讀｜每課一組閱讀題，練習統測題型

《圓覺經》全名《大方廣圓覺修多羅了義經》，透過文殊師利等十二位菩薩與佛陀的問答，宣說如來圓覺妙理，揭櫫一切眾生具足圓覺妙心，是指引如何修行成佛的經典。《圓覺經》廣受唐代天台、華嚴、禪宗、密宗重視，北宋郭印提出佛教四書，清末吳坤修甄選釋氏十三經，它從未缺席，又早早流布高麗與鎌倉時代的朝鮮、日本。該經一卷之薄，允為東亞漢傳佛教「經中之睛」。是次新注新譯，深度利用東亞文獻以校勘、輯佚，紹述唐僧玄奘忠於原典及思想、語言原貌之傳統，從佛學乃至文學角度，予以精當闡釋，化深奧為易懂，內容至簡至要。〈導讀〉一文更明析該經結構、善本、善注、文體，乃至東亞古典時代地位諸議題。研讀佛教經典者，切莫錯過。The Sūtra of Perfect Englightenment 圓覺經, whose full title is The Nītârtha Sūtra on the canon of the great and expansive Perfect Enlightenment (Dà fāngguăng yuánjué xiūduōluó liǎoyì jīng) 大方廣圓覺修多羅了義經, uses a conversation between the Buddha and twelve Bodhisattvas, led by Mañjuśrī, to promulgate the wondrous doctrine of perfect enlightenment. It discloses that all sentient beings have an innate mind of perfect enlightenment, and guides them on how to train to attain Buddhahood. In the Tang dynasty, the Sūtra of Perfect Enlightenment was held in high esteem by the Tiantai, Huayan, Chan, and Vajrayāna (Esoteric) schools. And it was listed in the four Buddhist classics proposed by the Northern Song’s G

Izzy the Inventor has HAD ENOUGH. Bad Fairy Brenda has turned VERY BAD indeed, and Izzy wants to find a way to make her good. Unfortunately, this involves climbing up a beanstalk to the Land of the Giants, along with her sister and Henry the Unicorn. This journey will put Izzy's science skills to the test - she'll need catapults, light experiments and a pair of giant flying underpants...Every book contains ideas for science experiments and a QR code with links for more to try at home.Collect all the books in the series!

全方位重點 ALL IN ONE鞏固基礎｜課文結構、寫作手法以表格統整延伸知識｜彙整必讀、必考語文知識強化閱讀｜每課一組閱讀題，練習統測題型

A novel dialogue between Buddhism and Western psychology, grounded in original Pali texts. As mindfulness and meditation become mainstream therapeutic tools, their deep Buddhist roots are often stripped away and limit their effectiveness for clients from Buddhist cultural backgrounds. Early Buddhist Teachings: A Theoretical Foundation for Counseling restores these practices to their original context, offering a culturally congruent counseling model grounded in Pali scriptures and core Buddhist principles. This informative volume explores key Buddhist concepts including dependent co-arising, non-self, and impermanence, and places them in conversation with Western psychological theories. Supplemented with practical assessment tools and intervention techniques, this work provides mental health professionals with a new framework for integrating Buddhist teachings into counseling. For therapists, students, and counselors seeking to expand their approach, Early Buddhist Teachings offers a vi

⊙系統性內容編排：章節難度由淺至深安排，循序漸進建構知識。⊙實務應用導向：透過案例，學習運用各種統計方法分析問題，並以R語言的統計程式套件，解決不同的統計模式，達到做中學的學習效果。⊙提供習題演練：各章節皆附有習題，學習成效輕鬆驗收。【以R語言學習統計，邊做邊學好懂易上手】本書以R語言作為統計學教學的嚮導，運用R語言之程式套件中世界各地實際的研究個案與資料，讓學習者認識各種統計方法，解決不同的統計模式，也能了解統計在各方面的應用。書中章節安排難度由淺至深，循序漸進帶領學習者一一攻克各種統計方法，內容包含：R語言基礎指令操作、單變數資料、兩個與多個變數資料、機率、離散型機率分配、連續型機率分配、抽樣分配、常態近似與自助抽樣法、估計、統計假說檢定、變異數分析：多個母體平均數比較、簡單線性迴歸分析、多元線性迴歸分析、適合度檢定：類別資料分析、無母數統計等。各章節最末提供習題，讓學習者可透過演練驗收學習成效，加深記憶、鞏固知識。

A unique illustrated exploration of the development of finance that combines data from every part of the world and covers five thousand years of history “The book is a lot of fun. Data-fixated readers will enjoy unpicking its main content: a series of elegantly produced maps, graphs and other visualisations. These are eclectic in scope and ambitious in intent.”—Jonathan Guthrie, Financial Times From the emergence of money in the ancient world to today’s interconnected landscape of high-frequency trading and cryptocurrency, the story of finance has always taken place on an international stage.Finance is one of the most globalized and networked of human activities, and one of the most important social technologies ever invented. This volume, the first visually based book dedicated to finance, uses graphics and maps to bring the complex and abstract world of finance down to earth, showing how geography is fundamental for understanding finance, and vice versa. It illuminates the people—inc

適合程式設計新手，迅速進入資料科學領域。資料匯入、整理、變換、視覺化與模型建立。使用R和RStudio進行資料科學研究，利用tidyverse套件使工作更高效、流暢。這一版介紹Tidyverse的最新功能和最佳實務做法，並新增章節介紹從不同來源獲取資料，進一步實踐所學。「這本書更新了世界首屈一指的R資料科學實務指南，優秀程度令人驚歎，凡是與資料打交道的人都應該閱讀此書！」—Emma RandUniversity of York, UK運用R將資料轉化為洞察力、知識和理解。透過這本實用的書籍，有志於成為資料科學家的讀者將學會如何使用R和RStudio進行資料科學研究，並利用tidyverse這組專為協同工作而設計的套件，讓資料科學實務變得更快速、流暢且有趣。即使沒有程式設計的經驗，本書最新版也能幫助你迅速進入資料科學的領域。你將學會如何匯入、變換和視覺化資料，並傳達結果。你還將獲得資料科學流程的整體理解，以及管理細節所需的基本工具。這一版針對最新的tidyverse功能和最佳實務做法進行了更新，有新的章節示範如何從試算表、資料庫和網站獲取資料。其中的習題也將幫助你實踐所學。你將學到如何：‧視覺化：為資料探索和結果的交流創建圖表‧變換：找出變數型別及處理它們的工具‧匯入：將資料匯入R並轉換為方便分析的形式‧程式設計：學習R語言的工具，以更清晰的方式輕鬆解決資料問題‧溝通：使用Quarto整合說明、程式碼和分析結果

本書針對在行為科學界中，想以 R 著手進階統計分析的讀者而撰寫。第二版大幅改寫 R 程式，採用整齊資料（tidy）有關的資料整理套件與繪圖，並搭配管線運算子（pipe operator）。本書每一章皆以真實的案例為資料來源，實際演示資料分析一系列的歷程，使讀者更容易熟悉資料分析與 R 程式的使用。• 全部以精選之臺灣實際資料示範。• 分析流程完整，包括探索資料、設定模型分析與診斷模型三個步驟。• 所有分析可以完全重製。適用課程︰「統計軟體應用」、「統計模型應用」、「資料分析」等相關課程。適用對象︰大學、技專校院相關學系大學部、研究所之學生，亦適合實務工作者。

如何運用資料說故事？資料科學最重要的功能在於解讀與呈現其意義。將資料產生的意義加以串接與形成更多理解世界的線索，並且讓他們的讀者更快、更精準地理解現象背後的真相。自周敦頤說「文，所以載道也」，後有「文以載道」一說。對資料科學家，「文以載道」就是資料寫作學：讓資料分析成為書寫。如果文件需要對資料作圖表處理和統計分析，用R Markdown 製作文件就是最佳選擇。編輯R Markdown可以直接在R Studio當中進行，在寫R Code分析數據的同時，同時撰寫分析報告，不需要在不同的軟體中進行切換，上手相當容易。在本書中，將使用RStudio的免費平台，建立好讀者製表、製圖與繪製地圖的基本功，以及運用Markdown語法，將R語法及結果直接與你的解讀編織(knit) 在一起，進而轉為簡報檔或一本線上圖書。分享、讓大眾理解數據資料蘊含的脈絡與現象，是資料寫作最大的價值。

«每個人的故事都有它的意義——透過挖掘劉宰的生命故事，探索南宋士人的崇高使命感 «不再侷限皇帝達官顯要的歷史——重新建構南宋基層社會樣貌 ◎「與士大夫共治天下」不是說說而已——致仕歸鄉仍有志於社會 劉宰是何許人也？劉宰並非南宋重臣名宦，身分僅為地方士人官僚，他在官途順遂且尚處壯年之時，毅然辭官返鄉。由於他過往擔任地方基層官的種種經驗，加之家鄉鎮江府金壇縣位處南宋與金的邊境，是當時南宋政局動盪的首衝之地，於是他選擇「退而不休」，不只積極號召、凝聚鄉親人力，更多次推動大型社會公益活動。 ◎小人物立大功——誰說只有權有勢的官宦才能影響政局及社會 縱然劉宰不似同時代的史彌遠、韓侂冑等人威名赫赫，劉宰雖已脫離官場，他仍時常與當權者通信，並且依據自己在地方地所聞所見，提供政策解決方案，同時對時局提出建言。他作為政府官方與地方士人的中介，促使南宋地方政府與基層社會緊密連結，展現南宋時代的獨特士人社會力。 作者結合地理環境和時代政局的變動，描繪劉宰一生所關注、推動以及與時代環境緊密連結的家國事業，藉由認識劉宰他的人格特質以及他所代表的南宋時代的士人社會力微觀研究出發，剖析環境與資源對區域的發展影響，建構出更完整的南宋社會樣貌，試圖從與過往不同的視角理解南宋在中國歷史轉型期的關鍵地位。 Huang Kuanchung is a social historian, political historian, cultural historian, and intellectual historian all at once. All his talents are in apparent in this fascinating and important study of Liu Zai 劉宰in Southern Song local society and national politics. 黃寬重同時是社會、政治、文化和思想史學家。他所有的才能，在這部精彩且重要的關於南宋地方社會和國家政治的劉宰研究中，顯露無遺。——Peter Bol（

«每個人的故事都有它的意義——透過挖掘劉宰的生命故事，探索南宋士人的崇高使命感 «不再侷限皇帝達官顯要的歷史——重新建構南宋基層社會樣貌 ◎「與士大夫共治天下」不是說說而已——致仕歸鄉仍有志於社會 劉宰是何許人也？劉宰並非南宋重臣名宦，身分僅為地方士人官僚，他在官途順遂且尚處壯年之時，毅然辭官返鄉。由於他過往擔任地方基層官的種種經驗，加之家鄉鎮江府金壇縣位處南宋與金的邊境，是當時南宋政局動盪的首衝之地，於是他選擇「退而不休」，不只積極號召、凝聚鄉親人力，更多次推動大型社會公益活動。 ◎小人物立大功——誰說只有權有勢的官宦才能影響政局及社會 縱然劉宰不似同時代的史彌遠、韓侂冑等人威名赫赫，劉宰雖已脫離官場，他仍時常與當權者通信，並且依據自己在地方地所聞所見，提供政策解決方案，同時對時局提出建言。他作為政府官方與地方士人的中介，促使南宋地方政府與基層社會緊密連結，展現南宋時代的獨特士人社會力。 作者結合地理環境和時代政局的變動，描繪劉宰一生所關注、推動以及與時代環境緊密連結的家國事業，藉由認識劉宰他的人格特質以及他所代表的南宋時代的士人社會力微觀研究出發，剖析環境與資源對區域的發展影響，建構出更完整的南宋社會樣貌，試圖從與過往不同的視角理解南宋在中國歷史轉型期的關鍵地位。 Huang Kuanchung is a social historian, political historian, cultural historian, and intellectual historian all at once. All his talents are in apparent in this fascinating and important study of Liu Zai 劉宰in Southern Song local society and national politics. 黃寬重同時是社會、政治、文化和思想史學家。他所有的才能，在這部精彩且重要的關於南宋地方社會和國家政治的劉宰研究中，顯露無遺。——Peter Bol（包弼德）&n

Welcome to the LEGO (R) Dreamzzz (TM) universe! Build your Mateo minifigure before joining him on an epic adventure to protect the dream world from the evil Nightmare King.

榮獲美國凱迪克大獎與Openbook 「年度童書」多項大獎 《翠翠掉下去了！》作者—科瑞．R. 塔博 最新萌作！ 我們都有「想要更多」的時候 但「獲得」不一定快樂，「失去」不一定難過 或許「分享」能帶來更快樂的滿足！！ ૮ฅ・ﻌ・აฅ 有一天，小狗賽門叼著一根骨頭來到池塘邊， 遇到了另一隻長得一模一樣的狗狗。 只是他嘴裡叼著的骨頭，比自己的「更棒」！ 賽門企圖想跟水裡的狗交換，認為那一定是根「更棒的」骨頭。 並用盡各種方法：大眼瞪小眼比賽、追尾巴比賽……軟硬兼施卻都換不來那根「更棒的」骨頭。究竟小狗賽門怎樣才能成功交換呢？ ꔛ本書特色ꔛ ★改編經典：跳脫傳統寓意，一起參與更多探討空間★ 改編《伊索寓言》:〈貪心的狗〉，跳脫原作「做人不貪心，懂得珍惜知足」寓意，作者為其延伸輕鬆又正向的結局，從中探討「失去」與「獲得」的定義。 ★親子共讀首選：向可愛的狗狗學習換位思考，提升孩子情緒力★ 透由簡單的故事，參與主人翁產生同理心並化為具體行動的過程，其結尾更是留下滿滿的韻味。十分適合引導小讀者思考其動機、轉換視角、建立同理心，並學習分享的快樂！ ★書本翻轉創意力：巧妙利用書的開本，身歷其境感受狗與倒影的距離！★ 延用《翠翠掉下去了！》互動式翻頁設計，讀者必須打直書本，由下往上翻頁閱讀。除了增添池塘上下方位的趣味，也能翻轉書本、觀察水中倒影的世界。池塘邊更出現前作主角—水鳥翠翠等小動物，適合與孩子一同尋找小彩蛋。 ★童趣又清爽的最萌畫風：在閱讀裡打開想像力★ 作者用童趣的蠟筆和柔美的水彩筆觸，充分將可愛質樸的故事表現的活靈活現。故事中更生動描繪主人翁狗狗賽門的神情，閱讀時大小讀者必定會心一笑。 *有注音 *推薦閱讀年齡：3歲～7歲親子共讀、7歲以上可自行閱讀。

第一本結合管理數學和Python、R應用的工具書，輕鬆獲得雙倍效果！管理的問題，就用數學來解決吧！令人驚呼的超強特色：1.淺顯易懂的口吻加上超豐富內容，一本掌握管理數學！2.附有精彩的範例、習題與解析，滿足所有練習慾望！3.用Python、R簡單搞定繁雜的數學計算，手把手跟著步驟走！讓數據分析成為管理的後盾，成就更無懈可擊的經營決策！管理數學為一門重要的基礎，不只是為了商業管理和決策，也是學習資料科學的第一步。現今不論是商管領域的學生或是從業人員，為了跟上世界的腳步，都必須學習程式語言，如果能在學習管理數學時搭配Python、R做使用，不只符合世界潮流，也等同開啓資料分析的大門。本書作者投入融合「計量經濟學和資料科學」的計量資料科學 (Econometric Data Science) 多年，對於以計量經濟學為基礎的資料科學猶有心得，本書由淺入深地介紹微分、積分、矩陣代數和數學規劃等管理數學必需的基礎與商管應用，此外，為達到與程式學習相輔相成之效，作者編排章節亦十分用心，在管理數學的16堂課中，穿插步驟式的Python、R教學單元，讓讀者學完數學原理和計算之後，能立刻熟悉Python與R的應用方式，學習效率更加倍！輕鬆就學會管理數學！

ONE OF THE MOST SPOKEN DIALECTS in China, Southeast Asia, and globally, Cantonese was nevertheless deemed a local dialect enjoying little prestige among the intellectuals. Not much was recorded in official documents or gazetteers about the early history of Hong Kong. The Cantonese language and its origin remained much of a mystery until the mid-20th century when scholars started to accord it with increasing attention. Thanks to dedicated efforts of early missionaries, pedagogues, and linguists, we can now trace back the evolution of modern Cantonese since the 19th century— how differences in sounds, words, and grammar distinguish the old from contemporary speech today. In this book, Hung-nin Samuel Cheung, an acclaimed scholar on the study of Cantonese, offers profound insights to various firsthand century-old materials including language manuals, Bible translations, and maps of Hong Kong, with findings that will be useful for ongoing efforts to study the development of